Formula for treating traumatic and burn scar itching and application

Abstract

The invention is applicable to the field of skin repair medicine research, and provides a formula for treating traumatic and burn scar itching and application, the formula comprises the following components in percentage by weight: 0.1-5% of lavender essential oil, 0.1-5% of rosemary essential oil, 0.02-1% of geranium essential oil, 10-20% of grape seed oil and 85-90% of refined coconut oil, and the formula is prepared by weighing, uniformly mixing, quantifying, filtering and sterilizing in a water bath. According to the formula, the itching relieving, inflammation diminishing and healing promoting effects of lavender, rosemary and geranium essential oil are utilized, the natural plant oil auxiliary materials are combined, and the problems that an existing treatment scheme is poor in curative effect and high in irritation are solved. Clinical experiments show that the itching relieving effect is remarkable and lasts for 12 hours, side effects are avoided, and a safe and effective natural treatment choice is provided for scar itching.

Description

Technical Field

[0001] The present invention belongs to the field of research on skin repair drugs, and particularly relates to a formula and application for treating pruritus of traumatic and post-burn scars. Background Art

[0002] Keloids formed during the skin wound healing process are often accompanied by pruritus symptoms, which seriously affect the quality of life of patients. Clinically, the treatment of keloids mostly focuses on improving appearance, while there are fewer solutions for relieving pruritus symptoms. Currently, oral antihistamines or glucocorticoids have poor effects on treating scar pruritus, and consumers have an increasing interest in natural health care alternatives. Essential oils are increasingly widely used in the field of skin care, but essential oil formulas containing irritating ingredients such as ethanol cannot be used on sensitive scar skin, and existing research does not cover the targeted application of scar pruritus.

[0003] In the prior art, the treatment attention is usually focused on improving the appearance of scars, while the pruritus symptoms related to keloids are easily ignored. Although there are a large number of methods for treating keloids clinically, there are still problems such as poor efficacy and high recurrence rate. The treatment plan for scar pruritus lacks pertinence, the clinical drug efficacy is not ideal, the traditional essential oil formula cannot be applied to scar skin due to containing irritating ingredients, and there is a blank in the application of natural essential oils in the field of scar pruritus. Summary of the Invention

[0004] The purpose of the present invention is to provide a formula for treating pruritus of traumatic and post-burn scars, aiming to solve the technical problems existing in the prior art determined in the background art.

[0005] The present invention is realized as follows. A formula for treating pruritus of traumatic and post-burn scars, calculated by weight percentage, the formula includes: 0.1 - 5% lavender essential oil, 0.1 - 5% rosemary essential oil, 0.02 - 1% geranium essential oil, 10 - 20% grape seed oil, 85 - 90% refined coconut oil.

[0006] As a further scheme of the present invention, the preparation method of the formula for treating pruritus of traumatic and post-burn scars is: At room temperature, weigh 50% refined coconut oil, 10% - 20% grape seed oil, and 0.1% - 5% lavender essential oil, 0.1% - 5% rosemary essential oil, 0.02% - 1% geranium essential oil by weight; Add the weighed ingredients into a clean container in sequence, vibrate and mix evenly to obtain a mixed oil; Add refined coconut oil to the mixed oil to 100%, vibrate and mix evenly to obtain a secondary mixed oil; Filter the secondary mixed oil through a filter with a filter membrane pore size of 0.5 microns; Place the filtered secondary mixed oil in a sealed container, heat it in a water bath at 95°C, keep it warm for 3 minutes for sterilization, and obtain the final product after cooling.

[0007] As a further aspect of the present invention, cold-pressed coconut oil, sweet almond oil, and jojoba oil are used to replace the refined coconut oil and grape seed oil.

[0008] As a further aspect of the present invention, without changing the proportion of essential oils, natural beeswax is added to grape seed oil and refined coconut oil to prepare a paste.

[0009] As a further aspect of the present invention, the preparation method of the lavender essential oil is as follows: Weigh dried lavender flowers and place them in a distillation container. Sterile steam at 120°C is introduced from the bottom. A condenser is connected to the top of the distillation container. The water temperature of the condenser is 2 - 4°C. The steam enters the condenser after passing through the dried lavender flowers to obtain a condensate (a mixture of essential oil and hydrosol). Stop distillation after 50 minutes. After collecting the condensate, let it stand for 2 hours. The upper layer is the essential oil and the lower layer is the hydrosol. Separate the condensate to obtain lavender essential oil.

[0010] As a further aspect of the present invention, the raw material for preparing the rosemary essential oil is Rosmarinus officinalis L. 'Verbenone', and the preparation method is the same as that of the lavender essential oil.

[0011] As a further aspect of the present invention, the raw materials for preparing the geranium essential oil are the stems, leaves, and flowers of fresh Pelargonium graveolens L'Hér., and the preparation method is the same as that of the lavender essential oil.

[0012] The beneficial effects of the present invention are as follows: The formula provided by the present invention for treating pruritus of traumatic and post-burn scars is composed of a combination of lavender essential oil, rosemary essential oil, and geranium essential oil. Among them, lavender essential oil has the effects of relieving itching, pain, and inflammation; geranium essential oil has the effects of promoting skin regeneration and wound healing; rosemary essential oil has the effects of antibacterial inflammation and relieving skin itching. After the three are combined, they have a significant therapeutic effect on the pruritus of traumatic and post-burn scars, with an action time of up to 12 hours and no side effects. And it is sterilized by high-temperature water bath, so there is no risk of infecting the wound during use.

[0013] The essential oils used in this formula are prepared by the traditional distillation method, and the excipients are natural vegetable oils, without ingredients such as ethanol, fragrance, preservatives, and emulsifiers, and are non-toxic and have no side effects, with safety, and are especially suitable for use on the skin during the rehabilitation period of trauma or burns. Specific embodiments

[0014] In order to make the objectives, technical solutions and advantages of the present invention more clear and understandable, the present invention will be further described in detail below in conjunction with embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0015] A formula for treating pruritus of traumatic and post-burn scars, in terms of weight percentage, the formula includes: 0.1-5% lavender essential oil, 0.1-5% rosemary essential oil, 0.02-1% geranium essential oil, 10-20% grape seed oil, 85-90% refined coconut oil.

[0016] The preparation method of the formula for treating pruritus of traumatic and post-burn scars is as follows: Weighing: At room temperature, weigh 50% refined coconut oil, 10%-20% grape seed oil, and 0.1%-5% lavender essential oil, 0.1%-5% rosemary essential oil, 0.02%-1% geranium essential oil by weight; Mixing: Add the weighed ingredients to a clean container in sequence, and shake and mix to obtain a mixed oil; Quantification: Add refined coconut oil to the mixed oil to 100%, shake and mix to obtain a secondary mixed oil; Filtration: Filter the secondary mixed oil through a filter with a filter membrane pore size of 0.5 microns; Sterilization: Place the filtered secondary mixed oil in a sealed container, water bath at 95°C, keep warm for 3 minutes for sterilization, and cool to obtain the final product.

[0017] Example 1: Product preparation.

[0018] Essential oil preparation. Weigh 1000 g of dried lavender flowers and place them in a distillation container; introduce 120°C sterile steam at the bottom, connect a condenser to the top of the distillation container, the water temperature of the condenser is 2-4°C, the steam enters the condenser after passing through the dried lavender flowers, and obtain a condensate (a mixture of essential oil and hydrosol); stop distillation after 50 minutes, let the condensate stand for 2 hours after collection, the upper layer is the essential oil and the lower layer is the hydrosol, and separate the essential oil and the hydrosol to obtain lavender essential oil. Prepare rosemary essential oil in the same way, using verbenone rosemary. Prepare geranium essential oil in the same way, using the stems, leaves and flowers of fresh rose geranium.

[0019] Weighing: Under room temperature conditions, weigh 50 g of refined coconut oil and 15 g of grape seed oil; accurately weigh 1 g of lavender essential oil, 1 g of rosemary essential oil, and 0.1 g of geranium essential oil.

[0020] Mixing: Add the ingredients weighed in the above steps to the same clean container in sequence, and shake and mix.

[0021] Quantification: Add refined coconut oil to the mixed oil in the above step until it reaches 100 g, and shake well to mix evenly.

[0022] Filtration: Filter the above mixed oil through a filter with a membrane pore size of 0.5 microns.

[0023] Sterilization: Place the filtered mixed oil obtained above in a sealed container, heat it in a water bath at 95 °C for 3 minutes, and after cooling, the product A of the present invention is obtained.

[0024] Example 2: Preparation of the product.

[0025] The preparation of the essential oil is the same as that in Example 1.

[0026] Weighing: At room temperature, weigh 50 g of refined coconut oil and 10 g of grape seed oil by weight; accurately weigh 0.1 g of lavender essential oil, 0.1 g of rosemary essential oil, and 0.02 g of geranium essential oil.

[0027] Mixing: Add the components weighed in the above steps to the same clean container in sequence, and shake well to mix evenly.

[0028] Quantification: Add refined coconut oil to the mixed oil in the above step until it reaches 100 g, and shake well to mix evenly.

[0029] Filtration: Filter the above mixed oil through a filter with a membrane pore size of 0.5 microns.

[0030] Sterilization: Place the filtered mixed oil obtained above in a sealed container, heat it in a water bath at 95 °C for 3 minutes, and after cooling, the product B of the present invention is obtained.

[0031] Example 3: Preparation of the product.

[0032] The preparation of the essential oil is the same as that in Example 1.

[0033] Weighing: At room temperature, weigh 50 g of refined coconut oil and 20 g of grape seed oil by weight; accurately weigh 5 g of lavender essential oil, 5 g of rosemary essential oil, and 1 g of geranium essential oil.

[0034] Mixing: Add the components weighed in the above steps to the same clean container in sequence, and shake well to mix evenly.

[0035] Quantification: Add refined coconut oil to the mixed oil in the above step until it reaches 100 g, and shake well to mix evenly.

[0036] Filtration: Filter the above mixed oil through a filter with a membrane pore size of 0.5 microns.

[0037] Sterilization: Place the filtered mixed oil obtained above in a sealed container, heat it in a water bath at 95 °C for 3 minutes, and after cooling, the product C of the present invention is obtained.

[0038] Example 4: Clinical Application (Trauma Surgery) Implementation method: Eighty patients (aged 15 to 60 years old) who received hand trauma treatment in the surgery department and had scar itching within 3 months after surgery were randomly divided into four groups, a control group (n = 20) and experimental groups (divided into groups A, B, and C, with 20 people in each group). The control group was treated with the traditional treatment method, and the experimental groups were treated with the scar antipruritic oil of the present invention (products A, B, and C obtained in the examples). After 1 hour and 12 hours of treatment, the effective rates of treating itching in the two groups were compared. The drug was administered once every 12 hours; the treatment continued for 3 days, and the itching scores before and after treatment were evaluated 12 hours after the last drug administration.

[0039] Observation indicators: ① Compare the itching scores of the two groups of patients before treatment and at 1 hour and 12 hours after treatment; ② Compare the itching scores after 3 days of continuous treatment. Itching was evaluated using the visual analogue scale, where the value 0 indicates "no itching" and 10 indicates "the most severe itching imaginable". Data statistics: Measurement data were (x±s), paired sample t-tests were used within the group, and independent sample t-tests were used between groups; p < 0.05 indicated a statistically significant difference.

[0040] Results: The itching scores of each group of patients before treatment, at 1 hour, 12 hours, and 3 days after treatment (n = 20, x±s) are shown in Tables 1 to 3.

[0041] Table 1 Itching scores of each group of patients before treatment and 1 hour after treatment (n = 20, x±s)

[0042] Table 2 Itching scores of each group of patients before treatment and 12 hours after treatment (n = 20, x±s)

[0043] Table 3 Itching scores of each group of patients before treatment and 3 days after treatment (n = 20, x±s)

[0044] It can be seen from the data that: ① Before treatment, there was no difference in the itching scores among the groups of patients. After 1 hour of treatment, compared with before treatment, the itching scores were significantly reduced, p < 0.01. By comparing the control group and the experimental groups, it was found that the antipruritic effect of the experimental groups was better than that of the control group, p < 0.01. ② After 12 hours of treatment, the control group had no antipruritic effect compared with before treatment, but the experimental groups still had a significant antipruritic effect compared with before treatment, p < 0.01, and there was still a significant antipruritic effect compared with the control group, p < 0.01. ③ After 3 days of continuous treatment, there was no difference in the antipruritic effect of the control group compared with before treatment, p > 0.05; but after 3 days of treatment in the experimental groups, compared with before treatment, the antipruritic effect was extremely significant, p < 0.01, and the antipruritic effect was also significantly better than that of the control group.

[0045] Example 5: Clinical Application (Burns) Implementation method: 60 patients (aged 18 - 64 years old) in the rehabilitation period of burn plastic surgery were selected, and itching symptoms occurred within 3 months after treatment. These patients were randomly divided into four groups, a control group (n = 15) and experimental groups (divided into groups A, B, and C, with 15 people in each group). The control group adopted the traditional treatment method, and the experimental groups adopted the scar itching-relieving oil of the present invention for treatment (products A, B, and C obtained from the examples). After 1 hour and 8 hours of treatment, the effects of treating itching in the two groups were compared.

[0046] Observation indicators: The itching scores of the two groups of patients before treatment and 1 hour and 8 hours after treatment were compared. Itching was evaluated by the visual analogue scale, where the value 0 indicates "no itching" and 10 indicates "the most severe itching imaginable". Data statistics: Measurement data were (x ± s), paired sample t-tests were used within groups, and independent sample t-tests were used between groups; p < 0.05 indicated a statistically significant difference.

[0047] Results: The itching scores of each group of patients before treatment and 1 hour and 8 hours after treatment (n = 15, x ± s) are shown in Table 4 - Table 5.

[0048] Table 4 Itching scores of each group of patients before treatment and 1 hour after treatment (n = 15, x ± s)

[0049] Table 5 Itching scores of each group of patients before treatment and 12 hours after treatment (n = 15, x ± s)

[0050] It can be seen from the data that: ① Before treatment, there was no difference in the itching scores among the groups. After 1 hour of treatment, compared with before treatment, the itching scores were significantly reduced, p < 0.01. By comparing the control group and the experimental groups, it was found that the itching-relieving effect of the experimental groups was better than that of the control group, p < 0.01. ② After 12 hours of treatment, compared with before treatment, the control group had no itching-relieving effect, but the experimental groups still had a significant itching-relieving effect, p < 0.01, and compared with the control group, the experimental groups still had a significant itching-relieving effect, p < 0.01.

[0051] The technical features of the above-described embodiments can be combined arbitrarily. For the sake of concise description, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, it should be considered as within the scope described in this specification.

[0052] The above-described embodiments merely represent several implementation manners of the present invention. The description thereof is relatively specific and detailed, but it should not be construed as a limitation to the scope of the patent of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can still be made, and these all fall within the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the appended claims.

[0053] The above is only the preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent replacements, and improvements made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A formula for treating pruritus of scars after trauma and burns, characterized in that, In terms of weight percentage, the formula includes: 0.1 - 5% lavender essential oil, 0.1 - 5% rosemary essential oil, 0.02 - 1% geranium essential oil, 10 - 20% grape seed oil, and 85 - 90% refined coconut oil.

2. The formulation according to claim 1, wherein The preparation method of the formula for treating pruritus of traumatic and post - burn scars is as follows: At room temperature, weigh 50% refined coconut oil, 10% - 20% grape seed oil, 0.1% - 5% lavender essential oil, 0.1% - 5% rosemary essential oil, and 0.02% - 1% geranium essential oil by weight parts; Add the weighed components into a clean container in sequence and shake well to obtain a mixed oil; Add refined coconut oil to the mixed oil until it reaches 100%, and shake well to obtain a secondary mixed oil; Filter the secondary mixed oil through a filter with a membrane pore size of 0.5 microns; Place the filtered secondary mixed oil in a sealed container, heat it in a water bath at 95°C, keep it warm for 3 minutes for sterilization, and obtain the final product after cooling.

3. The formulation according to claim 1, characterized in that Use cold - pressed coconut oil, sweet almond oil, and jojoba oil to replace the refined coconut oil and grape seed oil.

4. The formulation according to claim 1, wherein Without changing the proportion of essential oils, add natural beeswax to grape seed oil and refined coconut oil to prepare an ointment.

5. The formulation according to claim 2, wherein The preparation method of the lavender essential oil is as follows: Weigh dried lavender flowers and place them in a distillation container. Pass 120°C sterile steam at the bottom. Connect a condenser to the top of the distillation container. The water temperature of the condenser is 2 - 4°C. The steam enters the condenser after passing through the dried lavender flowers to obtain a condensate. Stop distillation after 50 minutes of distillation. After collecting the condensate, let it stand for 2 hours. The upper layer is the essential oil and the lower layer is the hydrosol. Separate the condensate to obtain lavender essential oil.

6. The formulation according to claim 2, characterized in that, The raw material for preparing the rosemary essential oil is verbenone rosemary, and the preparation method is as follows: Weigh rosemary and place it in a distillation container. Pass 120°C sterile steam at the bottom. Connect a condenser to the top of the distillation container. The water temperature of the condenser is 2 - 4°C. The steam enters the condenser after passing through the rosemary to obtain a condensate. Stop distillation after 50 minutes of distillation. After collecting the condensate, let it stand for 2 hours. The upper layer is the essential oil and the lower layer is the hydrosol. Separate the condensate to obtain rosemary essential oil.

7. The formulation according to claim 2, wherein The raw material for preparing the geranium essential oil is the stems, leaves, and flowers of fresh rose geranium, and the preparation method is as follows: Weigh the stems, leaves, and flowers of fresh geranium and place them in a distillation container. Pass 120°C sterile steam at the bottom. Connect a condenser to the top of the distillation container. The water temperature of the condenser is 2 - 4°C. The steam enters the condenser after passing through the geranium to obtain a condensate. Stop distillation after 50 minutes of distillation. After collecting the condensate, let it stand for 2 hours. The upper layer is the essential oil and the lower layer is the hydrosol. Separate the condensate to obtain geranium essential oil.

8. Use of the formula according to claim 1 in the preparation of an external medicine for treating pruritus of traumatic and post - burn scars.

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