111 results about "Ceramide AP" patented technology

The invention relates to the technical field of repair compositions, and discloses a repair composition based on mussel mucin and application of the repair composition in skin barrier repair. The invention discloses a mussel mucoprotein-zinc composite microcapsule repair agent, which is prepared from the following components in parts by weight: mussel mucoprotein-zinc composite microcapsules, modified carboxymethyl chitosan, isolactone palmitate, a pH response type ceramide slow release system, dimeticone, cetostearyl alcohol, a calcium ion activating agent, an auxiliary repair factor, beheneth-25, caprylic / capric triglyceride, glyceryl monostearate, glyceryl distearate, pentanediol and citric acid. The preparation method comprises the following steps: adding ethanol, phenoxyethanol / ethylhexylglycerin, trehalose, beta-glucan and purified water; according to the whole technical scheme, through functional complementation and process optimization of all the components, synergistic interaction is achieved, the transpedermis water loss amount can be rapidly reduced, the water content of the skin cuticle is increased, the damaged skin barrier structure can be repaired from the source, and the resistance and stability of the skin are remarkably improved.

The invention discloses a ceramide-containing composition as well as a preparation method and application thereof, and belongs to the technical field of daily chemical products and medicines. The composition comprises 0.1%-5.0% of ceramide, 1.8%-2.7% of an emulsifier, 1.2%-2.5% of an emulsion stabilizer, 8%-14% of a solvent, 3%-5% of an emollient and 0.7%-0.95% of a stabilizing aid, the composition obtained by compounding the components has high stability, and the phenomena of particle precipitation, oil-water separation and the like are avoided; meanwhile, all the components are mutually matched and have a synergistic effect, and the effects of fading, repairing and resisting wrinkles can be achieved.

202300151 Foreign Filing 48 Abstract The invention relates to compositions comprising (pseudo-) ceramide and / or sphingoid base and a solvent composed of at least two components, a process for producing a formulation (pseudo-) ceramide and / or sphingoid base and the use of at least one of said composed solvent for 5 stabilization of (pseudo-) ceramide and / or sphingoid base containing composition.

A method, preferably a cosmetic and / or non-therapeutic method - of re-balancing a ceramide profile of a ceramide-containing tissue; or - of maintaining a ceramide profile of a ceramide-containing tissue; or - of preventing or treating a disruption of a ceramide profile of a ceramide-containing tissue, wherein the method comprises a step of application of niacinamide to such ceramide-containing tissue.

The invention relates to the non-therapeutic nutricosmetic use of a composition in a form suitable for oral administration comprising a wheat extract in a physiologically acceptable medium. The invention is characterized in that the wheat extract contains 35-40% of triglycerides and diglycerides, 20-30% of glycolipids, 7-10% of phospholipids and 2-4% of ceramides and glycosylceramides, by weight relative to the total weight of the extract, and is used to reduce excessive sebum secretion in the skin of the face.

The present disclosure provides a soothing repair composition for dry sensitive skin and its preparation method and application, belonging to the technical field of cosmetics. The soothing repair composition of the present disclosure is a liposome structure. Cephalin and ceramide-EOP form a cephalin-ceramide complex, which serves as the shell layer of the liposome. The plant moulting hormone and glycerophosphoinositol choline salt are wrapped inside the liposome. The soothing repair composition with the liposome structure has excellent moisturizing, soothing and repairing effects.

The invention relates to the technical field of cosmetics, in particular to a preservative-free cosmetic composition for barrier repair as well as a preparation method and application of the preservative-free cosmetic composition. The invention relates to a preservative-free cosmetic composition for barrier repair, which comprises the following components in percentage by weight: 4.0-6.0% of 1, 2-pentanediol; 0.5% to 1.0% of 1, 2-hexanediol; 0.1% to 0.5% of cerayl; 0.5%-1.0% of phytosterol; 4.0%-6.0% of stearic acid; 4.0%-7.0% of hydrogenated lecithin; 0 to 0.3 percent of caryophylline; 0-0.2% of a eucommia ulmoides bark extract; and the balance of water. The composition of 1, 2-pentanediol and 1, 2-hexanediol is adopted to replace a traditional chemical preservative, and on the premise that the preservative effect is achieved, the possibility of causing skin irritation and allergy risks is reduced; ceramide and phytosterol can participate in construction of a skin barrier and supplement and repair a lipid structure of the skin barrier; stearic acid and hydrogenated lecithin form a stable emulsification basis, so that the two long-term contradictory requirements of no chemical preservative stimulation and effective barrier repair are met, and the unification of product safety and efficacy is realized.

The application belongs to the technical field of molecular biology, and particularly relates to metabolic markers for evaluating the prognosis of patients with hypertrophic cardiomyopathy and application thereof. The application determines that one or more of 3-hydroxyrilotene, asparagine-lysine, cyclohexylamine, arachidonic acid, aconitic acid, propionyl carnitine, ceramide, tryptophan, 3-hydroxysebacic acid, traumatic acid, phosphatidylcholine, alanine-proline, lysophosphatidylcholine, taurine and S-garlicin cysteine are related to the prognosis of hypertrophic cardiomyopathy, can evaluate the prognosis of patients with hypertrophic cardiomyopathy after undergoing muscle resection of interventricular septum, and shows accurate judgment on all-cause death or rehospitalization, cardiovascular events and postoperative new-onset arrhythmia. Finally, all the prognostic biomarkers are reproduced in an independent cohort, which is helpful for postoperative risk evaluation of patients with hypertrophic cardiomyopathy, has high specificity and high sensitivity.

The granulator comprises a machine body and a bearing plate, the bearing plate is installed on one side of the machine body, two sets of electric push rods are installed at the top end of the bearing plate, push arms are installed at the output ends of the electric push rods, a supporting plate is arranged above the electric push rods, and the supporting plate is connected with the bearing plate. The device comprises a supporting plate, the supporting plate is connected with a push arm, a rotating plate is arranged above the supporting plate, a movable shaft is movably installed at the center of the supporting plate and connected with the rotating plate, a driving motor is installed at the bottom end of the supporting plate, a driving shaft is installed at the output end of the driving motor, and the surface of the driving shaft is sleeved with a transmission gear. The surface of the movable shaft on one side of the transmission gear is sleeved with a driven gear. According to the utility model, convenient high-hydraulic-pressure shearing processing of homogenized liquid is realized, the liquid can be conveniently input in sequence, and the liquid homogenizing effect is improved.

The present invention provides the use of at least one sphingolipid for a hair treatment for inducing hair growth and / or inhibiting hair loss, including eyelashes and eyebrows. Said sphingolipid is preferably a ceramide having a fatty acid with a long hydrocarbon chain of C18-C24, mostly C20-C22, and a phytosphingosine base. Furthermore, and advantageously, the treatment is global, capable to also improve the properties of the scalp and hair themselves.

The invention discloses supramolecular ceramide and a preparation method thereof, and belongs to the technical field of supramolecules. The preparation method comprises the following steps: mixing and heating ceramide and tetrahydroxypropyl ethylenediamine to obtain supramolecular ceramide; in the method for preparing the supramolecular ceramide, polyether molecules can also be added; the preparation method specifically comprises the following steps: mixing and heating ceramide, tetrahydroxypropyl ethylenediamine and polyether molecules to obtain the supramolecular ceramide. The supramolecular ceramide disclosed by the invention can be dissolved in water and also can be dissolved in oil. The supramolecular ceramide prepared by the preparation method disclosed by the invention is good in solubility, good in compatibility and good in stability; and the preparation process is simple and suitable for industrial large-scale use.

The invention discloses bifidobacterium breve CCFM1505 capable of regulating skin ceramide de novo synthesis and improving skin health and a metagen thereof, and belongs to the technical field of microorganisms and medicines. The bifidobacterium breve CCFM1505 obtained through screening shows the effect of remarkably promoting skin ceramide synthesis in the aspects of external use and oral administration. The viable bacteria of the bifidobacterium breve CCFM1505 and the metabiotics thereof, especially the thallus lysate of the bifidobacterium breve, are orally taken, so that the content of ceramide in the skin tissue is remarkably increased, and meanwhile, the effects of increasing of transpedermis water loss, reducing of the water content of cuticle and inflammatory response caused by skin injury and reducing of the ceramide content can be effectively regulated and controlled, and the skin healing effect is improved. Therefore, the skin health is improved. Therefore, the bifidobacterium breve has a huge application prospect in preparation of external or oral medicines for promoting synthesis of skin ceramide and improving skin health, as well as in preparation of foods, health-care products or cosmetics.

The present invention relates to the field of active ingredient preparation, and more particularly to a method for preparing and applying a ceramide derived from the golden oyster mushroom (Pleurotus citrinipileatus), possessing moisturizing, brightening, anti-aging, and skin barrier-maintaining properties. The method comprises the following steps: collection and pretreatment; fermentation treatment; separation and extraction; and refining. The advantage lies in the fact that the method for preparing and applying this ceramide, through the optimization of fermentation conditions and separation and extraction techniques, allows for the efficient preparation of the ceramide from the golden oyster mushroom (Pleurotus citrinipileatus) and increases the yield and purity of the ceramide.

The invention relates to the technical field of cosmetics, in particular to a soothing composition as well as a preparation method and application thereof. The soothing composition is prepared from the following components in percentage by mass: 10 to 20 percent of polyglycerol-10 laurate and other emulsifiers, 10 to 20 percent of palmitamide MEA, 5 to 15 percent of acetamide MEA, 2 to 8 percent of stearyl glycyrrhetinate, 5 to 15 percent of squalane and 0.5 to 2 percent of ceramide NP. The invention also provides a preparation method of the soothing composition, and the soothing composition is quick and long-acting in soothing effect, and can synchronously improve the barrier, anti-inflammatory and moisturizing effects.

The present application relates to the technical field of detection, in particular to a method for detecting multiple amino acids, hormones and ceramides in blood and cerebrospinal fluid by liquid chromatography tandem mass spectrometry. Specifically comprising: preparing standard curve equation I and standard curve equation II respectively, pretreating the sample to be tested to obtain sample I for detecting amino acids and hormones and sample II for detecting ceramides; using high performance liquid chromatography mass spectrometry to detect respectively, substituting the detection results of sample I into standard curve equation I and substituting the detection results of sample II into standard curve equation II to obtain the content of multiple amino acids, hormones and ceramides in the sample to be tested. The present application can realize the combined detection of seven kinds of amino acids, eleven kinds of hormones and three kinds of ceramides by collecting blood and cerebrospinal fluid once. The detection method of the present application greatly saves the analysis time and reduces the analysis cost.

The present specification relates to a composition which comprises a ceramide or a pseudo-ceramide and a lipid complex including a fatty acid, and thus forms a stable formulation and relieves skin irritation. According to the present disclosure, the composition comprises a lipid complex having a structure similar to that of the stratum corneum, and thus can exhibit an excellent skin irritation relief effect when applied to sensitive skin.

The object of this disclosure is to provide a topical composition comprising ceramide 2 and tocopherol and / or its derivatives that can suppress creaming. [Solution] A topical composition containing (A) ceramide 2, (B) tocopherol and / or its derivatives, and (C) heparin-like substance has suppressed creaming.

This invention discloses a repair composition containing multiple ceramides and its preparation method, belonging to the field of cosmetic technology. The repair composition, by mass parts, comprises ceramide AP, ceramide EOP, ceramide NP, phytosphingosine, Centella asiatica extract, Portulaca oleracea extract, Hydrangea macrophylla extract, ectoine, and tripeptide-1. This invention utilizes multiple ceramides and phytosphingosine to biomimetically replenish the lipids of the stratum corneum, combined with the synergistic effects of various plant active ingredients and active peptides, to effectively achieve multiple effects such as skin barrier repair, soothing and anti-inflammatory properties, and anti-allergy. This invention also provides a barrier repair serum containing this repair composition and its preparation method. The serum has stable physicochemical properties and, verified by in vitro cell experiments and human efficacy tests, can rapidly repair damaged skin barriers, improve sensitive symptoms such as redness and stinging, and is gentle and non-irritating, suitable for daily skincare use by people with sensitive skin and damaged skin barriers.

The present invention provides a basis for using soluble fiber, particularly compositions comprising Agave fructans, to prevent or treat the accumulation of lipids, particularly ceramides in the liver and brain and lipofuscin in the liver, improving the overall integrity of both organs, with treatment being feasible to prevent fatty liver disease and also prevent Alzheimer's disease (AD). In the present invention, we analyze alterations in lipid metabolism in the liver and ceramide production in the brain of transgenic mice (APP / PS1, TG) for AD. Our results indicate that microvesicular lipid accumulation within hepatocytes is increased in TG mice compared to the control group. Furthermore, in the brains of TG mice, a greater accumulation of ceramides is observed in the somatosensory cortex and entorhinal cortex; in the CA1 region of the hippocampus and in the motor cortex, no significant increase was observed when compared to the control group.

The application belongs to the technical field of skin care products, and discloses a kind of repair anti-aging skin care composition and preparation method thereof;The composition comprises ceramide complex, polyphenol supramolecular complex, polyol humectant, emollient oil, oil-soluble emulsifier, water-soluble thickener, ectoine, preservative, chelating agent and pH regulator;The ceramide complex is compounded by ceramide NP, ceramide AP, ceramide EOP, phytosphingosine and cholesterols according to molar ratio, and the polyphenol supramolecular complex is ternary inclusion nanocomposite formed by oligomeric procyanidins, hydroxypropyl-beta-cyclodextrin and ceramide NP through supramolecular self-assembly;The composition has barrier repair and anti-aging dual effects, and solves the problem that ceramide repair components and polyphenol anti-aging components are difficult to be stable in the same formula system.

The invention discloses a method for synthesizing retinoic acid ceramide ester through enzyme catalysis and application of the retinoic acid ceramide ester, and belongs to the technical field of cosmetic raw material synthesis. According to the method, retinoic acid and ceramide NP serve as substrates, specific immobilized lipase serves as a catalyst, and in a non-aqueous phase organic solvent, the target product is efficiently synthesized through the steps of raw material preparation, anaerobic reaction system building, directional esterification reaction, aftertreatment and purification detection. The method solves the problems of low substrate solubility, more byproducts, difficulty in catalyst recovery and the like in the traditional process, has the advantages of mild reaction conditions, capability of retaining the activity of the raw materials, high product purity and anti-aging and barrier repair effects, and can be widely used for preparing raw materials of anti-wrinkle and repair cosmetics.

This composition for promoting ceramide production or aquaporin-3 production contains a residue obtained by extracting a pigment from safflower.

The invention relates to the technical field of assay and inspection, in particular to a method for detecting ceramide and phosphatidyl ethanolamine in neonatal dried blood spots, and the preparation method comprises the following steps: S1, drawing a standard curve equation: preparing an internal standard extract; preparing a mixed standard solution; preparing standard substance solutions with a series of concentrations; adding the internal standard extraction liquid into the standard substance solution, carrying out pretreatment, and carrying out HPLC-MS / MS detection to respectively obtain a ceramide standard curve and a phosphatidyl ethanolamine standard curve; and S2, detecting the contents of ceramide and phosphatidyl ethanolamine in the dried blood spot to be detected, namely adding the internal standard extract into the dried blood spot to be detected, performing pretreatment, performing HPLC-MS / MS detection, and obtaining the contents of ceramide and phosphatidyl ethanolamine according to a ceramide standard curve and a phosphatidyl ethanolamine standard curve respectively. The detection method provided by the embodiment of the invention has the characteristics of high accuracy, good sensitivity, stability and simplicity and convenience in operation.

By combining specific ingredients, we provide a low-viscosity liquid cosmetic with minimal skin irritation, in which ceramides are stably solubilized. [Solution] A liquid cosmetic composition comprising the following components (A) to (E) and having a viscosity of less than 400 mPa·s. (A) Ceramides 0.00001~0.1% by mass (B) One or more selected from 0.002 to 2.0% by mass of phospholipids and / or 0.0002 to 0.2% by mass of dilauroyl glutamate lysine salt. (C) Polyglycerol fatty acid ester in which all hydroxyl groups are esterified with fatty acids 0.004-4.0% by mass (D) One or two selected from glycerin and 1,3-butylene glycol (E)Water

The invention relates to a ceramide nanoemulsion as well as a preparation method and application thereof, in particular to the ceramide nanoemulsion which comprises the following components: meadowfoam seed ceramide NP, ceramide AP and ceramide EOP, and further comprises an oil phase and a water phase, the oil phase is prepared from meadowfoam seed oil, tocopheryl acetate, caprylic / capric triglyceride, hexyldecanol and polyglycerol-10 myristate, the water phase is prepared from water, glycerol, hydrogenated lecithin, 1, 2-hexanediol and p-hydroxyacetophenone, and the ceramide nanoemulsion has multiple excellent skin care effects.

The invention belongs to the field of biomedicine technology, and discloses a plant oil ceramide, which is obtained by reacting a plant oil fatty acid with a sphingoid base compound, wherein the sphingoid base compound is selected from sphingosine, phytosphingosine, and dihydrosphingosine, and the plant oil fatty acid is selected from olive oil fatty acid, camellia oil fatty acid, sea buckthorn oil fatty acid, grape seed oil fatty acid, nut oil fatty acid, borage oil fatty acid, rosehip oil fatty acid, soybean oil fatty acid, rice bran oil fatty acid and the like. This invention also discloses a synthesis method and use of plant oil ceramide. Said plant oil ceramide exhibits outstanding performance in skin's natural barrier repair, anti-inflammatory activity, tissue healing, anti-aging effects, and more, with broad application prospects in cosmetics, health supplements, and biopharmaceuticals.

The invention relates to ceramide liposome as well as a preparation method and application thereof. The ceramide liposome is prepared from the following raw materials: water, an alcohol solvent, phospholipid, cholesterol, a co-emulsifier and an active component, the active components comprise ceramide and a candida albicans / glucose / flat nuclear wood oil fermentation product. The invention develops a liposome product simultaneously loading ceramide and candida albicans / glucose / flat nuclear wood oil fermentation products, the two active components are mutually matched and have synergistic interaction in the aspect of skin barrier repair, the transdermal permeation effect of the active components can be improved by virtue of a liposome form, and the bioavailability of the liposome product is improved. Compared with unfermented flat nuclear wood oil, the candida albicans / glucose / flat nuclear wood oil fermentation product is selected, so that the hydrophilicity and stability of the liposome can be improved, the encapsulation performance of the liposome on ceramide and the transdermal permeation effect of the ceramide can be improved, and finally the skin barrier repairing effect of the liposome product is improved.

One aspect of the present disclosure relates to a hyaluronic acid hydrogel to which ceramide is bound.SOLUTION: One aspect of the present disclosure includes a hyaluronic acid hydrogel containing hyaluronic acid or a salt thereof, and emulsified particles bound to the hyaluronic acid hydrogel, wherein the emulsified particles contain at least one of a ceramide or a pseudoceramide. [Advantageous Effects] According to an aspect of the present invention, it is possible to provide a composition, particularly a composition of a solubilized formulation, which stably contains both ceramide and hyaluronic acid by simply mixing a hyaluronic acid hydrogel to which ceramide is bound.SELECTED DRAWING: Figure 1

The application relates to the technical field of skin care raw materials, and particularly discloses a repairing composition and a preparation method thereof. The repairing composition comprises the following components in mass fractions: ceramide NP 3.5-4.5 parts; mother bacteria / rice fermentation product filtrate 3-4 parts; composite extract 6.5-10 parts; preservative 0.5-1.5 parts; auxiliary agent 4-6 parts; solvent 38-48.5 parts; and the composite extract is a compound of mussel extract, sea fennel extract, plantain leaf Eragrostis pilosa seed oil and red ganoderma extract. The application has the advantages of high efficiency soothing, anti-inflammation, repairing of skin barrier, and good oil control effect, so that the repairing effect on oily skin is improved.