166 results about "Sterol ester" patented technology

A formulation for drug delivery, providing enhanced modulation of solubility, stability, absorption, metabolism, and/or pharmacokinetic profile of a lipophilic therapeutic agent by formulation with sterols and/or sterol esters, resulting in higher bioavailability of a therapeutic agent administered to a subject in need of such therapeutic agent. The formulation contains a therapeutic agent and a sterol or sterol ester, and can, optionally, further contain a solubilizer and/or an enhancing agent. Also described are pharmaceutical compositions containing the formulations and methods of making and methods of using the formulations and pharmaceutical compositions. Formulations of the disclosure can be constituted to minimize the synthesis of dihydrotestosterone when the therapeutic agent includes testosterone or testosterone esters.

The present invention provides a non-naturally occurring High-Density Lipoprotein-like peptide-phospholipid scaffold (“HPPS”) nanoparticle. More particularly, the invention provides a non-naturally occurring peptide-lipid nanoscaffold comprising: (a) at least one phospholipid; (b) at least one unsaturated lipid, preferably an unsaturated sterol ester, further preferably an unsaturated cholesterol ester, further preferably cholsteryl oleate; and (c) at least one peptide, the peptide comprising an amino acid sequence capable of forming at least one amphipathic a-helix; wherein the components a), b) and c) associate to form the peptide-phospholipid nanoscaffold. In embodiments of the present invention, a cell surface receptor ligand is incorporated into the HPPS. In one embodiment, the cell surface receptor ligand is covalently bonded to the peptide scaffold of the HPPS nanoparticles. In other embodiments, a cell surface receptor ligand is coupled to a lipid anchor and is displayed on the surface of the HPPS nanoparticles by incorporation of the lipid anchor into the phospholipids monolayer of the HPPS nanoparticle. The present invention also provides pharmaceutical formulations comprising HPPS nanoparticles and methods of making the HPPS nanoparticles.

A process for separating VE, sterol and sterolester from the deodored distillate of plant oil features that the sterol is separated out by directly dynamic crystallizing, the lipase is used to convert the fatty acid in oil and the neutral oil to methylester of fatty acid, and the molecular distillation is used to separate high-purity methylester of fatty acid and VE.

Provided are an oxidation hair dye and a hair bleach, in particular, an oxidation hair dye and a hair bleach effective in use on dyed hair which has solved the problems in using oxidation hair dye or hair bleach, specifically problems such as hair showing a hard and unfavorable texture when treated by oxidation hair dye and hair bleach due to damage to the hair from those agents. An oxidation hair dye characterized by comprising ceramides and/or sterol esters, lecithin or a lecithin derivative and silicones.

Antiperspirant compositions herein comprise an antiperspirant active, a carrier and a structurant for the carrier which comprises an effective concentration of a combination of at least one sterol and at least one sterol ester, to form a solid or a soft solid. The compositions can be anhydrous and in the form of a suspension of antiperspirant active, or can comprise aqueous emulsions.A particularly suitable sterol comprises beta sitosterol and a particularly preferred sterol ester comprises oryzanol. Preferably the mole ratio of sterol to sterol ester is in the range of 3:1 to 1:2.

The invention discloses a method wwhich extracts phytosterol from vegetable oil asphaltum, the technology of this method is simple, and the material is cheap and facile, the productivity of product is high, the cost of product is low. The method of this invention is translating the free fatty acid of material into fatty acid ester by using esterification, getting oil phase containing much sterol ester by wash, then getting the product via the alcoholysis of free fatty acid in material by organic solvent, forming a fire-new process flow, realizing the of natural sterol.

Compositions in powder form of sterols or stanol esters, and milk powder and/or proteins are disclosed. A process of making the compositions is also disclosed. The suitability of incorporation of the compositions in powder form in food products, for example beverages and milk products, is also disclosed.

Compositions containing extracts of Aloe which are suitable for dietary supplements and/or functional food products are disclosed. The compositions which further comprise extracts of other plants are also disclosed. The compositions of extracts of Aloe in combination with chitosans, fatty acids, sterols and/or sterol esters are additionally disclosed. The compositions disclosed induce satiety and/or reduce the appetite.

The invention provides morinda citrifolia enzyme skin whitening sunscreen cream and a preparation method thereof. The morinda citrifolia enzyme skin whitening sunscreen cream, in percentage by weight, comprises the following components: stearin, hexadecyl/octadecyl natural fatty alcohol, caprylic/capric triglyceride, isononyl isononanoate, jojoba oil, polydimethylsiloxane, sterol ester, vitamin E, methylparaben, propylparaben, glycerol, an amino acid moisturizer, allantoin, lauryl alcohol ether, morinda citrifolia enzyme and deionized water. The morinda citrifolia enzyme skin whitening sunscreen cream provided by the invention has obvious free radical scavenging capability, can effectively inhibit growth of melanin and has good ultraviolet absorption effect and realizes skin whitening, sunscreen and skin protection effects, the preparation method is simple and easy to operate, and production cost is relatively low.

A confectionery chew for lowering serum cholesterol in an animal in need thereof including a carbohydrate, a seeding agent, which can be a fondant, a structuring agent, which can be a protein, a starch, a hydrocolloid, and mixtures thereof, and cholesterol lowering agent selected from a sterol, a sterol ester, a stanol, a stanol ester, and mixtures thereof.

The invention discloses a phytosterol and sterol ester preparing method. The preparing method includes the steps that vegetable oil deodorized distillate is used as a raw material and is heated and filtered to remove impurities; the reaction material and low-carbon monohydric alcohol are fully mixed and heated and pass through a cationic resin column; the low-carbon monohydric alcohol and water are removed in a pressure reduction mode; crystallization is carried out, and coarse solid phase plant phytosterol and a liquid phase substance are obtained through filtering and separating; secondary crystallization is carried out, and refined solid phase plant phytosterol is obtained through filtering and separating; the obtained solid phase plant phytosterol is dried to obtain phytosterol; phytosterol and fatty acid methyl ester are mixed and heated to 85 DEG C to be fully dissolved; a catalyst sodium methylate is put, the temperature is raised to 135-150 DEG C for pressure-reduction reaction; the reaction liquid is cooled to 80 DEG C and washed to be neutral; after washing, the reaction liquid is subjected to molecular distillation to obtain phytosterol. The preparing method has the advantages of being low in production cost, stable in process index and high in product yield.

The invention relates to a method for the production of oxidation-stable sterol formulations, wherein catechins and/or the derivatives thereof are added to the sterols or sterol esters, and to the formulations produced according to said method. The catechins are preferably used in an amount of 20 to 1000 ppm, based on the sterol or on the sterol ester. Green tea extract may be incorporated as the catechin formulation. The formulations containing sterols produced according to said method have very high oxidative stability and have no displeasing aftertaste.

Personal care composition including a first skin and/or hair care active cetyl pyridinium chloride; and at least one additional skin and/or hair care active selected from the group consisting of tetrahydrocurcumin, sugar amine, vitamin B₃, retinoids, hydroquinone, peptides, phytosterol, dialkanoyl hydroxyproline, hexamidine, salicylic acid, n-acyl amino acid compounds, sunscreen actives, water soluble vitamins, oil soluble vitamins, hesperedin, mustard seed extract, glycyrrhizic acid, glycyrrhetinic acid, carnosine, Butylated Hydroxytoluene (BHT) and Butylated Hydroxyanisole (BHA), ergothioneine, vanillin or its derivatives, diethylhexyl syrinylidene malonate, melanostatine, sterol esters, idebenone, dehydroacetic acid, Licohalcone A, creatine, creatinine, feverfew extract, yeast extract, beta glucans, alpha glucans, their salts, their derivatives, their precursors, and/or combinations thereof; and a dermatologically acceptable carrier. The invention further relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of the personal care composition of the invention.

The invention provides a method for degumming with magnetic immobilized phospholipase A2. The method comprises the steps of adding magnetic immobilized PLA2 (phospholipase A2) into soybean raw oil for degumming, and recycling magnetic immobilized enzyme with a magnetic field after a reaction is finished. For determination of a phosphorus content after the degumming, oil yield and recycling times of immobilized PLA2, the obtained minimum phosphorus content after the degumming is 20ppm, and the relative activity of the immobilized enzyme keeps around 80% after the oil yield is increased by 1.2%, and magnetic immobilized PLA2 is continuously utilized for eight lots. After magnetic immobilized PLA2, phospholipid formation in degumming oil can be increased; separation of an oil phase and a gum phase is improved; formation of free fatty acid in the degumming oil can be controlled; and sterol can be re-esterified with free fatty acid to form sterol ester to become a part of edible oil. Therefore, physical refining is realized, and the yield of the degumming oil can be increased. The high quality degumming oil with a low phosphorus content can be produced, and the degumming oil contains higher-content functional plant sterol ester at the same time.

The invention relates to preparation and application of a gene and chemotherapeutic drug co-delivery anti-tumor nanoparticle of a target SR-BI (Scavenger Receptor-BI). The nanoparticle is a recombinant high density lipoprotein drug-loaded nanoparticle, comprises phospholipid, cholesterol, cholesteryl ester, apolipoprotein, cation lipid, a chemotherapeutic drug, a gene drug and the like, and is prepared by a film dispersion method. The invention aims at preparing the bionic tumor target drug-loaded nanoparticle, the preparation condition is mild, and the cost is low. The invention further provides the application of the gene and chemotherapeutic drug co-delivery anti-tumor nanoparticle. The gene and chemotherapeutic drug co-delivery anti-tumor nanoparticle has the advantages of spherical structure, good encapsulation efficiency, low cytotoxicity, good targeting, high safety, significant in-vitro anti-tumor effect and the like.

The invention relates to a process for isolating sterols and tocopherols from mixtures of fats and fatty derivatives and from residues left after they have been worked up. After splitting of the glycerides by hydrolysis and subsequent removal of the free fatty acids by distillation, the sterol esters still present are largely split into free sterols by an additional hydrolysis step.

A technique for increasing the strength of paperboard or corrugated paperboard by using laccase to treat the OCC pulp, unbleached chemical pulp, or semi-chemical pulp is disclosed. As the circulated white liquid used in making paperboard with said unbleached chemical pulp, semi-chemical pulp and OCC pulp contains a lot of fine fibers, sterol ester, abietic acid, lignan and lignin, which carry a great deal of anions to decrease the effect of strengthening agent and result in environmental pollution, the laccase is used for the catalytic oxidization of wooden fibers to generate the free phenoloxy radicals on the surfaces of wooden fibers and improve the binding strength between fibers.