366 results about "Ceramide AP" patented technology

The invention discloses a Parkinson's disease biomarker, a detection reagent and application, and the Parkinson's disease biomarker has the advantages of high sensitivity and low misdiagnosis rate, and can be effectively used for early diagnosis of Parkinson's disease and risk prediction of adverse events. The biomarker at least comprises one of the following indexes: a concentration ratio of C16 ceramide to C24 ceramide (Ce16: 0 / Cer24: 0), a concentration ratio of C18 ceramide to C24 ceramide (Ce18: 0 / Cer24: 0), a concentration ratio of C24: 1 ceramide to C24 ceramide (Ce24: 1 / Cer24: 0), and a combined index Cer16: 0, Cer18: 0, and a ratio of the total concentration of Cer24: 1 to the concentration of Cer24: 0 (Conc (Ce16: 0 + Cer18: 0 + Cer24: 1) / Conc (Ce24: 0).

The invention relates to the technical field of automatic control, in particular to a monitoring method and system for synthesizing ceramide based on alpha-hydroxy fatty acid, and the monitoring system for synthesizing ceramide based on alpha-hydroxy fatty acid comprises a raw material feeding module, a reaction control module, a quenching-crystallization joint control module and a data integration module; carrying out dynamic weighing monitoring on the raw materials based on the received synthesis instruction, and starting a reaction kettle according to weighing data; performing multi-dimensional data acquisition in real time according to the set reaction data, and performing dynamic feeding control according to the set reaction data; when the TLC detection substrate reaction is completed, the cooling process and the crystallization process are regulated and controlled in real time according to the reaction data until the end point judgment standard is met; according to a received synthesis completion instruction, product quality data is obtained, a monitoring data packet is generated, the synthesis instruction is marked and then stored, process control is accurately monitored and controlled, and the purity and crystal form of the product are ensured.

The invention relates to a composition containing ceramide and collagen tripeptide and a preparation method thereof, and belongs to the technical field of health care products. The invention discloses a composition containing ceramide and collagen tripeptide. The composition is prepared from the following raw materials: collagen tripeptide, rice bran oil powder, a herba houttuyniae extract, pineapple powder, konjaku flour, a grape seed extract, olive fruit powder, carnosine, pomegranate concentrated powder and a whey fermentation product. The grape seed extract, the olive fruit powder, the carnosine and the pomegranate concentrated powder inhibit the Maillard reaction of the collagen peptide and improve the utilization rate of collagen tripeptide; ceramide rich in the rice bran oil powder is a natural skin moisturizing factor, and is matched with the pineapple powder and the konjaku flour which have a keratin metabolism effect to maintain the health of cuticles; the herba houttuyniae extract and the whey fermentation product are matched to have an excellent anti-inflammatory effect, so that the components enhance the skin barrier in multiple dimensions through collagen synthesis, cuticle maintenance, anti-inflammatory and anti-oxidation.

The invention provides an acne-removing composition containing ceramide, a preparation method of the acne-removing composition and an acne-removing product, and the acne-removing composition is prepared from the following components in parts by weight: 5 to 10 parts of plant extract, 1 to 3 parts of ceramide, 1 to 3 parts of gentiopicroside-vitamin C eutectic, 1 to 3 parts of compound polysaccharide and 0.3 to 0.7 part of transdermal enhancer. The plant extract is prepared from a herba dendrobii fruticosae flower extract, a lasiocarpus trifoliatus extract and a hedera rhododendron extract in a mass ratio of 1: (1-3): (2-4); the compound polysaccharide is prepared from tremella polysaccharide, tamarind seed polysaccharide and ganoderma lucidum polysaccharide in a ratio of 1: (3-5): (0.5-0.8); the transdermal enhancer is prepared from a cucumber extract and a salvia miltiorrhiza root extract in a mass ratio of 1: (1-3). The plant extracts in the acne-removing composition take effect synergistically, the acne-removing effect is achieved from multiple aspects of bacteriostasis, anti-inflammation and oil control, the purpose of efficiently removing acnes without relapse is achieved, and the natural plant extracts are mild and non-irritant, do not cause burden to the skin and have good application prospects.

The invention provides essential oil containing ceramide and a preparation method of the essential oil. The essential oil containing ceramide is prepared from ceramide, mannosyl erythritol lipid, synthetic grease and natural vegetable grease. According to the ceramide-containing essential oil disclosed by the invention, complex components such as a surfactant and a stabilizer do not need to be added, and the added mannosyl erythritol lipid is natural sugar ester and has good biocompatibility and safety, so that the ceramide-containing essential oil disclosed by the invention is mild and non-irritant to skin and has excellent product safety; besides, according to the pure oil formulation formula, the purpose of improving the solubility and stability of ceramide can be achieved only by adding mannosyl erythritol lipid, the skin barrier maintaining effect of ceramide can be better played, the anti-inflammatory and skin repairing effects of ceramide are improved, and the skin health level is improved; the application range of ceramide in cosmetics is expanded.

The invention discloses a method for synthesizing ceramide NP through two-step enzyme catalysis, which comprises the following steps of: firstly, adding lipase into vegetable oil to catalyze and combine fatty acid to decompose into free fatty acid, and centrifuging to remove the lipase; a small amount of phytosphingosine is added into the hydrolyzed vegetable oil, the raw material vegetable oil is used as a solvent or a squalane system solvent for incubation, and then immobilized lipase is added for catalytic synthesis of ceramide. The invention establishes a two-enzyme method for efficiently synthesizing the ceramide NP compound, and the process is natural, environment-friendly and non-toxic. The reaction conditions are optimized through response surface analysis, meanwhile, the immobilized lipase shows excellent cycle performance, and the method is easy to operate, environmentally friendly, green and economical and has wide application prospects in the fields of cosmetics, health care products, biological medicine and the like.

The invention belongs to the technical field of biomedicine, and particularly relates to application of ceramide as a marker in prediction of hepatocellular carcinoma microvascular invasion risk. The invention finds that the preoperative plasma ceramide CER (d18: 1 / 16: 0) level can be used for predicting the MVI of HBV-HCC patients and evaluating the postoperative prognosis of the patients for the first time. The invention provides a preoperative non-invasive detection method based on plasma ceramide CER (d18: 1 / 16: 0), and trauma of traditional histopathology detection is avoided. According to the method, the occurrence risk of the MVI can be effectively reduced by simply detecting a blood sample of a patient. According to the method, the MVI risk of a patient is evaluated through a multi-factor prediction model, and a basis is provided for personalized treatment. The method is not only suitable for preoperative MVI risk assessment, but also can assist in making postoperative follow-up visit and treatment plans, and helps to reduce the postoperative recurrence rate and improve the survival rate of patients.

The invention belongs to the technical field of cosmetics, and discloses micro-emulsion essence water containing ceramide and a preparation method of the micro-emulsion essence water. The micro-emulsion essence containing ceramide is prepared from the following components: an emulsifier, a humectant, polypeptide, small molecular grease and water, the emulsifying agent comprises polyglycerol-10 oleate, the emulsifying agent does not contain a PEG and / or PPG structure, the humectant comprises glycerol and ceramide, and the small molecule grease comprises at least one of tridecane, undecane, isononyl isononanoate, propyl heptyl octoate, coconut oil alcohol-octoate / caprate, dicapryl carbonate and dioctyl ether. The micro-emulsion essence water containing ceramide has excellent stability, low viscosity, refreshing texture which is common to water and fine skin feeling, and also has excellent moisturizing and tightening effects.

The invention discloses a lipid composition for preparing extracellular vesicles, which is prepared from the following lipid substances in percentage by mass: 2 to 18 percent of phosphatidylcholine, 2 to 14 percent of phosphatidylethanolamine, 7 to 27 percent of sphingomyelin, 0.5 to 7 percent of ceramide, 1.5 to 2.5 percent of phosphatidylinositol, 30 to 70 percent of cholesterol and 5 to 8 percent of phosphatidylserine, the fatty acid carbon number of the lipid substance satisfies the following conditions: the fatty acid carbon number of phosphatidylcholine is 16-20, the fatty acid carbon number of phosphatidyl ethanolamine is 16-18, the fatty acid carbon number of sphingomyelin is 16-24, the fatty acid carbon number of ceramide is 16-24, the fatty acid carbon number of phosphatidylinositol is 16-20, the fatty acid carbon number of phosphatidylserine is 18-24, and the molar ratio of cholesterol to sphingomyelin is 4-7. The extracellular vesicles are prepared from the lipid composition and used for biomarkers or drug carriers, and efficient oral drug delivery is achieved.

The invention relates to the field of cosmetics, and discloses ceramide liposome and application thereof.The ceramide liposome is prepared from, by mass, 1.5-3 parts of ceramide NP, 1-3 parts of octyldodecanol, 0.5-2 parts of caprylic / capric triglyceride, 11-18 parts of hydrogenated lecithin, 2-6 parts of sucrose stearate, 3-7 parts of polyglycerol-10 oleate and 25-35 parts of glycerinum, and the balance is water. 0.5-8 parts of 1, 2-pentanediol, and the balance of water. The ceramide liposome provided by the invention has good stability at least at 40 DEG C, is not easy to cause lactic acid pricking pain and allergy after being smeared on skin, and can be used for sensitive skin; the skin care product can reduce skin transdermal moisture loss, maintain skin cutin moisture, reduce skin heme content, improve skin gloss, relieve skin dryness, relieve skin redness and improve skin fineness, and has the effects of moisturizing, repairing and relieving.

The invention belongs to the field of plant extract processing, and particularly relates to a preparation method and application of a ceramide-containing platycodon grandiflorum extract. The preparation method comprises the following steps: adding crushed radix platycodonis rhizomes and leaves into 45% ethanol for soaking, ultrasonically treating a material-liquid mixture for 40 minutes, and taking residual radix platycodonis dregs as a raw material for preparing ceramide. The preparation method comprises the following steps: carrying out solid fermentation on a platycodon grandiflorum herb residue mixed strain S.paucimobilis for 72 hours, then extracting to obtain a ceramide crude product, and purifying through macroporous resin to obtain the ceramide-containing platycodon grandiflorum extract. The platycodon grandiflorum extract obtained by the method contains natural ceramide from a plant source, has no irritation to chick embryos, can be used as a cosmetic raw material, has soothing and repairing effects, and is beneficial to increasing the additional economic value of platycodon grandiflorum and promoting ecological environment protection.

The invention provides a soothing and repairing composition for dry and sensitive skin as well as a preparation method and application of the soothing and repairing composition, and belongs to the technical field of cosmetics. The soothing and repairing composition is of a liposome structure, cephalin and ceramide-EOP form a cephalin-ceramide complex and serve as a shell layer of the liposome, and plant ecdysone and inositol choline glycerophosphate are wrapped in the liposome; the soothing and repairing composition with the liposome structure has excellent moisturizing, soothing and repairing effects.

The present invention relates to skin moisturizing external compositions containing a ceramide, a cholesterol, and a fatty acid, and more particularly, to skin moisturizing external compositions capable of preventing skin troubles such as atopy by forming a dense lamellar structure, which is an intercellular lipid structure, and improving the skin barrier, and may include a ceramide having long-chain fatty acids, a cholesterol, a long-chain fatty acid, and purified water as active ingredients.

The invention relates to the field of skin care products, and discloses a ceramide liposome for skin care products and a preparation method thereof, the ceramide liposome comprises the following components by weight: 5-10 parts of hydrogenated lecithin, 0.5-2 parts of modified cholesterol, 0.5-2 parts of ceramide, 0.1-2.5 parts of sucrose stearate, 0.1-1 part of polyglycerol-10 stearate, and 15-30 parts of an organic solvent; the modified cholesterol is prepared by grafting glycine cholesteryl ester and carboxymethyl chitosan through a chemical reaction, the glycine cholesteryl ester is prepared from cholesterol, N-t-butyloxycarboryl glycine and trifluoroacetic acid as raw materials, and the carboxymethyl chitosan is prepared by grafting chloroacetic acid and chitosan. According to the invention, hydrogenated lecithin, modified cholesterol, ceramide, sucrose stearate and polyglycerol-10 stearate are used as raw materials to prepare the ceramide liposome with good stability, good skin barrier repairing property and good moisturizing and water locking effects.

The invention relates to the technical field of repair compositions, and discloses a repair composition based on mussel mucin and application of the repair composition in skin barrier repair. The invention discloses a mussel mucoprotein-zinc composite microcapsule repair agent, which is prepared from the following components in parts by weight: mussel mucoprotein-zinc composite microcapsules, modified carboxymethyl chitosan, isolactone palmitate, a pH response type ceramide slow release system, dimeticone, cetostearyl alcohol, a calcium ion activating agent, an auxiliary repair factor, beheneth-25, caprylic / capric triglyceride, glyceryl monostearate, glyceryl distearate, pentanediol and citric acid. The preparation method comprises the following steps: adding ethanol, phenoxyethanol / ethylhexylglycerin, trehalose, beta-glucan and purified water; according to the whole technical scheme, through functional complementation and process optimization of all the components, synergistic interaction is achieved, the transpedermis water loss amount can be rapidly reduced, the water content of the skin cuticle is increased, the damaged skin barrier structure can be repaired from the source, and the resistance and stability of the skin are remarkably improved.

The invention belongs to the technical field of biological medicines, and discloses ceramide derived from asiatic acid, which has a structure shown in a general formula I or an isomer shown in the general formula I: # imgabs0, in which R1 is selected from one of the following structures: # imgabs1 # R2 is a hydroxyl group or a hydrogen atom. The invention further discloses a synthesis method and application of the ceramide derived from the asiatic acid, the asiatic acid or madecassic acid fragment with good fat solubility is introduced, the solubility of the ceramide is improved, and the ceramide is more convenient to apply in a formula; the compound disclosed by the invention has an obvious inhibiting effect on interleukin 6 (IL-6) inflammatory factors, can also inhibit the overexpression of a TRPV1 receptor of sensitive skin, and can obviously reduce the expression of hyaluronidase, so that the compound has a very good soothing effect.

The invention provides a super-hydrophilic high-transdermal ceramide liposome and a preparation method thereof. The invention further provides a preparation method of the super-hydrophilic high-transdermal ceramide liposome. The invention further provides an application of the super-hydrophilic high-transdermal ceramide liposome in cosmetics. The invention also provides a cosmetic. According to the preparation method and application of the super-hydrophilic high-transdermal ceramide lipidosome, the super-hydrophilic high-transdermal ceramide lipidosome is obtained, industrial mass production is easy, use of a surfactant is avoided, and the super-hydrophilic high-transdermal ceramide lipidosome has the advantages of being good in water solubility, high in transparency, good in stability, high in transdermal efficiency, remarkable in effect and the like.

The invention discloses a ceramide-containing composition as well as a preparation method and application thereof, and belongs to the technical field of daily chemical products and medicines. The composition comprises 0.1%-5.0% of ceramide, 1.8%-2.7% of an emulsifier, 1.2%-2.5% of an emulsion stabilizer, 8%-14% of a solvent, 3%-5% of an emollient and 0.7%-0.95% of a stabilizing aid, the composition obtained by compounding the components has high stability, and the phenomena of particle precipitation, oil-water separation and the like are avoided; meanwhile, all the components are mutually matched and have a synergistic effect, and the effects of fading, repairing and resisting wrinkles can be achieved.

The present invention relates to a method for stabilizing ceramide and to a cosmetic composition containing stabilized ceramide and, more specifically, to a method for homogenizing and stabilizing ceramide by self-assembling the ceramide together with β-sitosterol, resveratrol, and allantoin which are other physiologically active substances using a microfluidic chip and a high pressure homogenizer, and to a technique for using ceramide and nanoparticles containing β-sitosterol, resveratrol, and allantoin, which are produced by means of the stabilizing method, as a cosmetic material for skin moisturizing, anti-oxidation, skin inflammation relief, skin barrier enhancement, and skin itching relief.

The invention belongs to the technical field of biological medicines, and particularly relates to a royal jelly acid derivative and a synthesis method, a pharmaceutical composition and application thereof. The royal jelly acid derivative is a compound shown as a formula (I), or an enantiomer, a diastereoisomer and a tautomer thereof, or a solvate or a pharmaceutically acceptable salt thereof. A series of royal jelly acid derivatives with novel structures are constructed by using a natural component royal jelly acid derived from royal jelly as an initial raw material, the royal jelly acid derivatives can play a role in resisting pulmonary fibrosis by inhibiting the activity of fibroblasts, the effect of the royal jelly acid derivatives is equivalent to that of pirfenidone, and the royal jelly acid derivatives are expected to be developed into candidate drugs for resisting pulmonary fibrosis. The ceramide NP has excellent effects in anti-inflammatory, anti-allergic and itching-relieving aspects, has a better effect than known ceramide NP, and can be used for preparing health care products, cosmetics and medicines. And # imgabs0 #.

The invention belongs to the field of cosmetics, and discloses a ceramide E-containing polypeptide composition and application thereof. The polypeptide composition containing ceramide E is prepared from the following components in parts by mass: 5 to 10 parts of ceramide E, 3 to 6 parts of fibronectin, 3 to 6 parts of palmitoyl pentapeptide-4, 1.5 to 3.5 parts of ergothioneine, 20 to 40 parts of oil-phase solvent, 1.5 to 4.5 parts of caprylic / capric triglyceride, 0.5 to 2.5 parts of soybean lecithin, 0.5 to 1.5 parts of polysorbate-80, 0.1 to 0.5 part of cholesterol and the balance of water, wherein the total mass part of the water is 100. In the polypeptide composition disclosed by the invention, ceramide E, fibronectin, ergothioneine and palmitoyl pentapeptide-4 are mutually promoted and have synergistic interaction, and a final product shows very good repairing and antioxidant effects.

The invention discloses a liposome precursor composition, which is prepared from the following ingredients in percentage by mass: 40 to 53 percent of polyhydric alcohol, 35 to 45 percent of panthenol, 10 to 15 percent of lecithin and 2 to 4 percent of ceramide NP. According to the liposome precursor composition disclosed by the invention, the problem that ceramide is not matched with a common formula system is effectively improved by adding panthenol with a specific content and combining the combined action of lecithin and polyhydric alcohol, and the stability, the water solubility and the permeability on the skin surface of a ceramide system are remarkably enhanced; the ceramide can play a better role in the epidermal layer and the corium layer of the skin. The invention also discloses a preparation method of the liposome precursor composition, in the method, chemical penetration enhancers which are not welcomed by cosmetics such as azone and the like are not used, and any unwelcomed solubilizers or surfactants are not introduced, so that the safe and effective application of the ceramide NP is realized.

The invention belongs to the technical field of gene engineering, and particularly relates to a genetically engineered bacterium of galactosylceramide as well as a construction method and application of the genetically engineered bacterium of galactosylceramide. On the basis of an existing delta pyrG aspergillus oryzae auxotroph strain, the metabolic flux of neutral glycosphingolipid is enhanced through overexpression of an AoCerS gene; meanwhile, the expression of a neutral sphingolipid glucosylceramide (GlcCers) synthetase gene AoUGCG is inhibited, so that the common intermediate metabolite flux of the GlcCers and galactosylceramide (GalCers) flows to the synthesis of the GalCers. The GalCers relative content of the constructed aspergillus oryzae engineering strain is increased by more than two times compared with that of a control strain, and is increased by about 70% compared with that of the control strain.

The invention relates to a method for increasing the content of ceramide in fermented tea-seed oil and application of the ceramide in skin care products, and the method comprises the following steps: taking a mixture containing tea-seed oil and a culture medium, and carrying out sterilization treatment to obtain an initial fermentation system; inoculating bumblebee candida into the initial fermentation system, carrying out fermentation culture until first culture time is reached, and adding a carbon source; continuously carrying out fermentation culture until the final culture time is reached, so as to obtain fermentation liquor; the fermentation broth is subjected to layering, centrifugation, dehydration and deodorization treatment after being inactivated so as to obtain the fermented tea seed oil, and the preservation number of the candida bumblebee is CGMCC No.25797. The fermented tea seed oil prepared by the technical scheme provided by the invention has more excellent barrier repairing and skin stability maintaining functions on human skin cells, and also has more remarkable effects in the aspects of relieving, anti-inflammation, moisturizing, anti-oxidation and the like.

The invention discloses a scalp micro-ecological regulation washing and care composition containing lactobacillus metagen, and particularly relates to the technical field of daily chemical washing and care products. The washing and care composition comprises the following specific components in percentage by weight: 3%-8% of lactobacillus metagen, 1%-3% of prebiotics, 0.05%-0.2% of natural antibacterial peptide, 0.5%-1.5% of a ceramide compound, 0.3%-0.7% of a pH regulator, 0.5%-2% of a microcapsule wrapping agent, 0.2%-0.6% of a natural preservative and the balance of deionized water, wherein the total percentage is 100%. According to the invention, various components are scientifically compounded, so that the washing and care composition has an excellent effect, the lactobacillus retrogen, the natural antibacterial peptide and the natural preservative cooperate to inhibit bacteria, the diameter of an inhibition zone for common pathogenic bacteria is 14-20mm, and the prebiotics and the lactobacillus retrogen regulate scalp micro-ecology, so that the flora diversity index is increased by 30-45%; the ceramide compound and dipotassium glycyrrhizinate cooperate to reduce the TEWL value by 30%-50%, the scalp barrier is repaired, and the product is good in stability, safe, reliable and capable of comprehensively caring scalp health.

The invention provides a composition for repairing a skin barrier as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The invention discloses a composition for repairing a skin barrier. The composition comprises ceramide NP1, ceramide AP, ceramide EOP, asiaticoside and DNA sodium. The composition is used for repairing skin from related proteins such as endogenous and endogenous injury, inflammatory factor inhibition, light injury, skin cuticle barrier and the like, and can deeply resist inflammation, relieve and maintain stability in an endogenous and endogenous two-way manner, and repair the damaged skin barrier in a multi-level and multi-dimensional manner, so that the skin problems such as skin dryness, roughness, desquamation, redness and swelling, pruritus and the like are improved.

The invention discloses an anti-wrinkle repairing face cream and a preparation method thereof, a mixture of cetyl-PG hydroxyethyl palmitamide is ceramide E. The ceramide E in the anti-wrinkle repairing face cream has an important regulating effect on life activities such as cell differentiation, proliferation, apoptosis and aging, and the ceramide is used as a main component of intercellular lipid of skin cuticle, so that the anti-wrinkle repairing face cream has a good anti-wrinkle effect on the skin cuticle. The protein not only serves as a second messenger molecule in a sphingomyelin pathway, but also plays an important role in an epidermal stratum corneum formation process, and has the effects of maintaining a skin barrier, preserving moisture, resisting aging, whitening, treating diseases and the like.

The present invention provides a biopolysaccharide that synergistically promotes the expression of ceramide synthase and / or hyaluronic acid synthase and its application, belonging to the technical field of traditional Chinese medicine. The biopolysaccharide is prepared from polygonatum and yam as raw materials through alternating enzymatic hydrolysis, extraction, impurity removal, molecular interception, compounding and other processes to promote the expression of ceramide synthase. The polysaccharide also promotes the expression of hyaluronic acid synthase and can be used in external preparations for the treatment and prevention of dryness, itching and skin barrier defects caused by weakened expression of ceramide synthase and hyaluronic acid synthase.

To provide a water-in-oil emulsion composition with superior moisturizing and protective effects for the purpose of alleviating and healing xerodermic conditions, and further to provide a dermatological topical agent that delivers a high healing effect in a short time.SOLUTION: An oil-in-water emulsion composition is prepared that contains human-type ceramides delivering a healing effect against xerodermic conditions in a short time, in addition to the moisturizing effect of heparinoids. The oil-in-water emulsion composition enables the production of a dermatological topical agent that delivers a high healing effect against xerodermic conditions in a short time, while overcoming the drawbacks of water-in-oil creams.SELECTED DRAWING: None

The invention discloses a ceramide detection kit and a method for detecting ceramide by using the detection kit. The detection kit comprises a calibration product, a quality control product, a protein precipitant and a mobile phase additive, substrates adopted by the calibration product and the quality control product are alternative substrates, and the alternative substrates are blank biological liquid substrates prepared by the following method: mixing biological liquid with a stripping solvent, and stirring to obtain a mixed solution; layering to obtain a first organic phase layer and a first main phase layer, and removing the first organic phase layer to obtain the first main phase layer which is a blank biological liquid matrix; the stripping solvent comprises alcohol and ether, the content of the alcohol is 1%-35% by mass, and the content of the ether is 65%-99% by mass.