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51 results about "Marbofloxacin" patented technology

Marbofloxacin is a carboxylic acid derivative third generation fluoroquinolone antibiotic. It is used in veterinary medicine under the trade names Marbocyl,Forcyl and Zeniquin. A formulation of marbofloxacin combined with clotrimazole and dexamethasone is available under the name Aurizon (CAS number 115550-35-1).

Novel method for preparing marbofloxacin

The invention mainly discloses a novel method for preparing marbofloxacin, which comprises the following steps: under the protection of inert gases, 2,3,4,5-phenyl tetrafluoride formoxyl alkyl ester forms negative ions with alkali in an inert organic solvent, is condensed with imidic salt to obtain N-dimethyl substitutive enamine derivative, and reacts with N - methyl hydrazide in organic acid to obtain N-methyl-N-acyl substitutive enamine derivative; under the reflux state, the N-methyl-N-acyl substitutive enamine derivative is catalyzed by alkali to obtain quinoline carboxylic ether; the quinoline carboxylic ether takes water as a solvent, is catalyzed with alkali at proper temperature and is neutralized to obtain quinoline carboxylic acid; under the action of an acid-binding agent, the quinoline carboxylic acid is condensed with N-methyl piperazine to obtain a condensed piperazine substance; the condensed piperazine substance is heated to proper temperature in an alkalis hydroxid water solution, is kept at the temperature and is neutralized to obtain hydrolysate; and the hydrolysate takes water as a solvent and is reacted with dialkoxy methane or methylene halide to obtain the marbofloxacin under the catalysis of the catalyzer. The invention has high yield, thereby facilitating industrialized production at large scale.
Owner:ZHEJIANG GUOBANG PHARMA

Marbofloxacin-calcium chelate and synthetic method and application thereof

The invention discloses a marbofloxacin-calcium chelate and a synthetic method and application thereof. The synthetic method of the marbofloxacin-calcium chelate comprises the following steps: 1, weighing marbofloxacin and calcium nitrate according to a stoichiometric ratio, then weighing triethylamine with the equal substance amount with the marbofloxacin, and dissolving in a polar solvent; 2, performing a reaction on the obtained solution under the condition of 20 to 70 DEG C; 3, when a product exists in the reaction solution mainly in a precipitate mode, filtering the obtained reaction solution and washing and drying precipitates to obtain the target product, and when the product is mainly dissolved in the reaction solution, concentrating the obtained reaction solution to remove most of solvent, adding excessive ethanol, separating out the precipitates and washing and drying the precipitates to obtain the target product. By inspecting the in-vitro antibacteral activity and the in-vivo acute toxicity of the chelate by the applicant, a result shows that the in-vitro bacteriostasis effect of the marbofloxacin-calcium chelate is equivalent to that of the marbofloxacin, but the in-vivo acute toxicity of the marbofloxacin-calcium chelate is obviously lower than that of the marbofloxacin. The structural formula of the marbofloxacin-calcium chelate is as shown in the following formula (referring to the specification).
Owner:GUANGXI NORMAL UNIV

New application of quinolone compounds in prevention and treatment of plant bacterial diseases such as citrus canker

The invention discloses a new application of quinolone compounds as bactericides in prevention and treatment of bacterial diseases and citrus canker of crops. The quinolone compounds comprise floroxacin, enofloxacin, gatifloxacin, moxifloxacin hydrochloride, enrofloxacin, marbofloxacin, floxacin, mononorfloxacin mesylate, prulifloxacin, Balofloxacin, pazufloxacin mesylate, pipemidic acid, sparfloxacin, difloxacin hydrochloride, lomefloxacin hydrochloride, pefloxacin, tosufloxacin mesylate, Cinoxacin, galafloxacin, besifloxacin hydrochloride, ofloxacin, nalidixic acid, Clinafloxacin and Sitafloxacin. The quinolone compounds can be used for preventing and treating bacterial diseases caused by citrus canker pathogens, especially gatifloxacin, moxifloxacin hydrochloride, mononorfloxacin mesylate, sparfloxacin, tosufloxacin mesylate, clinafloxacin and sitafloxacin, has excellent bacteriostatic activity on citrus canker pathogens, and can be used for preventing and treating bacterial diseases of crops.
Owner:LANZHOU UNIVERSITY

Otic formulations, methods and devices

The present invention relates to a formulation and method for treating an ear infection, especially otomycosis and otitis externa, by administering a one-time only treatment comprising an antibiotic, antifungal, and an anti-inflammatory in a thick, otic carrier. In one embodiment, the formulation comprises a therapeutically effective amount of active ingredients including a marbofloxacin, terbinafine and / or clotrimazole and dexamethasone.
Owner:DECHRA VETERINARY PROD
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