44 results about "Antipruritic Effect" patented technology

The present invention relates to a traditional Chinese medicine composition for treating psoriasis, and its preparation method and use. The traditional Chinese medicine composition is prepared from the following raw materials: Portulaca oleracea, Sophora flavescens, Dictamni bark, Honeysuckle, Kochia scoparia, Phellodendron amurense, Platycladus orientalis leaves, Paeonia lactiflora, and Lithospermum officinale. The traditional Chinese medicine composition of the present invention has a scientific and reasonable formulation, synergistic efficacy, a small number of ingredients, and controlled quality. The combination of monarch, minister, adjuvant, and envoy in the present invention's formulation is scientific and reasonable. The combination of anti-inflammatory and immunomodulatory heat-clearing, blood-cooling, and antipruritic drugs can effectively eliminate the cause of the disease and enhance the antipruritic effect, exerting anti-inflammatory, antiproliferative, and local vasoconstrictive effects, with the advantages of increased efficacy and reduced toxicity, and can reduce the risk of recurrence. This promotes epithelial tissue repair, maintains the dynamic balance of skin keratinization, effectively prevents the recurrence of psoriasis, and reduces the suffering of patients.

Provided is a portable pruritus treatment device which is capable of achieving a sufficient antipruritic effect in lieu of a drug therapy that causes systemic symptoms, and with which a patient can repeatedly perform radiation at home.　This pruritus treatment device is characterized in having a light beam source for emitting a light beam and a light beam radiation probe for radiating the light beam, and is characterized in that the light beam emitted by the light source is percutaneously radiated from the light beam radiation probe toward sensory nerves that dominate a pruritus occurrence site of the skin or the mucosal epithelium.

This invention discloses a traditional Chinese medicine composition for treating senile pruritus and its preparation method. The composition consists of the following raw materials in parts by weight: Angelica sinensis 15-25 parts, Astragalus membranaceus 12-20 parts, Paeonia lactiflora 10-18 parts, Saposhnikovia divaricata 8-15 parts, Dictamnus dasycarpus 6-12 parts, Kochia scoparia 6-12 parts, Schizonepeta tenuifolia 6-10 parts, Ligusticum chuanxiong 5-10 parts, Ophiopogon japonicus 4-8 parts, and Glycyrrhiza uralensis 3-6 parts. The preparation method includes: raw material pretreatment, water extraction, alcohol extraction, consolidation and concentration, and optional addition of excipients to prepare a bath liquid or powder. This invention is based on the pathogenesis of "deficiency of Qi and blood, blood deficiency and wind dryness," using Angelica sinensis and Astragalus membranaceus as the principal herbs to invigorate Qi and nourish blood to strengthen the body's foundation, and using adjuvant herbs to dispel wind and moisten dryness to treat the symptoms, achieving both symptomatic and root-cause treatment. Comparative experiments have shown that this invention produces unexpected synergistic effects in terms of barrier repair, antipruritic effect, and extraction rate. This invention has a standardized process, is easy to use, and is suitable for widespread application.

The invention provides a compound traditional Chinese medicine antipruritic composition and camellia oil containing the same. The compound traditional Chinese medicine antipruritic composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 0.1-25 parts of baeckea frutescens, 0.2-30 parts of perfoliote knotweed herb, 0.5-30 parts of eriocarpous glochidion herb, 1-35 parts of purslane herb, 0.1-25 parts of sweet wormwood herb, 0.1-25 parts of mosla dianthera, 1-25 parts of xanthium sibiricum and 0.1-5 parts of duckweed. The antipruritic composition is prepared by extracting traditional Chinese medicines, is safe in components and has a relatively good antipruritic effect, and when the antipruritic composition is further added into the camellia oil, the antipruritic composition is mild and non-irritant to skin and has very good antipruritic activity.

The invention relates to the field of cosmetics, in particular to a traditional Chinese medicine compound body lotion with relieving and itching relieving effects and a preparation method thereof. Comprising the following components in percentage by weight: 1%-3% of coptis chinensis paste, 0.05%-0.15% of a white birch bark extract, 0.05%-0.15% of a radix scrophulariae extract, 0.01%-0.03% of sodium hyaluronate, 0.3%-0.7% of butyrospermum parkii butter, 0.15%-0.35% of carbomer, 1%-3% of a first emulsifier and the balance of water. The first emulsifier is prepared from isostearyl alcohol, butanediol cocoate and ethyl cellulose; carbomer and the first emulsifier form a double-gel latex system. All the active substances improve the skin microenvironment together, conditions are created for the active ingredients to play roles and skin self-repairing, and synergism of barrier repairing and moisture maintaining is achieved. The synergistic active ingredients and the first emulsifier form a double-gel latex system as a carrier through carbomer, and the effect of the double-gel latex system can be better exerted.

The invention belongs to the technical field of plant essential oil, and discloses gaultheria yunnanensis composite essential oil and a preparation method thereof. The essential oil comprises the following raw materials: 40-60 parts of gaultheria yunnanensis essential oil, 10-20 parts of peppermint oil and 20-30 parts of ginger oil. The gaultheria yunnanensis essential oil is used as a core raw material and matched with the peppermint oil and the ginger oil, the effects of the gaultheria yunnanensis essential oil, the peppermint oil and the ginger oil are complementary, the anti-inflammatory and analgesic effects of the gaultheria yunnanensis essential oil, the cooling and itching-relieving effects of the peppermint oil and the effects of the ginger oil for promoting blood circulation to remove blood stasis and warming channels and expelling cold are mutually matched, and the problem The compound essential oil can comprehensively relieve various discomforts such as muscle and joint pain, swelling, mosquito bite itching and chilblain, the relieving effect is better than that of existing single essential oil or conventional compound essential oil, the effective components of methyl salicylate, menthol and gingerol of the three essential oils jointly act on pain and inflammation targets, and the relieving effect is improved.

The invention provides gel based on collagen liposome. The gel comprises the following components in parts by mass: 2 parts of shikonin liposome; 2 parts of collagen peptide liposome; 1 part of elastin peptide liposome; and 1 part of carbomer. According to the gel based on the collagen liposome provided by the invention, the alkannin liposome compound gel has an obvious cleaning capability, namely, the alkannin liposome compound gel has a very strong anti-oxidation capability. The alkannin liposome compound gel has an obvious cleaning effect on H2O2 (hydrogen peroxide). The alkannin liposome compound gel has an excellent itching relieving effect. The alkannin liposome compound gel has the effect of resisting eczema. The alkannin liposome compound gel also has an inhibition effect on staphylococcus aureus and escherichia coli. The invention further provides a preparation method of the gel based on the collagen lipidosome and application of the gel based on the collagen lipidosome in the aspect of drugs for treating skin diseases.

The invention discloses an application of Vietnam ginseng saponin R18. According to the invention, a Ca < 2 + > biosensor is utilized to co-transfect Hela cells with MRGPRX4, the activation effect of Vietnam ginsenoside R18 on MRGPRX4 is detected, and the Vietnam ginsenoside R18 is confirmed to be an agonist of MRGRPX4. The Vietnam ginsenoside R18 acts on a mouse through subcutaneous injection to cause itching of the mouse, so that the Vietnam ginsenoside R18 can be used as a tool medicine for studying itching and is used for screening a G protein coupled receptor antagonist with an itching relieving effect or preparing an itching causing model; the traditional Chinese medicine quality is controlled, and the itching side effect of the traditional Chinese medicine is prevented.

The invention provides shampoo for controlling oil and relieving itching and a preparation method thereof, and relates to the technical field of shampoo. The shampoo is prepared from the following raw materials in parts by weight: 10 to 14 parts of camellia oil, 20 to 30 parts of plant extract, 7 to 10 parts of euglena parviflora root powder, 3 to 6 parts of vitamin E, 10 to 13 parts of butyrospermum parviflora butter, 6 to 8 parts of hydrolyzed silk protein, 7 to 9 parts of euglena parviflora polysaccharide, 4 to 7 parts of amino acid, 14 to 18 parts of surfactant, 2 to 4 parts of hydroxyethyl cellulose and 70 to 90 parts of water. The shampoo has good foaming and scalp dirt cleaning performance and can inhibit excessive secretion of sebaceous gland cells and reduce scalp grease generation, active ingredients can permeate into the inner layer of scalp to supplement moisture and nutrition, meanwhile, a protective layer can be formed on the surface layer of the scalp, the damaged scalp barrier of children is repaired, the scalp resistance is enhanced, and the hair is protected. Therefore, good oil control and itching relieving effects are achieved, and the effect is mild.

The utility model provides an antipruritic instrument, relates to medical instrument field, the antipruritic instrument includes: antipruritic probe, floating structure, host computer, cap, the floating structure is connected with the one end of antipruritic instrument host computer and the one end of antipruritic probe respectively, and the floating structure makes antipruritic probe can float at multi-angle when contacting human body skin bite position, and effectively fit skin, and the antipruritic instrument has the antipruritic effect. The oppression feeling of a traditional itching relieving instrument on the skin due to a fixed itching relieving probe is avoided, and effective itching relieving is achieved; meanwhile, due to the fact that the floating structure can adapt to the fluctuating state of the skin at different positions, the applicability of the itching relieving instrument is improved.

The present invention provides a plant extract, composition, preparation method, and application thereof, exhibiting triple antibacterial, antioxidant, and antipruritic effects. These extracts relate to the technical field of daily chemical products. The plant extract comprises a and b; a comprises Terminalia chebula fruit extract; b is a plum fruit extract, or at least one of a rose flower extract, a rose flower extract, or a tribulus terrestris fruit extract and a plum fruit extract; when b is a plum fruit extract, the weight ratio of a to b is 2-4:1; when b is at least one of a rose flower extract, a rose flower extract, or a tribulus terrestris fruit extract and a plum fruit extract, the weight ratio of a to b is 1:1. The plant extract exhibits excellent antibacterial, antioxidant, and antipruritic effects, achieving a strong synergistic effect, thereby achieving enhanced results when applied to skin care products. This invention addresses the technical problem of the prior art lacking a plant extract that simultaneously exhibits triple antibacterial, antioxidant, and antipruritic effects.

The invention discloses a pharmaceutical composition for treating eczema, application of the pharmaceutical composition and an external preparation based on the pharmaceutical composition, and belongs to the technical field of traditional Chinese medicines. Three medicinal materials including dandelion, polygonum aviculare and polygonum flaccidum are taken as raw materials, water and ethanol with different concentrations are taken as extraction solvents, the extracted extracts are taken as active ingredients of external preparations such as lotion, cream, gel and cream, the itching relieving effect can be quickly and effectively achieved through combination of the active ingredients, and the traditional Chinese medicine composition is suitable for treating eczema and has a wide application prospect. The symptoms of eczema scabbing, redness and swelling and pruritus are remarkably improved, and eczema is not prone to And the preparation is simple in process and suitable for industrial production.

The invention discloses a traditional Chinese medicine composition for relieving itching. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6-50g of radix scutellariae, 6-50g of fructus gardeniae, 6-50g of fructus forsythiae, 6-50g of flos lonicerae and 6-50g of radix geutianae. According to the invention, the radix scutellariae for inhibiting histamine release, the fructus forsythiae for antagonizing histamine receptors and the felwort for blocking itching signal transduction are subjected to multi-way action to cover the whole link of itching-inducing medium generation-receptor combination-signal transmission, so that rapid itching relieving is realized; the cape jasmine for promoting prothrombin activation, the baical skullcap root for enhancing platelet aggregation and the honeysuckle flower for contracting blood vessels act together, so that the blood coagulation time is shortened, and the effect fluctuation of a single hemostasis mechanism is avoided; the five medicines jointly inhibit the release of inflammatory factors, enhance the local antibacterial ability, relieve inflammatory pruritus, prevent wound infection, avoid vicious circle of itching-grasping-infection-aggravated itching, and reduce the infection risk after bleeding.

This invention discloses a traditional Chinese medicine composition for treating skin diseases and its preparation method, belonging to the field of traditional Chinese medicine technology. It is made from the following raw materials in parts by weight: 8-12 parts of Phellodendron bark, 8-12 parts of Cnidium monnieri fruit, 8-12 parts of Dictamnus dasycarpus root bark, 8-12 parts of Stemona japonica root bark, 8-12 parts of alum, 8-12 parts of Carthamus tinctorius flower, 8-12 parts of dragon's blood, 8-12 parts of Panax notoginseng root bark, 8-12 parts of myrrh, 8-12 parts of frankincense, and 1-3 parts of propolis. This invention also provides an external preparation containing this composition and its preparation method. The preparation method includes pulverizing the raw materials, adding 60%-80% ethanol, soaking at 50-80℃ for 2-7 days, pressing, filtering, and allowing to stand, then collecting the supernatant. Pharmacological experiments show that the composition of this invention has significant antibacterial, anti-inflammatory, and antipruritic effects; clinical observations show a total effective rate of 80%-95% for psoriasis, eczema, rashes, pruritus, herpes, urticaria, and insect bite itching. The formulation of this invention is scientific, the process is stable, and the efficacy is definite, making it suitable for clinical application.

The invention discloses an anti-dandruff and itching-relieving shampoo and a preparation method thereof, and the anti-dandruff and itching-relieving shampoo comprises the following components in parts by weight: 10-20 parts of an amino acid surfactant, 5-10 parts of an anti-dandruff agent, 3-8 parts of an itching-relieving agent, 5-10 parts of a humectant, 2-5 parts of a conditioner, 0.1-0.5 part of a preservative, 0.1-0.5 part of essence and the balance of deionized water. By reasonably selecting the amino acid surfactant, the anti-dandruff agent, the antipruritic agent, the humectant, the conditioner and other components and optimizing the proportion of all the components, the prepared shampoo is remarkable in anti-dandruff effect, lasting in antipruritic effect, mild and non-irritating.

The invention relates to the technical field of daily necessities, and discloses an anti-dandruff shampoo soap and a preparation method thereof.The anti-dandruff shampoo soap is prepared from, by mass, 45%-50% of sodium lauryl sulfate; 3%-6% of guar gum hydroxypropyl trimethyl ammonium chloride; 4%-6% of cetostearyl alcohol; 11%-13% of shea butter; 0.8%-1% of coconut oil; 10%-12% of sodium cocoyl glutamate; 3%-5% of pyridone ethanolamine salt; 4%-5% of polyvinylpyrrolidone; 0.4%-1% of a lucid ganoderma extract; 0.3%-1% of a soapberry peel extract; 0.2%-1% of a ginseng root extract; 0.1%-1% of an angelica sinensis extract; 0.5%-1% of a cacumen biotae extract; 0.8%-1% of a polygonum multiflorum extract; and the balance of water. The anti-dandruff and itching-relieving shampoo has remarkable anti-dandruff and itching-relieving effects, a natural plant formula prepared from the adopted functional components is healthier for human bodies and has a health-care effect on hair, the formula is safer, toxic and side effects and irritation are smaller, and the conditions of skin microecosystem imbalance such as skin allergy and inflammation are not likely to be caused.

This invention discloses a compound traditional Chinese medicine detoxifying ointment and its preparation method. The compound traditional Chinese medicine detoxifying ointment comprises a traditional Chinese medicine extract, triclosan, a gel matrix, a cooling and antipruritic agent, a moisturizer, a surfactant, a pH adjuster, and purified water. The traditional Chinese medicine extract is prepared by a group extraction process using five medicinal slices—honeysuckle, scutellaria, coptis, rhubarb, and corydalis—in a specific ratio: honeysuckle, scutellaria, and corydalis form the first group, while coptis and rhubarb form the second group. These are extracted separately by ethanol reflux extraction and microfiltration purification, then a colloidal dispersion system is formed using a pH segmented control method, followed by concentrating the extracts. This invention, through the synergistic combination of the traditional Chinese medicine extract, low-concentration triclosan, and the cooling and antipruritic agent, enables the product to possess multiple effects, including highly effective broad-spectrum antibacterial properties, cooling and antipruritic effects, and blood-activating and analgesic effects. Furthermore, it is non-irritating to the skin, exhibits good stability, and is suitable for industrial production.

The present disclosure relates generally to cosmetic compositions comprising a Crocus sativus flower extract, and their use for skin treatment, particularly as anti-dandruff. The compositions provide very significant anti-dandruff, anti-fungal, anti-erythema, skin soothing, and antipruritic effects, and also improve skin barrier integrity.

The invention relates to the field of biological medicine technology and daily chemical products, and particularly discloses a composition containing glycoprotein and sparassis crispa extract and application of the composition in preparation of scalp or hair care products. The composition containing the glycoprotein and the sparassis crispa extract comprises the glycoprotein and the sparassis crispa extract, wherein the weight ratio of the glycoprotein to the sparassis crispa extract is (1-10): (1-10). Researches show that the composition has the effect of relieving itching; besides, glycoprotein has excellent moisturizing performance, can effectively lock scalp moisture, has a certain anti-inflammatory effect and is beneficial to relieving scalp inflammation; the sparassis crispa extract is rich in antioxidants and can effectively neutralize free radicals and reduce damage of oxidation pressure to scalp cells. Therefore, the composition disclosed by the invention can comprehensively and systematically improve the scalp environment, promote the scalp health and provide a better growth environment for the hair by combining the two components for use.

The invention designs a novel double-target peptide agonist targeting peripheral Kappa and Mu opioid receptors or pharmaceutically acceptable salts of the double-target peptide agonist, namely, chimeric peptides MKOP001 and MKOP002 are newly constructed on the basis of a DN-9 and dynorphin efficient analogue [des-Arg7] Dyn A (1-11)-NH2 sequence. An in-vitro calcium mobilization experiment and an acute analgesic experiment show that the brand new peptide agonists MKOP001 and MKOP002 can simultaneously activate Kappa and Mu opioid receptors and generate efficient analgesic activity. In addition, further research shows that both the MKOP001 and the MKOP002 can generate a remarkable itching relieving effect. Therefore, the peripheral restrictive Kappa and Mu opioid receptor double-target peptide molecules MKOP001 and MKOP002 or pharmaceutically acceptable salts thereof have very high application value in the aspect of preparing high-efficiency and low-side-effect analgesic or antipruritic drugs.

This invention discloses an antipruritic gel containing 3-hydroxydecanoic acid microemulsion and its preparation method. The gel combines the natural antipruritic ingredient 3-hydroxydecanoic acid and peppermint oil. By preparing it into a microemulsion form, nano-sized droplets are combined with skin absorption enhancers and gel sustained-release agents, thereby improving transdermal absorption efficiency and prolonging the residence time in the skin to achieve a long-lasting antipruritic effect. 3-hydroxydecanoic acid exerts its antipruritic effect through anti-inflammatory action, blocking pruritus signaling pathways, and reducing mast cell degranulation. This antipruritic gel is stable at room temperature, easy to use, and suitable for relieving skin itching caused by mosquito bites, histamine, or non-histamine substances.

The invention discloses a composition with effects of controlling oil, removing dandruff and relieving itching, the composition is prepared from the following components in parts by weight: 10-50 parts of a composite micelle carrier, 0.1-10 parts of dihydroquercetin and 0.1-50 parts of panthenol, and meanwhile, the invention also provides a preparation method and application of the composition. The solubility and bioavailability of the composition are improved through a process technology, the biological activity of the composition can be effectively protected, and the composition has good oil-controlling, dandruff-removing and itching-relieving effects and has a wide market prospect.

This invention discloses a long-acting antipruritic and antibacterial topical skin preparation, comprising N-ethyl-γ-L-glutamine, 1-1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphate-N-(L-γ-glutamyl-N-ethyl)-ethanolamine (POPE-N-Et-Gln-α), chlorhexidine acetate, and saffron extract as active ingredients, formulated into a hydrogel or cream with a pharmaceutically acceptable matrix. POPE-N-Et-Gln-α provides rapid transdermal action, while N-ethyl-γ-L-glutamine offers sustained-release and long-lasting effects; saffron extract provides anti-inflammatory and antioxidant effects, and chlorhexidine acetate provides antibacterial and antifungal effects. This invention is hormone-free and non-addictive, achieving both rapid and long-lasting antipruritic effects, and is suitable for eczema, urticaria, dry skin, neurodermatitis, psoriasis, microbial infections, and skin itching caused by insect bites.

In order to develop the natural plant ointment with anti-inflammatory, antipruritic and sunscreen functions, anti-inflammatory components are screened through a xylene induced mouse ear swelling experiment, and the antipruritic effect is evaluated and the proportion is optimized through hyaluronidase and dextran induced pruritic experiments. Results show that the 95% alcohol extract of the chicory roots has the best anti-inflammatory effect; when the ratio of the No.2 alkanet alcohol extract to the No.1 alkanet water decoction to the cichorium intybus stem alcohol extract to the vernonia esculenta alcohol extract to the perilla frutescens water extract is 1: 3: 8: 3: 5, the hyaluronidase inhibition rate reaches 31.62%, and the itching relieving effect is optimal. And finally determining that the minimum effective drug content of the ointment is 0.40% of the total drug content, wherein the ratio of the chicory stem alcohol extract to the 95% alcohol extract of the second lithospermum to the alcohol extract of the vernonia anthelmintica seeds is 8: 1: 3. The O / W type ointment has remarkable anti-inflammatory and itching-relieving effects and has certain ultraviolet-proof capability. The research provides a scientific basis for developing safe and effective natural plant itching-relieving sunscreen products.

The invention relates to a washing and caring composition with dandruff removing, itching relieving and repairing effects and a preparation method of the washing and caring composition, and belongs to the technical field of daily chemicals. Aiming at dandruff formation and itching factors of scalp, the piroctone olamine salt, palmitoyl tetrapeptide-10, tetrapeptide-1 and speranskia herb extract are correspondingly compounded to play a role in removing dandruff and relieving itching, and the limitation of a single component is made up by compounding chemical components and plant extracts, so that more efficient and milder scalp care is realized. In addition, the dihydrooat acyl o-aminobenzoic acid, pyridoxine tripalmitate and quaternary ammonium salt-73 are combined for use, so that the shampoo also has an excellent synergistic repairing capability on scalp with symptoms such as acne, red and swollen, slight folliculitis and the like.

The application discloses a traditional Chinese medicine compound preparation for external use for relieving post-herpetic neuralgia and trigeminal neuralgia, which comprises effective components and auxiliary materials; the effective components specifically comprise rhizoma corydalis, rhabdophis nigrscens, chuanxiong rhizome, radix paeoniae alba, radix stellae, zanthoxylum bungeanum, menthol, and borneol; and the auxiliary materials comprise carbomer 940, glycerol, choline chloride, triethanolamine, and disodium edetate. The traditional Chinese medicine preparation can effectively relieve post-herpetic neuralgia and trigeminal neuralgia and has an antipruritic effect.

The application discloses an anti-itching, phlegm-dissolving and throat-relieving granule and a preparation method thereof, and particularly relates to the technical field of traditional Chinese medicine compound preparations. The anti-itching, phlegm-dissolving and throat-relieving granule is prepared from sixteen kinds of traditional Chinese medicines, such as Inula japonica, bitter apricot kernel and Jiang Banxia, through water decocting, filtering, vacuum concentration, drying, crushing, and dry granulation by adding dextrin and pregelatinized starch. The core of the application lies in determining the compound composition and the matching extraction, concentration, drying and granulation process, so as to obtain the granule with stable process and the effects of relieving cough and phlegm, relieving throat and stopping itching. The sixteen kinds of traditional Chinese medicines are matched to form a compound system with the effects of promoting lung and relieving qi, descending qi and dissolving phlegm, relieving throat and stopping itching, and the compound system can be used for relieving symptoms such as cough and throat itching, uncomfortable expectoration, sore throat and coughing and panting. The extraction, concentration, drying, crushing, auxiliary material mixing and dry granulation process are used to obtain the granule which is convenient to sub-pack and take.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for inhibiting bacteria, relieving itching and deodorizing, a traditional Chinese medicine foot bath lotion and a preparation method thereof. The traditional Chinese medicine composition comprises folium artemisiae argyi, rhizoma atractylodis, aluminite, radix sophorae flavescentis, herba eupatorii, fructus kochiae, cortex dictamni, flos carthami and cortex phellodendri. The foot bath powder can effectively treat foot problems, remove foot peculiar smell, achieve the effects of inhibiting bacteria and relieving itching, and do not cause harm and irritation to skin.

The present invention discloses a traditional Chinese medicine composition with soothing and anti-allergic effects, as well as its preparation method and application. The composition comprises a Sophora flavescens extract, a Phellodendron amurense extract, and a Monkey Ear Ring extract in a mass ratio of (2-4):(1-2):(0.5-1). The composition significantly inhibits hyaluronidase activity, with an inhibition rate exceeding 67.68%. It can also rapidly relieve yam juice-induced skin pruritus within 5.5 minutes, with an antipruritic effect duration 26.5% shorter than that of the positive control group. This composition achieves a "fast antipruritic and strong soothing" effect through multi-target synergistic action, and its efficacy is significantly superior to that of single components and two-component combinations. Skin irritation experiments have verified that the composition has no allergic risk. The present invention solves the technical problems of existing chemical anti-allergic agents with high irritation and natural ingredients with limited efficacy. It can be widely used in cosmetic dosage forms such as creams and essences, providing an innovative solution for the development of safe and effective natural anti-allergic products.

This invention relates to the field of traditional Chinese medicine, and more particularly to a traditional Chinese medicine composition, its preparation method, and its application. The invention provides a traditional Chinese medicine composition, by weight, comprising the following components or their processed forms: Ephedra 2-10 parts, Coptis chinensis 2-5 parts, Dictamnus dasycarpus root bark 5-10 parts, Cicadae periostracum 3-6 parts, Spirodela polyrhiza 3-9 parts, Schizonepeta tenuifolia 5-10 parts, Astragalus membranaceus 9-20 parts, Eriobotrya japonica leaf 5-10 parts, Salvia miltiorrhiza 5-15 parts, Atractylodes macrocephala 5-12 parts, Sophora flavescens 4-9 parts, and Glycyrrhiza uralensis 3-10 parts. This invention has unique advantages in treating chronic urticaria, reducing the frequency of urticaria attacks, improving antipruritic effects, reducing recurrence, and prolonging the recurrence period.