A method of producing an o-disubstituted aromatic compound, containing: continuously conducting at least the following steps (a) to (d):
(a) a step of mono-lithiating one halogen atom of an o-dihaloaromatic compound, using a first microreactor;
(b) a step of making the thus-obtained monolithiated product to react with an electrophilic compound, using a second microreactor, to obtain a monosubstituted-monohaloaromatic compound;
(c) a step of lithiating the other halogen atom of the o-dihaloaromatic compound, using a third microreactor; and
(d) a step of making the thus-obtained lithiated product successively to react with an electrophilic compound, using a forth microreactor.