32 results about "Ceramide AP" patented technology

202300151 Foreign Filing 48 Abstract The invention relates to compositions comprising (pseudo-) ceramide and / or sphingoid base and a solvent composed of at least two components, a process for producing a formulation (pseudo-) ceramide and / or sphingoid base and the use of at least one of said composed solvent for 5 stabilization of (pseudo-) ceramide and / or sphingoid base containing composition.

The application belongs to the technical field of molecular biology, and particularly relates to metabolic markers for evaluating the prognosis of patients with hypertrophic cardiomyopathy and application thereof. The application determines that one or more of 3-hydroxyrilotene, asparagine-lysine, cyclohexylamine, arachidonic acid, aconitic acid, propionyl carnitine, ceramide, tryptophan, 3-hydroxysebacic acid, traumatic acid, phosphatidylcholine, alanine-proline, lysophosphatidylcholine, taurine and S-garlicin cysteine are related to the prognosis of hypertrophic cardiomyopathy, can evaluate the prognosis of patients with hypertrophic cardiomyopathy after undergoing muscle resection of interventricular septum, and shows accurate judgment on all-cause death or rehospitalization, cardiovascular events and postoperative new-onset arrhythmia. Finally, all the prognostic biomarkers are reproduced in an independent cohort, which is helpful for postoperative risk evaluation of patients with hypertrophic cardiomyopathy, has high specificity and high sensitivity.

The present invention relates to the field of active ingredient preparation, and more particularly to a method for preparing and applying a ceramide derived from the golden oyster mushroom (Pleurotus citrinipileatus), possessing moisturizing, brightening, anti-aging, and skin barrier-maintaining properties. The method comprises the following steps: collection and pretreatment; fermentation treatment; separation and extraction; and refining. The advantage lies in the fact that the method for preparing and applying this ceramide, through the optimization of fermentation conditions and separation and extraction techniques, allows for the efficient preparation of the ceramide from the golden oyster mushroom (Pleurotus citrinipileatus) and increases the yield and purity of the ceramide.

The object of this disclosure is to provide a topical composition comprising ceramide 2 and tocopherol and / or its derivatives that can suppress creaming. [Solution] A topical composition containing (A) ceramide 2, (B) tocopherol and / or its derivatives, and (C) heparin-like substance has suppressed creaming.

This invention discloses a repair composition containing multiple ceramides and its preparation method, belonging to the field of cosmetic technology. The repair composition, by mass parts, comprises ceramide AP, ceramide EOP, ceramide NP, phytosphingosine, Centella asiatica extract, Portulaca oleracea extract, Hydrangea macrophylla extract, ectoine, and tripeptide-1. This invention utilizes multiple ceramides and phytosphingosine to biomimetically replenish the lipids of the stratum corneum, combined with the synergistic effects of various plant active ingredients and active peptides, to effectively achieve multiple effects such as skin barrier repair, soothing and anti-inflammatory properties, and anti-allergy. This invention also provides a barrier repair serum containing this repair composition and its preparation method. The serum has stable physicochemical properties and, verified by in vitro cell experiments and human efficacy tests, can rapidly repair damaged skin barriers, improve sensitive symptoms such as redness and stinging, and is gentle and non-irritating, suitable for daily skincare use by people with sensitive skin and damaged skin barriers.

The present invention provides a basis for using soluble fiber, particularly compositions comprising Agave fructans, to prevent or treat the accumulation of lipids, particularly ceramides in the liver and brain and lipofuscin in the liver, improving the overall integrity of both organs, with treatment being feasible to prevent fatty liver disease and also prevent Alzheimer's disease (AD). In the present invention, we analyze alterations in lipid metabolism in the liver and ceramide production in the brain of transgenic mice (APP / PS1, TG) for AD. Our results indicate that microvesicular lipid accumulation within hepatocytes is increased in TG mice compared to the control group. Furthermore, in the brains of TG mice, a greater accumulation of ceramides is observed in the somatosensory cortex and entorhinal cortex; in the CA1 region of the hippocampus and in the motor cortex, no significant increase was observed when compared to the control group.

The application belongs to the technical field of skin care products, and discloses a kind of repair anti-aging skin care composition and preparation method thereof;The composition comprises ceramide complex, polyphenol supramolecular complex, polyol humectant, emollient oil, oil-soluble emulsifier, water-soluble thickener, ectoine, preservative, chelating agent and pH regulator;The ceramide complex is compounded by ceramide NP, ceramide AP, ceramide EOP, phytosphingosine and cholesterols according to molar ratio, and the polyphenol supramolecular complex is ternary inclusion nanocomposite formed by oligomeric procyanidins, hydroxypropyl-beta-cyclodextrin and ceramide NP through supramolecular self-assembly;The composition has barrier repair and anti-aging dual effects, and solves the problem that ceramide repair components and polyphenol anti-aging components are difficult to be stable in the same formula system.

The application relates to the technical field of skin care raw materials, and particularly discloses a repairing composition and a preparation method thereof. The repairing composition comprises the following components in mass fractions: ceramide NP 3.5-4.5 parts; mother bacteria / rice fermentation product filtrate 3-4 parts; composite extract 6.5-10 parts; preservative 0.5-1.5 parts; auxiliary agent 4-6 parts; solvent 38-48.5 parts; and the composite extract is a compound of mussel extract, sea fennel extract, plantain leaf Eragrostis pilosa seed oil and red ganoderma extract. The application has the advantages of high efficiency soothing, anti-inflammation, repairing of skin barrier, and good oil control effect, so that the repairing effect on oily skin is improved.

The object of this disclosure is to provide an external emulsifying composition containing ceramide 2 that can suppress separation at the liquid surface. [Solution] The external emulsifying composition containing (A) ceramide 2 and (B) isopropylmethylphenol has suppressed separation at the liquid surface.

The present application belongs to the technical field of biological medicine, and particularly relates to a composition for promoting synthesis of an OAHFA derivative family, a microneedle patch and application thereof in preventing and treating dry eye syndrome. The present application first selects an OAHFA derivative as a dry eye treatment target and relies on activation of a PPARγ signal pathway to exert drug efficacy. The composition is compounded from 0.2% to 0.5% PPARγ agonists, 2.0% to 4.0% super-long chain fatty acids and 0.3% to 0.8% ceramides, three effective components. The super-long chain fatty acids supply synthesis substrates, and the ceramides stabilize the interface. The three components synergistically improve the curative effect. The composition described in the present application adopts soluble microneedles for local administration, and the drug release rate is not less than 70% in 30 min. The effect is rapid and the puncture is painless, and the patient compliance is excellent. Local administration eliminates systemic exposure of the drug, and the drug safety is high, and there is no serious adverse reaction.

This invention discloses a ceramide, its purification method, preparation method, and applications, relating to the field of natural compound separation technology. The purification method for ceramide includes membrane separation of crude ceramide extract, using a membrane material with a molecular weight cutoff of 150–1000 Da. By employing membrane separation to purify the crude ceramide and controlling the membrane material's molecular weight cutoff, ceramide can be enriched on one side of the membrane, while odorous impurities are enriched on the other side. This results in significant removal of odor from the purified ceramide, and the odor does not return after a period of time. This method is simple, has good odor removal effect, and can complete purification without complex organic solvents, leading to a wider range of applications for the obtained ceramide.

The application provides a biomimetic vesicle with controllable membrane rigidity and flexibility, a preparation method and application, and comprises the following steps: mixing a membrane rigidity adjusting component and a membrane flexibility adjusting component according to a design ratio, stirring under heating conditions until complete melting and uniformity; adding an aqueous phase in which a hydrophilic active ingredient is dissolved into the mixed system, heating and stirring to form a primary emulsion; supplementing deionized water into the primary emulsion to a target mass, and carrying out high shear homogenization and pulse ultrasonic treatment to obtain the biomimetic vesicle; the membrane rigidity adjusting component comprises ceramide and cholesterol; the membrane flexibility adjusting component comprises soybean phospholipid, DLGL and MEL-B; the ratio among MEL-B, DLGL, soybean phospholipid, ceramide and cholesterol is 5:1:0.75:0.375:0.1875; the biomimetic vesicle obtained by the application has deep and persistent retention and absorption effects in skin penetration in vivo, is superior to free active ingredients, and has the development value of cosmetic and transdermal drug delivery preparations.

Topical compositions for managing sensitive skin comprise: a moisturizing component containing hyaluronic acid; an antioxidant component containing ascorbic acid; a peptide component containing collagen peptides; a ceramide component containing ceramides; and a retinoid component containing retinol. The % w / w of collagen peptides is 2.5 to 4 times larger than that of ceramides.

A transparent or translucent oil-in-water emulsified composition comprising following components (A), (B), (C), (D), (E), and (F): (A) a ceramide; (B) an anionic surfactant selected from the group consisting of N-acyl-N-alkyltaurine, N-acyl-L-glutamic acid, and salts thereof; (C) a nonionic surfactant having an HLB of 10 or more; (D) a dihydric alcohol having 6 to 10 carbon atoms; (E) a dihydric alcohol having 5 or less carbon atoms; and (F) water.

This invention relates to the field of cosmetic technology, and more particularly to a sensitive skin anti-wrinkle barrier repair composition containing purslane extract and its application. The composition of this invention comprises purslane extract, astragalus extract, centella asiatica extract, ectoine, and ceramide complex lipids; the ceramide complex lipids include one or more of ceramides, cholesterol, and fatty acids. This invention uses purslane extract as a soothing and stabilizing base, combined with astragalus extract, centella asiatica extract, ectoine, and ceramide complex lipids to form a complex care system that combines soothing, anti-wrinkle, barrier repair, and improved skin tolerance. Experimental results show that the composition of this invention can improve problems such as fine lines, dry lines, redness, stinging, fragile barrier, dryness, tightness, and decreased tolerance in sensitive skin. It is gentle, stable, and can be prepared into various cosmetic formulations such as face cream, serum, lotion, repair cream, sleeping mask, essence, and gel cream, suitable for industrial production and daily skincare use.

The object of this disclosure is to provide a topical composition containing ceramide 2 and a heparin-like substance that can suppress insolubilization during manufacturing and creaming during storage. [Solution] The topical composition containing (A) ceramide 2, (B) heparin-like substance, and (C) petrolatum has been designed to suppress insolubilization during manufacturing and creaming during storage.

This invention discloses a ginsenoside-modified ceramide liposome, its preparation method, and its application, belonging to the field of cosmetic preparation technology. The liposome is composed of ceramide, phosphatidylcholine, ginsenoside Rg3, and water. Addressing the shortcomings of existing ceramide liposomes, such as poor physical stability and low transdermal absorption, this invention innovatively utilizes the unique amphiphilic molecular structure of ginsenoside Rg3, embedding it as a functional modifier into the liposome bilayer. The hydrophobic steroidal backbone of Rg3 is tightly bound to the lipid tail through hydrophobic interactions, with the hydrophilic sugar chains facing the aqueous phase. This not only acts as a "molecular anchor," significantly enhancing the density of the lipid bilayer and improving the physical stability and drug encapsulation efficiency of the liposome, but also endows the liposome with excellent antioxidant, anti-inflammatory, and skin microcirculation-promoting bioactivity. The liposomes prepared by this invention achieve deep transdermal delivery and long-lasting release of ceramides, effectively repairing damaged skin barriers; and utilize the bioactivity of Rg3 to achieve multiple effects of moisturizing, anti-aging, and repair. The preparation method of this invention is simple, mild, and reproducible. The resulting product can be widely used in the preparation of various skin care products such as creams, lotions, and serums, and has significant market application prospects.

The present invention relates to compositions comprising: (a) a carotenoid selected from the group consisting of octahydrolycopene, hexahydrolycopene, zeta carotene, or any combination thereof; and (b) a ceramide, said compositions having a synergistic effect in inhibiting or reducing collagen loss, and methods of use thereof.

The application discloses application of apolipoprotein III in prevention and treatment of Bombyx mori nuclear polyhedrosis virus infection and belongs to the cross field of molecular biology technology field and virus prevention and treatment. The application first finds that Bombyx mori apolipoprotein III (ApoLp-III) promotes biosynthesis and accumulation of ceramide, thereby inhibits mTORC1 signal pathway activity, induces cell G1 phase arrest, and effectively blocks a new mechanism of Bombyx mori nuclear polyhedrosis virus (BmNPV) replication. Based on the mechanism, the application provides application of ApoLp-III in inhibition of BmNPV proliferation, prevention and treatment of BmNPV infection, improvement of the ability of Bombyx mori to resist BmNPV or cultivation of a BmNPV-resistant Bombyx mori strain. The application provides a brand-new technical strategy and germplasm resource for realizing green, efficient and sustainable prevention and control of BmNPV.

The application discloses a method for synthesizing ceramide ester of retinoic acid by catalysis of an enzyme and application thereof, and belongs to the technical field of cosmetic raw material synthesis. The method uses retinoic acid and ceramide NP as substrates, adopts specific immobilized lipase as a catalyst, and efficiently synthesizes a target product in a non-aqueous organic solvent through the steps of raw material preparation, an oxygen-free reaction system building, directional esterification, post-treatment and purification detection. The method solves the problems of low substrate solubility, many by-products and difficult catalyst recovery in traditional processes, has mild reaction conditions, can retain the activity of raw materials, has high product purity, has the effects of anti-aging and barrier repair, and can be widely used in the preparation of anti-wrinkle and repair cosmetic raw materials.

The object of this disclosure is to provide a topical composition comprising ceramide 2 and isopropyl myristate that can suppress creaming. [Solution] A topical composition containing (A) ceramide 2, (B) isopropyl myristate, and (C) heparinoid has suppressed creaming.

The present application relates to the field of cosmetics, especially to an anti-aging essence and a preparation device, which is composed of A phase, B phase, C phase and D phase, and the components of each phase are as follows according to weight percentage: A phase: deionized water 16.15%, rose hydrolat 18.00%, propylene glycol 5.00%, glycerol 4.00%, xanthan gum 0.15%, carbomer 940 0.10%, panthenol (vitamin B5) 2.00%, boswelia (30% aqueous solution) 10.00%, ikedoin 2.00%, nicotinamide 2.00%, sodium hyaluronate compound 0.50%; B phase: polyglyceryl-6 distearate 1.20%, squalane 3.00%, isononyl isononanoate 2.00%, octyldodecanol 5.00%, rosehip oil 0.50%, argan oil 0.50%, ceramide compound powder 0.50%, cholesterol 0.30%, free fatty acid (C18-C22) 0.20%, Transcutol P 4.00%, oleanolic acid (ligustrum lucidum extract) 0.50%, plant extract compound liquid 5.00%, ergothioneine 0.30%. The advantages are that the active ingredient utilization rate is improved, the efficacy is comprehensive and the synergistic effect is strong, and the preparation device can make the mixing of each component more uniform, greatly improving the mixing efficiency.

Abstract The present invention provides novel methods of identifying, monitoring or determining the risk of developing a protein misfolding neurodegenerative disorder in a subject, particularly an alpha synucleinopathy (including Parkinson’s disease and dementia with Lewy bodies) using extracellular vesicle samples. Corresponding methods for selecting a treatment and assaying for the presence of a pathological prion-like protein (or one or more ceramide species) in an extracellular vesicle sample are also provided. Abstract The present invention provides novel methods of identifying, monitoring or determining the risk of developing a protein misfolding neurodegenerative disorder in a subject, particularly an alpha synucleinopathy (including Parkinson's disease and dementia with Lewy bodies) using extracellular vesicle samples. Corresponding methods for selecting a treatment and assaying for the presence of a pathological prion-like protein (or one or more ceramide species) in an extracellular vesicle sample are also provided. 20 24 27 84 87 17 D ec 2 02 4 A b s t r a c t 2 0 2 4 2 7 8 4 8 7 1 7 D e c 2 0 2 4

The present disclosure belongs to the technical field of biological medicines. Disclosed is a novel ceramide which has a structure represented as formula IFurther disclosed in the present disclosure are a preparation method for and the use of the ceramide. The present disclosure uses naturally-sourced and readily-available 10-hydroxycarboxylic acid as a starting raw material to construct the ceramide having a novel structure. The preparation method has a simple and convenient synthetic route and is suitable for large-scale production. Meanwhile, the obtained ceramide shows more excellent effects in the aspects of tissue repair, anti-inflammatory repair, tissue healing, moisturizing and anti-aging, and thus can be used in the fields of health care products, cosmetics and drugs.

This invention relates to the field of pharmaceutical technology, and more particularly to a long-lasting collagen moisturizing and repairing agent, an eye drop, and a method for preparing the same. The long-lasting collagen moisturizing and repairing agent of this invention comprises the following components in parts by weight: 0.01-0.08 parts of type III collagen peptides, 0.05-0.2 parts of sodium hyaluronate, 0.02-0.06 parts of ceramide, 0.01-0.05 parts of lutein, 1-3 parts of propylene glycol, and 0.005-0.02 parts of vitamin B12. The components of this invention are safe and non-irritating. The eye drop prepared according to the above components can maintain a moisturizing effect for 4-6 hours, providing a new approach for the development of eye drops.

This invention relates to the field of cosmetic technology, providing a barrier repair composition for dry and sensitive skin containing purslane extract and its application. The composition comprises purslane extract, Bletilla striata extract, Hemerocallis fulva extract, ceramide complex lipids, and ectoine. This invention uses purslane as a soothing and stabilizing base, combined with Bletilla striata for film-forming repair, Hemerocallis fulva for soothing repair, barrier lipid replenishment, and anti-stress components, forming a multi-pathway synergistic care system that can improve dry and sensitive skin problems such as dryness, tightness, stinging, itching, flaking, fine cracks, barrier fragility, and seasonal discomfort. Experimental results show that the composition of this invention is mild and stable, suitable for industrial production and daily dry and sensitive skin care.

This invention discloses a method for preparing ceramide 3 by acylation catalyzed by a composite microbial enzyme. The method uses plant sphingosine and mixed long-chain fatty acids as raw materials, and a binary composite microbial lipase with *Candida albicans* lipase as the main enzyme and *Aspergillus oryzae* / *Rhizopus oryzae* lipase as the coenzyme as the catalyst. The enzyme-catalyzed acylation reaction is followed by filtration, vacuum distillation, recrystallization, and drying to obtain the final product. This invention's composite enzyme system achieves highly efficient synergistic catalysis of the mixed fatty acid substrate, resulting in a ceramide 3 yield ≥90%, total purity ≥93%, and oleic acid-based ceramide 3 as the main component ≥85%. The distribution of minor components closely matches that of natural ceramides. The reaction conditions are mild, with no chemical residues. The composite enzyme is recyclable and reusable. The preparation process is simple, has high tolerance for error, and is easily scaled up industrially. The product can be widely used in the pharmaceutical and cosmetic fields.

The present application belongs to the technical field of cosmetics, and particularly relates to a cream containing Mauritia flexuosa fruit oil ceramide, a preparation method and application. Specifically, the cream is prepared by taking Mauritia flexuosa fruit oil ceramide, batyl alcohol and ruscogenin as main components. The cream containing the combination of Mauritia flexuosa fruit oil ceramide, batyl alcohol and ruscogenin can significantly promote the generation of barrier-related protein FLG and the generation of laminin, has the effects of repairing skin barrier and anti-aging of the true epidermal junction layer, can significantly improve the problem of large high-low temperature emulsification particle size of the cream containing high content of ceramide, is mild and non-irritating, and thus has good practical application value.

The purpose of the present disclosure is to provide a novel component that is useful as an active ingredient in an autophagy inducer. A vegetable ceramide according to the present disclosure is useful as an active ingredient in an autophagy inducer.

To provide a composition that can improve or maintain vascular functions, or in particular, can improve or maintain vascular functions, hematologic properties, a blood flow and the like.SOLUTION: The present invention provides a composition containing procyanidin, and ceramide or nucleic acids.SELECTED DRAWING: Figure 1