The invention discloses a reaction treatment method of heliotropin intermediate 3,4- dioxymethylene
mandelic acid. The method comprises the following reaction treatment steps: firstly, adding
glyoxylic acid in a reaction kettle, adding 1,3-benzodioxole under stirring action, and cooling the
glyoxylic acid and 1,3-benzodioxole mixed liquid with brine ice; adding a catalyst, namely concentrated
sulfuric acid; then dripping a water-insoluble
inert solvent, namely
dichloromethane, into a head tank, carrying sampling detection on a reaction mixture, and stopping reaction when the content of 1,3-benzodioxole in the reaction mixture is not reduced any more; and finally, adding water into the reaction kettle, uniformly stirring, discharging and filtering by suction to obtain the
solid material, namely 3,4- dioxymethylene
mandelic acid. According to the reaction treatment method, the feeding sequence is regulated in the early stage to improve the
mixing effect and increase the
reaction speed, and the water-insoluble
inert solvent is added to dilute the reaction mixture, so that the stirring effect is not influenced, the reaction time is shortened, and the problem of hard stirring in the late reaction stage can be solved.