85 results about "Antipruritic Effect" patented technology

The invention discloses an external traditional Chinese medicine mixture aiming at genital skin mucosa ulceration wound repair and a preparation method thereof, relates to the field of traditional Chinese medicines, and aims to provide a genital skin mucosa ulceration wound repair medicine which has the effects of promoting wound repair and relieving itching, and is simple in component, small in allergy probability, light and thin in dosage form and good in skin feeling. The traditional Chinese medicine mixture is prepared from chicken butter, honeysuckle stem, felwort, cortex dictamni, fructus kochiae, radix scutellariae, cortex phellodendri, angelica sinensis, radix rehmanniae, radix arnebiae seu lithospermi, sanguisorba officinalis and bletilla striata. The traditional Chinese medicine mixture disclosed by the invention realizes simultaneous treatment of pruritus vulvae and ulceration, fills the treatment blank, relieves symptoms as soon as possible, shortens the treatment cycle and saves expenditure. The curative effect is prominent, and current clinical requirements are met. Cost and loss are reduced. Preparation is convenient, high-end machines are not needed, and preparation can be carried out at home.

The present invention relates to a traditional Chinese medicine composition for treating psoriasis, and its preparation method and use. The traditional Chinese medicine composition is prepared from the following raw materials: Portulaca oleracea, Sophora flavescens, Dictamni bark, Honeysuckle, Kochia scoparia, Phellodendron amurense, Platycladus orientalis leaves, Paeonia lactiflora, and Lithospermum officinale. The traditional Chinese medicine composition of the present invention has a scientific and reasonable formulation, synergistic efficacy, a small number of ingredients, and controlled quality. The combination of monarch, minister, adjuvant, and envoy in the present invention's formulation is scientific and reasonable. The combination of anti-inflammatory and immunomodulatory heat-clearing, blood-cooling, and antipruritic drugs can effectively eliminate the cause of the disease and enhance the antipruritic effect, exerting anti-inflammatory, antiproliferative, and local vasoconstrictive effects, with the advantages of increased efficacy and reduced toxicity, and can reduce the risk of recurrence. This promotes epithelial tissue repair, maintains the dynamic balance of skin keratinization, effectively prevents the recurrence of psoriasis, and reduces the suffering of patients.

The invention provides a plant extract with triple effects of inhibiting bacteria, resisting oxidation and relieving itching, a composition and a preparation method and application of the plant extract and the composition, and relates to the technical field of daily chemical products. A comprises a myrobalan fruit extract; b is a plum fruit extract, or at least one of a rose flower extract, a Chinese rose flower extract or a tribulus terrestris fruit extract and the plum fruit extract; when b is the plum fruit extract, the weight ratio of a to b is (2-4): 1; when b is at least one of the rose extract, the China rose extract or the tribulus terrestris fruit extract and the plum fruit extract, the weight ratio of a to b is 1: 1. The composition can play good antibacterial, antioxidant and antipruritic roles and realize a relatively strong synergistic effect, so that a better effect can be achieved when the composition is applied to a skin care product. The technical problem that in the prior art, a plant extract capable of simultaneously achieving the effects of inhibiting bacteria, resisting oxidation and relieving itching is lacked is solved.

The invention discloses a private part cleaning solution with an antipruritic effect and a processing technology thereof, the private part cleaning solution comprises the following raw materials by weight: 10%-20% of a natural plant extract, the natural plant extract comprises 5%-10% of a chamomile extract, 3%-8% of tea tree essential oil, and the balance of water; 5%-10% of a surfactant, wherein the surfactant is cocamidopropyl betaine; the humectant comprises glycerol and sodium hyaluronate, and the weight ratio of the glycerol to the sodium hyaluronate is 2: 1. The invention relates to the technical field of cleaning and nursing materials. According to the private part cleaning solution with the itching relieving effect and the processing technology of the private part cleaning solution, the pH value of the cleaning solution is adjusted to be within the private part physiological pH range of 3.8-4.5 through lactic acid, the acid-base balance and the micro-ecological environment of private parts can be maintained, natural plant extracts such as chamomile extracts and tea tree essential oil have the antibacterial and anti-inflammatory functions, irritation to skin can be reduced, and the effect of relieving itching is achieved. The cleaning liquid is mild in property, is suitable for daily use, and has good protection and maintenance effects on private skin.

Provided is a portable pruritus treatment device which is capable of achieving a sufficient antipruritic effect in lieu of a drug therapy that causes systemic symptoms, and with which a patient can repeatedly perform radiation at home.　This pruritus treatment device is characterized in having a light beam source for emitting a light beam and a light beam radiation probe for radiating the light beam, and is characterized in that the light beam emitted by the light source is percutaneously radiated from the light beam radiation probe toward sensory nerves that dominate a pruritus occurrence site of the skin or the mucosal epithelium.

This invention discloses a traditional Chinese medicine composition for treating senile pruritus and its preparation method. The composition consists of the following raw materials in parts by weight: Angelica sinensis 15-25 parts, Astragalus membranaceus 12-20 parts, Paeonia lactiflora 10-18 parts, Saposhnikovia divaricata 8-15 parts, Dictamnus dasycarpus 6-12 parts, Kochia scoparia 6-12 parts, Schizonepeta tenuifolia 6-10 parts, Ligusticum chuanxiong 5-10 parts, Ophiopogon japonicus 4-8 parts, and Glycyrrhiza uralensis 3-6 parts. The preparation method includes: raw material pretreatment, water extraction, alcohol extraction, consolidation and concentration, and optional addition of excipients to prepare a bath liquid or powder. This invention is based on the pathogenesis of "deficiency of Qi and blood, blood deficiency and wind dryness," using Angelica sinensis and Astragalus membranaceus as the principal herbs to invigorate Qi and nourish blood to strengthen the body's foundation, and using adjuvant herbs to dispel wind and moisten dryness to treat the symptoms, achieving both symptomatic and root-cause treatment. Comparative experiments have shown that this invention produces unexpected synergistic effects in terms of barrier repair, antipruritic effect, and extraction rate. This invention has a standardized process, is easy to use, and is suitable for widespread application.

The invention provides a compound traditional Chinese medicine antipruritic composition and camellia oil containing the same. The compound traditional Chinese medicine antipruritic composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 0.1-25 parts of baeckea frutescens, 0.2-30 parts of perfoliote knotweed herb, 0.5-30 parts of eriocarpous glochidion herb, 1-35 parts of purslane herb, 0.1-25 parts of sweet wormwood herb, 0.1-25 parts of mosla dianthera, 1-25 parts of xanthium sibiricum and 0.1-5 parts of duckweed. The antipruritic composition is prepared by extracting traditional Chinese medicines, is safe in components and has a relatively good antipruritic effect, and when the antipruritic composition is further added into the camellia oil, the antipruritic composition is mild and non-irritant to skin and has very good antipruritic activity.

The invention relates to the field of cosmetics, in particular to a traditional Chinese medicine compound body lotion with relieving and itching relieving effects and a preparation method thereof. Comprising the following components in percentage by weight: 1%-3% of coptis chinensis paste, 0.05%-0.15% of a white birch bark extract, 0.05%-0.15% of a radix scrophulariae extract, 0.01%-0.03% of sodium hyaluronate, 0.3%-0.7% of butyrospermum parkii butter, 0.15%-0.35% of carbomer, 1%-3% of a first emulsifier and the balance of water. The first emulsifier is prepared from isostearyl alcohol, butanediol cocoate and ethyl cellulose; carbomer and the first emulsifier form a double-gel latex system. All the active substances improve the skin microenvironment together, conditions are created for the active ingredients to play roles and skin self-repairing, and synergism of barrier repairing and moisture maintaining is achieved. The synergistic active ingredients and the first emulsifier form a double-gel latex system as a carrier through carbomer, and the effect of the double-gel latex system can be better exerted.

The external preparation is prepared from the following Chinese herbal medicines in parts by weight: 4 to 20 parts of herba artemisiae scopariae, 2 to 10 parts of cicada slough, 2 to 10 parts of cortex phellodendri, 4 to 20 parts of radix arnebiae seu lithospermi, 2 to 10 parts of radix sophorae flavescentis, 4 to 20 parts of herba agrimoniae, 4 to 20 parts of fructus xanthii, 4 to 20 parts of fructus tribuli, 4 to 20 parts of cortex moutan, 2 to 10 parts of radix rehmanniae, 4 to 20 parts of radix clematidis, 4 to 20 parts of rhizoma dioscoreae, 4 to 20 parts of spina gleditsiae, 4 to 20 parts of herba sedi and 4 to 20 parts of radix saposhnikoviae. The preparation method of the external preparation comprises the following steps: wrapping the weighed raw materials with gauze, soaking in 60-70L of cold water for 2-5 hours, boiling with big fire, decocting with small fire for 4-5 hours, closing the small fire, and taking out soup, thereby obtaining the external preparation. The external preparation developed by the invention has the effects of clearing away heat and toxic materials, promoting diuresis, dispelling wind and arresting itching, and especially has an obvious treatment effect and no toxic or side effect after being assisted by medicated bath.

The invention discloses a traditional Chinese medicine preparation for treating herpes pain and itch as well as a preparation method and application of the traditional Chinese medicine preparation, and belongs to the technical field of traditional Chinese medicines. 30 to 45 parts of paniculate swallowwort root; 25-35 parts of lithospermum erythrorhizon; 25 to 35 parts of sedum sarmentosum; and 8-12 parts of borneol. The traditional Chinese medicine preparation for treating herpes pain and itching is reasonable in formula, simple in raw material components and low in cost, has the effects of clearing heat, promoting diuresis, detoxifying, cooling blood, relieving itching and pain, and has obvious anti-inflammatory, analgesic and itching-relieving effects; the traditional Chinese medicine is used for treating heat sores caused by excessive lung and stomach heat and liver and gallbladder damp-heat syndromes, can effectively treat pruritus and pain caused by herpes, and is quick in effect and remarkable in curative effect; the traditional Chinese medicine composition can be used for preventing and treating itching and pain caused by herpes zoster and pain and itching of postherpetic nerves, and has a good prevention and treatment effect; the traditional Chinese medicine composition is safe, free of toxic and side effects, free of drug resistance, simple in preparation method and wide in application prospect.

The invention belongs to the technical field of plant essential oil, and discloses gaultheria yunnanensis composite essential oil and a preparation method thereof. The essential oil comprises the following raw materials: 40-60 parts of gaultheria yunnanensis essential oil, 10-20 parts of peppermint oil and 20-30 parts of ginger oil. The gaultheria yunnanensis essential oil is used as a core raw material and matched with the peppermint oil and the ginger oil, the effects of the gaultheria yunnanensis essential oil, the peppermint oil and the ginger oil are complementary, the anti-inflammatory and analgesic effects of the gaultheria yunnanensis essential oil, the cooling and itching-relieving effects of the peppermint oil and the effects of the ginger oil for promoting blood circulation to remove blood stasis and warming channels and expelling cold are mutually matched, and the problem The compound essential oil can comprehensively relieve various discomforts such as muscle and joint pain, swelling, mosquito bite itching and chilblain, the relieving effect is better than that of existing single essential oil or conventional compound essential oil, the effective components of methyl salicylate, menthol and gingerol of the three essential oils jointly act on pain and inflammation targets, and the relieving effect is improved.

The invention discloses a yarn with itching relieving and antibacterial functions and a preparation method thereof. According to the yarn with the itching relieving and antibacterial functions, polyester fibers serve as base material fibers, alum with the antibacterial and itching relieving functions serves as an additive, itching relieving functionalized in-situ polyester chips added with itching relieving composition slurry are added, the raw materials are the same as the raw materials of the base material, and the interfacial compatibility of the yarn can be enhanced; the antibacterial and antipruritic effects can be achieved together with the alum; in order to ensure the antibacterial property of the yarn, a novel antibacterial microcapsule prepared from nano antibacterial filler is used as an antibacterial agent. The yarn prepared by the invention has obvious antibacterial and itching-relieving effects, and the technical scheme of the invention can solve the problem that in the prior art, direct sensory experience of pruritus or scratchiness is brought to a human body in the use process of chemical fiber base material fibers.

The invention provides gel based on collagen liposome. The gel comprises the following components in parts by mass: 2 parts of shikonin liposome; 2 parts of collagen peptide liposome; 1 part of elastin peptide liposome; and 1 part of carbomer. According to the gel based on the collagen liposome provided by the invention, the alkannin liposome compound gel has an obvious cleaning capability, namely, the alkannin liposome compound gel has a very strong anti-oxidation capability. The alkannin liposome compound gel has an obvious cleaning effect on H2O2 (hydrogen peroxide). The alkannin liposome compound gel has an excellent itching relieving effect. The alkannin liposome compound gel has the effect of resisting eczema. The alkannin liposome compound gel also has an inhibition effect on staphylococcus aureus and escherichia coli. The invention further provides a preparation method of the gel based on the collagen lipidosome and application of the gel based on the collagen lipidosome in the aspect of drugs for treating skin diseases.

The invention discloses an application of Vietnam ginseng saponin R18. According to the invention, a Ca < 2 + > biosensor is utilized to co-transfect Hela cells with MRGPRX4, the activation effect of Vietnam ginsenoside R18 on MRGPRX4 is detected, and the Vietnam ginsenoside R18 is confirmed to be an agonist of MRGRPX4. The Vietnam ginsenoside R18 acts on a mouse through subcutaneous injection to cause itching of the mouse, so that the Vietnam ginsenoside R18 can be used as a tool medicine for studying itching and is used for screening a G protein coupled receptor antagonist with an itching relieving effect or preparing an itching causing model; the traditional Chinese medicine quality is controlled, and the itching side effect of the traditional Chinese medicine is prevented.

The invention provides shampoo for controlling oil and relieving itching and a preparation method thereof, and relates to the technical field of shampoo. The shampoo is prepared from the following raw materials in parts by weight: 10 to 14 parts of camellia oil, 20 to 30 parts of plant extract, 7 to 10 parts of euglena parviflora root powder, 3 to 6 parts of vitamin E, 10 to 13 parts of butyrospermum parviflora butter, 6 to 8 parts of hydrolyzed silk protein, 7 to 9 parts of euglena parviflora polysaccharide, 4 to 7 parts of amino acid, 14 to 18 parts of surfactant, 2 to 4 parts of hydroxyethyl cellulose and 70 to 90 parts of water. The shampoo has good foaming and scalp dirt cleaning performance and can inhibit excessive secretion of sebaceous gland cells and reduce scalp grease generation, active ingredients can permeate into the inner layer of scalp to supplement moisture and nutrition, meanwhile, a protective layer can be formed on the surface layer of the scalp, the damaged scalp barrier of children is repaired, the scalp resistance is enhanced, and the hair is protected. Therefore, good oil control and itching relieving effects are achieved, and the effect is mild.

The utility model provides an antipruritic instrument, relates to medical instrument field, the antipruritic instrument includes: antipruritic probe, floating structure, host computer, cap, the floating structure is connected with the one end of antipruritic instrument host computer and the one end of antipruritic probe respectively, and the floating structure makes antipruritic probe can float at multi-angle when contacting human body skin bite position, and effectively fit skin, and the antipruritic instrument has the antipruritic effect. The oppression feeling of a traditional itching relieving instrument on the skin due to a fixed itching relieving probe is avoided, and effective itching relieving is achieved; meanwhile, due to the fact that the floating structure can adapt to the fluctuating state of the skin at different positions, the applicability of the itching relieving instrument is improved.

The present invention provides a plant extract, composition, preparation method, and application thereof, exhibiting triple antibacterial, antioxidant, and antipruritic effects. These extracts relate to the technical field of daily chemical products. The plant extract comprises a and b; a comprises Terminalia chebula fruit extract; b is a plum fruit extract, or at least one of a rose flower extract, a rose flower extract, or a tribulus terrestris fruit extract and a plum fruit extract; when b is a plum fruit extract, the weight ratio of a to b is 2-4:1; when b is at least one of a rose flower extract, a rose flower extract, or a tribulus terrestris fruit extract and a plum fruit extract, the weight ratio of a to b is 1:1. The plant extract exhibits excellent antibacterial, antioxidant, and antipruritic effects, achieving a strong synergistic effect, thereby achieving enhanced results when applied to skin care products. This invention addresses the technical problem of the prior art lacking a plant extract that simultaneously exhibits triple antibacterial, antioxidant, and antipruritic effects.

The invention discloses a pharmaceutical composition for treating eczema, application of the pharmaceutical composition and an external preparation based on the pharmaceutical composition, and belongs to the technical field of traditional Chinese medicines. Three medicinal materials including dandelion, polygonum aviculare and polygonum flaccidum are taken as raw materials, water and ethanol with different concentrations are taken as extraction solvents, the extracted extracts are taken as active ingredients of external preparations such as lotion, cream, gel and cream, the itching relieving effect can be quickly and effectively achieved through combination of the active ingredients, and the traditional Chinese medicine composition is suitable for treating eczema and has a wide application prospect. The symptoms of eczema scabbing, redness and swelling and pruritus are remarkably improved, and eczema is not prone to And the preparation is simple in process and suitable for industrial production.

The invention discloses a traditional Chinese medicine composition for relieving itching. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6-50g of radix scutellariae, 6-50g of fructus gardeniae, 6-50g of fructus forsythiae, 6-50g of flos lonicerae and 6-50g of radix geutianae. According to the invention, the radix scutellariae for inhibiting histamine release, the fructus forsythiae for antagonizing histamine receptors and the felwort for blocking itching signal transduction are subjected to multi-way action to cover the whole link of itching-inducing medium generation-receptor combination-signal transmission, so that rapid itching relieving is realized; the cape jasmine for promoting prothrombin activation, the baical skullcap root for enhancing platelet aggregation and the honeysuckle flower for contracting blood vessels act together, so that the blood coagulation time is shortened, and the effect fluctuation of a single hemostasis mechanism is avoided; the five medicines jointly inhibit the release of inflammatory factors, enhance the local antibacterial ability, relieve inflammatory pruritus, prevent wound infection, avoid vicious circle of itching-grasping-infection-aggravated itching, and reduce the infection risk after bleeding.

This invention discloses a traditional Chinese medicine composition for treating skin diseases and its preparation method, belonging to the field of traditional Chinese medicine technology. It is made from the following raw materials in parts by weight: 8-12 parts of Phellodendron bark, 8-12 parts of Cnidium monnieri fruit, 8-12 parts of Dictamnus dasycarpus root bark, 8-12 parts of Stemona japonica root bark, 8-12 parts of alum, 8-12 parts of Carthamus tinctorius flower, 8-12 parts of dragon's blood, 8-12 parts of Panax notoginseng root bark, 8-12 parts of myrrh, 8-12 parts of frankincense, and 1-3 parts of propolis. This invention also provides an external preparation containing this composition and its preparation method. The preparation method includes pulverizing the raw materials, adding 60%-80% ethanol, soaking at 50-80℃ for 2-7 days, pressing, filtering, and allowing to stand, then collecting the supernatant. Pharmacological experiments show that the composition of this invention has significant antibacterial, anti-inflammatory, and antipruritic effects; clinical observations show a total effective rate of 80%-95% for psoriasis, eczema, rashes, pruritus, herpes, urticaria, and insect bite itching. The formulation of this invention is scientific, the process is stable, and the efficacy is definite, making it suitable for clinical application.

The invention discloses an anti-dandruff and itching-relieving shampoo and a preparation method thereof, and the anti-dandruff and itching-relieving shampoo comprises the following components in parts by weight: 10-20 parts of an amino acid surfactant, 5-10 parts of an anti-dandruff agent, 3-8 parts of an itching-relieving agent, 5-10 parts of a humectant, 2-5 parts of a conditioner, 0.1-0.5 part of a preservative, 0.1-0.5 part of essence and the balance of deionized water. By reasonably selecting the amino acid surfactant, the anti-dandruff agent, the antipruritic agent, the humectant, the conditioner and other components and optimizing the proportion of all the components, the prepared shampoo is remarkable in anti-dandruff effect, lasting in antipruritic effect, mild and non-irritating.

The invention is applicable to the field of skin repair medicine research, and provides a formula for treating traumatic and burn scar itching and application, the formula comprises the following components in percentage by weight: 0.1-5% of lavender essential oil, 0.1-5% of rosemary essential oil, 0.02-1% of geranium essential oil, 10-20% of grape seed oil and 85-90% of refined coconut oil, and the formula is prepared by weighing, uniformly mixing, quantifying, filtering and sterilizing in a water bath. According to the formula, the itching relieving, inflammation diminishing and healing promoting effects of lavender, rosemary and geranium essential oil are utilized, the natural plant oil auxiliary materials are combined, and the problems that an existing treatment scheme is poor in curative effect and high in irritation are solved. Clinical experiments show that the itching relieving effect is remarkable and lasts for 12 hours, side effects are avoided, and a safe and effective natural treatment choice is provided for scar itching.

The invention relates to the technical field of daily necessities, and discloses an anti-dandruff shampoo soap and a preparation method thereof.The anti-dandruff shampoo soap is prepared from, by mass, 45%-50% of sodium lauryl sulfate; 3%-6% of guar gum hydroxypropyl trimethyl ammonium chloride; 4%-6% of cetostearyl alcohol; 11%-13% of shea butter; 0.8%-1% of coconut oil; 10%-12% of sodium cocoyl glutamate; 3%-5% of pyridone ethanolamine salt; 4%-5% of polyvinylpyrrolidone; 0.4%-1% of a lucid ganoderma extract; 0.3%-1% of a soapberry peel extract; 0.2%-1% of a ginseng root extract; 0.1%-1% of an angelica sinensis extract; 0.5%-1% of a cacumen biotae extract; 0.8%-1% of a polygonum multiflorum extract; and the balance of water. The anti-dandruff and itching-relieving shampoo has remarkable anti-dandruff and itching-relieving effects, a natural plant formula prepared from the adopted functional components is healthier for human bodies and has a health-care effect on hair, the formula is safer, toxic and side effects and irritation are smaller, and the conditions of skin microecosystem imbalance such as skin allergy and inflammation are not likely to be caused.

The invention relates to the field of spinning, and discloses a preparation method of Chinese herbal medicine yarn with antibacterial and antipruritic effects, which comprises the following steps: preparing Chinese herbal medicine microcapsules; preparing Chinese herbal medicine water-soluble fibers; antibacterial and itching-relieving functional yarns are manufactured; composite yarns are manufactured; and performing functional finishing on the yarns. The nylon, the chitin fiber and the semi-water-soluble Chinese herbal medicine fiber serve as a yarn center inner wrapping layer, the chitin and the lyocell fiber are wound outside the yarn center inner wrapping layer to form the yarn, and in each washing process of a product, the yarn is formed along with dissolution of part of the water-soluble fiber. When the antibacterial antipruritic fabric is worn, part of the Chinese herbal medicine microcapsules in the antibacterial antipruritic fabric is released and transferred into the swollen chitin and lyocell fibers, the microcapsules are broken along with friction in the wearing process, the Chinese herbal medicine components are released, and finally the continuous antibacterial antipruritic effect is achieved.

This invention discloses a compound traditional Chinese medicine detoxifying ointment and its preparation method. The compound traditional Chinese medicine detoxifying ointment comprises a traditional Chinese medicine extract, triclosan, a gel matrix, a cooling and antipruritic agent, a moisturizer, a surfactant, a pH adjuster, and purified water. The traditional Chinese medicine extract is prepared by a group extraction process using five medicinal slices—honeysuckle, scutellaria, coptis, rhubarb, and corydalis—in a specific ratio: honeysuckle, scutellaria, and corydalis form the first group, while coptis and rhubarb form the second group. These are extracted separately by ethanol reflux extraction and microfiltration purification, then a colloidal dispersion system is formed using a pH segmented control method, followed by concentrating the extracts. This invention, through the synergistic combination of the traditional Chinese medicine extract, low-concentration triclosan, and the cooling and antipruritic agent, enables the product to possess multiple effects, including highly effective broad-spectrum antibacterial properties, cooling and antipruritic effects, and blood-activating and analgesic effects. Furthermore, it is non-irritating to the skin, exhibits good stability, and is suitable for industrial production.

The present disclosure relates generally to cosmetic compositions comprising a Crocus sativus flower extract, and their use for skin treatment, particularly as anti-dandruff. The compositions provide very significant anti-dandruff, anti-fungal, anti-erythema, skin soothing, and antipruritic effects, and also improve skin barrier integrity.

The invention provides an extract with an antipruritic effect, a preparation method of the extract and application of the extract in preparation of skin care products. Comprising the following components in parts by mass: 12-16 parts of a chrysanthellum indicum extract, 10-14 parts of a pseudo-ginseng extract, 1-4 parts of a purslane extract, 3-8 parts of a tea leaf extract, 5-11 parts of a mint leaf extract, 1-5 parts of a bitter gourd extract, 4-10 parts of a gynura succulent extract, 1-3 parts of an actinidia chinensis extract, 3-7 parts of a panax japonicus extract and 4-9 parts of a soapberry extract. According to the extract prepared by the invention, a plurality of components are compounded and have a synergistic effect, so that the extract has an excellent itching relieving effect.

The invention relates to the field of biological medicine technology and daily chemical products, and particularly discloses a composition containing glycoprotein and sparassis crispa extract and application of the composition in preparation of scalp or hair care products. The composition containing the glycoprotein and the sparassis crispa extract comprises the glycoprotein and the sparassis crispa extract, wherein the weight ratio of the glycoprotein to the sparassis crispa extract is (1-10): (1-10). Researches show that the composition has the effect of relieving itching; besides, glycoprotein has excellent moisturizing performance, can effectively lock scalp moisture, has a certain anti-inflammatory effect and is beneficial to relieving scalp inflammation; the sparassis crispa extract is rich in antioxidants and can effectively neutralize free radicals and reduce damage of oxidation pressure to scalp cells. Therefore, the composition disclosed by the invention can comprehensively and systematically improve the scalp environment, promote the scalp health and provide a better growth environment for the hair by combining the two components for use.

The invention designs a novel double-target peptide agonist targeting peripheral Kappa and Mu opioid receptors or pharmaceutically acceptable salts of the double-target peptide agonist, namely, chimeric peptides MKOP001 and MKOP002 are newly constructed on the basis of a DN-9 and dynorphin efficient analogue [des-Arg7] Dyn A (1-11)-NH2 sequence. An in-vitro calcium mobilization experiment and an acute analgesic experiment show that the brand new peptide agonists MKOP001 and MKOP002 can simultaneously activate Kappa and Mu opioid receptors and generate efficient analgesic activity. In addition, further research shows that both the MKOP001 and the MKOP002 can generate a remarkable itching relieving effect. Therefore, the peripheral restrictive Kappa and Mu opioid receptor double-target peptide molecules MKOP001 and MKOP002 or pharmaceutically acceptable salts thereof have very high application value in the aspect of preparing high-efficiency and low-side-effect analgesic or antipruritic drugs.

This invention discloses an antipruritic gel containing 3-hydroxydecanoic acid microemulsion and its preparation method. The gel combines the natural antipruritic ingredient 3-hydroxydecanoic acid and peppermint oil. By preparing it into a microemulsion form, nano-sized droplets are combined with skin absorption enhancers and gel sustained-release agents, thereby improving transdermal absorption efficiency and prolonging the residence time in the skin to achieve a long-lasting antipruritic effect. 3-hydroxydecanoic acid exerts its antipruritic effect through anti-inflammatory action, blocking pruritus signaling pathways, and reducing mast cell degranulation. This antipruritic gel is stable at room temperature, easy to use, and suitable for relieving skin itching caused by mosquito bites, histamine, or non-histamine substances.