66 results about "Skin itching" patented technology

Provided are a use of epicatechin or a legume extract containing epicatechin for preparing a composition for tranquilizing skin, and a skin itch treatment method comprising a step of applying a cosmetic composition to the skin of an individual causing itch, the cosmetic composition being the composition for tranquilizing skin.

The invention belongs to the technical field of microorganisms, and particularly relates to an extracellular vesicle of phytobacterium plantarum and application of the extracellular vesicle. Specifically, the plant lactobacillus extracellular vesicles can promote HaCaT cells to generate ceramide, up-regulate expression of key genes in a skin ceramide synthesis route and recover a skin barrier; the expression of proinflammatory factors in a cell inflammation model can be reduced, and a relatively good anti-inflammatory effect is achieved. A mouse skin injury model verifies that the EVs has good skin infiltration capacity and can remarkably reduce the skin injury score, relieve skin itch, improve the skin water content and reduce expression of proinflammatory factors in skin tissue and expression of pruritus-related cell factors.

The present invention relates to a composition for improving skin, which comprises beta-sitosterol and betulin and, in the case of the composition, reduces dermatoneuropathic stimulation-inducing factors, increases the expression of moisturizing-related factors, increases skin absorbance, improves skin penetration, inhibits mast cell activity, and improves skin quality. Thus, it has been confirmed that the composition has excellent skin-calming and skin-irritation-relieving effects, and thus can be usefully used in skin-improving cosmetics, pharmaceuticals, and the like.

The invention provides an external composition for improving the sub-health state of people in a high-glucose lifestyle and application of the external composition, and belongs to the technical field of biological agents. The composition provided by the invention is prepared from the following components: caffeine silanol C, a radix sophorae flavescentis extract, a lotus leaf extract, a corn poppy extract, a bitter gourd extract, soy isoflavone, beta-glucan, a tea leaf extract, an apple extract, resveratrol, a pueraria mirifica extract, a propolis extract, an angelica sinensis root extract, a radix ophiopogonis extract and a rhizoma anemarrhenae root extract. The composition is prepared from a fructus gardeniae extract, a Thermus thermophilus fermentation product, oligopeptide-1 and carnosine. The composition provided by the invention can be prepared into an external preparation, is suitable for people in the high-glucose lifestyle, has the technical effects of improving the sub-health states of the people in the high-glucose lifestyle, such as weakness, skin itch, dark skin color, thirst, frequent urination and the like, and improves the life quality of the people in the high-glucose lifestyle.

The invention provides an oral medicine formula for treating psoriasis, and relates to the field of traditional Chinese medicine formulas. The oral medicine for treating psoriasis is prepared from the following raw materials by weight: 10 g of astragalus membranaceus, 50 g of rhizoma smilacis glabrae, 10 g of salvia miltiorrhiza, 10 g of cassia twig, 10 g of cicada slough, 10 g of ligusticum wallichii, 30 g of angelica sinensis and 10 g of honey-fried licorice root. Salvia miltiorrhiza, ligusticum wallichii, angelica sinensis and other medicines have the effects of promoting blood circulation to remove blood stasis, can improve the blood circulation state of skin and promote repair of skin lesions, and have a certain curative effect on blood stasis type psoriasis patients; cassia twig and cicada slough have the effects of dispelling wind and arresting itching, can relieve the symptom of skin itch, and improve the life quality of patients; astragalus membranaceus, angelica sinensis and honey-fried licorice root have the effects of reinforcing qi and nourishing blood, can improve the overall physique of a patient, enhance the immunity of the body and contribute to disease recovery, the clinical effective rate reaches 70% or above, one treatment course lasts for three months, and the cure rate can reach 40% or above.

The present application belongs to the field of daily cosmetics, and particularly relates to a toner composition containing irises root extract and a preparation method thereof, which comprises the following components calculated by weight percentage: 1.0-5.0% of irises root extract; 0.05-1.0% of menthol; 1.0-10.0% of humectant; 0.01-1.0% of antioxidant; 0.005-0.2% of chelating agent; 0.01-1.0% of preservative; 0.01-3% of essence; 0.01-0.4% of neutralizing agent; and the balance of deionized water. The synergistic effect of irises root extract and menthol can improve the effects of the composition on skin itching, repair and calming, enhance the function of the skin, thereby reducing the possibility of skin tightness, redness and inflammation, and helping the skin to maintain a healthy state.

The present application relates to a preparation method of high-efficiency stable mulberry root extract containing oxyresveratrol and its application in relieving skin itching, and belongs to the technical field of cosmetics. The preparation method of the mulberry root extract containing oxyresveratrol comprises the following steps: drying and crushing the root of a mulberry tree, adding the crushed root into an aqueous solution of a eutectic solvent to perform ultrasonic extraction, centrifuging the product to obtain the mulberry root extract containing oxyresveratrol. The present application is based on a green solvent system composed of betaine and 1,3-propanediol / ethyl lactate, and combines with mild ultrasonic conditions to realize the efficient extraction of oxyresveratrol from the mulberry root, so that the extraction rate is improved and the risk of high-temperature oxidation is avoided. Moreover, the obtained extract can not only long-acting inhibit the itch receptor MRGPX1, but also is suitable for sensitive skin due to the removal of irritating components, and has high efficiency and biocompatibility, thereby breaking through the environmental pollution and technical bottleneck of the traditional method and having a wide market application prospect.

The invention discloses a traditional Chinese medicine composition for treating diabetic skin itch and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The composition is prepared from angelica sinensis, astragalus membranaceus, radix paeoniae rubra, cortex dictamni, rehmannia, ligusticum wallichii, scalded peach kernels, safflower carthamus, fried tribulus terrestris, divaricate saposhnikovia roots and cicada slough according to a specific weight ratio. On the basis of a classic famous formula of the Chinese angelica potion, the Chinese angelica potion is innovatively prepared aiming at the core pathogenesis of qi deficiency, blood stasis, damp-heat and wind-dryness of diabetic skin itch. The radix paeoniae rubra and the radix paeoniae alba are used for enhancing the effects of cooling blood and dissipating blood stasis; peach kernel and safflower are added to strengthen blood circulation activation and collateral dredging; cortex dictamni is added to enhance dampness eliminating and detoxification; cicada slough and herba schizonepetae are used for enhancing wind dispelling and heat clearing, and the nature is Polygonum multiflorum and liquorice are removed, so that the safety is improved. The whole formula has the effects of tonifying qi, promoting blood circulation, eliminating dampness, detoxifying, dispelling wind and moistening dryness. The invention also provides a preparation method of the composition. The composition can be used for preparing medicines for treating skin diseases such as diabetic skin itch and eczema, and is remarkable in curative effect and high in safety.

The utility model relates to the technical field of shoulder joint orthosis, and discloses a shoulder joint orthosis with good air permeability, which comprises a side plate, a first support plate is movably hinged to the left side of the top end of the side plate, and a second support plate is arranged on the left side of the first support plate. According to the shoulder joint orthosis with the good air permeability, the protection pad, the waist protection pad and the second ventilation holes are arranged, lyocell fibers are natural plant fibers and have the advantages of being natural in gloss, smooth in hand feeling, high in strength, good in moisture permeability and air permeability and the like, and the second ventilation holes and the first ventilation holes can further improve the air permeability of the waist protection pad and other assemblies; the problems of skin itch, skin eczema, chronic dermatitis and the like caused by air tightness after wearing are prevented, so that the air permeability of the shoulder joint orthosis is improved, a patient can be protected, the comfort of the patient during use is improved, and the problems that the air permeability of the shoulder joint orthosis is poor, and skin itch of the patient is likely to be caused are solved.

The utility model relates to the technical field of medical instruments, in particular to a disposable electrocardio-electrode which comprises a backing, an adhesive layer arranged below the backing, a conductive electrode arranged between the backing and the adhesive layer, and a copper buckle connected to the top end of the conductive electrode in a sleeved mode. A conductive adhesive layer is arranged below the conductive electrode, and release paper is arranged below the backing, the adhesive layer and the conductive adhesive layer; a ventilation mechanism is arranged on the inner side of the back lining, and a stabilizing mechanism is arranged among the back lining, the adhesive layer and the conductive electrode. Due to the existence of the breathable layer, the first breathable groove and the second breathable groove, the breathability of the electrode is improved, sweat on the surface of skin can be discharged in time, the possibility that the skin is in a humid environment for a long time is reduced, and a user does not feel uncomfortable due to the fact that the skin below the electrode is too humid during 24-hour dynamic electrocardiogram monitoring. The occurrence rate of skin problems such as skin itch and red swelling is reduced.

The present invention relates to a pharmaceutical composition for preventing or treating allergic skin diseases or skin itch, and more particularly, to a pharmaceutical composition for preventing or treating allergic skin diseases or skin itch, containing ABT-751 or TN-16 as an active ingredient, a cosmetic composition for preventing or ameliorating allergic skin diseases or skin itch, which contains ABT-751 or TN-16 as an active ingredient; and a cosmetic composition for moisturizing skin, which contains ABT-751 or TN-16 as an active ingredient. The composition for preventing or improving and treating atopic dermatitis according to the present invention effectively increases the expression of silk protein in skin cells and improves the skin barrier function, thereby having the effect of effectively improving or treating the symptoms of allergic skin diseases including atopic dermatitis or skin itch. And it is confirmed that an excellent skin moisturizing effect is exhibited.

This invention discloses a traditional Chinese medicine composition for health maintenance and deworming, and its preparation method, comprising the following raw materials in parts by weight: 12-18 parts of Artemisia annua, 8-15 parts of Rhizoma Scutellariae, 10-18 parts of Fructus Cnidii, 12-18 parts of Folium Platycladi, 8-15 parts of Radix Stemonae, 15-25 parts of Radix Smilax, 6-12 parts of Radix Sophorae Flavescentis, 10-15 parts of Cortex Dictamni, and 5-15 parts of pharmaceutical excipients, wherein the pharmaceutical excipients include soluble starch or dextrin. This invention relates to traditional Chinese medicine compositions. In the field of compound technology, this invention uses Artemisia annua as the principal drug to kill parasites and clear heat; Stemona japonica, Cnidium monnieri, and Sophora flavescens as assistant drugs to dry dampness, kill parasites, and relieve itching; Rhizoma Scutellariae, Fructus Platycladi, and Cortex Dictamni as adjuvant drugs to clear heat, detoxify, and have antibacterial and anti-inflammatory effects; and Smilax china to promote blood circulation, remove blood stasis, and have anti-inflammatory effects. The components work together to directly kill or inhibit internal and external parasites, while clearing away damp-heat toxins caused by parasite metabolism and improving accompanying symptoms such as skin itching, fatigue, and loss of appetite.

The invention belongs to the field of daily necessities, and provides moisturizing nutrition cream suitable for diabetics aiming at the problems that the skin of the diabetics is easy to dry and the skin barrier is damaged. The moisturizing and nourishing cream is prepared from the following active ingredients: dipotassium glycyrrhizinate, acetylchitosamine, phytosphingosine, bisabolol, a daisy flower extract, a betula platyphylla (BETULA ALBA) leaf extract and a honey extract. Tests of volunteers find that the moisturizing nutritional cream has a remarkable moisturizing effect and a skin barrier repairing effect, no irritating preservative or antioxidant is added, the problem of skin itch caused by irritating components is avoided, and the moisturizing nutritional cream is safe, mild and non-irritating and meets the requirement of daily skin care of diabetes patients.

The present application relates to the use of a substance that regulates BCL11A gene and / or its encoded product in the preparation of a drug for reversing skin photoaging, wherein the skin photoaging includes skin cell aging caused by sunlight, light, etc., and the skin cells include keratinocytes, dermal fibroblasts, melanocytes. The regulation is to up-regulate the expression of BCL11A gene and / or promote the production of its encoded product. Typical clinical manifestations of the skin photoaging include wrinkles, dry skin, loose skin, dilated capillaries, uneven skin pigmentation, and skin itching. The substance that regulates BCL11A gene and / or its encoded product includes a substance that regulates BCL11A gene DNA molecules and a substance that regulates the expression of BCL11A translation product protein molecules. The reversal of skin photoaging is manifested in reducing the proportion of cells positive for aging-related beta-galactosidase staining in skin cells and reducing the expression of aging-related protein p16 and DNA damage protein gammaH2AX.

This invention discloses an antipruritic gel containing 3-hydroxydecanoic acid microemulsion and its preparation method. The gel combines the natural antipruritic ingredient 3-hydroxydecanoic acid and peppermint oil. By preparing it into a microemulsion form, nano-sized droplets are combined with skin absorption enhancers and gel sustained-release agents, thereby improving transdermal absorption efficiency and prolonging the residence time in the skin to achieve a long-lasting antipruritic effect. 3-hydroxydecanoic acid exerts its antipruritic effect through anti-inflammatory action, blocking pruritus signaling pathways, and reducing mast cell degranulation. This antipruritic gel is stable at room temperature, easy to use, and suitable for relieving skin itching caused by mosquito bites, histamine, or non-histamine substances.

This invention discloses a long-acting antipruritic and antibacterial topical skin preparation, comprising N-ethyl-γ-L-glutamine, 1-1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphate-N-(L-γ-glutamyl-N-ethyl)-ethanolamine (POPE-N-Et-Gln-α), chlorhexidine acetate, and saffron extract as active ingredients, formulated into a hydrogel or cream with a pharmaceutically acceptable matrix. POPE-N-Et-Gln-α provides rapid transdermal action, while N-ethyl-γ-L-glutamine offers sustained-release and long-lasting effects; saffron extract provides anti-inflammatory and antioxidant effects, and chlorhexidine acetate provides antibacterial and antifungal effects. This invention is hormone-free and non-addictive, achieving both rapid and long-lasting antipruritic effects, and is suitable for eczema, urticaria, dry skin, neurodermatitis, psoriasis, microbial infections, and skin itching caused by insect bites.

The invention discloses a Uygur medicine composition and a preparation method thereof, belongs to the technical field of Uygur medicine, and particularly relates to a humifuse euphorbia herb fermentation and distillation integrated device and a preparation method thereof. The medicine composition comprises the following components in parts by weight: 300-500 parts of humifuse euphorbia herb and 100-300 parts of sulfur. The Uygur medicine composition disclosed by the invention integrates functions of clearing blood, relieving itching, clearing away heat and toxic materials, and can play a role in treating various skin diseases such as dermatitis, psoriasis, skin itch and the like; in application, the two medicines cooperate to achieve a treatment effect; in preparation, medicines and auxiliary materials are combined, and humifuse euphorbia herb and sulfur have a synergistic effect. The composition comprises the humifuse euphorbia herb fermentation distillation extract and the sulfur ointment for oral administration and external application, and the synergistic effect is good. According to the application, two kinds of lactobacillus plantarum and lactobacillus rhamnosus which are beneficial to repairing skin ecology are screened, a fermentation technology and herbal medicines are combined for the first time to obtain the Uygur medicine composition for treating skin diseases, equipment is innovated into fermentation and distillation integration, and a new method is provided for preparing skin treatment medicines.

The invention discloses a scurf expanding and taking device and a using method thereof, and belongs to the technical field of dermatological detection. Comprising a device box; an extension box is mounted at one end of the device box; rollers are mounted on the outer walls of the two sides of the device box and the extension box; a brushing mechanism is mounted between the inner cavity of the extension box and the device box; a collecting mechanism is mounted at the top of the device box and is connected with a brushing mechanism; a medicine storage box is mounted at the top of the device box; a smearing mechanism is mounted at the bottom of the device box; a driving mechanism is installed in a device box, a brushing mechanism, a rolling wheel and a smearing mechanism are synchronously driven through the driving mechanism, skin is slightly brushed through the brushing mechanism to enable scurf to fall off, then the scurf is synchronously collected through a collecting mechanism, automatic walking is achieved through the rolling wheel, and therefore area collection is conducted, the collection strength is low, and skin damage is avoided; and during walking, medicine is smeared on a collection part synchronously, so that the purposes of calming and diminishing inflammation are achieved, and skin itch and infection are avoided.

The invention provides a traditional Chinese medicine composition for treating and preventing skin itch and a preparation method thereof, and belongs to the technical field of medical, dental or dressing preparations. The traditional Chinese medicine composition is composed of rehmannia, angelica sinensis, cortex dictamni, salvia miltiorrhiza, liquorice, scutellaria baicalensis and rhizoma smilacis glabrae. Wherein the angelica sinensis and the cortex dictamni are subjected to carbon dioxide supercritical extraction; the rehmannia is extracted by water; the salvia miltiorrhiza, the liquorice, the scutellaria baicalensis and the rhizoma smilacis glabrae are subjected to three-stage extraction by carbon dioxide supercritical matching with According to the invention, a traditional Chinese medicine compatibility theory, a modern extraction and separation technology and a nano-targeting delivery system are deeply fused, so that remarkable advantages are formed in component activity retention, bioavailability improvement and adaptation disease targeting, and a high-value reference path is provided for modern research and development of traditional Chinese medicine compound preparations; the product is expected to become a breakthrough product in the field of skin disease treatment.

The recurrence rate of atopic dermatitis is extremely high, the recurrence rate of moderate and severe atopic dermatitis is 37-53% every year, and the living quality of patients is greatly affected. The invention provides the traditional Chinese medicine composition for treating atopic dermatitis by taking'spleen strengthening, kidney nourishing, yin nourishing and dryness moistening 'as a core treatment rule, and the traditional Chinese medicine composition can relieve skin itch, promote skin lesion fading and reduce the recurrence rate. The traditional Chinese medicine composition accords with the idea of'prevention of disease 'of traditional Chinese medicine, has important value in chronic disease management, and has good effectiveness and safety through clinical verification. Meanwhile, the application of the invention can reduce the medical expenditure of disease recurrence, and has good economic value. At present, no medicine for controlling atopic dermatitis or eczema relapse exists in the market, and the research of the project proves that the traditional Chinese medicine composition has a remarkable curative effect on prevention of atopic dermatitis relapse.

This invention relates to the field of zebrafish model technology, and discloses a method for constructing and applying a chemically induced zebrafish eczema model. The invention constructs a zebrafish eczema model by inducing sensitization and challenge in zebrafish after egg hatching. A two-stage induction method is used to simulate the sensitization and challenge phases of the eczema induction mechanism. Successful model construction is indicated by the repetitive behavioral characteristics observed after both inductions. This invention also reveals that under specific chemical inducer doses, zebrafish exhibit aggregation on the sidewalls of culture dishes and rubbing against the walls, a behavior corresponding to the skin itching symptoms induced by eczema inflammation, which can be directly observed with the naked eye. This model is highly efficient and predictive, and can be used to evaluate the efficacy of drugs, health foods, and other foods in improving eczema.

The present disclosure relates to a composition for skin improvement comprising beta-sitosterol and betulin. It was confirmed that the composition has excellent effects of skin-soothing and relieving skin irritation by reducing skin nerve stimulation-inducing factors, increasing the expression of moisturizing-related factors, increasing skin absorption, improving skin permeation, and inhibiting mast cell activity, and thus can be effectively used in cosmetics, quasi-drugs, etc. for skin improvement.

The invention discloses a traditional Chinese medicine composition with relieving and anti-allergy effects as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from a radix sophorae flavescentis extract, a cortex phellodendri extract and a pithecellobium clypearia extract in a mass ratio of (2-4): (1-2): (0.5-1). The composition can remarkably inhibit hyaluronidase activity, the inhibition rate reaches 67.68% or above, skin itch reaction induced by Chinese yam juice can be rapidly relieved within 5.5 min, the itching relieving aging of the composition is shortened by 26.5% compared with that of a positive control group, and therefore the effects of rapid itching relieving and strong relieving are achieved through the multi-target-point synergistic effect, and the effect of the composition is remarkably superior to that of a single component or a combination of every two components. A skin irritation experiment verifies that the composition has no sensitization risk. The technical problems that an existing chemical anti-allergy agent is large in irritation and single in effect of natural components are solved, the anti-allergy composition can be widely applied to cosmetic dosage forms such as cream and essence, and an innovative solution is provided for developing safe and efficient natural anti-allergy products.

The invention relates to the technical field of skin care, in particular to a plant extract for inhibiting TRPV1 receptors and relieving and a preparation method thereof.The plant extract is prepared by extracting portulaca oleracea, rosemary leaves and citrus peel according to the weight ratio of (1-3): (1-5): (0.1-0.2), and the citrus peel is dried peel of sweet oranges, grapefruits or lemons. The preparation method comprises the steps of raw material pretreatment, extraction solvent preparation, extraction and post-treatment, according to the plant extract capable of inhibiting the TRPV1 receptor and relieving and the preparation method thereof, the purslane, the rosemary leaves and the citrus peel are combined according to the specific weight ratio of (1-3): (1-5): (0.1-0.2), flavone and alkaloid in the purslane, carnosic acid and rosmarinic acid in the rosemary, carnosic acid and rosmarinic acid in the rosemary and the citrus peel are mixed, and the TRPV1 receptor inhibiting and relieving plant extract is obtained. Three active ingredients of polymethoxylated flavonoids in the citrus peel form a synergistic effect, so that activation of a key receptor TRPV1 of skin itch and stabbing pain is directly inhibited from the upstream, neurogenic inflammation is blocked from the source, expression of core inflammatory factors such as TNF-alpha and IL-6 is synergistically inhibited from the downstream, and the effect of the composition is superior to that of a single plant extract and a mixture with a non-optimal ratio.

To provide a body cleansing composition that can significantly reduce skin itching in winter, and a method for reducing skin itching in winter using the body cleansing composition. [Solution] A body cleansing composition containing (A) dimethicone having a kinematic viscosity of 3 cSt or more and less than 20 cSt at 25°C and / or (B) polysilicone-13 represented by the following general formula (1). TIFF2026105574000014.tif41167 x, y, and z represent repeating numbers and are integers greater than or equal to 1.

The invention belongs to the technical field of microorganisms, and particularly relates to a bifidobacterium animalis subsp. Lactis microbial agent, application and a product thereof. The bifidobacterium animalis subsp. Lactis provided by the invention is bifidobacterium animalis subsp. Lactis BL-5M, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.33449. By means of intervention of the animal bifidobacterium subsp. Lactis BL-5M, the skin itch degree can be reduced, and the scratching behavior is reduced; skin spongy edema, abnormal keratosis and spinous hyperplasia phenomena are relieved; the diseased skin tissue structure repair is promoted; skin dermal superficial layer inflammatory cell infiltration is relieved, and the anti-inflammatory capacity of the body is improved; the serum IgE level is obviously reduced, and the anti-allergy or desensitization capability of the body is improved; the symptoms such as erythema, edema and pruritus of people with easily-contacted allergic constitution are effectively reduced, and the uncomfortable body feeling is reduced.

The application discloses high oxidation potential water and a manufacturing method and application thereof. Weak acid citric acid or composite acid is used as raw water, electrolytic water devices of conductive diamond electrodes are used for electrolysis, and electrolytic water spray or water spray with high oxidation potential of greater than or equal to 1200mv is obtained. The pH of the weak acid citric acid or composite acid is between 3 and 3.5, and the raw water can further contain small molecule hyaluronic acid HA35. It is found through research that the high oxidation potential water manufactured by using weak acid citric acid or composite acid with less irritancy and odor as raw water or by adding small molecule hyaluronic acid HA35 on the basis of the above raw water has high oxidation potential, and has better effects on skin itching, skin swelling, tinea pedis itching, facial beauty, and microorganism killing, so that the instant manufacturing of the high oxidation potential water is not affected by temperature rise, and the biological function of the high oxidation potential water can be guaranteed even when the temperature rises.

The invention relates to an external ointment for treating eczema and a preparation method thereof. Sinkiang lithospermum erythrorhizon, radix sophorae flavescentis and cortex phellodendri are used as monarch drugs. Sinkiang lithospermum erythrorhizon clears heat, cools blood, detoxifies and promotes eruption, radix sophorae flavescentis and cortex phellodendri clear heat, eliminate dampness, dispel wind and arrest itching, and directly act on the root of eczema damp-heat toxin. Salvia miltiorrhiza, radix rehmanniae, radix paeoniae rubra, cortex moutan and purslane are used as ministerial drugs. The radix rehmanniae, the radix paeoniae rubra and the cortex moutan are used for cooling blood and clearing heat, and the purslane is used for clearing away heat and toxic materials and assisting the monarch drug to enhance the effects of clearing heat and cooling blood, and dispersing blood stasis and relieving itching. Cynanchum paniculatum, radix saposhnikoviae, radix angelicae, platycodon grandiflorum, sanguisorba officinalis and cortex dictamni are used as adjuvant drugs. Radix cynanchi paniculati and divaricate saposhnikovia root dispel wind and arrest itching, radix angelicae dahuricae eliminates dampness and arrest itching, platycodon grandiflorum carries medicine and is transdermal, sanguisorba officinalis is used for cooling blood and astringing, cortex dictamni is used for clearing heat and eliminating dampness, and monarch and ministerial medicines are jointly assisted in A trace amount of dexamethasone is used for assisting rapid anti-inflammation, uncomfortable symptoms such as skin itch, papule and scabbing caused by eczema can be relieved, and instant pain of a patient can be rapidly relieved; skin barrier damage caused by eczema is improved, and normal physiological function recovery of skin is promoted.

The present application belongs to the field of microbial technology, and particularly relates to a plant lacto-plantarum extracellular vesicle and application thereof. Specifically, the plant lacto-plantarum extracellular vesicle can promote HaCaT cells to generate ceramide, up-regulate the expression of key genes in the ceramide synthesis pathway of skin, and restore the skin barrier. The plant lacto-plantarum extracellular vesicle can reduce the expression of pro-inflammatory factors in a cell inflammation model, and has good anti-inflammatory effect. The mouse skin damage model verification shows that the EVs have good skin penetration ability, can significantly reduce the skin damage score, relieve skin itching, improve the skin water content, and reduce the expression of pro-inflammatory factors and the expression of itching-related cytokines in the skin tissue.