72 results about "Mandelic acid" patented technology

The invention belongs to the technical field of automatic control, and discloses a cyclopropylamine (R)-mandelate crystallization process feedback control method, which comprises the following steps: acquiring the concentration, solvent temperature, stirring speed and pH value of cyclopropylamine (R)-mandelate in a solvent in real time, and forming a state parameter set reflecting the real-time state of a cyclopropylamine (R)-mandelate crystallization system; based on the state parameter set, deriving a solute supersaturation degree change rate, a nucleation rate and a crystal growth rate by adopting an explicit kinetic relationship to obtain a kinetic feature set of the cyclopropylamine (R)-mandelate; collecting the grain size, the shape and the crystallization uniformity of the crystal, and constructing a corresponding crystal quality prediction function in combination with the kinetic feature set of the cyclopropylamine (R)-mandelate to obtain a predicted crystal quality index; comparing the actually detected crystal morphology index with the predicted crystal quality index, and calculating to obtain a deviation value; the crystal quality of the cyclopropylamine (R)-mandelate is improved.

The invention relates to an allergy-relieving acne-removing composition and a preparation method and application thereof, and the allergy-relieving acne-removing composition comprises the following raw materials in parts by mass: 1-10 parts of VB-IP, 5-20 parts of hydroxyethyl urea, 1-5 parts of coated salicylic acid, 2-10 parts of wild soybean, 1-5 parts of clerodendranthus spicatus, 1-5 parts of rosewood seeds, 1-10 parts of lactobionic acid, 1-10 parts of gluconolactone, 1-10 parts of mandelic acid, 1-10 parts of glycollic acid, 1-5 parts of octyl dodecyl glucoside and 1-5 parts of cetearyl glucoside. 0.5 to 2 parts of phenoxyethanol and 5 to 30 parts of deionized water; the composition comprises the following components: a wild soybean fermentation extract, a clerodendranthus spicatus fermentation extract and a rosewood seed fermentation extract. Compared with the prior art, the formula is stable, penetration can be promoted, cutin renewal can be accelerated, a sebum film can be repaired, sebum can be adjusted, and the acne removing and skin care effects are good.

The invention discloses a composition for relieving, repairing and promoting skin regeneration as well as a preparation method and application of the composition. The composition is prepared from the following raw materials in parts by weight: 0.1 to 5 parts of mandelic acid, 0.5 to 10 parts of a cynanchum atratum extract, 1 to 8 parts of a xylitol compound, 0.5 to 15 parts of regenerated silicon, 1 to 10 parts of a starfish regeneration repair factor, 0.3 to 1.5 parts of trimethylolpropane tri (3-mercaptopropionic acid) ester, 0.05 to 0.5 part of calcium chloride, 0.1 to 1 part of an additive, 0.2 to 2 parts of chitosan-polycaprolactone, 0.2 to 1 part of a pH regulator and 5 to 15 parts of a solvent. 0.3 to 0.8 part of an antioxidant and 3 to 10 parts of a humectant; the additive is hyaluronic acid or formylated hyaluronic acid. Through a multi-channel synergistic effect, the effects of relieving, repairing and promoting skin regeneration are improved.

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to clofazimine-organic acid co-crystals, a preparation method and application thereof. The clofazimine-organic acid co-crystal is one of clofazimine-ferulic acid monohydrate co-crystal, clofazimine-ferulic acid co-crystal, clofazimine-glutaric acid co-crystal, clofazimine-glycolic acid co-crystal (CFZ-GA 1:1), clofazimine-glycolic acid co-crystal (CFZ-GA 1:1.5), clofazimine-salicylic acid co-crystal, clofazimine-L-aspartic acid co-crystal, clofazimine-L-pyroglutamic acid co-crystal, clofazimine-gallic acid co-crystal, clofazimine-succinic acid co-crystal, clofazimine-tartaric acid co-crystal and clofazimine-DL-mandelic acid co-crystal. The clofazimine-organic acid co-crystal provided by the application significantly improves the solubility and fluidity of clofazimine, thereby improving the bioavailability of clofazimine, and has a broad medicinal prospect.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a melogabalin-S-mandelic acid crystal form and a preparation method thereof. According to the crystal form, a basic structural unit is composed of one molecule of melogabalin and one molecule of S-mandelic acid, the solubility and storage stability of melogabalin are improved, the impurity content is reduced, the product quality is improved, meanwhile, the preparation method is simple, convenient and easy to operate, and the crystal form has a good application prospect in industrial production.

The invention provides a cosmetic composition and a preparation method thereof. In particular, the cosmetic composition comprises: a linear saturated dicarboxylic acid having 4 to 10 carbon atoms; mandelic acid or a derivative thereof; and polyaspartic acid or a derivative thereof. The cosmetic composition according to the technical scheme of the invention contains higher content of straight-chain saturated dicarboxylic acid with 4-10 carbon atoms, and has excellent cutin removal and acne inhibition effects when azelaic acid is used as the straight-chain saturated dicarboxylic acid with 4-10 carbon atoms.

The present invention discloses the construction and application of a recombinant Gluconobacter oxydans, belonging to the fields of genetic engineering and whole-cell catalysis. The present invention heterologously expresses an epoxide hydrolase from Sphingomonas in Gluconobacter oxydans, and simultaneously utilizes the alcohol and aldehyde dehydrogenases bound to the membrane of Gluconobacter oxydans itself to synthesize R-mandelic acid in a one-step process using styrene oxide as a substrate. The present invention combines the transcriptome data of Gluconobacter oxydans, screens 7 strong promoters using green fluorescent protein as a reporter gene, and determines the strongest promoter P for expressing the epoxide hydrolase gene. 12780 , ultimately significantly increasing the yield of R-mandelic acid.

The preparation of high-value-added aromatic carboxylic acids via CO2 carboxylation coupling through activation of the benzyl C-H bond in alcohols / amines is a green and sustainable pathway to achieve CO2 resource utilization and contribute to carbon neutrality. However, this field currently faces challenges such as poor catalyst selectivity, low CO2 activation efficiency, and a narrow substrate applicability range, making it difficult to meet practical application needs. To address this issue, this patent discovers that in a heterogeneous electrocatalytic system, cuprous selenide (V2), rich in selenium vacancies, can be used... Se -Cu 2‑x Using Se as the core catalyst, it can not only efficiently promote the synergistic activation of benzyl C-H bonds and CO2 carboxylation, significantly improving the overall catalytic activity of the reaction, but also achieve precise chemoselective carboxylation control for different types of substrates. Specifically, this V Se -Cu 2‑x Se electrocatalysts can efficiently and selectively activate the benzyl C-H bond in alcohols and subsequently induce CO2 carboxylation, exhibiting excellent chemoselectivity in the conversion of benzyl alcohol to mandelic acid and its derivatives. Simultaneously, they also demonstrate excellent catalytic performance for amines, selectively catalyzing the carboxylation of amine substrates such as benzylamine with CO2 to directionally generate phenylglycine and aromatic amine-derived carboxylates. Crucially, in addition to typical benzyl alcohol and benzylamine, the substrate applicability of this catalytic system can be extended to various alcohols and amine derivatives, realizing the carboxylation transformation from simple model substrates to diverse functional molecules, providing a new approach for the large-scale preparation of high-value-added aromatic carboxylates.

The invention relates to the technical field of bioengineering bacteria. The invention provides a saccharomyces cerevisiae engineering bacterium capable of synthesizing p-anisaldehyde from the beginning and a construction method of the engineering bacterium. A saccharomyces cerevisiae recombinant strain JS1-15 is used as an original strain; the saccharomyces cerevisiae engineering bacteria are obtained by heterologous expression of 4-hydroxymandelic acid synthetase HmaS, heme oxygenase HMO, benzoyl formate decarboxylase BFD and methyltransferase 4VPMT1. The saccharomyces cerevisiae engineering bacteria are used for preparing the saccharomyces cerevisiae engineering bacteria. The saccharomyces cerevisiae engineering bacterium disclosed by the invention can realize a complete de novo biosynthesis path from 4-hydroxyphenylpyruvic acid to p-anisaldehyde by taking glucose as a unique carbon source, and has good industrial application potential.

The present invention belongs to the field of medicinal chemistry and relates to a triazine-thiazolidinone compound and its preparation method and application. Its structural formula is wherein R1 is any one of alkyl, pyranyl, indolyl, phenyl or thienyl. Its pharmaceutically acceptable salt is the acid salt of the compound, and the acid is any one of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, boric acid, methanesulfonic acid, p-toluenesulfonic acid, naphthalenesulfonic acid, benzenesulfonic acid, citric acid, lactic acid, pyruvic acid, tartaric acid, acetic acid, trifluoroacetic acid, maleic acid, succinic acid, mandelic acid, fumaric acid, salicylic acid or phenylacetic acid. The triazine-thiazolidinone compound skeleton provided by the present invention is novel, has a good inhibitory effect on glucose transporter 1 (GLUT1), and its inhibitory effect in HT29 cells is much better than that of positive control compound BAY-876, with good potential for further development as an anti-tumor drug.

Disclosed herein are topical compositions comprising Centella asiatica extract and mandelic acid, wherein the compositions have a pH of less than 5, and methods of using the compositions to decrease cellular senescence in skin and treat dermatoporosis. Topical compositions comprising Centella asiatica extract and mandelic acid are effective to reduce the number of senescent cells in mammalian dermis, reduce the senescence-associated secretory phenotype (SASP), downregulate at least one SASP-associated gene, increase the expression of at least one cell cycle-related gene in dermal fibroblasts, downregulate at least one gene associated with skin inflammation, and increase fibroblast cell turnover.

The invention discloses a bio-based nonionic dispersant and a preparation method thereof, and belongs to the field of chemical engineering. According to the preparation method, mandelic acid and fatty alcohol which are biologically sourced are adopted as raw materials, bio-based mandelic acid ester containing a mandelic acid structure is obtained through a simple esterification reaction, then the bio-based mandelic acid ester and ethylene oxide are subjected to a ring-opening polymerization reaction, and the bio-based dispersing agent with a novel structure is obtained. And pigment color paste prepared by using the polycarboxylate superplasticizer as a dispersing agent has the characteristics of small pigment particle size, narrow distribution and good stability, and the polycarboxylate superplasticizer is low in price, easy to obtain, low in potential toxicity and biodegradable.

The invention provides atomoxetine hydrochloride and a preparation method thereof, and relates to the technical field of medicinal chemistry and organic synthesis. The method provided by the invention comprises the following steps: adopting acetophenone, methylamine hydrochloride and a formaldehyde aqueous solution as raw materials, carrying out Mannich reaction to construct a beta-amino carbonyl skeleton, reducing carbonyl into hydroxyl by adopting sodium borohydride, then reacting with di-tert-butyl dicarbonate to form an amino protecting group, adopting o-methylphenol as a raw material, and preparing the beta-amino carbonyl skeleton. The method comprises the following steps: adding p-toluenesulfonic acid monohydrate and a (2-hydroxybenzyl) phosphine oxide catalyst to construct an ether bond through a Mitsunobu reaction, then removing a t-butyloxycarboryl protecting group, and carrying out chiral resolution and salinization reaction by using S-mandelic acid to obtain atomoxetine hydrochloride. The method of dropwise adding the formaldehyde aqueous solution in batches and controlling the reaction temperature is adopted, so that the generation of impurities can be reduced, and the yield is effectively improved; the p-toluenesulfonic acid monohydrate and the (2-hydroxybenzyl) phosphine oxide catalyst capable of participating in catalytic circulation are used for catalyzing the Mitsunobu reaction, the economic principle is met, and the purity and the yield of the product are greatly improved.

Methods and compositions suitable for treating acne, disrupting biofilms, and / or killing bacteria contained in biofilms are provided. [Solution] A particular method involves contacting skin requiring such treatment with a composition comprising two α-hydroxy acids and a polyhydroxy acid. Another particular method involves applying a composition comprising a first α-hydroxy acid, a second α-hydroxy acid, and a polyhydroxy acid to a surface having a biofilm. A particular composition is a. Glycolic acid in an amount of approximately 0.1% to 7.5% by weight, b. Approximately 0.1% to 5% by weight of gluconolactone, c. Approximately 0.1% to 5% by weight of mandelic acid, d. Glycol and, e. Salt-resistant thickening polymer, It contains, and the total amount of glycolic acid, gluconolactone, and mandelic acid is less than about 15% by weight of the total composition.

The invention relates to the technical field of oilfield chemistry, in particular to an environment-friendly biological blocking remover for oil extraction and a processing technology of the environment-friendly biological blocking remover. The environment-friendly biological blocking remover is prepared from the following components in percentage by weight: 4 to 6 percent of alkyl glycoside, 4 to 6 percent of sophorolipid, 3 to 5 percent of methylglycine diacetic acid, 5 to 8 percent of rhamnolipid, 6 to 8 percent of compound microorganism fermentation liquor, 5 to 8 percent of lipase, 5 to 8 percent of protease, 6 to 8 percent of polymer degrading enzyme, 2 to 4 percent of citric acid, 2 to 4 percent of mandelic acid, 1 to 2 percent of glycerol, 1 to 2 percent of trehalose and 31 to 57 percent of deionized water. The biological enzyme, the biological surfactant, the organic acid and the chelating agent cooperate to fundamentally disintegrate blockages, meanwhile, the microcapsule technology and the nano-bubble technology are used, the action period is greatly prolonged, blockages of deeper parts can be treated, and the treatment effect is good. And corrosion and damage of strong acid and strong alkali to underground pipe columns, tools and stratum rocks are avoided, and secondary damage caused by plug removal operation is prevented.

The invention discloses a nitrilase mutant with high activity and stereoselectivity and application of the nitrilase mutant in synthesis of chiral carboxylic acid. The mutant is obtained by performing single mutation or multiple mutation on 79th, 166th, 167th and 246th amino acids of an amino acid sequence shown as SEQ ID NO.1. The invention further discloses a preparation method of the nitrilase mutant. According to the invention, the nitrilase OsNIT-mut is subjected to molecular modification through (semi) rational design, and a mutant with synergistically improved hydrolysis reaction specificity and stereoselectivity is obtained. The content of mandelic acid in a product of the mutant OsNIT-mut / V246N / T166G / R79Y / A167N for catalyzing mandelonitrile is 90.5%, the e.e. Value of R-mandelic acid is increased to 95.2%, and the relative hydrolytic activity is 399.1%. The nitrilase mutant can be applied to green industrial catalytic synthesis of chiral mandelic acid through regulation and control of hydrolysis reaction specificity and stereoselectivity, and has important significance.

The invention relates to the technical field of cosmetics, in particular to a preparation method of a supramolecular oleic acid control enzyme composition and application of the supramolecular oleic acid control enzyme composition in cosmetics. The invention relates to a preparation method of a supramolecular controlled oleic enzyme composition. The preparation method comprises the following steps: preparation of a supramolecular NaDES solvent: carrying out a reaction on mandelic acid, betaine and capryloyl glycine to obtain the supramolecular NaDES solvent; preparation of a supramolecular acid enzyme composition: reacting the papain and bromelain compound with a supramolecular NaDES solvent to obtain the supramolecular acid enzyme composition; mandelic acid, betaine and capryloyl glycine are prepared into a supramolecular deep eutectic solvent and a protease compound, and the protease compound is immobilized in the supramolecular deep eutectic solvent, so that the method has the characteristics of simplicity in operation, good solubility, good stability and the like; the finally obtained supramolecular oleate-controlling enzyme composition can realize the combination of acid, amino acid derivatives and enzyme, and achieves the effects of synergistically removing waste cutin and blocked pores of skin, controlling oil, quickly improving the texture and appearance of skin and promoting metabolism of skin.

The application discloses a preparation method of (2R, 5S)-4-Boc-2, 5-dimethyl piperazine. Trans-2, 5-dimethyl piperazine is used as raw material, reacts with di-tert-butyl dicarbonate to generate N-Boc-2, 5-dimethyl piperazine, then is subjected to splitting by L-(+)-mandelic acid to obtain (2R, 5S)-4-Boc-2, 5-dimethyl piperazine mandelic acid salt, and then is separated to obtain 2R, 5S)-4-Boc-2, 5-dimethyl piperazine. The raw material used in the application is cheap and easy to obtain, the reaction condition is mild, the operation is simple, the total reaction yield is high, and the application is suitable for industrial production.

The present invention provides a method for preparing enantiopure α-methoxyphenylacetic acid. The method comprises: using (R / S)-mandelic acid as the main raw material, performing an O-alkylation reaction with a methylating agent in the presence of an alkaline reagent, followed by purification and dissociation using an organic base to obtain enantiopure α-methoxyphenylacetic acid with a purity of up to 99.0%. The method achieves a maximum yield of 88.6% in an aprotic mixed solvent. This process reduces the amount of methylating agent used and increases the conversion rate to 99.5%. The organic base salt formation purification is efficient, produces a good crystal form, and is easily filtered. The process is simple, highly safe, and suitable for industrial-scale production.

The invention discloses a chitosan / sodium carboxymethyl cellulose / calcium ion antibacterial composite hydrogel self-supporting membrane as well as a preparation method and application thereof. The composite hydrogel membrane takes nano-hydroxyapatite as a multifunctional calcium source and an adsorption enhancing component, and chitosan and sodium carboxymethyl cellulose are crosslinked through mandelic acid steam to form a dual-network matrix. The hydrogel film prepared by the method has the advantages of large metal ion adsorption capacity, excellent antibacterial property, good mechanical property and the like, and can realize the targets of high-efficiency removal of heavy metal ions in industrial wastewater and low-consumption pollution degradation.

This invention provides a method for producing safinamide and its salts that have high optical purity with reduced enantiomerity. [Solution] A method for producing a salt of safinamide having high optical purity is provided, by contacting a mixture containing safinamide and its enantiomers with an acid selected from the group consisting of L-tartaric acid, L-glutamic acid, and D-mandelic acid in a reaction solvent.

The invention relates to the technical field of cosmetics, and particularly discloses a plant extract nourishing makeup removal wet tissue and a preparation method thereof, the plant extract nourishing makeup removal wet tissue comprises the following raw materials by weight: 15-20 parts of an efficient cleaning component, 2-3 parts of a water locking and moisturizing component, 4-8 parts of a plant extract active component, 0.08-0.16 part of a stabilizer, and 84-92 parts of deionized water; the invention starts from two aspects: firstly, the essential oil, the mandelic acid and the glycyrrhizin are compounded; through the synergistic effect of the three components, the trouble that traditional cleansing oil needs to be emulsified is avoided, and the problem that common cleansing water is poor in cleansing power, so that cleaning is not thorough or skin is damaged due to repeated wiping is solved; 2, compounding a cactus extracting solution, an olive leaf extract, a soapberry bark extract and a synergistic surfactant, and performing enzymolysis and fermentation to obtain a plant extraction active component; through the synergistic effect of the multiple components, the dry and tight feeling after makeup removal is reduced, skin irritation is relieved, and meanwhile the antibacterial performance of the makeup removal wet tissue is improved.

The invention relates to the technical field of high polymer materials, in particular to a one-step sequence-controlled hydroxy acid block copolyester preparation method, which comprises: carrying out amine catalysis on mandelic acid and bromoacetyl bromide in acetonitrile to form ester, cyclizing with sodium bicarbonate in N, N-dimethylformamide, and recrystallizing to obtain PDD; the preparation method comprises the following steps: carrying out Mannich reaction on 2, 4-di-tert-butylphenol to obtain a ligand H3L, complexing the ligand H3L with zirconium alkoxide, and carrying out methyl lactate treatment to obtain [ONOO]-Zr; pDD and epsilon-caprolactone are heated and polymerized in the presence of a [ONOO]-Zr catalyst, benzoic acid is terminated, and precipitation and purification are performed to obtain sequence-controlled block copolyester P (PDD-b-CL). Compared with other sequence-controlled block copolymer synthesis methods, the one-step sequence-controlled hydroxy acid block copolyester preparation method provided by the invention has the advantages of mild reaction conditions and simplicity and convenience in operation.

The invention relates to the technical field of biological extraction, and particularly discloses a method for extracting active polypeptides from freshwater fish, which comprises the following steps: taking fresh freshwater fish bones, cleaning and homogenizing; deionized water containing mandelic acid is added into the homogenate according to the solid-to-liquid ratio of (3-5): 1, the deionized water contains 0.1-0.3 wt% of a mixture of D-mandelic acid and L-mandelic acid, and the weight ratio of the D-mandelic acid to the L-mandelic acid is (52-58): (0.3-0.7); stirring the mixed solution at a constant temperature of 47-52 DEG C, adjusting the pH value to 6.7-7.0, adding a compound enzyme preparation, and carrying out enzymolysis for 4-6 hours; nitrogen is introduced every 20-30 min in the enzymolysis process, and the introduction amount is 15-25 g / h; after enzymolysis is finished, heating enzymatic hydrolysate to 92-95 DEG C, maintaining enzyme deactivation for 8-12 min, adjusting the pH to be neutral, centrifuging for 10-15 min at the temperature of 4-10 DEG C and the speed of 7000-8000 r / min, and taking supernate to obtain active polypeptide; nitrogen is periodically introduced in the enzymolysis process to directionally activate phenolic hydroxyl groups of aromatic amino acids in freshwater fish active polypeptides, so that the phenolic hydroxyl groups become efficient electron donors, and the in-vitro oxidation resistance of the polypeptides is enhanced.

Personal care compositions comprising: from about 7 wt.% to about 12 wt.% lactic acid; from about 8 wt.% to about 20 wt.% glycolic acid; optionally, from about 4 wt.% to about 10 wt.% mandelic acid optionally gluconolactone; optionally salicylic acid; and a cosmetically acceptable carrier are described herein. Methods of making and using these compositions are also described.

The invention discloses a method for rapidly and simultaneously detecting catecholamine substances and creatinine in urine, relates to the technical field of clinical content and concentration analysis and detection of nerve substances, and adopts LC-MS / MS (liquid chromatography-mass spectrometry / mass spectrometry) to perform system integration development of multiple indexes. Seven items, including dopamine, epinephrine, noradrenaline, alphinephrine, noradrenaline, homovanillic acid and vanillic mandelic acid, of urine catecholamine and metabolites are developed and used for detecting pheochromocytoma and paraganglioma; the seven items include the dopamine, the epinephrine, the noradrenaline, the alphinephrine, the homovanillic acid and the vanillic mandelic acid; seven indexes can be detected at a time, the kit can be used for detecting random urine, great convenience is brought to patients, meanwhile, the seven indexes are analyzed together, and specificity and sensitivity of PPGL detection are improved; random urine detection needs the ratio of seven indexes to creatinine, creatinine in urine is often used as an internal reference and is used for concentration correction when substances in urine are excreted, the concentration of catecholamine and catecholamine metabolites in urine is corrected according to the content of creatinine in urine, and the influence of renal functions and drinking water factors on results is reduced.

Disclosed herein are topical compositions comprising an extract of centella asiatica and mandelic acid, where the pH of the composition is less than 5, and methods of using the compositions to reduce cellular senescence in the skin and to treat cutis laxa. A topical composition comprising a centella asiatica extract and mandelic acid is effective in reducing the number of senescent cells in mammalian dermis, reducing senescence-related secretory phenotypes (SASP), down-regulating at least one SASP-related gene, increasing expression of at least one cell cycle-related gene in dermal fibroblasts, and reducing the number of senescent cells in mammalian dermis. At least one gene associated with skin inflammation is down-regulated and the fibroblast turnover rate is increased.

The invention relates to a composite gel composition with synergistic blackhead removal and barrier repair functions. The composite gel composition comprises the following components: 1-2 parts of mandelic acid; 2-3 parts of tea tree essential oil; and 3-5 parts of carboxymethyl yeast glucan, wherein the substitution degree of the carboxymethyl yeast glucan is 65-70%. The mandelic acid is used for dissolving the blackheads, the tea tree essential oil is used for resisting bacteria and inflammation, the carboxymethyl yeast glucan, the purslane extract and the D-panthenol are used for synergistically promoting barrier repair, a'clearing-anti-inflammatory repair 'closed loop is formed, and the problem that the mandelic acid permeates and dissolves the blackheads is solved; the tea tree essential oil is antibacterial and anti-inflammatory; the carboxymethyl yeast glucan and the purslane extract synergistically resist inflammation, relieve and promote repair.

The invention discloses a preparation method of crocodile skin collagen peptide and application of a composition of the crocodile skin collagen peptide in antisepsis, anti-inflammation and skin repair. The crocodile skin collagen peptide provided by the invention is composed of 17 peptide fragments with the molecular weight of 700-1800 Da. The composition obtained by compounding crocodile skin collagen peptide, mandelic acid, lactobionic acid, asiaticoside and nicotinamide has multiple functions of antisepsis, anti-inflammation, skin repair and the like through multi-target point synergism, and the crocodile skin collagen peptide dominates oxidation resistance and skin repair and delays skin aging; mandelic acid is used for mildly conditioning cutin, effectively dredging pores and inhibiting growth and reproduction of acne-related flora; lactobionic acid promotes epidermis renewal, makes the skin moist and delicate, and reduces fine wrinkles; the asiaticoside is used for relieving, diminishing inflammation and relieving irritation reactions such as skin redness and swelling; nicotinamide can regulate sebum secretion, block melanin migration and brighten the skin color. The composition can effectively deal with acnes and complications, and solves the problems that an existing product is high in irritation, easy to leave marks and the like.

Disclosed herein are topical compositions comprising Centella asiatica extract and mandelic acid, wherein the compositions have a pH of less than 5, and methods of using the compositions to decrease cellular senescence in skin and treat dermatoporosis. Topical compositions comprising Centella asiatica extract and mandelic acid are effective to reduce the number of senescent cells in mammalian dermis, reduce the senescence-associated secretory phenotype (SASP), downregulate at least one SASP-associated gene, increase the expression of at least one cell cycle-related gene in dermal fibroblasts, downregulate at least one gene associated with skin inflammation, and increase fibroblast cell turnover.