8 results about "Skin itching" patented technology

The present application relates to the use of a substance that regulates BCL11A gene and / or its encoded product in the preparation of a drug for reversing skin photoaging, wherein the skin photoaging includes skin cell aging caused by sunlight, light, etc., and the skin cells include keratinocytes, dermal fibroblasts, melanocytes. The regulation is to up-regulate the expression of BCL11A gene and / or promote the production of its encoded product. Typical clinical manifestations of the skin photoaging include wrinkles, dry skin, loose skin, dilated capillaries, uneven skin pigmentation, and skin itching. The substance that regulates BCL11A gene and / or its encoded product includes a substance that regulates BCL11A gene DNA molecules and a substance that regulates the expression of BCL11A translation product protein molecules. The reversal of skin photoaging is manifested in reducing the proportion of cells positive for aging-related beta-galactosidase staining in skin cells and reducing the expression of aging-related protein p16 and DNA damage protein gammaH2AX.

This invention discloses a long-acting antipruritic and antibacterial topical skin preparation, comprising N-ethyl-γ-L-glutamine, 1-1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphate-N-(L-γ-glutamyl-N-ethyl)-ethanolamine (POPE-N-Et-Gln-α), chlorhexidine acetate, and saffron extract as active ingredients, formulated into a hydrogel or cream with a pharmaceutically acceptable matrix. POPE-N-Et-Gln-α provides rapid transdermal action, while N-ethyl-γ-L-glutamine offers sustained-release and long-lasting effects; saffron extract provides anti-inflammatory and antioxidant effects, and chlorhexidine acetate provides antibacterial and antifungal effects. This invention is hormone-free and non-addictive, achieving both rapid and long-lasting antipruritic effects, and is suitable for eczema, urticaria, dry skin, neurodermatitis, psoriasis, microbial infections, and skin itching caused by insect bites.

This invention relates to the field of zebrafish model technology, and discloses a method for constructing and applying a chemically induced zebrafish eczema model. The invention constructs a zebrafish eczema model by inducing sensitization and challenge in zebrafish after egg hatching. A two-stage induction method is used to simulate the sensitization and challenge phases of the eczema induction mechanism. Successful model construction is indicated by the repetitive behavioral characteristics observed after both inductions. This invention also reveals that under specific chemical inducer doses, zebrafish exhibit aggregation on the sidewalls of culture dishes and rubbing against the walls, a behavior corresponding to the skin itching symptoms induced by eczema inflammation, which can be directly observed with the naked eye. This model is highly efficient and predictive, and can be used to evaluate the efficacy of drugs, health foods, and other foods in improving eczema.

The present disclosure relates to a composition for skin improvement comprising beta-sitosterol and betulin. It was confirmed that the composition has excellent effects of skin-soothing and relieving skin irritation by reducing skin nerve stimulation-inducing factors, increasing the expression of moisturizing-related factors, increasing skin absorption, improving skin permeation, and inhibiting mast cell activity, and thus can be effectively used in cosmetics, quasi-drugs, etc. for skin improvement.

To provide a body cleansing composition that can significantly reduce skin itching in winter, and a method for reducing skin itching in winter using the body cleansing composition. [Solution] A body cleansing composition containing (A) dimethicone having a kinematic viscosity of 3 cSt or more and less than 20 cSt at 25°C and / or (B) polysilicone-13 represented by the following general formula (1). TIFF2026105574000014.tif41167 x, y, and z represent repeating numbers and are integers greater than or equal to 1.

The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition containing ox gall, a pharmaceutical preparation and application, the present application provides a traditional Chinese medicine composition containing ox gall, which has the effects of clearing heat and resolving toxins, cooling liver and resolving lung, dispersing wind and relieving pain, and the preparation has a wide range of uses, the preparation method of the composition provided by the present application is easy to operate, and through years of production practice accumulation, the quality of the obtained product is stable and controllable, and the product is used for preparing drugs for treating liver and lung heat accumulation, wind and fire disturbance, dizziness, oral and nasal sores, wind and fire toothache, sudden eye inflammation, skin itching and other diseases in clinic, and has a wide application value.

The application belongs to the technical field of medicine, and discloses skin health antipruritic liquid, which comprises raw material components: angelica, cortex moutan, white alum, forsythia, schizonepeta, baizhi, humulus, zanthoxylum, lotus house, artemisia leaf, duckweed, alkanna, aloe, honeycomb, polygonatum, stemona, sophora, fly Yang grass, cortex periplocae, melaleuca, ophiorrhiza, white milkweed, gallic, spilanthes, kochia, taraxacum, clematis, xuchangqing, biota, radix falcaliae, radix pterostupiae, red plate, snake skin, wind-preventing plant, hollyhock, oak flower, oak, radix scrophulariae, radix paeoniae, radix bupleuri, radix scrophulariae, radix paeoniae, radix scrophulariae, radix paeoniae, radix scrophulariae, borage, borax, the application has multiple effects of clearing heat and cooling blood, sterilizing and resisting inflammation, removing dampness and relieving itching, removing toxicity and resolving mass, etc., can improve or treat various skin problems such as eczema, herpes, allergic dermatitis, tinea pedis, hemorrhoids, acne, psoriasis and skin itching, and is suitable for a wide range of scenes; the process combination of crushing, screening, specific proportion mixing, fermentation, multiple filtration and accurate concentration ensures that the active ingredients in the raw materials are fully extracted and purified, avoids the loss of effective components, improves the curative effect intensity of unit volume of liquid medicine, and has quick effect after spraying, which is beneficial to actual application and operation.

The utility model provides a kind of skin itching relieving device suitable for skin itching patient. The skin itching relieving device suitable for skin itching patient includes: barrel, disinfecting component and itching stopping component, the itching stopping component includes external shell, rotating member is rotatably connected in the inside of the external shell, the inner wall of the barrel is fixedly connected with driving motor by fixed part, the output of the driving motor is fixedly connected with driving gear, the side of the driving gear is engaged with driven gear, the bottom of the driven gear is fixedly connected with pinion, the side of the pinion is engaged with large gear, the pinion and large gear are rotatably connected with barrel inner wall, the skin itching relieving device suitable for skin itching patient provided by the utility model has the advantages of small size, convenient to hold, convenient for user to clean and disinfect itching stopping structure.