347results about "Preparation by hydrogenation" patented technology

Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.

The invention discloses an impregnation liquid for preparing hydrogenated bisphenol A through bisphenol A hydrogenation. The impregnation liquid comprises a Ru complex, a water-soluble nonionic surfactant and water, wherein the molecular size of the Ru complex is greater than 1nm. According to the preparation method disclosed by the invention, by adopting the impregnation liquid containing the Ru complex of which the molecular size is greater than 1nm and the water-soluble nonionic surfactant, more Ru complex of which the molecular size is greater than 1nm can exist in mesoporous channels of an activated carbon carrier in an impregnation process, so that the contact probability of an active phase and a reactant bisphenol A molecule is increased; the purposes of improving the active metal utilization rate and improving the catalyst activity are achieved.

The invention provides an aldehyde hydrogenation catalyst and a preparation method thereof, and the preparation method comprises the following steps: step 1, preparing an aluminum precursor, a part of zinc precursor and a solvent into a zinc-aluminum mixed solution, and carrying out heating treatment; step 2, preparing a precipitant solution from a precipitant, a template agent and a solvent, and carrying out heating treatment; step 3, mixing the zinc-aluminum mixed solution with part of the precipitant solution, controlling the pH value to be less than 7, and heating and precipitating; 4, preparing the copper precursor, the remaining zinc precursor and a solvent into a zinc-copper mixed solution, and performing heating treatment; step 5, mixing the zinc-copper mixed solution, the residual precipitant solution and the mixture obtained in the step 3, and controlling the pH value to be greater than 7; and 6, adding an organosilane hydrophobic modifier, heating, stirring, separating to obtain a solid phase, drying, and roasting to obtain the catalyst. According to the invention, the anti-vacuole ability of the aldehyde hydrogenation catalyst is improved by introducing hydrophobic organosilane. By regulating and controlling pH values of different precipitation steps, stable generation of aluminum salt precipitates is facilitated, and free aluminum ions are reduced.

The present invention discloses a method for preparing enol by selective hydrogenation of alkynol. By adding an acidic substance to adjust the pH value of the reaction system and adding crown ether to inhibit the two main side reactions of self-coupling and over-hydrogenation of terminal alkyne, the purpose of improving low selectivity is achieved. The product has a pure odor and mild reaction conditions.

The invention belongs to the field of chemical production, and particularly relates to a production method of 1, 4-butanediol with low acetal content and low methyl butanediol content. The method comprises the following steps: (1) under the action of a first catalyst, acetylene reacts with a formaldehyde aqueous solution to generate a first reaction solution containing butynediol; (2) rectifying the first reaction solution to remove formaldehyde to obtain a first rectified reaction solution; (3) under the action of a second catalyst, carrying out a first hydrogenation reaction on the first rectification reaction liquid and first hydrogen to obtain a second reaction liquid containing 1, 4-butanediol; and (4) under the action of a third catalyst, carrying out a second hydrogenation reaction on the second reaction liquid and second hydrogen to prepare a third reaction liquid containing 1, 4-butanediol. The BDO product prepared by the method disclosed by the invention not only can meet the field of polymers with special requirements on color values, but also can be used in the field of lithium ion batteries with requirements on low methyl BDO content.

The application provides a preparation method of an octene aldehyde liquid-phase hydrogenation catalyst, and steps of the method comprise the following: (1) preparing a salt solution containing nickel ions, copper ions and aluminum ions, heating to 40-80 DEG C, adding a basic precipitator to react, and aging after the reaction is completed; (2) uniformly mixing the precipitate obtained after aging in step (1) with silica sol to obtain slurry; (3) washing and filtering the slurry, then adding alkali metal carbonate powder and boron nitride solid, uniformly mixing, and then shaping, drying and calcining to obtain the octene aldehyde liquid-phase hydrogenation catalyst. The preparation method is simple, green, environmentally friendly and easy to industrialize, the conversion rate and selectivity of the obtained octene aldehyde liquid-phase hydrogenation catalyst are high, and the catalyst is stable in performance and durable.

The invention discloses a magnetically separable reversed-phase catalyst, a preparation method thereof and application of the magnetically separable reversed-phase catalyst in hydrogenation upgrading recovery of aromatic polyester, and belongs to the technical field of reversed-phase catalysts and plastic recovery. The catalyst is formed by loading a metal oxide (MOx) on a metal carrier nickel, and is applied to hydrogenation recovery of aromatic polyester and conversion of aromatic polyester into high value-added aliphatic polyester. After dispersion, carrying out catalytic hydrogenation reaction on the aromatic polyester at a set temperature, a set rotating speed and a set hydrogen pressure, and completing conversion of the aromatic polyester after the reaction reaches a set time; according to the method, the aromatic polyester is completely converted into the fat polyester with high additional value by using the cheap and easily-separated reverse catalyst, so that the upgraded recycling of the polyester waste plastic is realized.

The invention provides a method for preparing hydrogenated bisphenol A by continuous catalytic hydrogenation of a fixed bed. The method comprises the following steps: step A, mixing and preheating a bisphenol A solution, a low-carbon amine additive and hydrogen in a gas-liquid mixing preheater to prepare a reaction material; step B, enabling the preheated reaction material to flow through a fixed bed reactor preloaded with a Ru-based catalyst, and carrying out catalytic hydrogenation reaction in the fixed bed reactor to generate a product material; step C, separating the product material through a gas-liquid separator to obtain a hydrogenated bisphenol A solution and hydrogen, and recycling the hydrogen; and rectifying the hydrogenated bisphenol A solution to obtain hydrogenated bisphenol A. The method provided by the invention effectively overcomes the defect that the single-batch reaction time of the existing catalytic hydrogenation process reaches 4-12 hours, and greatly shortens the continuous catalytic hydrogenation reaction time; by adding the low-carbon amine auxiliary agent, the reaction activity is promoted, and the generation of dehydroxylation byproducts is reduced; the selectivity of the product can be effectively guaranteed, the product is easy to separate, the safety is good, the cost is obviously reduced, and industrial application is easy.

The invention provides a preparation method, a product and application of an acid site / carrier decoupled metal-acid multifunctional catalyst, and belongs to the technical field of biomass energy utilization. According to the preparation method, a metal active site is provided by non-noble metal Ni, a neutral material h-BN is taken as a carrier, and a Ni element is reduced and loaded on h-BN under an alkaline condition by adopting a liquid phase reduction method, so that the Ni / h-BN catalyst is prepared; and then heteropoly acid is used for providing an acid site, the acid site is loaded on a Ni / h-BN catalyst through an impregnation method, and Ni-HSiW / h-BN is prepared. According to the present invention, by flexibly regulating and controlling the acid site (loaded or unloaded heteropolyacid), the required product can be selectively obtained when the obtained catalyst is used for catalyzing the lignin derivative hydrodeoxygenation reaction, and by regulating and controlling the temperature, the time and other parameters of the hydrodeoxygenation reaction, the high selectivity on the reaction product can be provided.

The application provides a catalyst for preparing an enol from an alkyne alcohol, a preparation method and a method for preparing the enol by using the catalyst. By precisely controlling the particle size, specific surface area and added toxicant of the Lindlar catalyst, the catalytic efficiency can be significantly improved, and the catalyst performance is quantified with each parameter, so that the catalyst can be widely applied in industrial production.

The invention relates to the technical field of catalysis, and discloses a combined catalyst and application thereof in preparation of 1, 4-cyclohexanedimethanol. The catalyst A and the cocatalyst in the combined catalyst have high reaction selectivity in the process of catalytically oxidizing paraxylene (PX) to prepare terephthalyl alcohol, so that the conversion rate of the PX and the yield of the terephthalyl alcohol are relatively high, and an oxidation product can be directly hydrogenated to prepare 1, 4-cyclohexanedimethanol without separation and purification; meanwhile, the hydrogenation catalytic performance of the catalyst B is excellent; under the combination, paraxylene can be directly converted into 1, 4-cyclohexanedimethanol through a one-step oxidation reaction and a one-step hydrogenation reaction, the technological process can be greatly shortened, and the catalyst is easy to separate and recover after reaction.

The invention relates to a nickel-ruthenium-based solid superacid hydrogenation catalyst and a preparation method and application thereof, the method comprises the following steps: (NH4) 2S2O8 is dissolved in methanol, ZrO2 is added, stirring and ultrasonic treatment are continued, stirring and filtering are carried out, precipitate is dried overnight, solids are ground into powder after being cooled, and the powder is roasted at 550 DEG C for 3 h to obtain S2O8 < 2-> / ZrO2; the preparation method comprises the following steps: dissolving nickel salt and ruthenium salt in deionized water, performing ultrasonic treatment, adding S2O82- / ZrO2, continuing ultrasonic treatment, adding a NaBH4 solution for reduction, and changing the solution from light green to dark black; and filtering the mixture, drying in vacuum, and grinding to obtain the hydrogenation catalyst. According to the invention, a second metal Ru is introduced to modify a monometal Ni-based solid superacid catalyst 10% Ni-S2O8 < 2-> / ZrO2, and the bimetallic Ni-Ru catalyst is prepared. The catalyst has higher catalytic activity when applied to catalytic hydrogenation of coal model compounds.

The invention relates to the field of catalysts, in particular to a furfuryl alcohol hydrogenation catalyst, a preparation method and application thereof and a preparation method of 1, 2-pentanediol. The furfuryl alcohol hydrogenation catalyst provided by the invention comprises a carrier, an auxiliary agent embedded in the carrier and Cu nanoparticles loaded on the carrier, the carrier is Al2O3, the auxiliary agent is selected from MgO and / or TiO2, and the content of the Cu nanoparticles is 10wt%-30wt% based on the total mass of the furfuryl alcohol hydrogenation catalyst. When the furfuryl alcohol hydrogenation catalyst provided by the invention is used for catalyzing furfuryl alcohol to prepare 1, 2-pentanediol, the technological process is simple, the reaction process is controllable, continuous preparation of a 1, 2-pentanediol product can be realized, the product quality is excellent and stable, the furfuryl alcohol hydrogenation conversion rate reaches 99.9%, and the selectivity of the product 1, 2-pentanediol reaches 60%.

The invention relates to the technical field of X oil recovery, and discloses a method for preparing cyclohexanol from a byproduct X oil in a cyclohexanone production process by a hydration method. The method comprises the following steps: (1) in the presence of hydrogen, introducing mixed reaction oil containing X oil and an organic solvent into a fixed bed reactor filled with a hydrogenation catalyst, and carrying out hydrotreatment to obtain a hydrotreatment effluent; (2) introducing the hydrotreating effluent into a desolventizing tower for first separation to obtain hydrogenated X oil and an organic solvent which can be recycled to the step (1); and (3) introducing the hydrogenated X oil into a cyclohexanol recovery tower for secondary separation to obtain gas-phase cyclohexanol and heavy X oil. According to the method provided by the invention, phenol in the X oil can be hydrogenated into cyclohexanol, efficient separation is carried out, effective utilization of phenol in the X oil is realized, and material loss in the production process is reduced.

The invention discloses an ionic liquid modified supported metal oxide and a preparation method and application thereof, the supported metal oxide takes a metal oxide as a carrier, platinum is supported on the metal oxide, and ionic liquid is electrostatically adsorbed on the metal oxide. According to the invention, the ionic liquid is used as an organic ligand to modify the platinum-loaded metal oxide, and the ionic liquid is used as a catalyst to realize the high activity of generating 1, 2-pentanediol in the selective hydrogenation process of furfuryl alcohol. Specifically, the selectivity of 1, 2-pentanediol can reach 76.8%, and compared with an original platinum-loaded metal oxide catalyst, the activity of the catalyst can be maximally improved by 491.2%.

The invention relates to the technical field of catalysts, in particular to a palladium-based catalyst derived from MOFs as well as a preparation method and application of the palladium-based catalyst. The preparation method comprises the following steps: firstly preparing an MOF material, then preparing a palladium-based MOF precursor, mixing the palladium-based MOF precursor with a nitrogen-containing precursor, heating and roasting in an inert atmosphere, and cooling to room temperature. An external nitrogen-containing precursor is introduced in the high-temperature pyrolysis process and is jointly roasted with a palladium-based MOF precursor, the nitrogen doping amount in the carbon carrier is remarkably increased, and high dispersion and electronic structure optimization of Pd particles are achieved by enhancing the anchoring effect and electronic regulation and control of nitrogen species on the Pd nanoparticles; therefore, high activity, high selectivity and high stability are simultaneously obtained in the selective hydrogenation reaction of 2-methyl-3-butyne-2-alcohol.

The application discloses a preparation method of an octene aldehyde liquid-phase hydrogenation catalyst, and the preparation method comprises the following steps: (1) adding a weak acid into a salt solution containing silver, magnesium and aluminum, uniformly stirring, then adding a glycerol aldehyde, continuously stirring until a colloid is formed, grinding the colloid to obtain a powder, sieving, and roasting to obtain a carrier; and (2) preparing a precursor solution containing nickel and zinc, placing the precursor solution and the carrier in an ultrasonic container to shake, pouring the shaken solution into a well-sealed ball mill tank, ball milling, and then drying and roasting to obtain the catalyst. The catalyst is prepared by adding a silver-containing compound when the carrier is prepared and the ball milling method, so that the selectivity and stability of the catalyst are improved.

The invention discloses a surface ruthenium-nitrogen coordinated Ru nano-particle catalyst, a preparation method and application of the surface ruthenium-nitrogen coordinated Ru nano-particle catalyst in bisphenol A hydrogenation reaction. Ruthenium acetylacetonate and a nitrogen-containing ligand form a porous precursor by adopting a sol-gel method, and then the porous precursor is subjected to inert gas pyrolysis and H2 / NH3 activation treatment. In an XPS (X-ray polystyrene) N1s spectrogram of the prepared Ru nano-particle catalyst, Ru-N coordination nitrogen at 399.0-399.5 eV accounts for 30%-60% of the total nitrogen atom. When the catalyst is applied to bisphenol A hydrogenation reaction, the sulfur content of the raw material is less than 100ppm, and the yield of hydrogenated bisphenol A can reach 94%; the attenuation is less than 5% after 5 cycles, and the sulfur adsorption capacity of the Ru nano-particle catalyst is less than 0.1 wt%. The surface ruthenium-nitrogen coordinated Ru nano-particle catalyst is high in activity, good in selectivity and excellent in sulfur tolerance, can stably play a role in a sulfur-containing environment, is simple and controllable in preparation process, and is beneficial to industrial production.

The invention provides a catalyst for synthesizing BDO and a preparation method of the catalyst. The catalyst comprises an active component, a structural aid and an acidic regulator, wherein the active component is a nanoscale Cu-Zn-Al ternary metal compound. The catalyst provided by the invention shows high conversion rate, high selectivity and long service life in BDO preparation, solves the problems of easy sintering, insufficient active sites and the like of the traditional catalyst, and has significant industrial application value.

The disclosure relates to the field of specialty chemicals. In particular, the disclosure provides novel 1,3-fatty-diol compounds and derivatives thereof which are useful e.g., in the production of personal care products, surfactants, detergents, polymers, paints, coatings, and as emulsifiers, emollients, and thickeners in cosmetics and foods, as industrial solvents and plasticizers, etc.

The invention relates to preparation and application of a high-elastic UV (ultraviolet) monomer diisooctyl itaconate. The n-butyraldehyde is used as a starting raw material, and the raw material is low in price and wide in source. The appropriate acidic ionic liquid catalyst is screened out, aldol condensation reaction and esterification reaction can be catalyzed at the same time, other solvents are not needed, after the reaction in the step (1) and the step (2) is completed in the reaction process, aftertreatment is not needed, the next-step reaction can be directly conducted, operation steps are saved, and industrialization is better facilitated.

The invention relates to a process for the manufacturing of biobased 3-methyl-delta-valerolactone (3MdVL) and 3-methyl-1,5-pentanediol (3MPD) via one- pot hydrogenation of anhydromevalonolactone (aMVL) in the presence of a Raney- Nickel catalyst. The hydrogenation occurs without solvent at a temperature from 120ºC-180ºC, preferably at 130ºC-170ºC and a pressure between 15-30 bar, preferably at a pressure between 18 and 22 bar. The hydrogenation time may vary between 3 and 25 hours, preferably between 6 and 24 hours.

The invention discloses a preparation method of a self-supporting noble metal catalyst rich in different phase structure interfaces, which comprises the following steps: S1, uniformly mixing a platinum precursor I, a nickel precursor, a reducing agent I and a solvent I, and carrying out solvothermal reduction reaction to obtain a platinum-nickel alloy nanobranch with a hexagonal structure; and S2, uniformly mixing the platinum-nickel alloy nanobranch with the hexagonal structure prepared in the step S1, which is taken as a seed, with a platinum precursor II, a reducing agent II and a solvent II, and carrying out secondary solvothermal reduction reaction to obtain the self-supporting noble metal catalyst rich in different-phase structure interfaces. The noble metal catalyst prepared by the method disclosed by the invention has a stable and novel morphology structure; meanwhile, the catalyst is rich in efficient catalytic interfaces, and rich reaction sites are provided for improving the catalytic selectivity of the catalyst.

The invention discloses a method for preparing 1, 4-butanediol (BDO), which comprises the following steps: S1, jointly dispersing a metal nickel salt, a cobalt salt, a spiropyrane compound and vinyl modified Fe304 nanoparticles in an imidazole ionic liquid, and carrying out free radical polymerization reaction to obtain a catalyst; s2, water containing BDO and pre-hydrogenated cyclohexane are mixed according to a certain oil-water ratio, a catalyst is added, an emulsion is formed through ultraviolet light induction, and hydro-conversion is carried out under hydrogen pressure; s3, switching the wavelength of the visible light, applying a magnetic field, separating by-products through gradient temperature and pressure control, and purifying BDO; s4, carrying out hydrogen reduction treatment on the recovered catalyst for cyclic utilization; metal nickel salt, cobalt salt, spiropyran-6-carboxylic acid methyl ester and vinyl modified Fe304 nanoparticles are jointly dispersed in imidazole ionic liquid for free radical polymerization reaction, and the metal nickel salt and cobalt salt are combined to enhance the active center of the catalyst for hydrogenation reaction, so that hydroconversion of BDO can be more efficiently promoted.

A process for producing 1,4-cyclohexanedimethanol by depolymerizing one or more recycled terephthalate-based polyesters or copolyesters via solvolysis with one or more glycols or alcohols and contacting the depolymerization product with an ester hydrogenolysis catalyst and hydrogen to produce a hydrogenolysis product and contacting the hydrogenolysis product with a hydrogenation catalyst and hydrogen to produce 1,4- cyclohexanedimethanol.

The invention relates to the technical field of chemical pesticides, in particular to a synthesis method of phyllocnistis appendiculata sex pheromone. According to the synthesis method of the phyllocnistis appendiculata sex pheromone, provided by the invention, the synthesis steps are simplified, the yield of most reactions is 90% or above, the synthesis method is simple and convenient, a target product can be obtained in the shortest time, the phyllocnistis appendiculata sex pheromone (10R, 14R)-10, 14-dimethyl octadecene is prepared through 14-step reactions, and the total yield is 38.5%; according to the method, the phyllocnistis appendiculata sex pheromones (5R, 9R)-5, 9-dimethyl octadecane and (5R, 9R)-5, 9-dimethyl heptadecane are prepared through a reaction in 12 steps, and the total yields are 52.8% and 52.3% respectively.

The invention discloses a hydrophobic Ru nano-particle catalyst, a preparation method and application of the hydrophobic Ru nano-particle catalyst in bisphenol A hydrogenation reaction. The catalyst is prepared by dissolving a ruthenium salt precursor, mixing the ruthenium salt precursor with a surfactant containing nitrogen, phosphorus or sulfur, and reacting through a reducing agent in an inert atmosphere. The preparation method is simple and efficient, and reduction-modification coupling is realized in one step. Different from a traditional supported Ru catalyst, active sites of the carrier-free hydrophobic Ru nanoparticle catalyst are fully exposed, the particle size distribution uniformity of nanoparticles is excellent, and the dynamic light scattering PDI is smaller than or equal to 0.19. In the bisphenol A hydrogenation reaction, the raw material conversion rate reaches 95% or above, the selectivity of the target product hydrogenated bisphenol A reaches 95% or above, the conversion rate and the selective attenuation rate are both smaller than 5% after 5 cycles, and excellent cycle stability is achieved.

The invention discloses a preparation method of dicyclopentyl methacrylate, which comprises the following steps: carrying out hydration reaction on dicyclopentadiene serving as a starting raw material to obtain an intermediate I, carrying out hydrogenation reaction to obtain an intermediate II, and carrying out esterification reaction to obtain the dicyclopentyl methacrylate. The reaction temperature is 40-60 DEG C, and the mass ratio of dicyclopentadiene to phosphoric acid is (1.1-1.3): 1; the hydrogenation reaction takes palladium on carbon as a catalyst, the reaction temperature is 38-48 DEG C, and the mass ratio of the intermediate I to the palladium on carbon is 1: (0.001-0.01); the esterification reaction is carried out on the intermediate II and methacryloyl chloride under the catalytic action of an acid-binding agent triethyl diamine, the reaction temperature is-2 DEG C to 5 DEG C, and the molar ratio of the intermediate II to the methacryloyl chloride to the triethyl diamine is 1: (1.2-1.8): (2-3); the product purity reaches 99.80% or above, the total amount of metal impurities is lower than 70 ppb, the quality of the product is far higher than that of commercially available products, and the product meets the quality requirement of a resist raw material for photoresist.

The application provides a preparation of a composite carrier catalyst and application thereof, and comprises the following steps: S1, first ball milling of an active raw material, wherein a binder is added in the first ball milling process to obtain component A, and the catalyst carrier comprises alumina, cerium oxide and lanthanum oxide; a plurality of catalyst carriers are mixed and then subjected to second ball milling, wherein nitric acid solution is added in the second ball milling process to obtain component B, and component A and component B are mixed and subjected to third ball milling to obtain a mixture; S2, the mixture is subjected to kneading and granulation, and the granulated material is calcined to obtain a precursor; and S3, the precursor is subjected to reduction and passivation to obtain the composite carrier catalyst. The application loads the active raw material through a multi-stage ball milling process, and the loading amount of the active component of the obtained catalyst is far higher than that of the impregnation method, and meanwhile, the defects caused by the introduction of impurities due to the use of lye in the coprecipitation method are completely avoided, so that the advantages of high loading amount and high purity are combined, and the obtained catalyst has excellent activity and stability, and the process is green and environmentally friendly.