256 results about "Ceramide AP" patented technology

The invention relates to the technical field of automatic control, in particular to a monitoring method and system for synthesizing ceramide based on alpha-hydroxy fatty acid, and the monitoring system for synthesizing ceramide based on alpha-hydroxy fatty acid comprises a raw material feeding module, a reaction control module, a quenching-crystallization joint control module and a data integration module; carrying out dynamic weighing monitoring on the raw materials based on the received synthesis instruction, and starting a reaction kettle according to weighing data; performing multi-dimensional data acquisition in real time according to the set reaction data, and performing dynamic feeding control according to the set reaction data; when the TLC detection substrate reaction is completed, the cooling process and the crystallization process are regulated and controlled in real time according to the reaction data until the end point judgment standard is met; according to a received synthesis completion instruction, product quality data is obtained, a monitoring data packet is generated, the synthesis instruction is marked and then stored, process control is accurately monitored and controlled, and the purity and crystal form of the product are ensured.

The invention provides an acne-removing composition containing ceramide, a preparation method of the acne-removing composition and an acne-removing product, and the acne-removing composition is prepared from the following components in parts by weight: 5 to 10 parts of plant extract, 1 to 3 parts of ceramide, 1 to 3 parts of gentiopicroside-vitamin C eutectic, 1 to 3 parts of compound polysaccharide and 0.3 to 0.7 part of transdermal enhancer. The plant extract is prepared from a herba dendrobii fruticosae flower extract, a lasiocarpus trifoliatus extract and a hedera rhododendron extract in a mass ratio of 1: (1-3): (2-4); the compound polysaccharide is prepared from tremella polysaccharide, tamarind seed polysaccharide and ganoderma lucidum polysaccharide in a ratio of 1: (3-5): (0.5-0.8); the transdermal enhancer is prepared from a cucumber extract and a salvia miltiorrhiza root extract in a mass ratio of 1: (1-3). The plant extracts in the acne-removing composition take effect synergistically, the acne-removing effect is achieved from multiple aspects of bacteriostasis, anti-inflammation and oil control, the purpose of efficiently removing acnes without relapse is achieved, and the natural plant extracts are mild and non-irritant, do not cause burden to the skin and have good application prospects.

The invention discloses a method for synthesizing ceramide NP through two-step enzyme catalysis, which comprises the following steps of: firstly, adding lipase into vegetable oil to catalyze and combine fatty acid to decompose into free fatty acid, and centrifuging to remove the lipase; a small amount of phytosphingosine is added into the hydrolyzed vegetable oil, the raw material vegetable oil is used as a solvent or a squalane system solvent for incubation, and then immobilized lipase is added for catalytic synthesis of ceramide. The invention establishes a two-enzyme method for efficiently synthesizing the ceramide NP compound, and the process is natural, environment-friendly and non-toxic. The reaction conditions are optimized through response surface analysis, meanwhile, the immobilized lipase shows excellent cycle performance, and the method is easy to operate, environmentally friendly, green and economical and has wide application prospects in the fields of cosmetics, health care products, biological medicine and the like.

The invention discloses a lipid composition for preparing extracellular vesicles, which is prepared from the following lipid substances in percentage by mass: 2 to 18 percent of phosphatidylcholine, 2 to 14 percent of phosphatidylethanolamine, 7 to 27 percent of sphingomyelin, 0.5 to 7 percent of ceramide, 1.5 to 2.5 percent of phosphatidylinositol, 30 to 70 percent of cholesterol and 5 to 8 percent of phosphatidylserine, the fatty acid carbon number of the lipid substance satisfies the following conditions: the fatty acid carbon number of phosphatidylcholine is 16-20, the fatty acid carbon number of phosphatidyl ethanolamine is 16-18, the fatty acid carbon number of sphingomyelin is 16-24, the fatty acid carbon number of ceramide is 16-24, the fatty acid carbon number of phosphatidylinositol is 16-20, the fatty acid carbon number of phosphatidylserine is 18-24, and the molar ratio of cholesterol to sphingomyelin is 4-7. The extracellular vesicles are prepared from the lipid composition and used for biomarkers or drug carriers, and efficient oral drug delivery is achieved.

The invention belongs to the field of plant extract processing, and particularly relates to a preparation method and application of a ceramide-containing platycodon grandiflorum extract. The preparation method comprises the following steps: adding crushed radix platycodonis rhizomes and leaves into 45% ethanol for soaking, ultrasonically treating a material-liquid mixture for 40 minutes, and taking residual radix platycodonis dregs as a raw material for preparing ceramide. The preparation method comprises the following steps: carrying out solid fermentation on a platycodon grandiflorum herb residue mixed strain S.paucimobilis for 72 hours, then extracting to obtain a ceramide crude product, and purifying through macroporous resin to obtain the ceramide-containing platycodon grandiflorum extract. The platycodon grandiflorum extract obtained by the method contains natural ceramide from a plant source, has no irritation to chick embryos, can be used as a cosmetic raw material, has soothing and repairing effects, and is beneficial to increasing the additional economic value of platycodon grandiflorum and promoting ecological environment protection.

The invention relates to the technical field of repair compositions, and discloses a repair composition based on mussel mucin and application of the repair composition in skin barrier repair. The invention discloses a mussel mucoprotein-zinc composite microcapsule repair agent, which is prepared from the following components in parts by weight: mussel mucoprotein-zinc composite microcapsules, modified carboxymethyl chitosan, isolactone palmitate, a pH response type ceramide slow release system, dimeticone, cetostearyl alcohol, a calcium ion activating agent, an auxiliary repair factor, beheneth-25, caprylic / capric triglyceride, glyceryl monostearate, glyceryl distearate, pentanediol and citric acid. The preparation method comprises the following steps: adding ethanol, phenoxyethanol / ethylhexylglycerin, trehalose, beta-glucan and purified water; according to the whole technical scheme, through functional complementation and process optimization of all the components, synergistic interaction is achieved, the transpedermis water loss amount can be rapidly reduced, the water content of the skin cuticle is increased, the damaged skin barrier structure can be repaired from the source, and the resistance and stability of the skin are remarkably improved.

The invention provides a super-hydrophilic high-transdermal ceramide liposome and a preparation method thereof. The invention further provides a preparation method of the super-hydrophilic high-transdermal ceramide liposome. The invention further provides an application of the super-hydrophilic high-transdermal ceramide liposome in cosmetics. The invention also provides a cosmetic. According to the preparation method and application of the super-hydrophilic high-transdermal ceramide lipidosome, the super-hydrophilic high-transdermal ceramide lipidosome is obtained, industrial mass production is easy, use of a surfactant is avoided, and the super-hydrophilic high-transdermal ceramide lipidosome has the advantages of being good in water solubility, high in transparency, good in stability, high in transdermal efficiency, remarkable in effect and the like.

The invention discloses a ceramide-containing composition as well as a preparation method and application thereof, and belongs to the technical field of daily chemical products and medicines. The composition comprises 0.1%-5.0% of ceramide, 1.8%-2.7% of an emulsifier, 1.2%-2.5% of an emulsion stabilizer, 8%-14% of a solvent, 3%-5% of an emollient and 0.7%-0.95% of a stabilizing aid, the composition obtained by compounding the components has high stability, and the phenomena of particle precipitation, oil-water separation and the like are avoided; meanwhile, all the components are mutually matched and have a synergistic effect, and the effects of fading, repairing and resisting wrinkles can be achieved.

The invention belongs to the technical field of biological medicines, and particularly relates to a royal jelly acid derivative and a synthesis method, a pharmaceutical composition and application thereof. The royal jelly acid derivative is a compound shown as a formula (I), or an enantiomer, a diastereoisomer and a tautomer thereof, or a solvate or a pharmaceutically acceptable salt thereof. A series of royal jelly acid derivatives with novel structures are constructed by using a natural component royal jelly acid derived from royal jelly as an initial raw material, the royal jelly acid derivatives can play a role in resisting pulmonary fibrosis by inhibiting the activity of fibroblasts, the effect of the royal jelly acid derivatives is equivalent to that of pirfenidone, and the royal jelly acid derivatives are expected to be developed into candidate drugs for resisting pulmonary fibrosis. The ceramide NP has excellent effects in anti-inflammatory, anti-allergic and itching-relieving aspects, has a better effect than known ceramide NP, and can be used for preparing health care products, cosmetics and medicines. And # imgabs0 #.

The invention discloses a scalp micro-ecological regulation washing and care composition containing lactobacillus metagen, and particularly relates to the technical field of daily chemical washing and care products. The washing and care composition comprises the following specific components in percentage by weight: 3%-8% of lactobacillus metagen, 1%-3% of prebiotics, 0.05%-0.2% of natural antibacterial peptide, 0.5%-1.5% of a ceramide compound, 0.3%-0.7% of a pH regulator, 0.5%-2% of a microcapsule wrapping agent, 0.2%-0.6% of a natural preservative and the balance of deionized water, wherein the total percentage is 100%. According to the invention, various components are scientifically compounded, so that the washing and care composition has an excellent effect, the lactobacillus retrogen, the natural antibacterial peptide and the natural preservative cooperate to inhibit bacteria, the diameter of an inhibition zone for common pathogenic bacteria is 14-20mm, and the prebiotics and the lactobacillus retrogen regulate scalp micro-ecology, so that the flora diversity index is increased by 30-45%; the ceramide compound and dipotassium glycyrrhizinate cooperate to reduce the TEWL value by 30%-50%, the scalp barrier is repaired, and the product is good in stability, safe, reliable and capable of comprehensively caring scalp health.

The invention provides a composition for repairing a skin barrier as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The invention discloses a composition for repairing a skin barrier. The composition comprises ceramide NP1, ceramide AP, ceramide EOP, asiaticoside and DNA sodium. The composition is used for repairing skin from related proteins such as endogenous and endogenous injury, inflammatory factor inhibition, light injury, skin cuticle barrier and the like, and can deeply resist inflammation, relieve and maintain stability in an endogenous and endogenous two-way manner, and repair the damaged skin barrier in a multi-level and multi-dimensional manner, so that the skin problems such as skin dryness, roughness, desquamation, redness and swelling, pruritus and the like are improved.

The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and / or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and / or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. The method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and / or open wound patients.

202300151 Foreign Filing 48 Abstract The invention relates to compositions comprising (pseudo-) ceramide and / or sphingoid base and a solvent composed of at least two components, a process for producing a formulation (pseudo-) ceramide and / or sphingoid base and the use of at least one of said composed solvent for 5 stabilization of (pseudo-) ceramide and / or sphingoid base containing composition.

The application provides a formula system and a preparation method for improving the solubility and stability of ceramide NP, and belongs to the cosmetic field.The formula system comprises: an active ingredient, an emulsifier, a thickening agent and a solvent; the active ingredient is ceramide NP; the emulsifier comprises at least one of an anionic emulsifier, a natural polymer emulsifier, a non-ionic emulsifier and a phospholipid emulsifier; and the solvent comprises water, a polyhydric alcohol and an oil-soluble solvent.The formula system has an unexpected technical effect of greatly improving the stability of an oil-in-water cosmetic containing more ceramide NP by selecting suitable emulsifiers, thickening agents and solvents.

This application relates to the field of cosmetics, and specifically discloses a composition with a skin barrier repair function and its applications. The composition with a skin barrier repair function comprises the following components in parts by weight: 20-40 parts of functional microcapsules; 10-15 parts of Isatis indigotica extract; 3-5 parts of hydrolyzed Abelmoschus esculentus extract; the core material of the functional microcapsules comprises ceramide, vegetable oil and sterol, and the weight ratio of ceramide, vegetable oil and sterol is 1:(1.5-3):(0.8-1.5). The composition of the present application can be used to prepare cosmetics, and has the advantages of better soothing and repairing the skin.

One aspect of the present disclosure relates to a ceramide-bound hyaluronic acid hydrogel, and more particularly, the ceramide-bound hyaluronic acid hydrogel includes: a hyaluronic acid hydrogel including hyaluronic acid or a salt thereof; and emulsified particles bound to the hyaluronic acid hydrogel, wherein the emulsified particles includes at least one of a ceramide or a pseudoceramide. By simply mixing the ceramide-bound hyaluronic acid hydrogel according to one aspect of the present disclosure, a composition, particularly a composition of a solubilized formulation, including a ceramide and hyaluronic acid stably can be provided.

The invention discloses a scalp repair composition as well as a preparation method and application thereof. The scalp repair composition comprises sericin, ceramide NP, a purslane extract, polysorbate-20 and a water-phase matrix, the sericin and the ceramide NP are compounded to simulate a natural scalp cuticle structure, and barrier reconstruction is facilitated; the purslane extract is used for relieving pruritus and erythema in the repairing process; the pH value of the composition is 5.0-5.8, so that the composition is more suitable for the weakly acidic microenvironment of the scalp, and the irritation is effectively reduced. The composition can be applied to scalp repair essence, anti-hair loss products and medical auxiliary dressings, and has good safety and repair efficacy.

The invention discloses an efficient water-locking repair mask and a preparation method thereof, and belongs to the technical field of cosmetics, the efficient water-locking repair mask comprises the following components by mass: 0.5-2.0% of an astragalus membranacus extract fermentation broth, 0.1-0.5% of ceramide NP, 0.05-0.3% of a sodium hyaluronate composition, 0.1-0.3% of polyquaternium-51, 1-3% of a lactobacillus plantarum fermentation lysate, 1-5% of ethanol, and the balance of deionized water. The lactobacillus plantarum fermentation lysate comprises propionic acid and butyric acid. The Astragalus membranacus extract fermentation broth can remove allergic components and form a lipid-polysaccharide interpenetrating network with ceramide NP, and the Astragalus membranacus extract fermentation broth and ceramide NP synergistically simulate a natural barrier structure of skin, so that the order degree of cuticle lipid is improved, transdermal moisture loss is prevented, and the repairing and water locking functions are remarkably enhanced; butyric acid and propionic acid in the lactobacillus plantarum fermentation lysate promote penetration of ceramide NP by acidifying a cuticle microenvironment (pH 4.5), and the biological safety is high.

A method, preferably a cosmetic and / or non-therapeutic method - of re-balancing a ceramide profile of a ceramide-containing tissue; or - of maintaining a ceramide profile of a ceramide-containing tissue; or - of preventing or treating a disruption of a ceramide profile of a ceramide-containing tissue, wherein the method comprises a step of application of niacinamide to such ceramide-containing tissue.

The invention provides a dual ceramide essence inclusion. The dual ceramide essence inclusion is prepared from the following components in parts by weight: 1-6 parts of an active ingredient, 2-8 parts of an amphiphilic inclusion material and 40-70 parts of a microbe-derived vesicle material, wherein the active ingredients comprise ceramide NS / ceramide NG and ceramide AS; the amphiphilic inclusion material comprises the active component to form nanoparticles; the nanoparticle is wrapped by the microbe-derived vesicle material to form a ceramide / amphiphilic inclusion material / vesicle compound. The invention further provides a preparation method and application of the dual ceramide essence inclusion. The dual ceramide essence inclusion provided by the invention is high in stability and good in skin permeability, and has good repairing and anti-aging effects.

The invention discloses a Bifidobacterium pseudominutus, a metabolite C16 ceramide thereof and an application of the Bifidobacterium pseudominutus and the metabolite C16 ceramide, and belongs to the technical field of biological medicines. According to the invention, a strain of Bifidobacterium pseudocatenatum is separated and identified from excrement of a patient responding to immunotherapy, the Latin literature name of the Bifidobacterium pseudocatenatum is Bifidobacterium pseudocatenatum, the name of the Bifidobacterium pseudocatenatum is Bifidobacterium pseudocatenatum B.pseudoRX-bp02, the preservation number of the Bifidobacterium pseudocatenatum is GDMCC NO: 66417, and the Bifidobacterium pseudocatenatum can generate a metabolite C16 ceramide. The invention verifies that the bifidobacterium pseudocatenum and the metabolite C16 ceramide thereof have the functions of enhancing the anti-tumor immune response of a body, promoting the anti-tumor curative effect of a PD-1 antibody and remarkably inhibiting tumor growth in an animal body. The invention provides a new strategy for clinically improving the response rate of tumor immunotherapy crowds, expanding the benefited crowds of cancer immunotherapy (immunotherapy checkpoint inhibitors) and the like.

The non-therapeutic use of a water-in-oil emulsion stick composition comprising a humectant for boosting the natural level of ceramides in the human skin.

The invention relates to the non-therapeutic nutricosmetic use of a composition in a form suitable for oral administration comprising a wheat extract in a physiologically acceptable medium. The invention is characterized in that the wheat extract contains 35-40% of triglycerides and diglycerides, 20-30% of glycolipids, 7-10% of phospholipids and 2-4% of ceramides and glycosylceramides, by weight relative to the total weight of the extract, and is used to reduce excessive sebum secretion in the skin of the face.

The present disclosure provides a soothing repair composition for dry sensitive skin and its preparation method and application, belonging to the technical field of cosmetics. The soothing repair composition of the present disclosure is a liposome structure. Cephalin and ceramide-EOP form a cephalin-ceramide complex, which serves as the shell layer of the liposome. The plant moulting hormone and glycerophosphoinositol choline salt are wrapped inside the liposome. The soothing repair composition with the liposome structure has excellent moisturizing, soothing and repairing effects.

The invention discloses a skin care agent and a preparation method thereof, and belongs to the technical field of cosmetics. The preparation method of the skin care agent comprises the following steps: grinding ceramide, trihydroxy stearin and part of grease through a three-roller machine to obtain paste; mixing the paste with the remaining grease, and homogenizing; every 100 parts of the skin care agent is prepared from 0.5 to 5 parts of ceramide, 0.2 to 1 part of trihydroxy stearin and the balance of grease. According to the method, the ceramide and the trihydroxy stearin can be uniformly and stably dispersed in the grease directly through grinding at normal temperature, and the equipment cost and the energy consumption can be reduced. The obtained skin care agent is good in stability, not only has certain viscosity, but also is not prone to layering, fine and smooth in texture and weak in greasy feeling, and the barrier repairing effect of ceramide can be effectively reserved.

The invention relates to the field of lipidosome technology and skin external preparations, in particular to bionic ceramide coated retinol lipidosome and a preparation method and application of the bionic ceramide coated retinol lipidosome. The liposome is prepared from the following raw materials in parts by weight: 1.0 to 3.0 weight percent of ceramide NP, 1.0 to 3.0 weight percent of ceramide AP, 0.05 to 0.5 weight percent of ceramide EOP, 1.0 to 3.0 weight percent of cholesterol, 0.50 to 2.0 weight percent of meadowfoam seed oil, 3.0 to 10.0 weight percent of hydrogenated lecithin, 1.0 to 3.0 weight percent of retinol, 0.50 to 2.50 weight percent of tocopheryl acetate, 15.0 to 45.0 weight percent of caprylic / capric triglyceride MCT, 1.0 to 5.0 weight percent of propylene glycol, 15.0 to 45.0 weight percent of glycerol and the balance of water, the bionic layered film is constructed by the multi-subtype ceramide, cholesterol and hydrogenated lecithin, the oil phase and an antioxidant system are cooperated, the stability of retinol under light, heat and oxygen is remarkably improved, slow release is achieved, meanwhile, skin tolerance is improved, and the bionic layered film can be widely applied to essence, emulsion, face cream, ampoule and other external skin care preparations.

The present disclosure provides compositions and dosage forms thereof, wherein the compositions comprise hyaluronic acid and a lipid extract comprising a ceramide and glycolipid. The present disclosure further provides methods for improving a skin property in a subject by administering the composition or dosage form to the subject.

The invention relates to the technical field of cosmetics, in particular to a preservative-free cosmetic composition for barrier repair as well as a preparation method and application of the preservative-free cosmetic composition. The invention relates to a preservative-free cosmetic composition for barrier repair, which comprises the following components in percentage by weight: 4.0-6.0% of 1, 2-pentanediol; 0.5% to 1.0% of 1, 2-hexanediol; 0.1% to 0.5% of cerayl; 0.5%-1.0% of phytosterol; 4.0%-6.0% of stearic acid; 4.0%-7.0% of hydrogenated lecithin; 0 to 0.3 percent of caryophylline; 0-0.2% of a eucommia ulmoides bark extract; and the balance of water. The composition of 1, 2-pentanediol and 1, 2-hexanediol is adopted to replace a traditional chemical preservative, and on the premise that the preservative effect is achieved, the possibility of causing skin irritation and allergy risks is reduced; ceramide and phytosterol can participate in construction of a skin barrier and supplement and repair a lipid structure of the skin barrier; stearic acid and hydrogenated lecithin form a stable emulsification basis, so that the two long-term contradictory requirements of no chemical preservative stimulation and effective barrier repair are met, and the unification of product safety and efficacy is realized.

The application belongs to the technical field of molecular biology, and particularly relates to metabolic markers for evaluating the prognosis of patients with hypertrophic cardiomyopathy and application thereof. The application determines that one or more of 3-hydroxyrilotene, asparagine-lysine, cyclohexylamine, arachidonic acid, aconitic acid, propionyl carnitine, ceramide, tryptophan, 3-hydroxysebacic acid, traumatic acid, phosphatidylcholine, alanine-proline, lysophosphatidylcholine, taurine and S-garlicin cysteine are related to the prognosis of hypertrophic cardiomyopathy, can evaluate the prognosis of patients with hypertrophic cardiomyopathy after undergoing muscle resection of interventricular septum, and shows accurate judgment on all-cause death or rehospitalization, cardiovascular events and postoperative new-onset arrhythmia. Finally, all the prognostic biomarkers are reproduced in an independent cohort, which is helpful for postoperative risk evaluation of patients with hypertrophic cardiomyopathy, has high specificity and high sensitivity.

Use of ectoin ceramide in skin care. The ectoin ceramide has an excellent effect in the aspects of repairing the skin barrier, promoting skin tissue healing, resisting photoaging, moisturizing, resisting inflammation and soothing, and the like. Especially in the aspects of cell viability proliferation and resisting inflammation and soothing, the ectoin ceramide shows superior effects than ectoin, and has good application value in the fields of preparing cosmetics, drugs, and health care products with corresponding efficacy or indications.