434results about "Preparation by hydrogenation" patented technology

Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.

The invention discloses a method for preparing 1, 5-pentanediol by catalyzing furfural conversion, and belongs to the technical field of biomass conversion. The method for preparing 1, 5-pentanediol by catalyzing furfural conversion comprises the following steps: furfural is taken as a raw material, ethanol is taken as a solvent, hydrogenation ring-opening reaction is carried out under the action of a hydrogenation catalyst, 1, 5-pentanediol is obtained, the hydrogenation catalyst comprises the following raw materials in percentage by mass: 0-1 wt% of Fe, 1-10 wt% of Cu, 20-40 wt% of Co and 50-80 wt% of La, and the content of Fe is not 0. The metals in the hydrogenation catalyst have a synergistic effect, so that furfural can be efficiently and highly selectively converted into 1, 5-pentanediol. According to the method, trace Fe is added into the hydrogenation catalyst, so that the problem that byproducts such as tetrahydrofurfuryl alcohol are generated from furfural is solved, and the selectivity of 1, 5-pentanediol is greatly improved.

The invention discloses an impregnation liquid for preparing hydrogenated bisphenol A through bisphenol A hydrogenation. The impregnation liquid comprises a Ru complex, a water-soluble nonionic surfactant and water, wherein the molecular size of the Ru complex is greater than 1nm. According to the preparation method disclosed by the invention, by adopting the impregnation liquid containing the Ru complex of which the molecular size is greater than 1nm and the water-soluble nonionic surfactant, more Ru complex of which the molecular size is greater than 1nm can exist in mesoporous channels of an activated carbon carrier in an impregnation process, so that the contact probability of an active phase and a reactant bisphenol A molecule is increased; the purposes of improving the active metal utilization rate and improving the catalyst activity are achieved.

The invention provides an aldehyde hydrogenation catalyst and a preparation method thereof, and the preparation method comprises the following steps: step 1, preparing an aluminum precursor, a part of zinc precursor and a solvent into a zinc-aluminum mixed solution, and carrying out heating treatment; step 2, preparing a precipitant solution from a precipitant, a template agent and a solvent, and carrying out heating treatment; step 3, mixing the zinc-aluminum mixed solution with part of the precipitant solution, controlling the pH value to be less than 7, and heating and precipitating; 4, preparing the copper precursor, the remaining zinc precursor and a solvent into a zinc-copper mixed solution, and performing heating treatment; step 5, mixing the zinc-copper mixed solution, the residual precipitant solution and the mixture obtained in the step 3, and controlling the pH value to be greater than 7; and 6, adding an organosilane hydrophobic modifier, heating, stirring, separating to obtain a solid phase, drying, and roasting to obtain the catalyst. According to the invention, the anti-vacuole ability of the aldehyde hydrogenation catalyst is improved by introducing hydrophobic organosilane. By regulating and controlling pH values of different precipitation steps, stable generation of aluminum salt precipitates is facilitated, and free aluminum ions are reduced.

The present invention discloses a method for preparing enol by selective hydrogenation of alkynol. By adding an acidic substance to adjust the pH value of the reaction system and adding crown ether to inhibit the two main side reactions of self-coupling and over-hydrogenation of terminal alkyne, the purpose of improving low selectivity is achieved. The product has a pure odor and mild reaction conditions.

The invention belongs to the field of chemical production, and particularly relates to a production method of 1, 4-butanediol with low acetal content and low methyl butanediol content. The method comprises the following steps: (1) under the action of a first catalyst, acetylene reacts with a formaldehyde aqueous solution to generate a first reaction solution containing butynediol; (2) rectifying the first reaction solution to remove formaldehyde to obtain a first rectified reaction solution; (3) under the action of a second catalyst, carrying out a first hydrogenation reaction on the first rectification reaction liquid and first hydrogen to obtain a second reaction liquid containing 1, 4-butanediol; and (4) under the action of a third catalyst, carrying out a second hydrogenation reaction on the second reaction liquid and second hydrogen to prepare a third reaction liquid containing 1, 4-butanediol. The BDO product prepared by the method disclosed by the invention not only can meet the field of polymers with special requirements on color values, but also can be used in the field of lithium ion batteries with requirements on low methyl BDO content.

The application provides a preparation method of an octene aldehyde liquid-phase hydrogenation catalyst, and steps of the method comprise the following: (1) preparing a salt solution containing nickel ions, copper ions and aluminum ions, heating to 40-80 DEG C, adding a basic precipitator to react, and aging after the reaction is completed; (2) uniformly mixing the precipitate obtained after aging in step (1) with silica sol to obtain slurry; (3) washing and filtering the slurry, then adding alkali metal carbonate powder and boron nitride solid, uniformly mixing, and then shaping, drying and calcining to obtain the octene aldehyde liquid-phase hydrogenation catalyst. The preparation method is simple, green, environmentally friendly and easy to industrialize, the conversion rate and selectivity of the obtained octene aldehyde liquid-phase hydrogenation catalyst are high, and the catalyst is stable in performance and durable.

The invention discloses a magnetically separable reversed-phase catalyst, a preparation method thereof and application of the magnetically separable reversed-phase catalyst in hydrogenation upgrading recovery of aromatic polyester, and belongs to the technical field of reversed-phase catalysts and plastic recovery. The catalyst is formed by loading a metal oxide (MOx) on a metal carrier nickel, and is applied to hydrogenation recovery of aromatic polyester and conversion of aromatic polyester into high value-added aliphatic polyester. After dispersion, carrying out catalytic hydrogenation reaction on the aromatic polyester at a set temperature, a set rotating speed and a set hydrogen pressure, and completing conversion of the aromatic polyester after the reaction reaches a set time; according to the method, the aromatic polyester is completely converted into the fat polyester with high additional value by using the cheap and easily-separated reverse catalyst, so that the upgraded recycling of the polyester waste plastic is realized.

The invention provides a method for preparing hydrogenated bisphenol A by continuous catalytic hydrogenation of a fixed bed. The method comprises the following steps: step A, mixing and preheating a bisphenol A solution, a low-carbon amine additive and hydrogen in a gas-liquid mixing preheater to prepare a reaction material; step B, enabling the preheated reaction material to flow through a fixed bed reactor preloaded with a Ru-based catalyst, and carrying out catalytic hydrogenation reaction in the fixed bed reactor to generate a product material; step C, separating the product material through a gas-liquid separator to obtain a hydrogenated bisphenol A solution and hydrogen, and recycling the hydrogen; and rectifying the hydrogenated bisphenol A solution to obtain hydrogenated bisphenol A. The method provided by the invention effectively overcomes the defect that the single-batch reaction time of the existing catalytic hydrogenation process reaches 4-12 hours, and greatly shortens the continuous catalytic hydrogenation reaction time; by adding the low-carbon amine auxiliary agent, the reaction activity is promoted, and the generation of dehydroxylation byproducts is reduced; the selectivity of the product can be effectively guaranteed, the product is easy to separate, the safety is good, the cost is obviously reduced, and industrial application is easy.

The invention belongs to the technical field of organic synthesis catalysts, and particularly relates to a preparation method and application of a composite catalyst for synthesizing 1, 2-pentanediol through furfuryl alcohol hydrogenation. The preparation method comprises the following steps: preparing cerium nitrate, lanthanum nitrate, urea, a surfactant and water into an aqueous solution, dipping spherical gamma-Al2O3, and then sequentially carrying out hydrothermal reaction, drying and roasting to obtain CeO2-La2O3 / Al2O3; the preparation method comprises the following steps: preparing palladium chloride, ruthenium chloride, hydrochloric acid and water into an acidic solution, dipping CeO2-La2O3 / Al2O3, drying, roasting and performing hydrogen reduction in sequence, thereby obtaining the composite catalyst Pd-Ru-CeO2-La2O3 / Al2O3. The composite catalyst can be applied to preparation of 1, 2-pentanediol through furfuryl alcohol hydrogenation. By preparing the composite catalyst, the defects of the existing catalyst in the aspects of selectivity, stability and cost are overcome.

The invention relates to the technical field of catalytic materials, in particular to a catalyst and a preparation method and application thereof. The invention provides a catalyst. The catalyst comprises organosilane modified mesoporous silica and nickel-molybdenum bimetallic loaded in the organosilane modified mesoporous silica. Nickel in the catalyst can promote hydrogen activation and hydrogenation, and molybdenum plays a role in catalytic cracking reaction. On the catalyst, the synergistic effect generated by combination of bimetal and acidic sites is more beneficial to efficient HDO reaction (catalytic hydrodeoxygenation reaction). The result of the embodiment shows that when the conversion rate of the model compound guaiacol is 100%, the highest selectivity of the obtained product naphthenic alcohol can reach 50.1%; when the catalyst is applied to the hydrodeoxygenation conversion reaction process of biomass alcoholysis derivative oil, the yield of naphthenic alcohol is greatly increased, and the relative content is increased from 3.5% to 49.8%.

The invention provides a preparation method, a product and application of an acid site / carrier decoupled metal-acid multifunctional catalyst, and belongs to the technical field of biomass energy utilization. According to the preparation method, a metal active site is provided by non-noble metal Ni, a neutral material h-BN is taken as a carrier, and a Ni element is reduced and loaded on h-BN under an alkaline condition by adopting a liquid phase reduction method, so that the Ni / h-BN catalyst is prepared; and then heteropoly acid is used for providing an acid site, the acid site is loaded on a Ni / h-BN catalyst through an impregnation method, and Ni-HSiW / h-BN is prepared. According to the present invention, by flexibly regulating and controlling the acid site (loaded or unloaded heteropolyacid), the required product can be selectively obtained when the obtained catalyst is used for catalyzing the lignin derivative hydrodeoxygenation reaction, and by regulating and controlling the temperature, the time and other parameters of the hydrodeoxygenation reaction, the high selectivity on the reaction product can be provided.

The application provides a catalyst for preparing an enol from an alkyne alcohol, a preparation method and a method for preparing the enol by using the catalyst. By precisely controlling the particle size, specific surface area and added toxicant of the Lindlar catalyst, the catalytic efficiency can be significantly improved, and the catalyst performance is quantified with each parameter, so that the catalyst can be widely applied in industrial production.

The invention relates to the technical field of catalysis, and discloses a combined catalyst and application thereof in preparation of 1, 4-cyclohexanedimethanol. The catalyst A and the cocatalyst in the combined catalyst have high reaction selectivity in the process of catalytically oxidizing paraxylene (PX) to prepare terephthalyl alcohol, so that the conversion rate of the PX and the yield of the terephthalyl alcohol are relatively high, and an oxidation product can be directly hydrogenated to prepare 1, 4-cyclohexanedimethanol without separation and purification; meanwhile, the hydrogenation catalytic performance of the catalyst B is excellent; under the combination, paraxylene can be directly converted into 1, 4-cyclohexanedimethanol through a one-step oxidation reaction and a one-step hydrogenation reaction, the technological process can be greatly shortened, and the catalyst is easy to separate and recover after reaction.

Disclosed herein are deuterated compounds and transition metal catalyzed methods for making deuterated compounds. The disclosed methods are regioselective and enantioselective and may be utilized to prepare isomerically and / or enantiomerically pure or enriched deuterated compounds. The disclosed methods also may be modified in order to prepared fluorinated compounds.

The invention relates to the field of dihydric alcohol production, in particular to a catalyst suitable for high-yield production of 1, 5-pentanediol, a preparation method of the catalyst and a production method of 1, 5-pentanediol. Under the catalytic action of a nickel-based catalyst with a composite carrier, tetrahydrofurfuryl alcohol is subjected to one-step hydrogenation ring opening to generate 1, 5-pentanediol. According to the method, tetrahydrofurfuryl alcohol is adopted as a raw material and is converted into 1, 5-pentanediol on a hydrogenation-ring-opening bifunctional catalyst in a hydrogenation manner, and byproducts such as 1, 2-pentanediol, 2-methyltetrahydrofuran and n-pentanol are obtained. The composition of the hydrogenation-ring opening bifunctional catalyst is NiO-CoO / La2O3-ZrO2, the hydrogenation component is CuO-CoO and a composite oxide carrier La2O3-ZrO2, and the pressure conditions of the hydro-conversion process are as follows: the H2 pressure is 3.0-4.0 MPa, and the temperature is 165-195 DEG C. The invention also discloses a preparation method of the hydrogenation-ring opening bifunctional catalyst.

The invention relates to the technical field of chemical engineering, and discloses a preparation method of linalool. According to the preparation method, a proper amount of auxiliaries containing Zn, Co and Fe elements are added into dehydrolinalool serving as a reaction raw material, so that the catalyst can break through the catalytic characteristic of the catalyst in the hydrogenation reaction process, the hydrogenation degree of the raw material is regulated and controlled, a certain amount of by-products dihydrolinalool and cyclodehydrolinalool capable of regulating and controlling fragrance are generated, and through testing of a professional fragrance evaluator, the effect is remarkable. The linalool product prepared by the invention is more fragrant, and the product quality is improved. Meanwhile, before the hydrogenation reaction liquid is rectified and refined, the reaction liquid is washed with an alkali solution to be subjected to deacidification treatment, so that the linalool can be inhibited from being dehydrated in the rectification process, and the product purity and the qualified product yield are improved.

The invention relates to a nickel-ruthenium-based solid superacid hydrogenation catalyst and a preparation method and application thereof, the method comprises the following steps: (NH4) 2S2O8 is dissolved in methanol, ZrO2 is added, stirring and ultrasonic treatment are continued, stirring and filtering are carried out, precipitate is dried overnight, solids are ground into powder after being cooled, and the powder is roasted at 550 DEG C for 3 h to obtain S2O8 < 2-> / ZrO2; the preparation method comprises the following steps: dissolving nickel salt and ruthenium salt in deionized water, performing ultrasonic treatment, adding S2O82- / ZrO2, continuing ultrasonic treatment, adding a NaBH4 solution for reduction, and changing the solution from light green to dark black; and filtering the mixture, drying in vacuum, and grinding to obtain the hydrogenation catalyst. According to the invention, a second metal Ru is introduced to modify a monometal Ni-based solid superacid catalyst 10% Ni-S2O8 < 2-> / ZrO2, and the bimetallic Ni-Ru catalyst is prepared. The catalyst has higher catalytic activity when applied to catalytic hydrogenation of coal model compounds.

The invention relates to the field of catalysts, in particular to a furfuryl alcohol hydrogenation catalyst, a preparation method and application thereof and a preparation method of 1, 2-pentanediol. The furfuryl alcohol hydrogenation catalyst provided by the invention comprises a carrier, an auxiliary agent embedded in the carrier and Cu nanoparticles loaded on the carrier, the carrier is Al2O3, the auxiliary agent is selected from MgO and / or TiO2, and the content of the Cu nanoparticles is 10wt%-30wt% based on the total mass of the furfuryl alcohol hydrogenation catalyst. When the furfuryl alcohol hydrogenation catalyst provided by the invention is used for catalyzing furfuryl alcohol to prepare 1, 2-pentanediol, the technological process is simple, the reaction process is controllable, continuous preparation of a 1, 2-pentanediol product can be realized, the product quality is excellent and stable, the furfuryl alcohol hydrogenation conversion rate reaches 99.9%, and the selectivity of the product 1, 2-pentanediol reaches 60%.

The invention relates to a supported hydrogenation catalyst as well as a preparation method and application thereof, the novel supported hydrogenation catalyst is prepared by using nano aluminum oxide activated by methanol as a carrier, the novel supported hydrogenation catalyst has relatively high activity on hydrogenation of bisphenol compounds, and the trans-isomer proportion of hydrogenated bisphenol A is relatively high; meanwhile, metal components are dispersed more uniformly by utilizing adsorption sites generated by methanol activation, generation of deep hydrogenation products of bisphenol compounds is reduced, the hydrogenation performance of the supported hydrogenation catalyst on bisphenol A is improved, the loading capacity of noble metal active components is effectively reduced, and thus the preparation cost of the catalyst is reduced.

The invention relates to a mesoporous cerium oxide supported ruthenium catalyst and a preparation method and application thereof.The preparation method includes the steps that tri (2-aminoethyl) amine and aromatic aldehyde are subjected to an aldehyde-amine condensation polymerization reaction to form imine bonds, a porous organic cage-shaped polymer is obtained, the organic cage-shaped polymer serves as a template, cerium oxide crystals are synthesized through a hydrothermal reaction, and the mesoporous cerium oxide supported ruthenium catalyst is obtained. Roasting to remove the organic cage polymer to obtain a mesoporous cerium oxide carrier; ruthenium single atoms are dispersed and loaded in channels of the mesoporous cerium oxide carrier through a supercritical fluid deposition method, then reduction is carried out, and the mesoporous cerium oxide-loaded ruthenium catalyst which is low in ruthenium loading capacity, uniform in metal active center distribution, small in particle size and high in dispersity is obtained, can be used repeatedly without inactivation and is used for bisphenol A hydrogenation reaction, and the catalytic activity of the catalyst is improved. The conversion rate of bisphenol A and the selectivity of hydrogenated bisphenol A can be effectively improved.

The invention belongs to the field of sandalwood 803 preparation, and particularly relates to a preparation method of sandalwood 803. Sandalwood 803 is continuously produced in a fixed bed under the catalytic action of a solid acid catalyst and a hydrogenation catalyst, phenol and camphene are catalyzed by the solid acid catalyst to be subjected to an alkylation reaction, a terpene-phenol mixture in an alkylation reaction product is catalyzed by the hydrogenation catalyst to be subjected to a hydrogenation reaction, and the sandalwood 803 is prepared. The hydrogenation catalyst is a cobalt-based catalyst containing lanthanide oxides. Compared with the prior art, the continuous process for synthesizing the sandalwood 803 has the advantages that the sandalwood 803 can be continuously and uninterruptedly synthesized by selecting and preparing the solid acid catalyst and the hydrogenation catalyst which are high in activity and good in stability, so that the production efficiency of the sandalwood 803 is improved, the production cost is reduced, and large-scale production is facilitated.

The invention relates to a non-noble metal nano-porous high-entropy alloy catalyst as well as a preparation method and application thereof. The preparation method comprises the following steps that aluminum metal powder and transition metal powder are mixed according to the mass ratio of 1: (0.8-1.5) and smelted at the high temperature, and a smelted metal block is obtained; the obtained smelted metal blocks are smashed, and smelted metal powder is obtained; under the protection atmosphere of inert gas, the obtained smelted metal powder is subjected to ball milling, and ball-milled metal powder is obtained; and the obtained ball-milled metal powder is added into a first solvent, heating and stirring are conducted for a first reaction, and the non-noble metal nano-porous high-entropy alloy catalyst is obtained after separation. The high-entropy alloy is prepared in a high-temperature melting and high-energy ball milling mode, alloying between metals is achieved, the preparation method has the advantages that the preparation method is simple, components are easy to regulate and control, and the atom utilization rate is high, and the obtained high-entropy alloy has extremely high lignin catalytic conversion activity.

The invention relates to the technical field of X oil recovery, and discloses a method for preparing cyclohexanol from a byproduct X oil in a cyclohexanone production process by a hydration method. The method comprises the following steps: (1) in the presence of hydrogen, introducing mixed reaction oil containing X oil and an organic solvent into a fixed bed reactor filled with a hydrogenation catalyst, and carrying out hydrotreatment to obtain a hydrotreatment effluent; (2) introducing the hydrotreating effluent into a desolventizing tower for first separation to obtain hydrogenated X oil and an organic solvent which can be recycled to the step (1); and (3) introducing the hydrogenated X oil into a cyclohexanol recovery tower for secondary separation to obtain gas-phase cyclohexanol and heavy X oil. According to the method provided by the invention, phenol in the X oil can be hydrogenated into cyclohexanol, efficient separation is carried out, effective utilization of phenol in the X oil is realized, and material loss in the production process is reduced.

The invention discloses an ionic liquid modified supported metal oxide and a preparation method and application thereof, the supported metal oxide takes a metal oxide as a carrier, platinum is supported on the metal oxide, and ionic liquid is electrostatically adsorbed on the metal oxide. According to the invention, the ionic liquid is used as an organic ligand to modify the platinum-loaded metal oxide, and the ionic liquid is used as a catalyst to realize the high activity of generating 1, 2-pentanediol in the selective hydrogenation process of furfuryl alcohol. Specifically, the selectivity of 1, 2-pentanediol can reach 76.8%, and compared with an original platinum-loaded metal oxide catalyst, the activity of the catalyst can be maximally improved by 491.2%.

The invention relates to the technical field of catalysts, in particular to a palladium-based catalyst derived from MOFs as well as a preparation method and application of the palladium-based catalyst. The preparation method comprises the following steps: firstly preparing an MOF material, then preparing a palladium-based MOF precursor, mixing the palladium-based MOF precursor with a nitrogen-containing precursor, heating and roasting in an inert atmosphere, and cooling to room temperature. An external nitrogen-containing precursor is introduced in the high-temperature pyrolysis process and is jointly roasted with a palladium-based MOF precursor, the nitrogen doping amount in the carbon carrier is remarkably increased, and high dispersion and electronic structure optimization of Pd particles are achieved by enhancing the anchoring effect and electronic regulation and control of nitrogen species on the Pd nanoparticles; therefore, high activity, high selectivity and high stability are simultaneously obtained in the selective hydrogenation reaction of 2-methyl-3-butyne-2-alcohol.

The application discloses a preparation method of an octene aldehyde liquid-phase hydrogenation catalyst, and the preparation method comprises the following steps: (1) adding a weak acid into a salt solution containing silver, magnesium and aluminum, uniformly stirring, then adding a glycerol aldehyde, continuously stirring until a colloid is formed, grinding the colloid to obtain a powder, sieving, and roasting to obtain a carrier; and (2) preparing a precursor solution containing nickel and zinc, placing the precursor solution and the carrier in an ultrasonic container to shake, pouring the shaken solution into a well-sealed ball mill tank, ball milling, and then drying and roasting to obtain the catalyst. The catalyst is prepared by adding a silver-containing compound when the carrier is prepared and the ball milling method, so that the selectivity and stability of the catalyst are improved.

The invention discloses a surface ruthenium-nitrogen coordinated Ru nano-particle catalyst, a preparation method and application of the surface ruthenium-nitrogen coordinated Ru nano-particle catalyst in bisphenol A hydrogenation reaction. Ruthenium acetylacetonate and a nitrogen-containing ligand form a porous precursor by adopting a sol-gel method, and then the porous precursor is subjected to inert gas pyrolysis and H2 / NH3 activation treatment. In an XPS (X-ray polystyrene) N1s spectrogram of the prepared Ru nano-particle catalyst, Ru-N coordination nitrogen at 399.0-399.5 eV accounts for 30%-60% of the total nitrogen atom. When the catalyst is applied to bisphenol A hydrogenation reaction, the sulfur content of the raw material is less than 100ppm, and the yield of hydrogenated bisphenol A can reach 94%; the attenuation is less than 5% after 5 cycles, and the sulfur adsorption capacity of the Ru nano-particle catalyst is less than 0.1 wt%. The surface ruthenium-nitrogen coordinated Ru nano-particle catalyst is high in activity, good in selectivity and excellent in sulfur tolerance, can stably play a role in a sulfur-containing environment, is simple and controllable in preparation process, and is beneficial to industrial production.

The invention provides a catalyst for synthesizing BDO and a preparation method of the catalyst. The catalyst comprises an active component, a structural aid and an acidic regulator, wherein the active component is a nanoscale Cu-Zn-Al ternary metal compound. The catalyst provided by the invention shows high conversion rate, high selectivity and long service life in BDO preparation, solves the problems of easy sintering, insufficient active sites and the like of the traditional catalyst, and has significant industrial application value.