406 results about "Enamine" patented technology

Fast-curing modified siloxane compositions comprise; (1) an alkoxy- or silanol-functional silicone intermediate, (2) at least one amine reactive ingredient selected from the group consisting of acetoacetate-functional ingredients, acrylate-functional ingredients, and mixtures thereof, (3) an epoxy-functional ingredient, (4) a curing agent selected from the group consisting of amines, aminosilanes, ketimines, aldimines and mixtures thereof, and (5) water. Other ingredients useful in forming fast-curing modified siloxane compositions of this invention include silanes, organometallic catalysts, solvents, pigments, fillers and modifying agents. The above-identified ingredients are combined and reacted to form a fully cured protective film comprising a cross-linked enamine polysiloxane and/or acrylate polysiloxane chemical structure in a reduced amount of time when compared to conventional epoxy siloxane compositions.

The present invention relates to nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions comprising such compounds, methods of using such compounds and compositions, and to a method for the preparation of nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates via the direct reaction of nitric oxide with amidines and enamines, and to a method of converting amines into such compounds.

The invention discloses a microwave auxiliary preparation method of a keto-enamine covalently linked organic framework. The method comprises the following steps: charging 1 , 3 , 5-triformylphloroglucinol and p-phenylenediamine into solvent, and ultrasonically dispersing to form suspension; the solvent is mixed solvent of sym-trimethylbenzene, dioxane and acetum; freezing, by liquid nitrogen, vacuumizing and degassing the suspension for at least three times, then sealing, carrying out the thermal reaction for 1 hour under the assistance of microwaves at the temperature of 100 DEG C, and obtaining a crude product; and centrifuging the crude product, collecting insoluble matters, washing the insoluble matters sequentially by sym-trimethylbenzene and acetone to obtain the keto-enamine covalently linked organic framework, and obtaining the keto-enamine covalently linked organic framework. The method is pollution-free, the reaction condition is moderate and simple, the requirement on equipment is simple, and the method is suitable for the industrialized mass production.

A novel process is provided for producing pramipexole base or its optical isomeric mixture as defined hereinabove i.e. (R,S)-2-amino-6-propyl-4,5,6,7-tetrahydrobenzothiazole avoiding the use of borane tetrahydrofuran complex and using a more convenient reducing agent like sodium triacetoxyborohydride instead. The provided process comprises reacting the starting material (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole or its optical isomeric mixture as defined hereinabove i.e. (R,S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole with propionaldehyde in an organic solvent to obtain the respective enamine, which is subsequently reduced in situ, optionally without isolation, to obtain pramipexole or its optical isomeric mixture as defined hereinabove i.e. (R,S)-2-amino-6-propyl-4,5,6,7-tetrahydrobenzothiazole, and the acid addition salts thereof. The present invention also provides a process for purifying pramipexole dihydrochloride or the dihydrochloride salt of its optical isomeric mixture as defined hereinabove i.e. (R,S)-2-amino-6-propyl-4,5,6,7-tetrahydrobenzothiazole dihydrochloride by re-crystallization from a suitable solvent.

The invention belongs to the technical field of organic synthesis, in particular to a method for synthesizing L-menthol. The method for synthesizing L-menthol takes myrcene as an initial raw material and comprises the following steps: amination reaction: diethylamine and myrcene carry out amination reaction to obtain geranylamine; isomerization reaction: the geranylamine carries out isomerization reaction under the catalytic action of chiral catalyst to obtain intermediate enamine; hydrolysis reaction: the enamine carries out hydrolysis reaction in an acidic medium to produce intermediate D-citronellal; cyclization reaction: the D-citronellal generates L-isopulegol by lewis acid catalyst and organic solvent; and hydrogenation reaction: the L-isopulegol is hydrogenated to obtain L-menthol. The method for synthesizing L-menthol has the yield of more than 90 percent, the GC purity of higher than 99.0 percent and the specific rotation of -49 degrees to -50 degrees, the raw material myrcene has wide sources and lower cost, and the whole method has simple technology, good repeatability and high yield and is quite suitable for large-scale industrialized production.

The invention relates to a high-temperature-resistant silicon dioxide grafted tertiary amine nano blocking agent and a water-based drilling fluid, which belong to the technical field of oil and gas field drilling. The high-temperature-resistant silicon dioxide grafted tertiary amine nano blocking agent is synthesized from a hydroxyl-containing hydrazine compound, a diallyl compound, an enamine compound and an amino-containing silane coupling agent as raw materials through modification of silicon dioxide in a step-by-step synthesis method. The particle size of the plugging agent prepared from the high-temperature-resistant silicon dioxide grafted tertiary amine is 58-280 nm, the plugging performance of the plugging agent is remarkably improved compared with that of similar plugging agents, besides the plugging performance of the plugging agent, a plurality of external tertiary amine branched chains of the plugging agent further have very high adsorption performance and inhibition performance, and the plugging agent is resistant to high temperature and can be applied to deep wells and ultra-deep wells. The plugging agent also has the advantages of easily available raw materials, low price and the like, and the provided synthesis method is stable, reliable, simple, rapid and suitable for industrial production.

The invention discloses a method for preparing an enamine ketone compound, wherein the enamine ketone compound with two substituents on a nitrogen atom is prepared through an enolate intermediate. A formylation reaction is carried out by using a ketone compound with alpha-methyl or alpha-methylene as a substrate to obtain enolate; and a dehydration-condensation reaction of the enolate and dimethylamine hydrochloride is further carried out to obtain the enamine ketone compound. A reaction formula is as shown in the figure. The raw materials adopted by the method are all ordinary and easily obtained materials, and the method has simple preparation process and mild reaction condition, does not need large expensive equipment and is adaptable to industrialized large-scale production; moreover, the reaction selectivity is high, and the prepared enamine ketone has high yield, is easy to separate and purify and has broad application prospect.

A process is described for preparing 3-phenyl(thio)uracils or 3-phenyldithiouracils of the formula I, by reacting a phenyl iso(thio)cyanate of the formula II with an enamine of the formula III and, if appropriate, in a further step, the resulting 3-phenyl(thio)uracil or 3-phenyldithiouracil of the formula I where R¹=R^1a, when R¹=hydrogen, is reacted with an aminating agent of the formula IV to give 3-phenyl(thio)uracils or 3-phenyldithiouracils of the formula I where R¹=amino

where the variables R¹, R^1a, R², R³, R⁴, X¹, X², X³, Ar, A and L1 are each as defined in claim 1.

An electrophotographic photoreceptor of high durability capable of providing stable excellent electrical characteristics over a prolonged period of time, which electrophotographic photoreceptor excels in mechanical strength. Photosensitive layer (14) of electrophotographic photoreceptor (1) comprises a polyarylate resin having structural units, for example, those of aforementioned formula (1-3) and an enamine compound represented by, for example, aforementioned formula (2-1). By virtue of these, electrophotographic photoreceptor (1) of excellent mechanical strength and favorable electrical characteristics can be realized.

The invention discloses a high-temperature-resistant modified nano silicon dioxide blocking agent and an oil-based drilling fluid, and belongs to the technical field of oil and gas field drilling. The high-temperature-resistant modified nano silicon dioxide blocking agent is synthesized by modifying silicon dioxide with an enamine compound, a diallyl compound, an olefinic bond-containing long-chain alkyl ester compound, an amino-containing silane coupling agent and a cross-linking agent divinyl benzene through a step-by-step synthesis method. The particle size of the blocking agent prepared from the high-temperature-resistant modified nano silicon dioxide is 78-300 nm, the blocking performance is remarkably improved compared with that of similar blocking agents, and the blocking agent is resistant to high temperature and can be applied to deep wells and ultra-deep wells. The blocking agent also has the advantages of easily available raw materials, low price and the like, and the provided synthesis method is stable, reliable, simple, rapid and suitable for industrial production.

The synthesis process of eplerenone includes the following steps: double serial Michael addition/Aldo condensation reaction of 11alpha-hydroxyl curry ketone and acetone cyanohydrin to produce enamine, partially hydrolyzing the enamine to produce intermediate compound, opening ring of the intermediate compound to obtain the compound IX; eliminating reaction produced olefine ester from the compound IX, reaction with phosphorous oxychloride at room temperature for 12-24 hr, extracting with methane dichloride solvent, merging organic phase, washing and drying to obtain compound X; performing 9alpha, 11-double bond selective expoxidation, extracting the water layer with methane dichloride and merging the organic phase; washing with NaHSO3 solution, saturated Na2SO3 solution, dilute hydrochloric acid solution and saturated hydrochloric acid solution successively, drying, distillation at normal pressure and concentration to obtain eplerenone.

The invention provides a preparation method of an injectable high-strength chitin-based hydrogel product. The preparation method comprises the following steps: preparing binary or polybasic alkynyl modified hydrophilic polymer A, preparing an amino-containing chitin derivative B, mixing an aqueous solutions of A and B to form an injectable hydrogel precursor solution, and forming high-strenght hydrogel in situ under the physiological condition. The injectable hydrogel is prepared in situ under the physiological condition by utilizing spontaneous amine-alkyne click reaction and performing chemical crosslinking by forming enamine bond, any micromolecular catalysts, initiators or crosslinking agents are not needed, heating, ultraviolet or radiation is not needed, no toxicity and no irritationare realized, and any aftertreatment is not needed. In-situ physical crosslinking rapid formation is conducted by using a temperature-sensitive chitin derivative, and in-situ crosslinking is furtherconducted to prepare the injectable high-strength hydrogel. The hydrogel has high biocompatibility, pH sensitivity and biodegradability, and can be widely applied to the field of biological medicine.

A microorganism preparation method relates to the microorganism of stenotrophomonas maltrophilia of stenotrophomonas utilized by CCTCC NoM 204024 of its fermentation and decomposition or its cells or zymes decomposite substrates validamycin or validamycin imide to produce validamy enamine and validemy amine. Composition of the culture media is(weight/volume): validamycin 0.5-20.0%,(NH4)2 SO4 0.5%-10.0, KCL 0.5%-5.0%, Na2HPO4, 12H2 00.1%-10.0%, Na2H2PO4 2H2O 0.1-5.0%, MgSO4 0.01%-1.0% matched by running water, fermenting temperature: 20deg.C-40-deg.C initial PH:6.0-8.0 for 1-180h by ionic exchanges, chromatography and purify, the two products are finished.

The invention relates to a synthesis method of (R, S-) nicotine. The synthesis method comprises the following steps: with 3-bromopyridine and magnesium chips as raw materials, preparing a 3-bromopyridine Grignard reagent; then adding N-methylpyrrolidone into an above system, performing a condensation reaction, performing a hydrolysis reaction after completion of the reaction, cooling, adjusting the pH to be alkaline, extracting, separating out an organic phase, concentrating, and distilling to obtain an enamine intermediate I; performing a reduction reaction on the enamine intermediate I in the presence of a metal reduction catalyst to obtain a target product R, S-nicotine. By the synthesis method, a two-step method is innovatively provided for preparing the R, S-nicotine, the steps are few, the operation is simple and convenient, the yield is high and the cost is low; in addition, the synthesis method is suitable for industrial scale-up production.

The invention mainly discloses a novel method for preparing marbofloxacin, which comprises the following steps: under the protection of inert gases, 2,3,4,5-phenyl tetrafluoride formoxyl alkyl ester forms negative ions with alkali in an inert organic solvent, is condensed with imidic salt to obtain N-dimethyl substitutive enamine derivative, and reacts with N - methyl hydrazide in organic acid to obtain N-methyl-N-acyl substitutive enamine derivative; under the reflux state, the N-methyl-N-acyl substitutive enamine derivative is catalyzed by alkali to obtain quinoline carboxylic ether; the quinoline carboxylic ether takes water as a solvent, is catalyzed with alkali at proper temperature and is neutralized to obtain quinoline carboxylic acid; under the action of an acid-binding agent, the quinoline carboxylic acid is condensed with N-methyl piperazine to obtain a condensed piperazine substance; the condensed piperazine substance is heated to proper temperature in an alkalis hydroxid water solution, is kept at the temperature and is neutralized to obtain hydrolysate; and the hydrolysate takes water as a solvent and is reacted with dialkoxy methane or methylene halide to obtain the marbofloxacin under the catalysis of the catalyzer. The invention has high yield, thereby facilitating industrialized production at large scale.

The present invention relates to a diagnostic contrast agent comprising a water dispersible, near-infrared tricarbocyanine, enamine-functionalized dye having a Stoke shift of greater than 50 and represented by five general formulae. The present invention also relates to a method for making a dye-conjugate utilizing the novel dye and a method of identifying a biological compound using the novel dye conjugate.

The invention provides enhancer for high-temperature resistant oil-based drilling fluid as well as a preparation method and application of the enhancer. The preparation method comprises the following steps: a, sequentially adding 150-250 parts by weight of dimer acids, 100-150 parts by weight of triethylene glycol momobutyl ether, 30-50 parts by weight of diethanol amine into a reaction container; stirring and performing heat reaction; b, adding 10-17 parts by weight of organic enamine for further reacting, and reducing the temperature after the reaction is finished; c, adding triethylene glycol momobutyl ether having the same weight parts in the step a and 20-30 parts by weight of propylene carbonate, uniformly stirring so as to obtain the enhancer for the high-temperature resistant oil-based drilling fluid. The invention also provides the enhancer for the high-temperature resistant oil-based drilling fluid prepared by using the preparation method and application of the enhancer in the oil-based drilling fluid. According to the enhancer, the shearing force of the oil-based drilling fluid can be improved, and the problems of barite sedimentation and poor carrying debris capability caused by low shearing force of the oil-based drilling fluid with high oil-water ratio can be solved.

An electrophotographic photoreceptor of high durability capable of providing stable excellent electrical characteristics over a prolonged period of time which electrophotographic photoreceptor excels in mechanical strength. A photosensitive layer (14) of an electrophotographic photoreceptor (1) includes a polyarylate resin having structural units, for example, those of the aforementioned formula (1-3) and an enamine compound represented by, for example, aforementioned formula (2-1). By virtue of these, the electrophotographic photoreceptor (1) of excellent mechanical strength and favorable electrical characteristics can be realized.

The invention relates to an interpenetrating polymer network prepared by in-situ ester interchange method and an application thereof. The framework formed by the reaction between the hydroxyl monomer containing at least two hydroxyl groups and the silicane coupling agent containing at least two siloxane groups is one of the components of the interpenetrating polymer network, wherein, the polymer framework formed by polymerization of enamine monomers and the polymer framework formed by hydroxyl groups and siloxane jointly constitute the interpenetrating polymer network. The interpenetrating polymer network has an organic-inorganic hybridization structure, and is an effective method to synthesize an interpenetrating polymer network. When being used as shape memory material, the interpenetrating polymer network is particularly suitable to the field of automatic intelligent material disassembly.

The invention relates to a gas pipeline drag reduction composition used in gas and particularly natural gas conveying pipeline drag reduction and a preparation method thereof, relating to a macromolecular compound composition and the pipeline system technical field. The composition is characterized in that: the composition consists of a long-chain acid mixture and enamine according to a molar ratio of between 1:1 and 1.5:1. The preparation method comprises the following steps that: after the long chain acid is added in a reactor and is heated to melting, the enamine is added and nitrogen is fed in to carry out protection and preheating; then, reflux and liquid separation are carried out; a method combining a programmed heating-up method, a vacuum method and an azeotropic agent is adopted to carry out reaction; and finally, when the reaction is finished, a product can be obtained after cooling down. The gas pipeline drag reduction composition has obvious drag reduction effect on gas pipelines, direct source of raw materials, simple operation, moderate reaction conditions, relatively simple process and low requirements on equipment, and is easy to realize large-scale industrialized production.