282 results about "Ceramide AP" patented technology

The invention relates to the technical field of automatic control, in particular to a monitoring method and system for synthesizing ceramide based on alpha-hydroxy fatty acid, and the monitoring system for synthesizing ceramide based on alpha-hydroxy fatty acid comprises a raw material feeding module, a reaction control module, a quenching-crystallization joint control module and a data integration module; carrying out dynamic weighing monitoring on the raw materials based on the received synthesis instruction, and starting a reaction kettle according to weighing data; performing multi-dimensional data acquisition in real time according to the set reaction data, and performing dynamic feeding control according to the set reaction data; when the TLC detection substrate reaction is completed, the cooling process and the crystallization process are regulated and controlled in real time according to the reaction data until the end point judgment standard is met; according to a received synthesis completion instruction, product quality data is obtained, a monitoring data packet is generated, the synthesis instruction is marked and then stored, process control is accurately monitored and controlled, and the purity and crystal form of the product are ensured.

The invention relates to a composition containing ceramide and collagen tripeptide and a preparation method thereof, and belongs to the technical field of health care products. The invention discloses a composition containing ceramide and collagen tripeptide. The composition is prepared from the following raw materials: collagen tripeptide, rice bran oil powder, a herba houttuyniae extract, pineapple powder, konjaku flour, a grape seed extract, olive fruit powder, carnosine, pomegranate concentrated powder and a whey fermentation product. The grape seed extract, the olive fruit powder, the carnosine and the pomegranate concentrated powder inhibit the Maillard reaction of the collagen peptide and improve the utilization rate of collagen tripeptide; ceramide rich in the rice bran oil powder is a natural skin moisturizing factor, and is matched with the pineapple powder and the konjaku flour which have a keratin metabolism effect to maintain the health of cuticles; the herba houttuyniae extract and the whey fermentation product are matched to have an excellent anti-inflammatory effect, so that the components enhance the skin barrier in multiple dimensions through collagen synthesis, cuticle maintenance, anti-inflammatory and anti-oxidation.

The invention provides an acne-removing composition containing ceramide, a preparation method of the acne-removing composition and an acne-removing product, and the acne-removing composition is prepared from the following components in parts by weight: 5 to 10 parts of plant extract, 1 to 3 parts of ceramide, 1 to 3 parts of gentiopicroside-vitamin C eutectic, 1 to 3 parts of compound polysaccharide and 0.3 to 0.7 part of transdermal enhancer. The plant extract is prepared from a herba dendrobii fruticosae flower extract, a lasiocarpus trifoliatus extract and a hedera rhododendron extract in a mass ratio of 1: (1-3): (2-4); the compound polysaccharide is prepared from tremella polysaccharide, tamarind seed polysaccharide and ganoderma lucidum polysaccharide in a ratio of 1: (3-5): (0.5-0.8); the transdermal enhancer is prepared from a cucumber extract and a salvia miltiorrhiza root extract in a mass ratio of 1: (1-3). The plant extracts in the acne-removing composition take effect synergistically, the acne-removing effect is achieved from multiple aspects of bacteriostasis, anti-inflammation and oil control, the purpose of efficiently removing acnes without relapse is achieved, and the natural plant extracts are mild and non-irritant, do not cause burden to the skin and have good application prospects.

The invention discloses a method for synthesizing ceramide NP through two-step enzyme catalysis, which comprises the following steps of: firstly, adding lipase into vegetable oil to catalyze and combine fatty acid to decompose into free fatty acid, and centrifuging to remove the lipase; a small amount of phytosphingosine is added into the hydrolyzed vegetable oil, the raw material vegetable oil is used as a solvent or a squalane system solvent for incubation, and then immobilized lipase is added for catalytic synthesis of ceramide. The invention establishes a two-enzyme method for efficiently synthesizing the ceramide NP compound, and the process is natural, environment-friendly and non-toxic. The reaction conditions are optimized through response surface analysis, meanwhile, the immobilized lipase shows excellent cycle performance, and the method is easy to operate, environmentally friendly, green and economical and has wide application prospects in the fields of cosmetics, health care products, biological medicine and the like.

The invention belongs to the technical field of biomedicine, and particularly relates to application of ceramide as a marker in prediction of hepatocellular carcinoma microvascular invasion risk. The invention finds that the preoperative plasma ceramide CER (d18: 1 / 16: 0) level can be used for predicting the MVI of HBV-HCC patients and evaluating the postoperative prognosis of the patients for the first time. The invention provides a preoperative non-invasive detection method based on plasma ceramide CER (d18: 1 / 16: 0), and trauma of traditional histopathology detection is avoided. According to the method, the occurrence risk of the MVI can be effectively reduced by simply detecting a blood sample of a patient. According to the method, the MVI risk of a patient is evaluated through a multi-factor prediction model, and a basis is provided for personalized treatment. The method is not only suitable for preoperative MVI risk assessment, but also can assist in making postoperative follow-up visit and treatment plans, and helps to reduce the postoperative recurrence rate and improve the survival rate of patients.

The invention discloses a lipid composition for preparing extracellular vesicles, which is prepared from the following lipid substances in percentage by mass: 2 to 18 percent of phosphatidylcholine, 2 to 14 percent of phosphatidylethanolamine, 7 to 27 percent of sphingomyelin, 0.5 to 7 percent of ceramide, 1.5 to 2.5 percent of phosphatidylinositol, 30 to 70 percent of cholesterol and 5 to 8 percent of phosphatidylserine, the fatty acid carbon number of the lipid substance satisfies the following conditions: the fatty acid carbon number of phosphatidylcholine is 16-20, the fatty acid carbon number of phosphatidyl ethanolamine is 16-18, the fatty acid carbon number of sphingomyelin is 16-24, the fatty acid carbon number of ceramide is 16-24, the fatty acid carbon number of phosphatidylinositol is 16-20, the fatty acid carbon number of phosphatidylserine is 18-24, and the molar ratio of cholesterol to sphingomyelin is 4-7. The extracellular vesicles are prepared from the lipid composition and used for biomarkers or drug carriers, and efficient oral drug delivery is achieved.

The invention relates to the field of cosmetics, and discloses ceramide liposome and application thereof.The ceramide liposome is prepared from, by mass, 1.5-3 parts of ceramide NP, 1-3 parts of octyldodecanol, 0.5-2 parts of caprylic / capric triglyceride, 11-18 parts of hydrogenated lecithin, 2-6 parts of sucrose stearate, 3-7 parts of polyglycerol-10 oleate and 25-35 parts of glycerinum, and the balance is water. 0.5-8 parts of 1, 2-pentanediol, and the balance of water. The ceramide liposome provided by the invention has good stability at least at 40 DEG C, is not easy to cause lactic acid pricking pain and allergy after being smeared on skin, and can be used for sensitive skin; the skin care product can reduce skin transdermal moisture loss, maintain skin cutin moisture, reduce skin heme content, improve skin gloss, relieve skin dryness, relieve skin redness and improve skin fineness, and has the effects of moisturizing, repairing and relieving.

The invention belongs to the field of plant extract processing, and particularly relates to a preparation method and application of a ceramide-containing platycodon grandiflorum extract. The preparation method comprises the following steps: adding crushed radix platycodonis rhizomes and leaves into 45% ethanol for soaking, ultrasonically treating a material-liquid mixture for 40 minutes, and taking residual radix platycodonis dregs as a raw material for preparing ceramide. The preparation method comprises the following steps: carrying out solid fermentation on a platycodon grandiflorum herb residue mixed strain S.paucimobilis for 72 hours, then extracting to obtain a ceramide crude product, and purifying through macroporous resin to obtain the ceramide-containing platycodon grandiflorum extract. The platycodon grandiflorum extract obtained by the method contains natural ceramide from a plant source, has no irritation to chick embryos, can be used as a cosmetic raw material, has soothing and repairing effects, and is beneficial to increasing the additional economic value of platycodon grandiflorum and promoting ecological environment protection.

The present invention relates to skin moisturizing external compositions containing a ceramide, a cholesterol, and a fatty acid, and more particularly, to skin moisturizing external compositions capable of preventing skin troubles such as atopy by forming a dense lamellar structure, which is an intercellular lipid structure, and improving the skin barrier, and may include a ceramide having long-chain fatty acids, a cholesterol, a long-chain fatty acid, and purified water as active ingredients.

The invention relates to the technical field of repair compositions, and discloses a repair composition based on mussel mucin and application of the repair composition in skin barrier repair. The invention discloses a mussel mucoprotein-zinc composite microcapsule repair agent, which is prepared from the following components in parts by weight: mussel mucoprotein-zinc composite microcapsules, modified carboxymethyl chitosan, isolactone palmitate, a pH response type ceramide slow release system, dimeticone, cetostearyl alcohol, a calcium ion activating agent, an auxiliary repair factor, beheneth-25, caprylic / capric triglyceride, glyceryl monostearate, glyceryl distearate, pentanediol and citric acid. The preparation method comprises the following steps: adding ethanol, phenoxyethanol / ethylhexylglycerin, trehalose, beta-glucan and purified water; according to the whole technical scheme, through functional complementation and process optimization of all the components, synergistic interaction is achieved, the transpedermis water loss amount can be rapidly reduced, the water content of the skin cuticle is increased, the damaged skin barrier structure can be repaired from the source, and the resistance and stability of the skin are remarkably improved.

The invention provides a super-hydrophilic high-transdermal ceramide liposome and a preparation method thereof. The invention further provides a preparation method of the super-hydrophilic high-transdermal ceramide liposome. The invention further provides an application of the super-hydrophilic high-transdermal ceramide liposome in cosmetics. The invention also provides a cosmetic. According to the preparation method and application of the super-hydrophilic high-transdermal ceramide lipidosome, the super-hydrophilic high-transdermal ceramide lipidosome is obtained, industrial mass production is easy, use of a surfactant is avoided, and the super-hydrophilic high-transdermal ceramide lipidosome has the advantages of being good in water solubility, high in transparency, good in stability, high in transdermal efficiency, remarkable in effect and the like.

The invention discloses a ceramide-containing composition as well as a preparation method and application thereof, and belongs to the technical field of daily chemical products and medicines. The composition comprises 0.1%-5.0% of ceramide, 1.8%-2.7% of an emulsifier, 1.2%-2.5% of an emulsion stabilizer, 8%-14% of a solvent, 3%-5% of an emollient and 0.7%-0.95% of a stabilizing aid, the composition obtained by compounding the components has high stability, and the phenomena of particle precipitation, oil-water separation and the like are avoided; meanwhile, all the components are mutually matched and have a synergistic effect, and the effects of fading, repairing and resisting wrinkles can be achieved.

The present invention relates to a method for stabilizing ceramide and to a cosmetic composition containing stabilized ceramide and, more specifically, to a method for homogenizing and stabilizing ceramide by self-assembling the ceramide together with β-sitosterol, resveratrol, and allantoin which are other physiologically active substances using a microfluidic chip and a high pressure homogenizer, and to a technique for using ceramide and nanoparticles containing β-sitosterol, resveratrol, and allantoin, which are produced by means of the stabilizing method, as a cosmetic material for skin moisturizing, anti-oxidation, skin inflammation relief, skin barrier enhancement, and skin itching relief.

The invention belongs to the technical field of biological medicines, and particularly relates to a royal jelly acid derivative and a synthesis method, a pharmaceutical composition and application thereof. The royal jelly acid derivative is a compound shown as a formula (I), or an enantiomer, a diastereoisomer and a tautomer thereof, or a solvate or a pharmaceutically acceptable salt thereof. A series of royal jelly acid derivatives with novel structures are constructed by using a natural component royal jelly acid derived from royal jelly as an initial raw material, the royal jelly acid derivatives can play a role in resisting pulmonary fibrosis by inhibiting the activity of fibroblasts, the effect of the royal jelly acid derivatives is equivalent to that of pirfenidone, and the royal jelly acid derivatives are expected to be developed into candidate drugs for resisting pulmonary fibrosis. The ceramide NP has excellent effects in anti-inflammatory, anti-allergic and itching-relieving aspects, has a better effect than known ceramide NP, and can be used for preparing health care products, cosmetics and medicines. And # imgabs0 #.

The invention belongs to the technical field of gene engineering, and particularly relates to a genetically engineered bacterium of galactosylceramide as well as a construction method and application of the genetically engineered bacterium of galactosylceramide. On the basis of an existing delta pyrG aspergillus oryzae auxotroph strain, the metabolic flux of neutral glycosphingolipid is enhanced through overexpression of an AoCerS gene; meanwhile, the expression of a neutral sphingolipid glucosylceramide (GlcCers) synthetase gene AoUGCG is inhibited, so that the common intermediate metabolite flux of the GlcCers and galactosylceramide (GalCers) flows to the synthesis of the GalCers. The GalCers relative content of the constructed aspergillus oryzae engineering strain is increased by more than two times compared with that of a control strain, and is increased by about 70% compared with that of the control strain.

The invention discloses a scalp micro-ecological regulation washing and care composition containing lactobacillus metagen, and particularly relates to the technical field of daily chemical washing and care products. The washing and care composition comprises the following specific components in percentage by weight: 3%-8% of lactobacillus metagen, 1%-3% of prebiotics, 0.05%-0.2% of natural antibacterial peptide, 0.5%-1.5% of a ceramide compound, 0.3%-0.7% of a pH regulator, 0.5%-2% of a microcapsule wrapping agent, 0.2%-0.6% of a natural preservative and the balance of deionized water, wherein the total percentage is 100%. According to the invention, various components are scientifically compounded, so that the washing and care composition has an excellent effect, the lactobacillus retrogen, the natural antibacterial peptide and the natural preservative cooperate to inhibit bacteria, the diameter of an inhibition zone for common pathogenic bacteria is 14-20mm, and the prebiotics and the lactobacillus retrogen regulate scalp micro-ecology, so that the flora diversity index is increased by 30-45%; the ceramide compound and dipotassium glycyrrhizinate cooperate to reduce the TEWL value by 30%-50%, the scalp barrier is repaired, and the product is good in stability, safe, reliable and capable of comprehensively caring scalp health.

The invention provides a composition for repairing a skin barrier as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The invention discloses a composition for repairing a skin barrier. The composition comprises ceramide NP1, ceramide AP, ceramide EOP, asiaticoside and DNA sodium. The composition is used for repairing skin from related proteins such as endogenous and endogenous injury, inflammatory factor inhibition, light injury, skin cuticle barrier and the like, and can deeply resist inflammation, relieve and maintain stability in an endogenous and endogenous two-way manner, and repair the damaged skin barrier in a multi-level and multi-dimensional manner, so that the skin problems such as skin dryness, roughness, desquamation, redness and swelling, pruritus and the like are improved.

The present invention provides a biopolysaccharide that synergistically promotes the expression of ceramide synthase and / or hyaluronic acid synthase and its application, belonging to the technical field of traditional Chinese medicine. The biopolysaccharide is prepared from polygonatum and yam as raw materials through alternating enzymatic hydrolysis, extraction, impurity removal, molecular interception, compounding and other processes to promote the expression of ceramide synthase. The polysaccharide also promotes the expression of hyaluronic acid synthase and can be used in external preparations for the treatment and prevention of dryness, itching and skin barrier defects caused by weakened expression of ceramide synthase and hyaluronic acid synthase.

The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and / or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and / or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. The method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and / or open wound patients.

The embodiment of the present application discloses an oil-in-water composition containing ceramides, and a preparation method and use thereof, which can reduce the phenomenon of crystallization. The oil-in-water composition containing ceramides includes: ceramides, wherein the ceramides are selected from ceramides or ceramide analogs; oil; an emulsifier including sucrose polystearate and sodium di(laurylamide glutamine) lysine; and water; wherein the content of the ceramides is 0.1-10%; the content of the emulsifier is 0.2-6.3%; the mass ratio of the sucrose polystearate to the sodium di(laurylamide glutamine) lysine is 5-60:1; the oil-in-water composition containing ceramides is formed by emulsifying the ceramides, the emulsifier, the oil and the water.

202300151 Foreign Filing 48 Abstract The invention relates to compositions comprising (pseudo-) ceramide and / or sphingoid base and a solvent composed of at least two components, a process for producing a formulation (pseudo-) ceramide and / or sphingoid base and the use of at least one of said composed solvent for 5 stabilization of (pseudo-) ceramide and / or sphingoid base containing composition.

The application provides a formula system and a preparation method for improving the solubility and stability of ceramide NP, and belongs to the cosmetic field.The formula system comprises: an active ingredient, an emulsifier, a thickening agent and a solvent; the active ingredient is ceramide NP; the emulsifier comprises at least one of an anionic emulsifier, a natural polymer emulsifier, a non-ionic emulsifier and a phospholipid emulsifier; and the solvent comprises water, a polyhydric alcohol and an oil-soluble solvent.The formula system has an unexpected technical effect of greatly improving the stability of an oil-in-water cosmetic containing more ceramide NP by selecting suitable emulsifiers, thickening agents and solvents.

This application relates to the field of cosmetics, and specifically discloses a composition with a skin barrier repair function and its applications. The composition with a skin barrier repair function comprises the following components in parts by weight: 20-40 parts of functional microcapsules; 10-15 parts of Isatis indigotica extract; 3-5 parts of hydrolyzed Abelmoschus esculentus extract; the core material of the functional microcapsules comprises ceramide, vegetable oil and sterol, and the weight ratio of ceramide, vegetable oil and sterol is 1:(1.5-3):(0.8-1.5). The composition of the present application can be used to prepare cosmetics, and has the advantages of better soothing and repairing the skin.

One aspect of the present disclosure relates to a ceramide-bound hyaluronic acid hydrogel, and more particularly, the ceramide-bound hyaluronic acid hydrogel includes: a hyaluronic acid hydrogel including hyaluronic acid or a salt thereof; and emulsified particles bound to the hyaluronic acid hydrogel, wherein the emulsified particles includes at least one of a ceramide or a pseudoceramide. By simply mixing the ceramide-bound hyaluronic acid hydrogel according to one aspect of the present disclosure, a composition, particularly a composition of a solubilized formulation, including a ceramide and hyaluronic acid stably can be provided.

The invention discloses a scalp repair composition as well as a preparation method and application thereof. The scalp repair composition comprises sericin, ceramide NP, a purslane extract, polysorbate-20 and a water-phase matrix, the sericin and the ceramide NP are compounded to simulate a natural scalp cuticle structure, and barrier reconstruction is facilitated; the purslane extract is used for relieving pruritus and erythema in the repairing process; the pH value of the composition is 5.0-5.8, so that the composition is more suitable for the weakly acidic microenvironment of the scalp, and the irritation is effectively reduced. The composition can be applied to scalp repair essence, anti-hair loss products and medical auxiliary dressings, and has good safety and repair efficacy.

The invention discloses an efficient water-locking repair mask and a preparation method thereof, and belongs to the technical field of cosmetics, the efficient water-locking repair mask comprises the following components by mass: 0.5-2.0% of an astragalus membranacus extract fermentation broth, 0.1-0.5% of ceramide NP, 0.05-0.3% of a sodium hyaluronate composition, 0.1-0.3% of polyquaternium-51, 1-3% of a lactobacillus plantarum fermentation lysate, 1-5% of ethanol, and the balance of deionized water. The lactobacillus plantarum fermentation lysate comprises propionic acid and butyric acid. The Astragalus membranacus extract fermentation broth can remove allergic components and form a lipid-polysaccharide interpenetrating network with ceramide NP, and the Astragalus membranacus extract fermentation broth and ceramide NP synergistically simulate a natural barrier structure of skin, so that the order degree of cuticle lipid is improved, transdermal moisture loss is prevented, and the repairing and water locking functions are remarkably enhanced; butyric acid and propionic acid in the lactobacillus plantarum fermentation lysate promote penetration of ceramide NP by acidifying a cuticle microenvironment (pH 4.5), and the biological safety is high.

A method, preferably a cosmetic and / or non-therapeutic method - of re-balancing a ceramide profile of a ceramide-containing tissue; or - of maintaining a ceramide profile of a ceramide-containing tissue; or - of preventing or treating a disruption of a ceramide profile of a ceramide-containing tissue, wherein the method comprises a step of application of niacinamide to such ceramide-containing tissue.

The invention provides a dual ceramide essence inclusion. The dual ceramide essence inclusion is prepared from the following components in parts by weight: 1-6 parts of an active ingredient, 2-8 parts of an amphiphilic inclusion material and 40-70 parts of a microbe-derived vesicle material, wherein the active ingredients comprise ceramide NS / ceramide NG and ceramide AS; the amphiphilic inclusion material comprises the active component to form nanoparticles; the nanoparticle is wrapped by the microbe-derived vesicle material to form a ceramide / amphiphilic inclusion material / vesicle compound. The invention further provides a preparation method and application of the dual ceramide essence inclusion. The dual ceramide essence inclusion provided by the invention is high in stability and good in skin permeability, and has good repairing and anti-aging effects.

The invention discloses a Bifidobacterium pseudominutus, a metabolite C16 ceramide thereof and an application of the Bifidobacterium pseudominutus and the metabolite C16 ceramide, and belongs to the technical field of biological medicines. According to the invention, a strain of Bifidobacterium pseudocatenatum is separated and identified from excrement of a patient responding to immunotherapy, the Latin literature name of the Bifidobacterium pseudocatenatum is Bifidobacterium pseudocatenatum, the name of the Bifidobacterium pseudocatenatum is Bifidobacterium pseudocatenatum B.pseudoRX-bp02, the preservation number of the Bifidobacterium pseudocatenatum is GDMCC NO: 66417, and the Bifidobacterium pseudocatenatum can generate a metabolite C16 ceramide. The invention verifies that the bifidobacterium pseudocatenum and the metabolite C16 ceramide thereof have the functions of enhancing the anti-tumor immune response of a body, promoting the anti-tumor curative effect of a PD-1 antibody and remarkably inhibiting tumor growth in an animal body. The invention provides a new strategy for clinically improving the response rate of tumor immunotherapy crowds, expanding the benefited crowds of cancer immunotherapy (immunotherapy checkpoint inhibitors) and the like.

The non-therapeutic use of a water-in-oil emulsion stick composition comprising a humectant for boosting the natural level of ceramides in the human skin.