176 results about "Ceramide AP" patented technology

The invention relates to the technical field of automatic control, in particular to a monitoring method and system for synthesizing ceramide based on alpha-hydroxy fatty acid, and the monitoring system for synthesizing ceramide based on alpha-hydroxy fatty acid comprises a raw material feeding module, a reaction control module, a quenching-crystallization joint control module and a data integration module; carrying out dynamic weighing monitoring on the raw materials based on the received synthesis instruction, and starting a reaction kettle according to weighing data; performing multi-dimensional data acquisition in real time according to the set reaction data, and performing dynamic feeding control according to the set reaction data; when the TLC detection substrate reaction is completed, the cooling process and the crystallization process are regulated and controlled in real time according to the reaction data until the end point judgment standard is met; according to a received synthesis completion instruction, product quality data is obtained, a monitoring data packet is generated, the synthesis instruction is marked and then stored, process control is accurately monitored and controlled, and the purity and crystal form of the product are ensured.

The invention discloses a method for synthesizing ceramide NP through two-step enzyme catalysis, which comprises the following steps of: firstly, adding lipase into vegetable oil to catalyze and combine fatty acid to decompose into free fatty acid, and centrifuging to remove the lipase; a small amount of phytosphingosine is added into the hydrolyzed vegetable oil, the raw material vegetable oil is used as a solvent or a squalane system solvent for incubation, and then immobilized lipase is added for catalytic synthesis of ceramide. The invention establishes a two-enzyme method for efficiently synthesizing the ceramide NP compound, and the process is natural, environment-friendly and non-toxic. The reaction conditions are optimized through response surface analysis, meanwhile, the immobilized lipase shows excellent cycle performance, and the method is easy to operate, environmentally friendly, green and economical and has wide application prospects in the fields of cosmetics, health care products, biological medicine and the like.

The invention relates to the technical field of repair compositions, and discloses a repair composition based on mussel mucin and application of the repair composition in skin barrier repair. The invention discloses a mussel mucoprotein-zinc composite microcapsule repair agent, which is prepared from the following components in parts by weight: mussel mucoprotein-zinc composite microcapsules, modified carboxymethyl chitosan, isolactone palmitate, a pH response type ceramide slow release system, dimeticone, cetostearyl alcohol, a calcium ion activating agent, an auxiliary repair factor, beheneth-25, caprylic / capric triglyceride, glyceryl monostearate, glyceryl distearate, pentanediol and citric acid. The preparation method comprises the following steps: adding ethanol, phenoxyethanol / ethylhexylglycerin, trehalose, beta-glucan and purified water; according to the whole technical scheme, through functional complementation and process optimization of all the components, synergistic interaction is achieved, the transpedermis water loss amount can be rapidly reduced, the water content of the skin cuticle is increased, the damaged skin barrier structure can be repaired from the source, and the resistance and stability of the skin are remarkably improved.

The invention discloses a ceramide-containing composition as well as a preparation method and application thereof, and belongs to the technical field of daily chemical products and medicines. The composition comprises 0.1%-5.0% of ceramide, 1.8%-2.7% of an emulsifier, 1.2%-2.5% of an emulsion stabilizer, 8%-14% of a solvent, 3%-5% of an emollient and 0.7%-0.95% of a stabilizing aid, the composition obtained by compounding the components has high stability, and the phenomena of particle precipitation, oil-water separation and the like are avoided; meanwhile, all the components are mutually matched and have a synergistic effect, and the effects of fading, repairing and resisting wrinkles can be achieved.

The invention discloses a scalp micro-ecological regulation washing and care composition containing lactobacillus metagen, and particularly relates to the technical field of daily chemical washing and care products. The washing and care composition comprises the following specific components in percentage by weight: 3%-8% of lactobacillus metagen, 1%-3% of prebiotics, 0.05%-0.2% of natural antibacterial peptide, 0.5%-1.5% of a ceramide compound, 0.3%-0.7% of a pH regulator, 0.5%-2% of a microcapsule wrapping agent, 0.2%-0.6% of a natural preservative and the balance of deionized water, wherein the total percentage is 100%. According to the invention, various components are scientifically compounded, so that the washing and care composition has an excellent effect, the lactobacillus retrogen, the natural antibacterial peptide and the natural preservative cooperate to inhibit bacteria, the diameter of an inhibition zone for common pathogenic bacteria is 14-20mm, and the prebiotics and the lactobacillus retrogen regulate scalp micro-ecology, so that the flora diversity index is increased by 30-45%; the ceramide compound and dipotassium glycyrrhizinate cooperate to reduce the TEWL value by 30%-50%, the scalp barrier is repaired, and the product is good in stability, safe, reliable and capable of comprehensively caring scalp health.

The invention provides a composition for repairing a skin barrier as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The invention discloses a composition for repairing a skin barrier. The composition comprises ceramide NP1, ceramide AP, ceramide EOP, asiaticoside and DNA sodium. The composition is used for repairing skin from related proteins such as endogenous and endogenous injury, inflammatory factor inhibition, light injury, skin cuticle barrier and the like, and can deeply resist inflammation, relieve and maintain stability in an endogenous and endogenous two-way manner, and repair the damaged skin barrier in a multi-level and multi-dimensional manner, so that the skin problems such as skin dryness, roughness, desquamation, redness and swelling, pruritus and the like are improved.

202300151 Foreign Filing 48 Abstract The invention relates to compositions comprising (pseudo-) ceramide and / or sphingoid base and a solvent composed of at least two components, a process for producing a formulation (pseudo-) ceramide and / or sphingoid base and the use of at least one of said composed solvent for 5 stabilization of (pseudo-) ceramide and / or sphingoid base containing composition.

The application provides a formula system and a preparation method for improving the solubility and stability of ceramide NP, and belongs to the cosmetic field.The formula system comprises: an active ingredient, an emulsifier, a thickening agent and a solvent; the active ingredient is ceramide NP; the emulsifier comprises at least one of an anionic emulsifier, a natural polymer emulsifier, a non-ionic emulsifier and a phospholipid emulsifier; and the solvent comprises water, a polyhydric alcohol and an oil-soluble solvent.The formula system has an unexpected technical effect of greatly improving the stability of an oil-in-water cosmetic containing more ceramide NP by selecting suitable emulsifiers, thickening agents and solvents.

One aspect of the present disclosure relates to a ceramide-bound hyaluronic acid hydrogel, and more particularly, the ceramide-bound hyaluronic acid hydrogel includes: a hyaluronic acid hydrogel including hyaluronic acid or a salt thereof; and emulsified particles bound to the hyaluronic acid hydrogel, wherein the emulsified particles includes at least one of a ceramide or a pseudoceramide. By simply mixing the ceramide-bound hyaluronic acid hydrogel according to one aspect of the present disclosure, a composition, particularly a composition of a solubilized formulation, including a ceramide and hyaluronic acid stably can be provided.

The invention discloses a scalp repair composition as well as a preparation method and application thereof. The scalp repair composition comprises sericin, ceramide NP, a purslane extract, polysorbate-20 and a water-phase matrix, the sericin and the ceramide NP are compounded to simulate a natural scalp cuticle structure, and barrier reconstruction is facilitated; the purslane extract is used for relieving pruritus and erythema in the repairing process; the pH value of the composition is 5.0-5.8, so that the composition is more suitable for the weakly acidic microenvironment of the scalp, and the irritation is effectively reduced. The composition can be applied to scalp repair essence, anti-hair loss products and medical auxiliary dressings, and has good safety and repair efficacy.

A method, preferably a cosmetic and / or non-therapeutic method - of re-balancing a ceramide profile of a ceramide-containing tissue; or - of maintaining a ceramide profile of a ceramide-containing tissue; or - of preventing or treating a disruption of a ceramide profile of a ceramide-containing tissue, wherein the method comprises a step of application of niacinamide to such ceramide-containing tissue.

The invention provides a dual ceramide essence inclusion. The dual ceramide essence inclusion is prepared from the following components in parts by weight: 1-6 parts of an active ingredient, 2-8 parts of an amphiphilic inclusion material and 40-70 parts of a microbe-derived vesicle material, wherein the active ingredients comprise ceramide NS / ceramide NG and ceramide AS; the amphiphilic inclusion material comprises the active component to form nanoparticles; the nanoparticle is wrapped by the microbe-derived vesicle material to form a ceramide / amphiphilic inclusion material / vesicle compound. The invention further provides a preparation method and application of the dual ceramide essence inclusion. The dual ceramide essence inclusion provided by the invention is high in stability and good in skin permeability, and has good repairing and anti-aging effects.

The invention discloses a Bifidobacterium pseudominutus, a metabolite C16 ceramide thereof and an application of the Bifidobacterium pseudominutus and the metabolite C16 ceramide, and belongs to the technical field of biological medicines. According to the invention, a strain of Bifidobacterium pseudocatenatum is separated and identified from excrement of a patient responding to immunotherapy, the Latin literature name of the Bifidobacterium pseudocatenatum is Bifidobacterium pseudocatenatum, the name of the Bifidobacterium pseudocatenatum is Bifidobacterium pseudocatenatum B.pseudoRX-bp02, the preservation number of the Bifidobacterium pseudocatenatum is GDMCC NO: 66417, and the Bifidobacterium pseudocatenatum can generate a metabolite C16 ceramide. The invention verifies that the bifidobacterium pseudocatenum and the metabolite C16 ceramide thereof have the functions of enhancing the anti-tumor immune response of a body, promoting the anti-tumor curative effect of a PD-1 antibody and remarkably inhibiting tumor growth in an animal body. The invention provides a new strategy for clinically improving the response rate of tumor immunotherapy crowds, expanding the benefited crowds of cancer immunotherapy (immunotherapy checkpoint inhibitors) and the like.

The non-therapeutic use of a water-in-oil emulsion stick composition comprising a humectant for boosting the natural level of ceramides in the human skin.

The invention relates to the non-therapeutic nutricosmetic use of a composition in a form suitable for oral administration comprising a wheat extract in a physiologically acceptable medium. The invention is characterized in that the wheat extract contains 35-40% of triglycerides and diglycerides, 20-30% of glycolipids, 7-10% of phospholipids and 2-4% of ceramides and glycosylceramides, by weight relative to the total weight of the extract, and is used to reduce excessive sebum secretion in the skin of the face.

The present disclosure provides a soothing repair composition for dry sensitive skin and its preparation method and application, belonging to the technical field of cosmetics. The soothing repair composition of the present disclosure is a liposome structure. Cephalin and ceramide-EOP form a cephalin-ceramide complex, which serves as the shell layer of the liposome. The plant moulting hormone and glycerophosphoinositol choline salt are wrapped inside the liposome. The soothing repair composition with the liposome structure has excellent moisturizing, soothing and repairing effects.

The invention discloses a skin care agent and a preparation method thereof, and belongs to the technical field of cosmetics. The preparation method of the skin care agent comprises the following steps: grinding ceramide, trihydroxy stearin and part of grease through a three-roller machine to obtain paste; mixing the paste with the remaining grease, and homogenizing; every 100 parts of the skin care agent is prepared from 0.5 to 5 parts of ceramide, 0.2 to 1 part of trihydroxy stearin and the balance of grease. According to the method, the ceramide and the trihydroxy stearin can be uniformly and stably dispersed in the grease directly through grinding at normal temperature, and the equipment cost and the energy consumption can be reduced. The obtained skin care agent is good in stability, not only has certain viscosity, but also is not prone to layering, fine and smooth in texture and weak in greasy feeling, and the barrier repairing effect of ceramide can be effectively reserved.

The invention relates to the field of lipidosome technology and skin external preparations, in particular to bionic ceramide coated retinol lipidosome and a preparation method and application of the bionic ceramide coated retinol lipidosome. The liposome is prepared from the following raw materials in parts by weight: 1.0 to 3.0 weight percent of ceramide NP, 1.0 to 3.0 weight percent of ceramide AP, 0.05 to 0.5 weight percent of ceramide EOP, 1.0 to 3.0 weight percent of cholesterol, 0.50 to 2.0 weight percent of meadowfoam seed oil, 3.0 to 10.0 weight percent of hydrogenated lecithin, 1.0 to 3.0 weight percent of retinol, 0.50 to 2.50 weight percent of tocopheryl acetate, 15.0 to 45.0 weight percent of caprylic / capric triglyceride MCT, 1.0 to 5.0 weight percent of propylene glycol, 15.0 to 45.0 weight percent of glycerol and the balance of water, the bionic layered film is constructed by the multi-subtype ceramide, cholesterol and hydrogenated lecithin, the oil phase and an antioxidant system are cooperated, the stability of retinol under light, heat and oxygen is remarkably improved, slow release is achieved, meanwhile, skin tolerance is improved, and the bionic layered film can be widely applied to essence, emulsion, face cream, ampoule and other external skin care preparations.

The present disclosure provides compositions and dosage forms thereof, wherein the compositions comprise hyaluronic acid and a lipid extract comprising a ceramide and glycolipid. The present disclosure further provides methods for improving a skin property in a subject by administering the composition or dosage form to the subject.

The invention relates to the technical field of cosmetics, in particular to a preservative-free cosmetic composition for barrier repair as well as a preparation method and application of the preservative-free cosmetic composition. The invention relates to a preservative-free cosmetic composition for barrier repair, which comprises the following components in percentage by weight: 4.0-6.0% of 1, 2-pentanediol; 0.5% to 1.0% of 1, 2-hexanediol; 0.1% to 0.5% of cerayl; 0.5%-1.0% of phytosterol; 4.0%-6.0% of stearic acid; 4.0%-7.0% of hydrogenated lecithin; 0 to 0.3 percent of caryophylline; 0-0.2% of a eucommia ulmoides bark extract; and the balance of water. The composition of 1, 2-pentanediol and 1, 2-hexanediol is adopted to replace a traditional chemical preservative, and on the premise that the preservative effect is achieved, the possibility of causing skin irritation and allergy risks is reduced; ceramide and phytosterol can participate in construction of a skin barrier and supplement and repair a lipid structure of the skin barrier; stearic acid and hydrogenated lecithin form a stable emulsification basis, so that the two long-term contradictory requirements of no chemical preservative stimulation and effective barrier repair are met, and the unification of product safety and efficacy is realized.

The application belongs to the technical field of molecular biology, and particularly relates to metabolic markers for evaluating the prognosis of patients with hypertrophic cardiomyopathy and application thereof. The application determines that one or more of 3-hydroxyrilotene, asparagine-lysine, cyclohexylamine, arachidonic acid, aconitic acid, propionyl carnitine, ceramide, tryptophan, 3-hydroxysebacic acid, traumatic acid, phosphatidylcholine, alanine-proline, lysophosphatidylcholine, taurine and S-garlicin cysteine are related to the prognosis of hypertrophic cardiomyopathy, can evaluate the prognosis of patients with hypertrophic cardiomyopathy after undergoing muscle resection of interventricular septum, and shows accurate judgment on all-cause death or rehospitalization, cardiovascular events and postoperative new-onset arrhythmia. Finally, all the prognostic biomarkers are reproduced in an independent cohort, which is helpful for postoperative risk evaluation of patients with hypertrophic cardiomyopathy, has high specificity and high sensitivity.

Use of ectoin ceramide in skin care. The ectoin ceramide has an excellent effect in the aspects of repairing the skin barrier, promoting skin tissue healing, resisting photoaging, moisturizing, resisting inflammation and soothing, and the like. Especially in the aspects of cell viability proliferation and resisting inflammation and soothing, the ectoin ceramide shows superior effects than ectoin, and has good application value in the fields of preparing cosmetics, drugs, and health care products with corresponding efficacy or indications.

The granulator comprises a machine body and a bearing plate, the bearing plate is installed on one side of the machine body, two sets of electric push rods are installed at the top end of the bearing plate, push arms are installed at the output ends of the electric push rods, a supporting plate is arranged above the electric push rods, and the supporting plate is connected with the bearing plate. The device comprises a supporting plate, the supporting plate is connected with a push arm, a rotating plate is arranged above the supporting plate, a movable shaft is movably installed at the center of the supporting plate and connected with the rotating plate, a driving motor is installed at the bottom end of the supporting plate, a driving shaft is installed at the output end of the driving motor, and the surface of the driving shaft is sleeved with a transmission gear. The surface of the movable shaft on one side of the transmission gear is sleeved with a driven gear. According to the utility model, convenient high-hydraulic-pressure shearing processing of homogenized liquid is realized, the liquid can be conveniently input in sequence, and the liquid homogenizing effect is improved.

The present invention provides the use of at least one sphingolipid for a hair treatment for inducing hair growth and / or inhibiting hair loss, including eyelashes and eyebrows. Said sphingolipid is preferably a ceramide having a fatty acid with a long hydrocarbon chain of C18-C24, mostly C20-C22, and a phytosphingosine base. Furthermore, and advantageously, the treatment is global, capable to also improve the properties of the scalp and hair themselves.

The invention discloses supramolecular ceramide and a preparation method thereof, and belongs to the technical field of supramolecules. The preparation method comprises the following steps: mixing and heating ceramide and tetrahydroxypropyl ethylenediamine to obtain supramolecular ceramide; in the method for preparing the supramolecular ceramide, polyether molecules can also be added; the preparation method specifically comprises the following steps: mixing and heating ceramide, tetrahydroxypropyl ethylenediamine and polyether molecules to obtain the supramolecular ceramide. The supramolecular ceramide disclosed by the invention can be dissolved in water and also can be dissolved in oil. The supramolecular ceramide prepared by the preparation method disclosed by the invention is good in solubility, good in compatibility and good in stability; and the preparation process is simple and suitable for industrial large-scale use.

The invention discloses bifidobacterium breve CCFM1505 capable of regulating skin ceramide de novo synthesis and improving skin health and a metagen thereof, and belongs to the technical field of microorganisms and medicines. The bifidobacterium breve CCFM1505 obtained through screening shows the effect of remarkably promoting skin ceramide synthesis in the aspects of external use and oral administration. The viable bacteria of the bifidobacterium breve CCFM1505 and the metabiotics thereof, especially the thallus lysate of the bifidobacterium breve, are orally taken, so that the content of ceramide in the skin tissue is remarkably increased, and meanwhile, the effects of increasing of transpedermis water loss, reducing of the water content of cuticle and inflammatory response caused by skin injury and reducing of the ceramide content can be effectively regulated and controlled, and the skin healing effect is improved. Therefore, the skin health is improved. Therefore, the bifidobacterium breve has a huge application prospect in preparation of external or oral medicines for promoting synthesis of skin ceramide and improving skin health, as well as in preparation of foods, health-care products or cosmetics.

The present invention relates to the field of active ingredient preparation, and more particularly to a method for preparing and applying a ceramide derived from the golden oyster mushroom (Pleurotus citrinipileatus), possessing moisturizing, brightening, anti-aging, and skin barrier-maintaining properties. The method comprises the following steps: collection and pretreatment; fermentation treatment; separation and extraction; and refining. The advantage lies in the fact that the method for preparing and applying this ceramide, through the optimization of fermentation conditions and separation and extraction techniques, allows for the efficient preparation of the ceramide from the golden oyster mushroom (Pleurotus citrinipileatus) and increases the yield and purity of the ceramide.

The invention relates to the technical field of cosmetics, in particular to a soothing composition as well as a preparation method and application thereof. The soothing composition is prepared from the following components in percentage by mass: 10 to 20 percent of polyglycerol-10 laurate and other emulsifiers, 10 to 20 percent of palmitamide MEA, 5 to 15 percent of acetamide MEA, 2 to 8 percent of stearyl glycyrrhetinate, 5 to 15 percent of squalane and 0.5 to 2 percent of ceramide NP. The invention also provides a preparation method of the soothing composition, and the soothing composition is quick and long-acting in soothing effect, and can synchronously improve the barrier, anti-inflammatory and moisturizing effects.

The present application relates to the technical field of detection, in particular to a method for detecting multiple amino acids, hormones and ceramides in blood and cerebrospinal fluid by liquid chromatography tandem mass spectrometry. Specifically comprising: preparing standard curve equation I and standard curve equation II respectively, pretreating the sample to be tested to obtain sample I for detecting amino acids and hormones and sample II for detecting ceramides; using high performance liquid chromatography mass spectrometry to detect respectively, substituting the detection results of sample I into standard curve equation I and substituting the detection results of sample II into standard curve equation II to obtain the content of multiple amino acids, hormones and ceramides in the sample to be tested. The present application can realize the combined detection of seven kinds of amino acids, eleven kinds of hormones and three kinds of ceramides by collecting blood and cerebrospinal fluid once. The detection method of the present application greatly saves the analysis time and reduces the analysis cost.

The utility model discloses a sampling observation device for ceramide NP preparation, and relates to the field of ceramide NP preparation. The sampling observation device comprises an extraction tube, one end of the extraction tube is provided with a first rubber ring, the inner wall of the first rubber ring is provided with an extraction head, and the inner wall of the extraction tube is provided with a transparent plate. According to the utility model, the connecting frame is arranged to play a connecting role on the magnifying lens, so that when the device is used, the arrangement operation process of the connecting frame and the magnifying lens is simple and convenient, an extract does not need to be transferred from the sampling device to a microscope, and the loss or pollution of a sample is avoided. When the device is used, magnified observation can be easily achieved, time and energy are saved, the quantitative sleeve is subjected to threaded adjustment through the arranged scalar rod, and when the device is used, the volume of sucked ceramide NP extract can be accurately controlled through the arrangement of the scalar rod and the quantitative sleeve. Therefore, the sampling quantity of each time is highly consistent, and the accuracy and repeatability of subsequent analysis and experiment results are ensured.