65 results about "Dihydrotestosterone" patented technology

The invention relates to the technical field of medicines, and discloses application of D-mannose in prevention and treatment of androgenetic alopecia. In the prior art, D-mannose can be a potential strategy for treating ferroptosis related diseases, can also be a non-prescription medicine supplement with high safety, and is used for treating neuritis diseases such as multiple sclerosis. The androgenic alopecia mouse model is constructed by utilizing dihydrotestosterone induction, the model mouse is subjected to mannose intervention, and the result shows that application of mannose can promote mouse hair growth, increase cortex thickness, promote hair regeneration and melanogenesis and effectively resist alopecia caused by dihydrotestosterone. The invention provides a new effect of mannose in prevention and treatment of androgenetic alopecia, and also provides a new strategy for prevention and treatment of androgenetic alopecia.

A formulation for drug delivery, providing enhanced modulation of solubility, stability, absorption, metabolism, and / or pharmacokinetic profile of a lipophilic therapeutic agent by formulation with sterols and / or sterol esters, resulting in higher bioavailability of a therapeutic agent administered to a subject in need of such therapeutic agent. The formulation contains a therapeutic agent and a sterol or sterol ester, and can, optionally, further contain a solubilizer and / or an enhancing agent. Also described are pharmaceutical compositions containing the formulations and methods of making and methods of using the formulations and pharmaceutical compositions. Formulations of the disclosure can be constituted to minimize the synthesis of dihydrotestosterone when the therapeutic agent includes testosterone or testosterone esters.

A natural supplement is described herein. The supplement includes a therapeutically effective amount of a composition. The composition includes: at least two materials having analgesic activity, at least two materials having anti-inflammatory activity, at least two materials having antioxidant activity, at least two materials having anti-neuralgic activity, at least two materials having blood circulation promotion activity, at least one material having Dihydrotestosterone (DHT) blocking activity, and at least one material having hair thickening activity or hair growth activity. The natural supplement not only provides pain relief from a variety of symptoms, but also promotes hair growth.

The invention discloses application of cannabidiol in preparation of a medicine for treating polycystic ovarian syndrome. Experiments on mice with dihydrotestosterone-induced polycystic ovarian syndrome show that cannabidiol can relieve the disorder state of the estrus cycle, improve the change of ovarian polycystic samples, reduce the number of atresia follicles, increase the number of corpus luteum, improve the level of serum progestational hormone, improve glucose and lipid metabolism and relieve anxiety for the first time; the traditional Chinese medicine composition can be used for treating polycystic ovarian syndrome. The invention provides a brand new thought for research and development of medicines for treating the polycystic ovarian syndrome, and has a wide application prospect.

The invention discloses an androgen alopecia slow-release therapeutic agent. The androgen alopecia slow-release therapeutic agent is rhizoma drynariae extracellular vesicles; or the rhizoma drynariae extracellular vesicles are compounded with minoxidil. The androgen alopecia slow-release therapeutic agent can effectively inhibit human hair follicle cell apoptosis and oxidative stress induced by dihydrotestosterone, and has excellent hair follicle targeting property and safety; the invention belongs to the technical field of medicine.

The invention provides an application of dimethylformamide in preparation of a product for preventing or treating androgenetic alopecia. When DHT (dihydrotestosterone) is used for constructing an androgenetic alopecia mouse model, it is found that after 30 mg / kg / d of dimethylformamide is given, the growth period of hair follicles is obviously accelerated, the hair density of a model mouse is effectively increased, and the hair recovery time is shortened. Organ-like experiments find that after the dimethylformamide treatment, the aggregation and fusion of the organ-like are obviously increased, and the NRF2 expression is also obviously enhanced. Therefore, the dimethylformamide has an effect of promoting the recovery of androgenetic alopecia and has the potential of being developed into corresponding medicines or cosmetics.

Disclosed are pharmaceutical and cosmetic compositions that include 5 Alpha Dihydrotestosterone (or alternatively, 5α-DHT, 5 Alpha-DHT, 5 Alpha DHT, 5a-DHT, DHT), and associated methods of use and treatment that can be used alone or in combination with other treatments to provide, improve, or promote general well-being and health, including mental health, in a subject. In particular the compositions, methods, and uses can provide, promote, support, and / or improve outcomes associated with gender reassignment, gender transitioning, and / or gender-affirming therapy in a subject who may be in need thereof.

The present invention relates to a method for detecting steroid hormones in serum, comprising the following steps: (1) adding 0.1 to 20 mg of a magnetic solid phase extractant to each milliliter of a sample to be tested, mixing, magnetically separating, and removing liquid; adding a washing solution, mixing, magnetically separating, and removing liquid; adding an eluent for elution, mixing, magnetically separating, and collecting the eluent to obtain a test solution; (2) detecting the hormone content in the test solution by liquid chromatography and tandem mass spectrometry; wherein the hormone is selected from any one of testosterone, androstenedione, dihydrotestosterone, dehydroepiandrosterone sulfate, and 17α-hydroxyprogesterone or a combination thereof; the magnetic solid phase extractant comprises a magnetic core ferrosoferric oxide, a middle layer structure silica wrapping the magnetic core, and an outer layer mesoporous structure, wherein the outer layer mesoporous structure is selected from any one of polystyrene and polystyrene divinylbenzene or a combination thereof. The present invention has the characteristics of good stability, high accuracy and sensitivity, strong specificity, high recovery rate, simple and controllable operation, fast analysis speed, etc., and can be used for simultaneous quantitative detection of multiple hormones in clinical practice.

Disclosed are pharmaceutical and cosmetic compositions that include 5 Alpha Dihydrotestosterone (or alternatively, 5α-DHT, 5 Alpha-DHT, 5 Alpha DHT, 5a-DHT, DHT), and associated methods of use and treatment that can be used alone or in combination with other treatments to provide, improve, or promote general well-being and health, including mental health, in a subject. In particular the compositions, methods, and uses can provide, promote, support, and / or improve outcomes associated with gender reassignment, gender transitioning, and / or gender-affirming therapy in a subject who may be in need thereof.

The present invention provides a composition for improving, preventing, or treating prostate disease, comprising hemp seed oil as an active ingredient. A functional composition comprising hemp seed oil as an active ingredient, according to the present invention, reduces the prostate weight of benign prostatic hyperplasia patients, reduces blood prostate-specific antigen (PSA), dihydrotestosterone (DHT), and 5-alpha reductase I levels, and also has excellent cell growth inhibitory ability with respect to prostate cancer cells. Thus, the functional composition comprising hemp seed oil as an active ingredient, according to the present invention, is expected to be capable of exhibiting a preventive, relieving, or therapeutic effect on prostate disease including benign prostatic hyperplasia and prostate cancer.

The present invention discloses a new therapeutic target and small molecule inhibitor for promoting hair growth and improving androgenic alopecia. We found that the key molecule of necroptosis, the mixed lineage kinase domain-like protein (MLKL), plays a key role in the regulation of the hair cycle. The small molecule drug NSA is used to target and inhibit the activation of MLKL, which can accelerate the transition from the resting phase to the growth phase of the hair follicles on the back of mice, thereby promoting hair growth. Furthermore, we used dihydrotestosterone DHT to induce an AGA mouse model. In the AGA mouse model, it was found that inhibiting MLKL can antagonize the inhibitory effect of DHT on mouse hair growth, indicating that inhibiting MLKL may have a certain improvement effect on AGA. Therefore, MLKL can be used as a therapeutic target for promoting hair growth and improving AGA, and its inhibitor NSA can target and inhibit MLKL activity to promote hair growth and treat AGA.

Provided is the composition capable of effectively exerting an effect on a change in a hormone balance. A composition for inhibiting the decrease in endogenous testosterone and / or dihydrotestosterone, the composition comprising Cordyceps militaris derived from Samia cynthia ricini and / or its extract is prepared.

Provided herein are antigen-binding protein-drug conjugates and compositions thereof that are useful, for example, for target-specific delivery of therapeutic moieties, e.g., testosterone analogs and / or derivatives. Dihydrotestosterone analogs, antibody-drug conjugates, and compositions which comprise glutaminyl-modified antibodies and dihydrotestosterone analogs and are provided.

The invention provides a traditional Chinese medicine composition for preventing hair loss and promoting hair growth and application thereof, and relates to the technical field of hair loss prevention and promoting hair growth, the traditional Chinese medicine composition is composed of Chinese doughnut, cockscomb, albizia flower, Chinese honey locust, schizonepeta, lithospermum, polygonum multiflorum, prepared rehmannia root, notopterygium root, radix angelicae pubescentis, ruddle and periostracum cicada; in-vitro experiments show that the traditional Chinese medicine composition can promote proliferation of human dermal papilla cells HDPC, relieve the damage degree of HDPC and induce cycle transformation of hair follicles, so that the effect of promoting hair growth is achieved; animal experiments show that the traditional Chinese medicine composition can significantly increase the number of hair follicles and the thickness of skin and dermis fat of mice, reduce the levels of mouse serum IL-2, TNF-alpha and TGF-beta1 and reduce the levels of testosterone, dihydrotestosterone and estradiol in mouse skin tissue, so that hair follicle fibrosis is inhibited, the growth period of hair follicles is accelerated, the growth period is prolonged, the hair loss phenomenon is improved, and the hair loss rate is increased. The hair growth is promoted.

The invention discloses an anti-hair-loss composition containing a cacumen biotae extract and a preparation method of the anti-hair-loss composition, and particularly belongs to the technical field of scalp care and raw material compounding. The anti-hair loss composition comprises the following components: 8-12 parts of a red ginseng extract, 8-12 parts of a Chinese arborvitae twig and leaf extract, 3-4 parts of a flat ground mushroom extract, 2-3 parts of a dendrobium officinale stem extract and 1-2 parts of lactobacillus / ginseng root fermentation product filtrate. The anti-alopecia composition provided by the invention has a remarkable effect of inhibiting the activity of 5alpha-reductase, can remarkably improve the alopecia phenomenon of mice, inhibits the generation of testosterone and dihydrotestosterone, and reduces the risk of androgen-derived alopecia.

The present disclosure describes a method for preventing or treating an abnormal mammary gland cytopathy characterized by cell proliferation in a subject. The method comprises administering to the subject an effective amount of an androgen agent in combination with an effective amount of an aromatase inhibitor, increasing the concentration of the androgen agent in serum to a level to increase the intramammary concentration of androgen in the mammary gland resulting from the action of 5 alpha-reductase on the androgen agent, the increased intramammary concentration of the androgen induces inhibition of c-Myc and / or mTOR expression or activity in the mammary gland associated with a lower intramammary concentration of the androgen. The increase in the serum concentration of the androgen agent and the increase in the intramammary concentration of the androgen are maintained for a predetermined period of time without substantially increasing the concentration of the androgen in the serum of the subject. Furthermore, the use of the aforementioned androgen and aromatase inhibitors for reducing the risk of breast cancer progression to hormone-resistant breast cancer, reducing the risk of HER2-positive breast cancer becoming insensitive to targeted HER-2 anti-cancer drug therapy, and for inducing inhibition of c-Myc and / or mTOR expression and / or activity is also described. In embodiments, the androgen agent may be testosterone and androgen 5 [alpha]-dihydrotestosterone (DHT).

The present invention relates to a composition for preventing, ameliorating or treating benign prostatic hyperplasia, containing a Hovenia dulcis extract as an active ingredient. Specifically, the Hovenia dulcis extract of the present invention was confirmed to inhibit the proliferation of hyperproliferative prostatic cells induced by dihydrotestosterone (DHT), which is a male hormone, and reduce prostate weight in an animal model with induced benign prostatic hyperplasia, and thus can be effectively used as a composition for preventing, ameliorating or treating benign prostatic hyperplasia.

Novel chemical agents are described herein. More specifically, a novel inhibitor of 17β-HSD7 for decreasing estradiol concentrations while restoring dihydrotestosterone (DHT) concentrations in breast cancer cells is disclosed herein. In a particular embodiment, the inhibitor of 17β-HSD7 has the following structure: (Formula I) A process for producing the novel inhibitors of 17β-HSD7 and their use in the manufacture of pharmaceutical formulations and / or combinations is also disclosed.

The application relates to the technical field of biology, and discloses a method for inducing a cell line of immortalized musk deer scent glands to synthesize dihydrotestosterone, wherein the cell line is obtained by transfecting a primary musk deer scent gland epithelial cell with a lentivirus carrying an SV40 Large T antigen and performing resistance screening; the cell line is in an epithelial cell form and stably expresses keratin 18, cholesterol side chain cleavage enzyme, 17 alpha-hydroxylase and 3 beta-hydroxysteroid dehydrogenase. Through lentivirus-mediated SV40 Large T antigen transfection, the primary musk deer scent gland epithelial cell breaks through the limit of replicative senescence and obtains unlimited proliferation capacity, effectively overcomes the defects that the primary cell is prone to fibrosis and rapidly loses metabolic function during in-vitro culture, provides a standardized cell model with a clear genetic background and persistent metabolic activity for biological manufacturing of dihydrotestosterone, and relieves the dependence on endangered animal live resources.

The invention discloses application of portulaca oleracea polysaccharide in preparation of a feed additive for preventing male animal reproductive injury caused by zearalenone. The animal is a lactation animal. Experimental verification proves that the portulaca oleracea polysaccharide has the following effects: (1) the portulaca oleracea polysaccharide can effectively relieve the damage of ZEA to a male reproductive system and recover the normal physiological status and sperm quantity of reproductive organs of male animals; (2) the damage of ZEA to male testis epididymis tissues can be obviously reduced; and testis and epididymis organ coefficient increase and tissue structure swelling caused by the testis and epididymis are improved, and an excellent protection effect is achieved. (3) serum androgen secretion disorder caused by ZEA can be effectively recovered; normal physiological functions are recovered by regulating secretion of testosterone and dihydrotestosterone. Therefore, when male reproductive injury caused by zearalenone of male animals is prevented, the portulaca oleracea polysaccharide can be added into animal feed as a feed additive.

The present invention relates to a composition for preventing or treating male pattern hair loss by adsorption and / or removal of dihydrotestosterone (DHT), and uses thereof, wherein the composition comprises a metal-organic framework, which penetrates hair follicles and, by adsorbing and / or removing DHT, can exhibit preventive or therapeutic effects against the progression of hair loss. In addition, when the composition is applied to the scalp as a hair serum or a hair cream comprising the metal-organic framework, the metal-organic framework penetrates hair follicles and can continuously adsorb / remove DHT that is continuously released in the body, and the metal-organic framework that has adsorbed and / or removed DHT can be discharged to the outside as the hair grows.

The present invention discloses serum metabolic markers and their application in evaluating the stability of intracranial artery plaques, belonging to the field of biomedical technology. The serum biomarkers are selected from one or a combination of phosphatidylcholine PC(15:0 / 15:1), phosphatidylcholine PC(14:0 / 18:2), phosphatidylethanol PE(18:2 / 18:3), phosphatidylethanol PE 18:1e / 18:1, 5α-dihydrotestosterone, D-fructose 6-phosphate, phosphatidylcholine PC(14:0 / 18:2), sphingomyelin SM(d28:0 / 14:1), phosphatidylcholine PC(20:3 / 22:6), and phosphatidylcholine PC(20:3 / 20:4), providing a new direction for the treatment or intervention of atherosclerosis.

This invention reverses male pattern baldness by shocking dormant hair follicles out of their androgen induced hibernation phase back to the active hair-growing anagenic phase. The invention integrates two functions: 1) It blocks synthesis of compounds holding the follicles in the telogenic / hibernating phase and 2) It stimulates synthesis of compounds animating the hair-growing / anagenic phase in the follicular activity cycle. One preferred embodiment comprises an enzyme inhibitor blocking the conversion of testosterone to dihydrotestosterone (DHT), a flavonoid simultaneously increasing synthesis of prostaglandins alternative to prostaglandin D2, and a selected cannabinoid compound stimulating restore the hair follicle to its normal growth cycle. This novel trimodal therapy restores the hair follicles to their normal cycling processes and maintains these restorative properties so long as this rebalance in maintained.

The application provides application of echinocystic acid in preparation of a 5alpha-reductase type II inhibitor product. In-vitro tests prove that the echinocystic acid has obvious inhibitory effect on 5alpha-reductase type II activity; experimental testosterone-induced androgenic alopecia mouse models prove that the echinocystic acid can promote hair growth of the mice and reduce dihydrotestosterone content in the skin of the mice, and can be used for preparing a product for inhibiting 5alpha-reductase type II activity and treating androgenic alopecia.

The invention provides a kit for simultaneously detecting six steroid hormones and application of the kit. The steroid hormones comprise testosterone, androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, dihydrotestosterone and 17alpha-hydroxyprogesterone. The kit comprises extract liquor, a mobile phase additive and a standard quality control product. The kit provided by the invention can be used for simultaneously detecting testosterone, androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, dihydrotestosterone and 17alpha-hydroxyprogesterone, and has the advantages of high accuracy, low quantitation limit and wide detection range.

The invention discloses application of a semen nigellae extract in preparation of a product for preventing and / or treating androgenetic alopecia. The total content of nigella alkaloid and nigella alkaloid 4-O-sulfite in the nigella seed extract is not less than 2%. The preparation process comprises the following steps: degreasing nigellum nigrum medicinal material powder with petroleum ether, extracting with an acidic aqueous solution, and enriching with macroporous adsorption resin and specifically purifying with anion exchange resin in sequence. Experiments show that the extract can most significantly reduce the levels of testosterone (T), dihydrotestosterone (DHT) and creatinine (Cr) in an androgenetic alopecia model mouse body, increase the level of estradiol (E2) and effectively promote back hair regeneration, and the effect of the extract is significantly superior to that of a water extract, an alcohol extract and a positive control drug. The extract is clear in component and controllable in quality, can be used for preparing medicines or wash supplies with multi-target anti-hair loss and hair growth functions, and provides a novel efficient natural raw material for treating androgenetic alopecia.

Provided are androstane and dihydrotestosterone compounds functionalized with carbocyclic groups or heterocyclic groups that may be saturated or unsaturated. The compounds may be used in methods of inhibiting cell growth of malignant cells and / or hyperplastic cells and / or treating individuals having diseases associated with malignant cell growth (e.g., cancer, such as, for example, prostate cancer) and / or hyperplastic cell growth and / or molecular imaging of malignant cells and / or hyperplastic cells and / or inducing degradation of a target protein. Also provided are compositions.

The invention discloses an oil control composition for regulating sebaceous glands and a preparation method and application thereof, and belongs to the technical field of cosmetics, the oil control composition for regulating sebaceous glands comprises the following components in parts by mass: 0.5-10 parts of 10-hydroxydecanoic acid, 5-25 parts of sarcosine and 5-50 parts of an oil control agent, the oil control agent comprises a Thermus thermophilus fermentation product, the mass percentage content of the Thermus thermophilus fermentation product in the oil control agent is not less than 80%; the 10-hydroxydecanoic acid, the sarcosine and the oil control agent are combined according to the specific mass parts to obtain the composition with an excellent oil control effect, and the composition can effectively inhibit 5 alpha-reductase in sebaceous gland cells, reduce conversion of testosterone to dihydrotestosterone (DHT), inhibit sebaceous gland secretion and reduce grease accumulation on the skin surface, so that the sebaceous gland skin-care effect is improved, and the skin-care effect is improved. Pore blockage is reduced, the number of active sebaceous gland bodies is reduced, the secretion activity of the active sebaceous gland bodies is reduced, and skin grease is effectively reduced.

The invention provides an application of echinocystic acid in preparation of a type II 5 alpha-reductase inhibitor product. In-vitro tests prove that echinocystic acid has an obvious inhibition effect on the activity of II type 5 alpha-reductase; experimental testosterone-induced androgenic alopecia mouse models prove that echinocystic acid can promote mouse hair growth and reduce the content of dihydrotestosterone in mouse skin, and can be used for preparing products for treating androgenic alopecia by inhibiting the activity of type II 5alpha-reductase.

The invention discloses application of ruscogenin in preparation of products for preventing and / or treating alopecia, and belongs to the technical field of medicines. The invention finds that ruscogenin can inhibit the activity of 5alpha-reductase, inhibit death of human dermal hair follicle nipple cells caused by dihydrotestosterone, promote proliferation of the human dermal hair follicle nipple cells and promote hair growth. The ruscogenin can be applied to preparation of products for preventing and / or treating alopecia, new application of the ruscogenin is provided, and a new choice is provided for preventing and treating alopecia.