25 results about "Antipruritic Effect" patented technology

This invention discloses a traditional Chinese medicine composition for treating senile pruritus and its preparation method. The composition consists of the following raw materials in parts by weight: Angelica sinensis 15-25 parts, Astragalus membranaceus 12-20 parts, Paeonia lactiflora 10-18 parts, Saposhnikovia divaricata 8-15 parts, Dictamnus dasycarpus 6-12 parts, Kochia scoparia 6-12 parts, Schizonepeta tenuifolia 6-10 parts, Ligusticum chuanxiong 5-10 parts, Ophiopogon japonicus 4-8 parts, and Glycyrrhiza uralensis 3-6 parts. The preparation method includes: raw material pretreatment, water extraction, alcohol extraction, consolidation and concentration, and optional addition of excipients to prepare a bath liquid or powder. This invention is based on the pathogenesis of "deficiency of Qi and blood, blood deficiency and wind dryness," using Angelica sinensis and Astragalus membranaceus as the principal herbs to invigorate Qi and nourish blood to strengthen the body's foundation, and using adjuvant herbs to dispel wind and moisten dryness to treat the symptoms, achieving both symptomatic and root-cause treatment. Comparative experiments have shown that this invention produces unexpected synergistic effects in terms of barrier repair, antipruritic effect, and extraction rate. This invention has a standardized process, is easy to use, and is suitable for widespread application.

The invention relates to the field of cosmetics, in particular to a traditional Chinese medicine compound body lotion with relieving and itching relieving effects and a preparation method thereof. Comprising the following components in percentage by weight: 1%-3% of coptis chinensis paste, 0.05%-0.15% of a white birch bark extract, 0.05%-0.15% of a radix scrophulariae extract, 0.01%-0.03% of sodium hyaluronate, 0.3%-0.7% of butyrospermum parkii butter, 0.15%-0.35% of carbomer, 1%-3% of a first emulsifier and the balance of water. The first emulsifier is prepared from isostearyl alcohol, butanediol cocoate and ethyl cellulose; carbomer and the first emulsifier form a double-gel latex system. All the active substances improve the skin microenvironment together, conditions are created for the active ingredients to play roles and skin self-repairing, and synergism of barrier repairing and moisture maintaining is achieved. The synergistic active ingredients and the first emulsifier form a double-gel latex system as a carrier through carbomer, and the effect of the double-gel latex system can be better exerted.

The invention belongs to the technical field of plant essential oil, and discloses gaultheria yunnanensis composite essential oil and a preparation method thereof. The essential oil comprises the following raw materials: 40-60 parts of gaultheria yunnanensis essential oil, 10-20 parts of peppermint oil and 20-30 parts of ginger oil. The gaultheria yunnanensis essential oil is used as a core raw material and matched with the peppermint oil and the ginger oil, the effects of the gaultheria yunnanensis essential oil, the peppermint oil and the ginger oil are complementary, the anti-inflammatory and analgesic effects of the gaultheria yunnanensis essential oil, the cooling and itching-relieving effects of the peppermint oil and the effects of the ginger oil for promoting blood circulation to remove blood stasis and warming channels and expelling cold are mutually matched, and the problem The compound essential oil can comprehensively relieve various discomforts such as muscle and joint pain, swelling, mosquito bite itching and chilblain, the relieving effect is better than that of existing single essential oil or conventional compound essential oil, the effective components of methyl salicylate, menthol and gingerol of the three essential oils jointly act on pain and inflammation targets, and the relieving effect is improved.

The invention provides gel based on collagen liposome. The gel comprises the following components in parts by mass: 2 parts of shikonin liposome; 2 parts of collagen peptide liposome; 1 part of elastin peptide liposome; and 1 part of carbomer. According to the gel based on the collagen liposome provided by the invention, the alkannin liposome compound gel has an obvious cleaning capability, namely, the alkannin liposome compound gel has a very strong anti-oxidation capability. The alkannin liposome compound gel has an obvious cleaning effect on H2O2 (hydrogen peroxide). The alkannin liposome compound gel has an excellent itching relieving effect. The alkannin liposome compound gel has the effect of resisting eczema. The alkannin liposome compound gel also has an inhibition effect on staphylococcus aureus and escherichia coli. The invention further provides a preparation method of the gel based on the collagen lipidosome and application of the gel based on the collagen lipidosome in the aspect of drugs for treating skin diseases.

The invention provides shampoo for controlling oil and relieving itching and a preparation method thereof, and relates to the technical field of shampoo. The shampoo is prepared from the following raw materials in parts by weight: 10 to 14 parts of camellia oil, 20 to 30 parts of plant extract, 7 to 10 parts of euglena parviflora root powder, 3 to 6 parts of vitamin E, 10 to 13 parts of butyrospermum parviflora butter, 6 to 8 parts of hydrolyzed silk protein, 7 to 9 parts of euglena parviflora polysaccharide, 4 to 7 parts of amino acid, 14 to 18 parts of surfactant, 2 to 4 parts of hydroxyethyl cellulose and 70 to 90 parts of water. The shampoo has good foaming and scalp dirt cleaning performance and can inhibit excessive secretion of sebaceous gland cells and reduce scalp grease generation, active ingredients can permeate into the inner layer of scalp to supplement moisture and nutrition, meanwhile, a protective layer can be formed on the surface layer of the scalp, the damaged scalp barrier of children is repaired, the scalp resistance is enhanced, and the hair is protected. Therefore, good oil control and itching relieving effects are achieved, and the effect is mild.

The invention discloses a pharmaceutical composition for treating eczema, application of the pharmaceutical composition and an external preparation based on the pharmaceutical composition, and belongs to the technical field of traditional Chinese medicines. Three medicinal materials including dandelion, polygonum aviculare and polygonum flaccidum are taken as raw materials, water and ethanol with different concentrations are taken as extraction solvents, the extracted extracts are taken as active ingredients of external preparations such as lotion, cream, gel and cream, the itching relieving effect can be quickly and effectively achieved through combination of the active ingredients, and the traditional Chinese medicine composition is suitable for treating eczema and has a wide application prospect. The symptoms of eczema scabbing, redness and swelling and pruritus are remarkably improved, and eczema is not prone to And the preparation is simple in process and suitable for industrial production.

This invention discloses a compound traditional Chinese medicine detoxifying ointment and its preparation method. The compound traditional Chinese medicine detoxifying ointment comprises a traditional Chinese medicine extract, triclosan, a gel matrix, a cooling and antipruritic agent, a moisturizer, a surfactant, a pH adjuster, and purified water. The traditional Chinese medicine extract is prepared by a group extraction process using five medicinal slices—honeysuckle, scutellaria, coptis, rhubarb, and corydalis—in a specific ratio: honeysuckle, scutellaria, and corydalis form the first group, while coptis and rhubarb form the second group. These are extracted separately by ethanol reflux extraction and microfiltration purification, then a colloidal dispersion system is formed using a pH segmented control method, followed by concentrating the extracts. This invention, through the synergistic combination of the traditional Chinese medicine extract, low-concentration triclosan, and the cooling and antipruritic agent, enables the product to possess multiple effects, including highly effective broad-spectrum antibacterial properties, cooling and antipruritic effects, and blood-activating and analgesic effects. Furthermore, it is non-irritating to the skin, exhibits good stability, and is suitable for industrial production.

The present disclosure relates generally to cosmetic compositions comprising a Crocus sativus flower extract, and their use for skin treatment, particularly as anti-dandruff. The compositions provide very significant anti-dandruff, anti-fungal, anti-erythema, skin soothing, and antipruritic effects, and also improve skin barrier integrity.

This invention discloses an antipruritic gel containing 3-hydroxydecanoic acid microemulsion and its preparation method. The gel combines the natural antipruritic ingredient 3-hydroxydecanoic acid and peppermint oil. By preparing it into a microemulsion form, nano-sized droplets are combined with skin absorption enhancers and gel sustained-release agents, thereby improving transdermal absorption efficiency and prolonging the residence time in the skin to achieve a long-lasting antipruritic effect. 3-hydroxydecanoic acid exerts its antipruritic effect through anti-inflammatory action, blocking pruritus signaling pathways, and reducing mast cell degranulation. This antipruritic gel is stable at room temperature, easy to use, and suitable for relieving skin itching caused by mosquito bites, histamine, or non-histamine substances.

This invention discloses a long-acting antipruritic and antibacterial topical skin preparation, comprising N-ethyl-γ-L-glutamine, 1-1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphate-N-(L-γ-glutamyl-N-ethyl)-ethanolamine (POPE-N-Et-Gln-α), chlorhexidine acetate, and saffron extract as active ingredients, formulated into a hydrogel or cream with a pharmaceutically acceptable matrix. POPE-N-Et-Gln-α provides rapid transdermal action, while N-ethyl-γ-L-glutamine offers sustained-release and long-lasting effects; saffron extract provides anti-inflammatory and antioxidant effects, and chlorhexidine acetate provides antibacterial and antifungal effects. This invention is hormone-free and non-addictive, achieving both rapid and long-lasting antipruritic effects, and is suitable for eczema, urticaria, dry skin, neurodermatitis, psoriasis, microbial infections, and skin itching caused by insect bites.

In order to develop the natural plant ointment with anti-inflammatory, antipruritic and sunscreen functions, anti-inflammatory components are screened through a xylene induced mouse ear swelling experiment, and the antipruritic effect is evaluated and the proportion is optimized through hyaluronidase and dextran induced pruritic experiments. Results show that the 95% alcohol extract of the chicory roots has the best anti-inflammatory effect; when the ratio of the No.2 alkanet alcohol extract to the No.1 alkanet water decoction to the cichorium intybus stem alcohol extract to the vernonia esculenta alcohol extract to the perilla frutescens water extract is 1: 3: 8: 3: 5, the hyaluronidase inhibition rate reaches 31.62%, and the itching relieving effect is optimal. And finally determining that the minimum effective drug content of the ointment is 0.40% of the total drug content, wherein the ratio of the chicory stem alcohol extract to the 95% alcohol extract of the second lithospermum to the alcohol extract of the vernonia anthelmintica seeds is 8: 1: 3. The O / W type ointment has remarkable anti-inflammatory and itching-relieving effects and has certain ultraviolet-proof capability. The research provides a scientific basis for developing safe and effective natural plant itching-relieving sunscreen products.

The invention relates to a washing and caring composition with dandruff removing, itching relieving and repairing effects and a preparation method of the washing and caring composition, and belongs to the technical field of daily chemicals. Aiming at dandruff formation and itching factors of scalp, the piroctone olamine salt, palmitoyl tetrapeptide-10, tetrapeptide-1 and speranskia herb extract are correspondingly compounded to play a role in removing dandruff and relieving itching, and the limitation of a single component is made up by compounding chemical components and plant extracts, so that more efficient and milder scalp care is realized. In addition, the dihydrooat acyl o-aminobenzoic acid, pyridoxine tripalmitate and quaternary ammonium salt-73 are combined for use, so that the shampoo also has an excellent synergistic repairing capability on scalp with symptoms such as acne, red and swollen, slight folliculitis and the like.

The application discloses a traditional Chinese medicine compound preparation for external use for relieving post-herpetic neuralgia and trigeminal neuralgia, which comprises effective components and auxiliary materials; the effective components specifically comprise rhizoma corydalis, rhabdophis nigrscens, chuanxiong rhizome, radix paeoniae alba, radix stellae, zanthoxylum bungeanum, menthol, and borneol; and the auxiliary materials comprise carbomer 940, glycerol, choline chloride, triethanolamine, and disodium edetate. The traditional Chinese medicine preparation can effectively relieve post-herpetic neuralgia and trigeminal neuralgia and has an antipruritic effect.

The application discloses an anti-itching, phlegm-dissolving and throat-relieving granule and a preparation method thereof, and particularly relates to the technical field of traditional Chinese medicine compound preparations. The anti-itching, phlegm-dissolving and throat-relieving granule is prepared from sixteen kinds of traditional Chinese medicines, such as Inula japonica, bitter apricot kernel and Jiang Banxia, through water decocting, filtering, vacuum concentration, drying, crushing, and dry granulation by adding dextrin and pregelatinized starch. The core of the application lies in determining the compound composition and the matching extraction, concentration, drying and granulation process, so as to obtain the granule with stable process and the effects of relieving cough and phlegm, relieving throat and stopping itching. The sixteen kinds of traditional Chinese medicines are matched to form a compound system with the effects of promoting lung and relieving qi, descending qi and dissolving phlegm, relieving throat and stopping itching, and the compound system can be used for relieving symptoms such as cough and throat itching, uncomfortable expectoration, sore throat and coughing and panting. The extraction, concentration, drying, crushing, auxiliary material mixing and dry granulation process are used to obtain the granule which is convenient to sub-pack and take.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for inhibiting bacteria, relieving itching and deodorizing, a traditional Chinese medicine foot bath lotion and a preparation method thereof. The traditional Chinese medicine composition comprises folium artemisiae argyi, rhizoma atractylodis, aluminite, radix sophorae flavescentis, herba eupatorii, fructus kochiae, cortex dictamni, flos carthami and cortex phellodendri. The foot bath powder can effectively treat foot problems, remove foot peculiar smell, achieve the effects of inhibiting bacteria and relieving itching, and do not cause harm and irritation to skin.

This invention relates to the field of traditional Chinese medicine, and more particularly to a traditional Chinese medicine composition, its preparation method, and its application. The invention provides a traditional Chinese medicine composition, by weight, comprising the following components or their processed forms: Ephedra 2-10 parts, Coptis chinensis 2-5 parts, Dictamnus dasycarpus root bark 5-10 parts, Cicadae periostracum 3-6 parts, Spirodela polyrhiza 3-9 parts, Schizonepeta tenuifolia 5-10 parts, Astragalus membranaceus 9-20 parts, Eriobotrya japonica leaf 5-10 parts, Salvia miltiorrhiza 5-15 parts, Atractylodes macrocephala 5-12 parts, Sophora flavescens 4-9 parts, and Glycyrrhiza uralensis 3-10 parts. This invention has unique advantages in treating chronic urticaria, reducing the frequency of urticaria attacks, improving antipruritic effects, reducing recurrence, and prolonging the recurrence period.

The application discloses a kind of acaricidal compositions, acaricidal additive containing the composition and its preparation method and application.The composition includes 4-terpineol, menthol, borneol, artificial ox gallstone, Ma Yinglong raw powder, mountain chicken pepper fruit oil, clove bud extract, thymus vulgaris extract, neem seed extract.The acaricidal additive includes the above-mentioned composition, and also contains polyhydric alcohol, emulsifier, preservative, deionized water.The application also provides a kind of application of acaricidal additive in the preparation of cream, emulsion, water agent or patch with acaricidal efficacy.The composition of the application not only improves the acaricidal effect of product, reduces the irritability of product, but also has good antipruritic effect.

This invention discloses a traditional Chinese medicine gynecological antibacterial wash with anti-inflammatory and antipruritic effects, belonging to the technical field of gynecological antibacterial washes. The wash is composed of selectively antibacterial traditional Chinese medicine extracts, prebiotic components, and a pharmaceutically acceptable carrier, with a pH value of 3.8-4.5. The selectively antibacterial traditional Chinese medicine extracts include dandelion extract, honeysuckle extract, and Cnidium monnieri extract. By setting the pH value to 3.8-4.5 and using selectively antibacterial traditional Chinese medicine extracts containing dandelion extract, honeysuckle extract, and Cnidium monnieri extract, this invention achieves inhibition zones ≥12mm in diameter against Candida albicans, Staphylococcus aureus, and Escherichia coli, and inhibition zones ≤4mm in diameter against Lactobacillus curvatureii and Lactobacillus japonicus. This effectively inhibits common gynecological pathogens while avoiding excessive killing of beneficial vaginal bacteria, thereby maintaining the vaginal microecological balance.

The invention relates to soothing anti-inflammatory microemulsion and a preparation method and application thereof.The soothing anti-inflammatory microemulsion comprises a mixture A and a solution A. The mixture A comprises oryzanol, palmitoyl ethanolamide (PEA) and an oil-carrying substance, and the mass ratio of palmitoyl ethanolamide to the oil-carrying substance in the mixture A is 1: (4-14); the solvent of the solution A is polyhydric alcohol, and the solute of the solution A comprises palmitoyl ethanolamide. The particle size range of the soothing anti-inflammatory micro-emulsion is 50 to 100 nm. The soothing anti-inflammatory microemulsion can be directly compounded in a cosmetic matrix, can improve the skin permeation efficiency and bioavailability of palmitoyl ethanolamide and oryzanol, and has good anti-inflammatory, skin barrier repairing and itching relieving effects.

The invention discloses a skin antibacterial and antipruritic pharmaceutical composition containing plant extracts and a preparation method thereof, the skin antibacterial and antipruritic pharmaceutical composition containing the plant extracts comprises the following components: at least two of the plant extracts selected from honeysuckle extracts, mint extracts, tea tree oil extracts and aloe extracts, an antibacterial agent selected from a natural antibacterial agent or a synthetic antibacterial and antipruritic agent, and a preservative selected from a natural antibacterial agent or a synthetic antibacterial and antipruritic agent. The invention relates to an anti-pruritic composition, which is prepared from an antihistamine agent or a natural anti-pruritic component, a carrier, a water-based gel, a cream or an oily substrate, and an additional additive, which is prepared from a humectant, a preservative and a pH (Potential of Hydrogen) regulator. During implementation, by optimizing the selection and proportion of the plant extracts and combining specific carriers and auxiliary components, the antibacterial and antipruritic effects are remarkably improved, and meanwhile, the side effect risk is reduced. According to the composition, the synergistic effect of various plant extracts is utilized, the skin permeability and durability are enhanced, and the composition is suitable for various skin problems such as eczema, dermatitis and mosquito bites. The preparation method is simple and efficient, is easy for industrial production, and has a wide market application prospect.

This invention discloses a nanoparticle of *Gynostemma pentaphyllum*, its preparation method, and its application. The nanoparticle is obtained by microwave calcination and quenching with rice vinegar from *Gynostemma pentaphyllum*. The microwave calcination temperature is 600-850℃, and the calcination time is 10-30 min. The particle size (D90) of the *Gynostemma pentaphyllum* nanoparticle is 100-500 nm. This invention, by combining microwave calcination and rice vinegar quenching, significantly reduces the particle size of the pulverized *Gynostemma pentaphyllum* powder, thereby greatly improving its in vitro dissolution rate. Furthermore, after modification with an alternating magnetic field, the rice vinegar quenching solution exhibits improved skin penetration efficiency and can be used as a topical preparation for detoxification, antipruritic effects, and skin repair, thus reducing resource waste and meeting the requirements of green pharmaceutical manufacturing.

The invention provides application of Atalafoline in preparation of a medicine for inhibiting itching perception of people and / or animals, and belongs to the technical field of biomedicine. The atalantia buxifolia alkali achieves the purpose of inhibiting pruritus induction by inhibiting activation of a human or animal TRPV3 ligand gated ion channel. The atalantia buxifolia alkali can enhance the resistance of human beings or animals to itching, and can be used as an active component to be developed into a medicine or a skin care product with an itching relieving effect so as to relieve the itching of the human beings or the animals. Meanwhile, the atalantia buxifolia alkali acts on a receptor TRPV3 or a functional acquired mutant thereof through targeting, and can be applied to research of related ion channel diseases and preparation of related therapeutic drugs.

This invention relates to a plant composition with redness-reducing and itch-relieving effects, its preparation method, and its application, belonging to the field of daily chemical technology; the plant composition contains the following raw materials: peony extract, ophiopogon japonicus extract, scutellaria baicalensis extract, atractylodes macrocephala powder, andrographis paniculata powder, chamomile extract, and forsythia suspensa root extract; the plant composition has the effects of reducing redness and itch-relieving, and is suitable for use in skin care products.

The invention relates to the technical field of daily chemicals, and particularly discloses an immobilized compound enzyme for high-yield production of maltotetraose, hydrolyzed plant starch with soothing and itching relieving effects, and a preparation method and application of the immobilized compound enzyme. The compound enzyme is immobilized, the immobilized compound enzyme capable of producing maltotetraose at high yield is prepared, the problems that the compound enzyme is poor in stability and prone to inactivation are solved, the enzymolysis reaction condition is widened, industrial production of maltotetraose prepared through an enzymolysis method is facilitated, and the production cost of maltotetraose is reduced; the preparation method of the hydrolyzed plant starch and the like are optimized, a variable-temperature enzymolysis technology is innovatively adopted, the problems that alpha-starch and beta-amylase are not specific in enzyme catalysis and starch is randomly decomposed in the reaction period are solved, generation of by-products is reduced, and the finally prepared hydrolyzed plant starch is high in maltotetraose ratio, good in hydrolysis effect and good in hydrolysis effect. The skin-care composition is suitable for being used as a raw material of cosmetics.

The invention provides a female external nursing product with antibacterial, anti-inflammatory and antipruritic effects and a preparation method thereof, and relates to the technical field of biological medicine nursing products. The invention provides an external nursing product for women, which is prepared from the following pure traditional Chinese medicinal materials: cortex ailanthi, saururus chinensis, pericarpium granati, chingma abutilon seeds, red halloysite, lysimachia clethroides, gynura plicata, evodia lepta leaves, peach leaves, pine needles, water gossypium, solanum lyratum and cyrtomium fortunei as raw materials. The traditional Chinese medicine raw materials in the product are scientific in compatibility and have a synergistic effect, the product shows an ultra-excellent antibacterial effect on staphylococcus aureus, escherichia coli and candida albicans, meanwhile, the product has good anti-inflammatory and anti-inflammatory effects, can achieve rapid itching relieving, and in addition, the product has no stimulation effect on vaginal mucosa of female white rabbits and has good safety. The product disclosed by the invention can be used for effectively improving the symptoms such as itching and causalgia, peculiar smell and abnormal secretion caused by colpitis mycotica, bacterial vaginitis, trichomonas vaginitis, senile vaginitis and the like.