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Biomarker for diagnosing white matter lesion and application thereof

A biomarker and white matter technology, applied in the field of biomarkers for diagnosing and diagnosing white matter lesions, can solve the problems of unclear prediction and diagnosis of white matter lesions, and achieve the effect of preventing and diagnosing white matter lesions.

Active Publication Date: 2021-05-14
BAO FENG BIOTECH (BEIJING) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is unclear which substance can be clearly detected as the prediction and diagnosis of white matter lesions.

Method used

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  • Biomarker for diagnosing white matter lesion and application thereof
  • Biomarker for diagnosing white matter lesion and application thereof
  • Biomarker for diagnosing white matter lesion and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Sample collection: Serum from patients with normal and white matter lesions clinically evaluated was selected for testing.

[0029] The sample group used for model establishment is 112 people, age range: over 45 years old, including 64 people in the control group and 48 people in the patient group.

[0030] The male to female ratio in the control population was 1:1, and magnetic resonance imaging showed no abnormalities.

[0031] The male to female ratio in the patient population was 1:1, and magnetic resonance imaging showed infarcts in the white matter of the brain.

[0032] Experimental Instruments and Reagents

[0033] Experimental equipment: 1. Vortex oscillator: model MX-S, Scilogex, USA; 2. High-resolution mass spectrometer: ESI-QTOF / MS; model: Xevo G2-S Q-TOF; manufacturer: Waters, Manchester, UK3. Refrigerated centrifuge: model D3024R, Scilogex, USA; 4. Ultra-high performance liquid chromatography: UPLC, model: ACQUITY UPLC I-Class system; manufacturer: Water...

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Abstract

The invention provides a biomarker for diagnosing white matter lesion and application thereof, and the biomarker is 6Z, 9Z, 20-eicosatrienoic acid. The biomarker 6Z, 9Z, 20-eicosatrienoic acid is combined with ceramide (m18: 1 (4E) / 24: 1 (15Z)), ephedrine A, cucurbitacine E, cholesteryl ester 22: 6 or ceramide (d18: 0 / 24: 1 (15Z)) for judging whether white matter lesion exists or not. The biomarker for diagnosing the white matter lesion is used for preparing a diagnostic reagent for predicting or diagnosing the white matter lesion, and is beneficial for diagnosing whether the white matter lesion tends to exist or not and preventing the white matter lesion in advance.

Description

technical field [0001] The invention belongs to the technical field of biological detection, and in particular relates to a biomarker for diagnosing cerebral white matter lesions and an application thereof. Background technique [0002] White matter lesion (WML) is a common neurodegenerative disease, the most typical pathological manifestations are damage to the integrity of white matter or demyelination, which is common in stroke, Alzheimer's disease, Multiple sclerosis, Parkinson's disease, schizophrenia and many other diseases. White matter is an important part of the central nervous system, where nerve fibers gather. Damage to the myelin sheath of central nerve cells in white matter can cause white matter lesions. The typical response of white matter to various harmful stimuli is demyelination, which can be a secondary manifestation of neurological diseases such as infection, degeneration, poisoning, trauma, and lack of infarction. White matter lesions mainly cause sym...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50
CPCG01N33/50G01N2800/28
Inventor 陈显扬宋王婷张珂薛腾韩佳睿
Owner BAO FENG BIOTECH (BEIJING) CO LTD
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