Composition containing ceramide as well as preparation method and application of composition

Abstract

The invention discloses a ceramide-containing composition as well as a preparation method and application thereof, and belongs to the technical field of daily chemical products and medicines. The composition comprises 0.1%-5.0% of ceramide, 1.8%-2.7% of an emulsifier, 1.2%-2.5% of an emulsion stabilizer, 8%-14% of a solvent, 3%-5% of an emollient and 0.7%-0.95% of a stabilizing aid, the composition obtained by compounding the components has high stability, and the phenomena of particle precipitation, oil-water separation and the like are avoided; meanwhile, all the components are mutually matched and have a synergistic effect, and the effects of fading, repairing and resisting wrinkles can be achieved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of daily chemical products and pharmaceutical products, in particular to a ceramide-containing composition and a preparation method and application thereof. BACKGROUND

[0002] With the modern environmental pollution, climate change, sudden increase of life pressure and high-frequency skin care, sensitive skin problems are manifested as skin dryness, desquamation, itching, redness and allergy and other uncomfortable symptoms. The damage of skin barrier function is an important reason for the repeated occurrence of these symptoms. At the same time, the anti-aging demand is becoming younger, and the use rate of anti-wrinkle products by consumers over 25 years old is increasing rapidly, and the market urgently needs an integrated solution that can meet the needs of soothing redness, barrier repair and anti-wrinkle at the same time. However, most of the single ingredients in the market cannot meet the multi-dimensional needs, such as dipotassium glycyrrhizinate which can soothe redness but has no repair and anti-wrinkle effect, phytosphingosine which can repair but cannot inhibit TRPV1 channel, and retinol which has anti-wrinkle effect but may further weaken the skin barrier, and is not suitable for sensitive skin. In order to solve the problem of single effect, most products on the market often use multiple functional ingredients (repair and soothing ingredients, anti-wrinkle ingredients, etc.) to compound, but the superposition of multiple ingredients will increase the burden on the skin and increase the development cost. The superposition of multiple ingredients also has the risk of poor formula stability.

[0003] Therefore, it is urgent to develop a formula with simple ingredients, good stability and multiple effects to meet the needs of consumers.

[0004] In view of this, the present application is proposed. SUMMARY

[0005] The purpose of the present application is to provide a ceramide-containing composition and a preparation method and application thereof. The composition prepared by the present application is relatively mild, suitable for sensitive skin people, and can realize the effects of long-term moisturizing, firming, repair and soothing, redness removal and wrinkle removal at the same time. The composition also has high stability.

[0006] The present application is realized as follows: In a first aspect, the present application provides a ceramide-containing composition, which comprises, by mass fraction: ceramide 0.1%-5.0%, emulsifier 1.8%-2.7%, emulsion stabilizer 1.2%-2.5%, solvent 8%-14%, emollient 3%-5% and stabilizing aid 0.7%-0.95%.

[0007] The emulsifier is selected from at least one of sodium methyltaurinate (SMT), glyceryl stearate and PEG-100 stearate.

[0008] The emulsification stabilizer is cetyl stearyl alcohol.

[0009] The solvent is selected from at least one of octyldodecanol, caprylic / capric triglyceride.

[0010] The emollient is selected from at least one of silicone compounds or synthetic oil esters; in some embodiments, the silicone compounds include dimethicone and other silicon oils.

[0011] In some embodiments, the other silicon oils include but are not limited to triethoxyl octyl silane, cyclopentasiloxane, cyclohexasiloxane; the synthetic oil esters include but are not limited to ethylhexyl palmitate, decyl cocoate, isononyl isononanoate.

[0012] The stabilizing aid is selected from at least one of Sepinov EMT10 (INCI name: hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, polysorbate-60, sorbitan isostearate), ghatti gum.

[0013] In the present application, the solvent helps to dissolve the ceramide, facilitating the stable dispersion of the ceramide in the entire system; the stabilizing aid enables the components in the entire composition system to exist stably and uniformly without precipitation of difficultly soluble substances; through the combination of the specific emulsifier, emulsification stabilizer, solvent, emollient, and stabilizing aid in the present application, the stability of the ceramide can be synergistically improved, so that the ceramide is uniformly dispersed and not easily precipitated and stratified, and the composition system helps the ceramide to fully exert its efficacy. At the same time, the components have synergistic effects, which can achieve good efficacy (the composition in the prior art only has a single efficacy, and if other efficacies are desired, corresponding efficacy ingredients are usually added, such as the composition in CN 119345056 A, which has a redness-removing effect, in order to have an anti-wrinkle effect, an anti-wrinkle agent is added, in order to have a whitening effect, a whitening agent is added, etc.), the entire composition system in the present application has simple components, and the components are compatible and synergistic with each other, without the need to add multiple efficacy ingredients (without redundancy, without stacking of multiple efficacy ingredients), so that multiple efficacies are achieved. The composition finally prepared by the method of the present application not only has the efficacy of moisturizing and repairing the skin barrier, but also can improve the skin gloss, enhance the skin elasticity, improve the skin redness, achieve the effect of reducing redness, and at the same time, the composition can also reduce wrinkles (such as the area, number, depth, and volume of crow's feet are reduced; the lengths of the nasolabial lines and the forehead lines are shortened), tighten the skin, make the skin healthier and younger, slow down aging, and is especially suitable for people with sensitive skin.

[0014] In some embodiments, the ceramide is selected from at least one of ceramide 3B and ceramide 3.

[0015] In some embodiments, the emulsifier is a combination of sodium methyl stearoyl taurate, glyceryl stearate and PEG-100 stearate. When sodium methyl stearoyl taurate, glyceryl stearate and PEG-100 stearate are used in combination, the mass ratio is (0.2-0.3):(0.8~1.2):(0.8~1.2).

[0016] In some embodiments, the solvent is a combination of octyldodecanol and caprylic / capric triglyceride; when caprylic / capric triglyceride is used in combination with octyldodecanol, the mass ratio is (6~10):(2~4).

[0017] In some embodiments, the stabilizing aid is a combination of Sepinov EMT10 and ghatti gum. When Sepinov EMT10 and ghatti gum are used in combination, the mass ratio is (0.5~0.7):(0.2~0.25).

[0018] In some embodiments, the composition further comprises a composition A selected from at least one of raspberry ketone, 1,2-hexanediol, 1,2-pentanediol, phenoxyethanol and ethylhexylglycerin.

[0019] In some embodiments, the composition A is raspberry ketone, 1,2-hexanediol or / and 1,2-pentanediol, i.e. raspberry ketone + 1,2-hexanediol, or raspberry ketone + 1,2-pentanediol, or raspberry ketone + 1,2-hexanediol + 1,2-pentanediol.

[0020] In some embodiments, the mass ratio of raspberry ketone to 1,2-hexanediol is (0.8~1.2):(0.8~1.2).

[0021] In some embodiments, the mass ratio of raspberry ketone to 1,2-pentanediol is (0.8~1.2):(4~6).

[0022] In some embodiments, the composition A is phenoxyethanol and ethylhexylglycerin, and the mass ratio is (78~82):(7~10).

[0023] In some embodiments, the composition further comprises a chelating agent selected from at least one of sodium phytate and disodium EDTA; the mass fraction of sodium phytate and / or EDTA in the composition is 0.03%~0.05%.

[0024] The chelating agent can chelate metal ions, which can avoid the interference of metal ions in actual mass production. The chelating agent can be selectively added when preparing the composition of the present application, so that higher stability can be obtained.

[0025] In a second aspect, the present application provides a preparation method of the above-mentioned composition, which comprises: The emulsifier, emulsion stabilizer, solvent, emollient and ceramide are mixed in proportion, and the obtained oil phase mixture is heated to 70-85°C while stirring; the deionized water, stabilizing aid and component A are mixed in proportion, and the obtained water phase mixture is heated to 70-85°C while stirring; the oil phase mixture is slowly added to the water phase mixture, and after homogenization, the stirring is started to cool down, and the stirring is stopped when the temperature is lowered to 20-45°C, and the product is discharged; The homogenization is carried out at a temperature of 75-85°C, a rotation speed of 5000-6000 rpm and for a time of 5-10 min.

[0026] In some embodiments, the homogenization is carried out at a temperature of 80°C, a rotation speed of 5500-6000 rpm and for a time of 5-8 min.

[0027] In a third aspect, the present application provides the use of the above-mentioned composition in the preparation of daily-use articles, including skin care products; and medicines, including medicines for treating skin.

[0028] In a fourth aspect, the present application provides a skin care product comprising the above-mentioned composition. In some embodiments, the skin care product includes facial cleanser, shampoo, skin care water, skin care milk, skin care cream and hair conditioner.

[0029] The skin care product of the present application can be prepared in any dosage form commonly prepared in the art, for example, but not limited to, solution, suspension, emulsion, paste, gel, cream, emulsion, powder, soap, surfactant-containing detergent, oil, powder foundation, emulsion foundation, wax foundation and spray.

[0030] The carrier included in the skin care product of the present application can use the carrier commonly used in the art according to the dosage form.

[0031] In the case where the dosage form of the present application is ointment, paste, cream or gel, animal oil, vegetable oil, paste, paraffin, starch, cellulose derivative, polyethylene glycol, silicon, bentonite, silica, talc or zinc oxide, etc. can be used as the carrier component.

[0032] In the case where the dosage form of the present application is powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder can be used as the carrier component.

[0033] In the case where the dosage form of the present application is a solution or emulsion, as the carrier component, a solvent, a solubilizing agent or an emulsifying agent, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol, oils, especially cottonseed oil, peanut oil, corn germ oil, olive oil, castor oil and sesame oil, glycerol fatty esters, polyethylene glycol or sorbitan fatty acid esters, can be used.

[0034] In the case where the dosage form of the present application is a suspension, as the carrier component, a diluent of liquid phase such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline cellulose, aluminum meta-hydroxide, bentonite, agar and the like can be used.

[0035] In the case where the dosage form of the present application is a cleansing cream containing a surfactant, as the carrier component, fatty alcohol sulfate, fatty alcohol ethersulfate, sulfosuccineic acid monoester, isethionate, imidazoline derivatives, methyl taurate, sarcosinate, fatty acid amide ether sulfate, alkyl amidobetaine, fatty alcohol (fatty alcohol), fatty acid glycerides, fatty acid diethanolamide, vegetable oil, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

[0036] In the case where the dosage form of the present application is a soap, as the carrier component, an alkali metal salt of a fatty acid, a fatty acid half ester salt, a fatty acid protein hydrolysate, a hydroxyethyl sulfonate, a lanolin derivative, a fatty alcohol, a vegetable oil, glycerin, a sugar, or the like can be used.

[0037] Likewise, the present application can also provide a pharmaceutical product containing the above composition. The above pharmaceutical product can be any conventional dosage form in the art, and the excipients contained in the pharmaceutical product of the present application can be excipients generally used in the art adjusted according to the dosage form, which will not be listed one by one here.

[0038] The present application has the following beneficial effects: The present application combines ceramide, an emulsifier, an emulsion stabilizer, a solvent, an emollient, and a stabilizing aid to obtain an efficacy agent for redness fading, repair, and wrinkle removal, and further combines component A and a chelating agent to prepare a redness fading, repair, and wrinkle removal composition. The composition has high stability and does not have phenomena such as particle precipitation and oil-water separation. Meanwhile, the components cooperate with each other to have a synergistic effect, and can have the effect of redness fading, repair, and wrinkle removal. BRIEF DESCRIPTION OF DRAWINGS

[0039] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed in the embodiments will be briefly introduced as follows. It should be understood that the following drawings only show some embodiments of the present application, and therefore should not be considered as a limitation on the scope, and for those skilled in the art, other related drawings can also be obtained without creative labor on the basis of these drawings.

[0040] Figure 1 Stability test results of Example 1; Figure 2 Stability test results of Example 7; Figure 3 Stability test results of Example 8; Figure 4 Stability test results of Example 9; Figure 5 Stability test results of Comparative Example 2; Figure 6 Stability test results of Comparative Example 3; Figure 7 Stability test results of Comparative Example 4. DETAILED DESCRIPTION

[0041] In order to make the purposes, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below. If specific conditions are not indicated in the embodiments, conventional conditions or conditions suggested by manufacturers are adopted. If manufacturers of reagents or instruments are not indicated, all are conventional products that can be purchased in the market.

[0042] The features and performances of the present application will be further described in detail below in combination with the embodiments.

[0043] Embodiment 1 The composition of this embodiment contains ceramide, and the components thereof are as follows in terms of mass fraction: 1.0% glyceryl stearate, 1.0% PEG-100 stearate, 0.2% SMT, 2% cetearyl alcohol, 8.0% caprylic / capric triglyceride, 2.0% octyldodecanol, 4.0% dimethicone, 0.1% ceramide 3B, 0.6% Sepinov EMT10, 0.2% guggul gum, 0.5% 1,2 hexanediol, 0.5% raspberry ketone, and deionized water is added to 100%.

[0044] The preparation method of the above composition is as follows: (1) The glyceryl stearate, PEG-100 stearate, cetearyl alcohol, caprylic / capric triglyceride, dimethicone, octyldodecanol and ceramide 3B are weighed into an oil phase beaker in the above proportions, mixed uniformly, and heated to 80-85°C while stirring.

[0045] (2) The deionized water, Sepinov EMT10, guggul gum, raspberry ketone and 1,2 hexanediol are weighed into a water phase beaker in the above proportions, mixed uniformly, and heated to 80-85°C while stirring.

[0046] (3) The material in the oil phase beaker is slowly poured into the water phase beaker while slowly homogenizing, and the homogenization is started at 5500 rpm for 5 min. After homogenization, stirring is started for cooling.

[0047] (4) When the temperature drops to 20-45°C, stop stirring and discharge the material.

[0048] The preparation method of Embodiments 2-9 is the same as that of Embodiment 1, and the corresponding components are shown in Table 1. Table 1 Component information of Embodiments 1-9

[0049] Embodiment 10 The composition of this embodiment also includes a chelating agent, which is sodium phytate with a mass fraction of 0.03%-0.05%.

[0050] The other embodiments in this embodiment are the same as those in Embodiment 1.

[0051] The composition prepared in this example is stable, delicate, and has no separation or oil-water layering after three months of storage.

[0052] Comparative Examples 1-8 were prepared in the same manner as Example 1, and the corresponding components are shown in Table 2: Table 2 Component information of Comparative Examples 1-8

[0053] Comparative Example 9 The difference from Example 1 is that the homogenization temperature is 60°C, and the final composition is not uniform, not delicate, and the material body is coarse, and it is not stable, and after storage, the material body becomes more and more coarse, and the separation amount becomes more and more.

[0054] Comparative Example 10 The difference from Example 1 is that the emulsifier is replaced by polyglyceryl-10 distearate + glyceryl stearate + PEG-100 stearate, and oil-water separation occurs during preparation, and the composition system is still not uniform after preparation.

[0055] Comparative Example 11 The difference from Example 1 is that the solvent is replaced by mineral oil + caprylic / capric triglyceride, and the composition system prepared has particles separated out after one week of storage at room temperature.

[0056] Comparative Example 12 The difference from Example 1 is that the mass ratio of solvent octyldodecanol to caprylic / capric triglyceride is 1:6, and the composition system prepared has particles separated out after one week of storage at room temperature.

[0057] Comparative Example 13 The difference from Example 1 is that the stabilizing aid is replaced by AVC + Euphorbia Antisyphilitica Gum, and a uniform composition system cannot be prepared, and the composition system prepared is layered immediately after preparation.

[0058] Comparative Example 14 The difference from Example 1 is that the mass ratio of stabilizing aids Sepinov EMT10 + Euphorbia Antisyphilitica Gum is 0.2:0.2, and a uniform composition system cannot be prepared, and the composition system prepared is layered immediately after preparation.

[0059] Experimental Example 1 The compositions prepared in Examples 1-9 and Comparative Examples 1-8 were subjected to stability verification, and the stability test conditions were: -20°C to room temperature cycle, 4°C, room temperature (RT), 45°C; the test time was -20°C for 48 hours to room temperature for 48 hours for 1 cycle, a total of 6 cycles for 24 days; 4°C, room temperature and 45°C were placed still for three months.

[0060] The test results of Examples 1-9 showed that the compositions had no particle precipitation, oil-water separation and other phenomena, and had high stability; the actual physical picture corresponding to Example 1 is shown in Figure 1 , the actual physical picture corresponding to Example 7 is shown in Figure 2 , the actual physical picture corresponding to Example 8 is shown in Figure 3 , and the actual physical picture corresponding to Example 9 is shown in Figure 4 .

[0061] Comparative Example 1 also had high stability; Comparative Example 2 had a delamination phenomenon at 45°C, as shown in Figure 5 ; Comparative Example 3 had a particle precipitation phenomenon in the -20°C to room temperature cycle, as shown in Figure 6 ; Comparative Example 4 had a particle precipitation phenomenon in the -20°C to room temperature cycle, as shown in Figure 7 ; Comparative Example 5 had mold spots; Comparative Example 6 had good stability but had a white strip phenomenon when smeared; Comparative Example 7 and Comparative Example 8 had delamination within 1 month at room temperature and were unstable.

[0062] Experimental Example 2 This experiment evaluated the safety of the compositions of Examples 1-6, as follows: 1. Dermatologist evaluation Table 3 Summary of Adverse Events

[0063] During the entire test process, 33 subjects in each group did not feel uncomfortable.

[0064] 2. Subject self-evaluation During the entire test process, 33 subjects in each group did not feel uncomfortable.

[0065] After the subjects in this subject population used Examples 1-6, the results of the subject self-evaluation satisfaction survey were: 90.91% agreed that the product had a light and non-sticky texture; 90.91% agreed that the product had good spreadability and was easy to apply and absorb; 81.82% agreed that the skin was glossier after using the product; 75.76% agreed that the skin was more moisturized after using the product; 87.88% agreed that the skin was improved in dryness after using the product; 78.79% agreed that the skin was improved in moisturization after using the product; 75.76% agreed that the skin was improved in wateriness after using the product; 81.82% agreed that the skin was nourished after using the product; 100% agreed that there was no discomfort such as itching, stinging, burning, etc. after using the product; 100% agreed that the product was mild and non-irritating; 90.91% were satisfied with the product as a whole; and 100% liked the product.

[0066] 3. Result evaluation Under the control of a dermatologist, 7 groups of 33 adult subjects aged 35-55 years were observed for 28 consecutive days under normal conditions using Examples 1-6 and Comparative Example 1 to evaluate the potential for causing adverse reactions to human skin. The results of the dermatologist's clinical evaluation were that none of the subjects had an adverse reaction after 28 consecutive days of using the test product.

[0067] Experimental Example 3 This experiment was a human efficacy test, which was as follows: 1. Human efficacy test scheme A total of 7 groups were formed, each of which recruited and screened 33 adult Asian healthy subjects, 5 males and 28 females, aged 35-55 years, with an average age of 48.52±5.84 years.

[0068] These subjects had sensitive skin, daily skin prone to redness, and skin that was loose, dull, and lacked luster; had visible forehead lines, crow's feet, and marionette lines; had a transepidermal water loss of ≥12 (or a total transepidermal water loss of ≥12); had no allergic diseases and no history of allergies to cosmetics and other external preparations; had not received skin treatment, cosmetic treatment, or other tests that could affect the results on the test site; had not used hormone drugs, immunosuppressants, etc. in the past month; could cooperate well with the test and maintain a regular lifestyle during the study period; could understand all the contents of the informed consent form by reading and agreed to sign the written informed consent form voluntarily; agreed not to use cosmetics, drugs, health products, etc. that could affect the results during the test period; and could not be exposed to sunlight, engage in outdoor sports, or travel for a long time during the entire test period.

[0069] Exclusion criteria: Anyone with any of the following conditions must be excluded from this study: Women who are planning to get pregnant or are pregnant or lactating and within six months after delivery; those with serious systemic diseases, immune deficiency or autoimmune diseases; those who have used any anti-inflammatory drugs in the test site within the past two months; those with highly sensitive constitution; those who are considered unsuitable for other reasons; those who cannot complete the required content according to the requirements of the test.

[0070] The amount of transdermal water loss, skin elasticity, skin gloss, and skin keratin layer moisture content, skin color L*, a* value, and ITA° before and after using the product were measured by using Examples 1 to 6 and Comparative Example 1 on the face (including the eye area) of the subjects for 28 consecutive days, and the skin red area color a* value, the proportion of the skin red area, the area, number, depth, and volume of the crow's feet, the length of the marionette lines, and the length of the lifting lines were analyzed.

[0071] The safety and moisturizing, repairing, soothing, anti-wrinkle, and firming effects of the test product were verified in combination with the self-evaluation of the subjects and the safety clinical evaluation of the subjects by the dermatologist, and whether the product is mild (non-irritating) and suitable for sensitive skin.

[0072] 2. Test product Table 4 Test method

[0073] 3. Test instrument Table 5 Test index

[0074] 4. Test results (change rate results obtained by calculating the average values of each parameter of the skin at each time point) Table 6 Test results

[0075] Table 7 Test results

[0076] Table 8 Test results

[0077] After the subjects use the compositions of examples 1-6 and comparative example 1 on the face (including the eye area) for 28 consecutive days, the amount of transdermal water loss, skin elasticity, skin gloss, and skin keratin layer moisture content, skin color L*, a* value and ITA° before and after using the product are measured, the skin red area color a* value, the proportion of the skin red area, the area, number, depth and volume of crow's feet, the length of marionette lines and the length of lifting lines of the face are analyzed, combined with the self-evaluation of the subjects, the results show that the compositions of examples 1-6 can reduce the amount of transdermal water loss, increase the water content of the skin keratin layer, improve the skin gloss, enhance the skin elasticity, brighten the skin, reduce the skin redness, reduce the red area, have a redness-reducing effect, in addition, can also reduce the area and volume of crow's feet, reduce the depth of crow's feet, make the length of marionette lines and lifting lines shorter.

[0078] Therefore, the composition of the present application has certain moisturizing, repairing, soothing, redness-reducing, anti-wrinkle, and firming effects, and the product is mild (non-irritating) and suitable for sensitive skin. However, the moisturizing and repairing effects of comparative example 1 are not as good as examples 1-6, and it does not have the effects of redness-reducing, anti-wrinkle, and firming, which shows that the components in the composition of the present application can be well matched and synergistic, so that the composition has multiple effects of redness-reducing, repairing, and anti-wrinkle. If the component ceramide is missing, the entire composition has almost no effects of redness-reducing, anti-wrinkle, and firming.

[0079] The above only describes the preferred embodiments of the present application and is not intended to limit the present application. For those skilled in the art, the present application can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. A composition containing ceramide, characterized in that, By mass fraction, its components include: ceramide 0.1%-5.0%, emulsifier 1.8%-2.7%, emulsion stabilizer 1.2%-2.5%, solvent 8%-14%, emollient 3%-5%, and stabilizing agent 0.7%-0.95%, with the balance being water; The emulsifier is selected from at least one of sodium methylstearoyl taurate, glyceryl stearate, and PEG-100 stearate; The emulsifying stabilizer is cetearyl alcohol; The solvent is selected from at least one of octyldodecyl alcohol and caprylic / capric triglyceride; The emollient is selected from at least one of silicone oil compounds or synthetic oil esters; The stabilizing agent is selected from at least one of Sepinov EMT10 and spiky gluten.

2. The composition according to claim 1, characterized in that, The ceramide is selected from at least one of ceramide 3B and ceramide 3.

3. The composition according to claim 1, characterized in that, The emulsifiers are sodium methylstearoyl taurate, glyceryl stearate, and PEG-100 stearate; Preferably, the mass ratio of sodium methylstearoyl taurate, glyceryl stearate and PEG-100 stearate in the emulsifier is 0.2-0.3:0.8~1.2:0.8~1.

2.

4. The composition according to claim 1, characterized in that, The solvent is octyldodecyl alcohol and octanoic acid / decanoic acid triglyceride; Preferably, the mass ratio of caprylic / capric triglyceride to octyldodecyl alcohol in the solvent is 6-10:2-4.

5. The composition according to claim 1, characterized in that, The stabilizing agents are Sepinov EMT10 and spiky jelly; Preferably, the mass ratio of Sepinov EMT10 to styrax spp. in the stabilizing agent is 0.5-0.7:0.2-0.

25.

6. The composition according to claim 1, characterized in that, The composition further includes component A, which is selected from at least one of raspberry ketone, 1,2-hexanediol, 1,2-pentanediol, phenoxyethanol and ethylhexylglycerol; Preferably, component A is raspberry ketone, 1,2-hexanediol, or / and 1,2-pentanediol; Preferably, the mass ratio of raspberry ketone to 1,2-hexanediol is 0.8~1.2:0.8~1.2; Preferably, the mass ratio of raspberry ketone to 1,2-pentanediol is 0.8~1.2:4~6; Preferably, component A is phenoxyethanol and ethylhexylglycerin in a mass ratio of 78~82:7~10.

7. The composition according to claim 1, characterized in that, The composition further includes a chelating agent selected from at least one of sodium phytate and disodium EDTA; Preferably, the mass fraction of sodium phytate and / or EDTA in the composition is 0.03% to 0.05%.

8. A method for preparing the composition according to any one of claims 1-7, characterized in that, include: The emulsifier, emulsion stabilizer, solvent, emollient and ceramide are mixed in proportion, and the resulting oil phase mixture is heated to 70~85℃ while stirring. Deionized water, stabilizer and component A are mixed in proportion, and the resulting aqueous mixture is heated to 70-85°C while stirring. Slowly add the oil phase mixture to the water phase mixture, homogenize, and then start stirring and cooling until the temperature drops to 20~45℃. Stop stirring and discharge the material. The homogenization conditions are: temperature 75~85℃, rotation speed 5000-6000rpm, and time 5-10min; Preferably, the homogenization temperature is 80°C; Preferably, the rotational speed of the homogenizer is 5500-6000 rpm; Preferably, the homogenization time is 5-8 minutes.

9. The use of the composition according to any one of claims 1-7 in the preparation of daily chemical products and pharmaceuticals, characterized in that, The daily chemical products include skin care products; the medicines include medicines for treating skin conditions; Preferably, the skin care products include facial cleanser, shampoo, skin lotion, skin cream, and hair conditioner; Preferably, the dosage forms of the daily chemical products and pharmaceuticals include ointments, pastes, emulsions, gels, solutions, suspensions, emulsions, patches, and sprays.

10. A skincare product, characterized in that, It comprises the composition according to any one of claims 1-7.

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