42 results about "Mandelic acid" patented technology

The invention belongs to the technical field of automatic control, and discloses a cyclopropylamine (R)-mandelate crystallization process feedback control method, which comprises the following steps: acquiring the concentration, solvent temperature, stirring speed and pH value of cyclopropylamine (R)-mandelate in a solvent in real time, and forming a state parameter set reflecting the real-time state of a cyclopropylamine (R)-mandelate crystallization system; based on the state parameter set, deriving a solute supersaturation degree change rate, a nucleation rate and a crystal growth rate by adopting an explicit kinetic relationship to obtain a kinetic feature set of the cyclopropylamine (R)-mandelate; collecting the grain size, the shape and the crystallization uniformity of the crystal, and constructing a corresponding crystal quality prediction function in combination with the kinetic feature set of the cyclopropylamine (R)-mandelate to obtain a predicted crystal quality index; comparing the actually detected crystal morphology index with the predicted crystal quality index, and calculating to obtain a deviation value; the crystal quality of the cyclopropylamine (R)-mandelate is improved.

The invention discloses a composition for relieving, repairing and promoting skin regeneration as well as a preparation method and application of the composition. The composition is prepared from the following raw materials in parts by weight: 0.1 to 5 parts of mandelic acid, 0.5 to 10 parts of a cynanchum atratum extract, 1 to 8 parts of a xylitol compound, 0.5 to 15 parts of regenerated silicon, 1 to 10 parts of a starfish regeneration repair factor, 0.3 to 1.5 parts of trimethylolpropane tri (3-mercaptopropionic acid) ester, 0.05 to 0.5 part of calcium chloride, 0.1 to 1 part of an additive, 0.2 to 2 parts of chitosan-polycaprolactone, 0.2 to 1 part of a pH regulator and 5 to 15 parts of a solvent. 0.3 to 0.8 part of an antioxidant and 3 to 10 parts of a humectant; the additive is hyaluronic acid or formylated hyaluronic acid. Through a multi-channel synergistic effect, the effects of relieving, repairing and promoting skin regeneration are improved.

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to clofazimine-organic acid co-crystals, a preparation method and application thereof. The clofazimine-organic acid co-crystal is one of clofazimine-ferulic acid monohydrate co-crystal, clofazimine-ferulic acid co-crystal, clofazimine-glutaric acid co-crystal, clofazimine-glycolic acid co-crystal (CFZ-GA 1:1), clofazimine-glycolic acid co-crystal (CFZ-GA 1:1.5), clofazimine-salicylic acid co-crystal, clofazimine-L-aspartic acid co-crystal, clofazimine-L-pyroglutamic acid co-crystal, clofazimine-gallic acid co-crystal, clofazimine-succinic acid co-crystal, clofazimine-tartaric acid co-crystal and clofazimine-DL-mandelic acid co-crystal. The clofazimine-organic acid co-crystal provided by the application significantly improves the solubility and fluidity of clofazimine, thereby improving the bioavailability of clofazimine, and has a broad medicinal prospect.

The invention provides a cosmetic composition and a preparation method thereof. In particular, the cosmetic composition comprises: a linear saturated dicarboxylic acid having 4 to 10 carbon atoms; mandelic acid or a derivative thereof; and polyaspartic acid or a derivative thereof. The cosmetic composition according to the technical scheme of the invention contains higher content of straight-chain saturated dicarboxylic acid with 4-10 carbon atoms, and has excellent cutin removal and acne inhibition effects when azelaic acid is used as the straight-chain saturated dicarboxylic acid with 4-10 carbon atoms.

The preparation of high-value-added aromatic carboxylic acids via CO2 carboxylation coupling through activation of the benzyl C-H bond in alcohols / amines is a green and sustainable pathway to achieve CO2 resource utilization and contribute to carbon neutrality. However, this field currently faces challenges such as poor catalyst selectivity, low CO2 activation efficiency, and a narrow substrate applicability range, making it difficult to meet practical application needs. To address this issue, this patent discovers that in a heterogeneous electrocatalytic system, cuprous selenide (V2), rich in selenium vacancies, can be used... Se -Cu 2‑x Using Se as the core catalyst, it can not only efficiently promote the synergistic activation of benzyl C-H bonds and CO2 carboxylation, significantly improving the overall catalytic activity of the reaction, but also achieve precise chemoselective carboxylation control for different types of substrates. Specifically, this V Se -Cu 2‑x Se electrocatalysts can efficiently and selectively activate the benzyl C-H bond in alcohols and subsequently induce CO2 carboxylation, exhibiting excellent chemoselectivity in the conversion of benzyl alcohol to mandelic acid and its derivatives. Simultaneously, they also demonstrate excellent catalytic performance for amines, selectively catalyzing the carboxylation of amine substrates such as benzylamine with CO2 to directionally generate phenylglycine and aromatic amine-derived carboxylates. Crucially, in addition to typical benzyl alcohol and benzylamine, the substrate applicability of this catalytic system can be extended to various alcohols and amine derivatives, realizing the carboxylation transformation from simple model substrates to diverse functional molecules, providing a new approach for the large-scale preparation of high-value-added aromatic carboxylates.

The invention relates to the technical field of bioengineering bacteria. The invention provides a saccharomyces cerevisiae engineering bacterium capable of synthesizing p-anisaldehyde from the beginning and a construction method of the engineering bacterium. A saccharomyces cerevisiae recombinant strain JS1-15 is used as an original strain; the saccharomyces cerevisiae engineering bacteria are obtained by heterologous expression of 4-hydroxymandelic acid synthetase HmaS, heme oxygenase HMO, benzoyl formate decarboxylase BFD and methyltransferase 4VPMT1. The saccharomyces cerevisiae engineering bacteria are used for preparing the saccharomyces cerevisiae engineering bacteria. The saccharomyces cerevisiae engineering bacterium disclosed by the invention can realize a complete de novo biosynthesis path from 4-hydroxyphenylpyruvic acid to p-anisaldehyde by taking glucose as a unique carbon source, and has good industrial application potential.

Disclosed herein are topical compositions comprising Centella asiatica extract and mandelic acid, wherein the compositions have a pH of less than 5, and methods of using the compositions to decrease cellular senescence in skin and treat dermatoporosis. Topical compositions comprising Centella asiatica extract and mandelic acid are effective to reduce the number of senescent cells in mammalian dermis, reduce the senescence-associated secretory phenotype (SASP), downregulate at least one SASP-associated gene, increase the expression of at least one cell cycle-related gene in dermal fibroblasts, downregulate at least one gene associated with skin inflammation, and increase fibroblast cell turnover.

The invention discloses a bio-based nonionic dispersant and a preparation method thereof, and belongs to the field of chemical engineering. According to the preparation method, mandelic acid and fatty alcohol which are biologically sourced are adopted as raw materials, bio-based mandelic acid ester containing a mandelic acid structure is obtained through a simple esterification reaction, then the bio-based mandelic acid ester and ethylene oxide are subjected to a ring-opening polymerization reaction, and the bio-based dispersing agent with a novel structure is obtained. And pigment color paste prepared by using the polycarboxylate superplasticizer as a dispersing agent has the characteristics of small pigment particle size, narrow distribution and good stability, and the polycarboxylate superplasticizer is low in price, easy to obtain, low in potential toxicity and biodegradable.

Methods and compositions suitable for treating acne, disrupting biofilms, and / or killing bacteria contained in biofilms are provided. [Solution] A particular method involves contacting skin requiring such treatment with a composition comprising two α-hydroxy acids and a polyhydroxy acid. Another particular method involves applying a composition comprising a first α-hydroxy acid, a second α-hydroxy acid, and a polyhydroxy acid to a surface having a biofilm. A particular composition is a. Glycolic acid in an amount of approximately 0.1% to 7.5% by weight, b. Approximately 0.1% to 5% by weight of gluconolactone, c. Approximately 0.1% to 5% by weight of mandelic acid, d. Glycol and, e. Salt-resistant thickening polymer, It contains, and the total amount of glycolic acid, gluconolactone, and mandelic acid is less than about 15% by weight of the total composition.

The invention relates to the technical field of oilfield chemistry, in particular to an environment-friendly biological blocking remover for oil extraction and a processing technology of the environment-friendly biological blocking remover. The environment-friendly biological blocking remover is prepared from the following components in percentage by weight: 4 to 6 percent of alkyl glycoside, 4 to 6 percent of sophorolipid, 3 to 5 percent of methylglycine diacetic acid, 5 to 8 percent of rhamnolipid, 6 to 8 percent of compound microorganism fermentation liquor, 5 to 8 percent of lipase, 5 to 8 percent of protease, 6 to 8 percent of polymer degrading enzyme, 2 to 4 percent of citric acid, 2 to 4 percent of mandelic acid, 1 to 2 percent of glycerol, 1 to 2 percent of trehalose and 31 to 57 percent of deionized water. The biological enzyme, the biological surfactant, the organic acid and the chelating agent cooperate to fundamentally disintegrate blockages, meanwhile, the microcapsule technology and the nano-bubble technology are used, the action period is greatly prolonged, blockages of deeper parts can be treated, and the treatment effect is good. And corrosion and damage of strong acid and strong alkali to underground pipe columns, tools and stratum rocks are avoided, and secondary damage caused by plug removal operation is prevented.

The invention relates to the technical field of cosmetics, in particular to a preparation method of a supramolecular oleic acid control enzyme composition and application of the supramolecular oleic acid control enzyme composition in cosmetics. The invention relates to a preparation method of a supramolecular controlled oleic enzyme composition. The preparation method comprises the following steps: preparation of a supramolecular NaDES solvent: carrying out a reaction on mandelic acid, betaine and capryloyl glycine to obtain the supramolecular NaDES solvent; preparation of a supramolecular acid enzyme composition: reacting the papain and bromelain compound with a supramolecular NaDES solvent to obtain the supramolecular acid enzyme composition; mandelic acid, betaine and capryloyl glycine are prepared into a supramolecular deep eutectic solvent and a protease compound, and the protease compound is immobilized in the supramolecular deep eutectic solvent, so that the method has the characteristics of simplicity in operation, good solubility, good stability and the like; the finally obtained supramolecular oleate-controlling enzyme composition can realize the combination of acid, amino acid derivatives and enzyme, and achieves the effects of synergistically removing waste cutin and blocked pores of skin, controlling oil, quickly improving the texture and appearance of skin and promoting metabolism of skin.

The application discloses a preparation method of (2R, 5S)-4-Boc-2, 5-dimethyl piperazine. Trans-2, 5-dimethyl piperazine is used as raw material, reacts with di-tert-butyl dicarbonate to generate N-Boc-2, 5-dimethyl piperazine, then is subjected to splitting by L-(+)-mandelic acid to obtain (2R, 5S)-4-Boc-2, 5-dimethyl piperazine mandelic acid salt, and then is separated to obtain 2R, 5S)-4-Boc-2, 5-dimethyl piperazine. The raw material used in the application is cheap and easy to obtain, the reaction condition is mild, the operation is simple, the total reaction yield is high, and the application is suitable for industrial production.

The invention discloses a chitosan / sodium carboxymethyl cellulose / calcium ion antibacterial composite hydrogel self-supporting membrane as well as a preparation method and application thereof. The composite hydrogel membrane takes nano-hydroxyapatite as a multifunctional calcium source and an adsorption enhancing component, and chitosan and sodium carboxymethyl cellulose are crosslinked through mandelic acid steam to form a dual-network matrix. The hydrogel film prepared by the method has the advantages of large metal ion adsorption capacity, excellent antibacterial property, good mechanical property and the like, and can realize the targets of high-efficiency removal of heavy metal ions in industrial wastewater and low-consumption pollution degradation.

This invention provides a method for producing safinamide and its salts that have high optical purity with reduced enantiomerity. [Solution] A method for producing a salt of safinamide having high optical purity is provided, by contacting a mixture containing safinamide and its enantiomers with an acid selected from the group consisting of L-tartaric acid, L-glutamic acid, and D-mandelic acid in a reaction solvent.

The invention relates to the technical field of cosmetics, and particularly discloses a plant extract nourishing makeup removal wet tissue and a preparation method thereof, the plant extract nourishing makeup removal wet tissue comprises the following raw materials by weight: 15-20 parts of an efficient cleaning component, 2-3 parts of a water locking and moisturizing component, 4-8 parts of a plant extract active component, 0.08-0.16 part of a stabilizer, and 84-92 parts of deionized water; the invention starts from two aspects: firstly, the essential oil, the mandelic acid and the glycyrrhizin are compounded; through the synergistic effect of the three components, the trouble that traditional cleansing oil needs to be emulsified is avoided, and the problem that common cleansing water is poor in cleansing power, so that cleaning is not thorough or skin is damaged due to repeated wiping is solved; 2, compounding a cactus extracting solution, an olive leaf extract, a soapberry bark extract and a synergistic surfactant, and performing enzymolysis and fermentation to obtain a plant extraction active component; through the synergistic effect of the multiple components, the dry and tight feeling after makeup removal is reduced, skin irritation is relieved, and meanwhile the antibacterial performance of the makeup removal wet tissue is improved.

The invention relates to the technical field of high polymer materials, in particular to a one-step sequence-controlled hydroxy acid block copolyester preparation method, which comprises: carrying out amine catalysis on mandelic acid and bromoacetyl bromide in acetonitrile to form ester, cyclizing with sodium bicarbonate in N, N-dimethylformamide, and recrystallizing to obtain PDD; the preparation method comprises the following steps: carrying out Mannich reaction on 2, 4-di-tert-butylphenol to obtain a ligand H3L, complexing the ligand H3L with zirconium alkoxide, and carrying out methyl lactate treatment to obtain [ONOO]-Zr; pDD and epsilon-caprolactone are heated and polymerized in the presence of a [ONOO]-Zr catalyst, benzoic acid is terminated, and precipitation and purification are performed to obtain sequence-controlled block copolyester P (PDD-b-CL). Compared with other sequence-controlled block copolymer synthesis methods, the one-step sequence-controlled hydroxy acid block copolyester preparation method provided by the invention has the advantages of mild reaction conditions and simplicity and convenience in operation.

The invention relates to a composite gel composition with synergistic blackhead removal and barrier repair functions. The composite gel composition comprises the following components: 1-2 parts of mandelic acid; 2-3 parts of tea tree essential oil; and 3-5 parts of carboxymethyl yeast glucan, wherein the substitution degree of the carboxymethyl yeast glucan is 65-70%. The mandelic acid is used for dissolving the blackheads, the tea tree essential oil is used for resisting bacteria and inflammation, the carboxymethyl yeast glucan, the purslane extract and the D-panthenol are used for synergistically promoting barrier repair, a'clearing-anti-inflammatory repair 'closed loop is formed, and the problem that the mandelic acid permeates and dissolves the blackheads is solved; the tea tree essential oil is antibacterial and anti-inflammatory; the carboxymethyl yeast glucan and the purslane extract synergistically resist inflammation, relieve and promote repair.

The invention discloses a preparation method of crocodile skin collagen peptide and application of a composition of the crocodile skin collagen peptide in antisepsis, anti-inflammation and skin repair. The crocodile skin collagen peptide provided by the invention is composed of 17 peptide fragments with the molecular weight of 700-1800 Da. The composition obtained by compounding crocodile skin collagen peptide, mandelic acid, lactobionic acid, asiaticoside and nicotinamide has multiple functions of antisepsis, anti-inflammation, skin repair and the like through multi-target point synergism, and the crocodile skin collagen peptide dominates oxidation resistance and skin repair and delays skin aging; mandelic acid is used for mildly conditioning cutin, effectively dredging pores and inhibiting growth and reproduction of acne-related flora; lactobionic acid promotes epidermis renewal, makes the skin moist and delicate, and reduces fine wrinkles; the asiaticoside is used for relieving, diminishing inflammation and relieving irritation reactions such as skin redness and swelling; nicotinamide can regulate sebum secretion, block melanin migration and brighten the skin color. The composition can effectively deal with acnes and complications, and solves the problems that an existing product is high in irritation, easy to leave marks and the like.

The present disclosure relates to fungicidal combinations and fungicidal compositions. The present disclosure provides a fungicidal combination and a fungicidal composition comprising fluazinam and at least a second fungicide selected from the group consisting of a mandelamide fungicide, a phthalimide fungicide, and a benzamide fungicide. The present disclosure also provides fungicidal combinations and fungicidal compositions for controlling or preventing resistant fungal diseases.

Disclosed herein are topical compositions comprising Centella asiatica (Centella asiatica) extract and mandelic acid, wherein the composition has a pH of less than 5, and methods of using the compositions to reduce cellular senescence in the skin and treat dermatoporosis. The topical composition comprising Centella asiatica extract and mandelic acid is effective in reducing the number of senescent cells in mammalian dermis, reducing the senescence-associated secretory phenotype (SASP), downregulating at least one SASP-related gene, increasing the expression of at least one cell cycle-related gene in dermal fibroblasts, downregulating at least one gene associated with skin inflammation, and increasing fibroblast turnover.

The invention discloses a method for extracting and removing a nitrogen-containing compound in fuel oil by using an acidic natural eutectic solvent. The method comprises the following steps: forming the acidic natural eutectic solvent from L-proline, mandelic acid and water, forming L-proline, ascorbic acid and water, and forming L-proline and glycollic acid / lactic acid; the method comprises the following steps: adding nitrogen-containing fuel oil and an acidic natural eutectic solvent into a reactor according to a certain mass ratio, and stirring at a certain temperature; standing and layering to obtain an upper-layer low-nitrogen oil product phase and a lower-layer nitrogen-rich eutectic solvent phase; and performing back extraction on the lower nitrogen-rich eutectic solvent phase to obtain a nitride-containing organic phase and a eutectic solvent phase, and performing reduced pressure distillation after liquid separation to obtain a nitrogen-containing compound and a regenerated eutectic solvent. The acidic natural eutectic solvent disclosed by the invention is simple in preparation process, easily available in raw materials, low in price, green and non-toxic, capable of efficiently removing alkaline and neutral nitrogen compounds in fuel oil at the same time, and excellent in cycle performance.

This invention relates to the preparation of high-purity levetiracetam (S)-2-(2-oxo-1-pyrrolidine)butyramide. The preparation of the high-purity levetiracetam begins with 2-(2-oxopyrrolidine-1-yl)butyric acid as the starting material. Through esterification and ammonolysis, a racemic levetiracetam is obtained, which is then resolved by R-mandelic acid to yield high-purity levetiracetam with a chiral content of over 99.9%, a chiral isomer content of less than 0.05%, and no chloride detected. The chiral isomer (R)-2-(2-oxo-1-pyrrolidine)butyramide recovered after resolution can be racemed and further resolved by R-mandelic acid for the preparation of levetiracetam, achieving a total yield of over 90%. The recovered R-mandelic acid can be reused repeatedly, significantly reducing the consumption of resolving agent. This reaction has a short procedure, is easy to operate, and has a stable yield, which significantly reduces the cost of preparing levetiracetam. In addition, it has a very high chiral content, making it suitable for large-scale industrial production.

The invention discloses a novel 2D chiral composite material utilizing in-situ polymerization and application thereof, by preparing interlayer ionic clay with lauryl sodium sulfate intercalation, and adopting an in-situ polymerization method, chiral molecules R-limonene and photoresponse molecules acrylonitrile are sequentially and alternately copolymerized in Mg-Al layered double hydroxide, so that the novel 2D chiral composite material utilizing in-situ polymerization is obtained. The novel 2D chiral composite material is prepared; lDH-S-C2 is combined with (R)-mandelic acid and (D)-ethyl lactate in a co-assembly mode to enhance fluorescence and precipitate, the purpose of visually recognizing the enantiomers is achieved for the first time, chiral signal transmission and amplification are achieved, after different metal ions are added into a DMF solution, recognition signals of LDH-S-C2 to the mandelic acid enantiomers are remarkably amplified, and especially when Ti < 4 + > is introduced, the recognition signals of LDH-S-C2 to the mandelic acid enantiomers are remarkably amplified. The fluorescence intensity of an assembly of LDH-S-C2 and (S)-mandelic acid is remarkably quenched, and is accompanied by an obvious macroscopic color change.

The present application belongs to the technical field of analytical chemistry, and particularly relates to a method for determining the content of hafnium in hafnium carbide. The method comprises the steps of sample weighing, high-temperature melting, dissolution and leaching, primary precipitation separation, precipitation dissolution, secondary precipitation separation and constant weight calculation, and uses mandelic acid as a secondary precipitant and a mixture of alkali salt and boric acid as a high-temperature flux. The method provided by the present application is simple in equipment, scientific, fast, reasonable and reliable in determination, and effectively fills the gap in the field of chemical composition detection of internal hafnium carbide materials.

The present application relates to a method for improving the yield of o-vanillin, and provides a novel metal ligand catalyst with the following structural formula: wherein M represents a transition metal such as iron, manganese, copper or chromium, and R represents H or methyl. The catalyst is introduced into a condensation reaction, which can greatly improve the ortho selectivity of mandelic acid, and further improve the yield of o-vanillin.

This invention discloses a chiral covalent organic framework composite membrane prepared by in-situ growth and its applications. This invention uses [NALC] as a reference. X -TAPB-DVA COF S As a functionalized material, a chiral covalent organic framework composite membrane was prepared by a secondary in-situ growth method using terephthalaldehyde (PAD) as the linker and 1,3,5-tris(4-aminophenyl)benzene (TAPB) as the nucleation site. This chiral covalent organic framework composite membrane can resolve enantiomers of mandelic acid, warfarin, naproxen, and ibuprofen, exhibiting a wide resolution range and stable resolution performance.

The invention belongs to the field of organic chemistry, and further relates to a method for recovering (R)-mandelic acid, which is characterized in that a solution containing (R)-sodium mandelate passes through activated cation exchange resin, and a solution flowing out in a certain pH range is collected. The (R)-mandelic acid is recovered in a continuous flowing manner, the resin can be recycled, and the material cost is low; collection of effluent is managed in an online pH value detection mode, operation is simple, automatic control can be achieved, and the labor cost is low. The recovered (R)-mandelic acid is high in quality and purity, few in impurities and high in recovery efficiency; the method is safe, environment-friendly, green and economical; the method has been successfully applied to recovery of 100 kg (R)-mandelic acid, and is suitable for industrial amplification; the application prospect is wide and the market potential is great.

The present invention relates to a mandelic acid addition salt of palmitoyl lysylvalyl-lysine and to cosmetic formulations containing said salt. Furthermore, the present invention relates to the use of mandelic acid for preparing a mandelic acid addition salt of palmitoyl lysylvalyl-lysine, which increases the storage stability of palmitoyl lysylvalyl-lysine.

The application discloses a method for improving the oxidation reaction activity of 3-methoxy-4-hydroxy mandelic acid reaction liquid. It is found for the first time that the benzene dimers and trimers exist in the oxidation reaction raw material. By controlling the content of the benzene dimers and trimers in the oxidation reaction raw material in the range of 100-500 ppm, the oxidation reaction selectivity is greater than or equal to 98%, and the yield of vanillin product can be effectively improved.

Provided are a supramolecular tranexamic acid-mandelic acid ionic salt as well as a preparation method therefor and a use thereof, relating to the technical field of pharmaceutical and cosmetic compounds. The supramolecular tranexamic acid-mandelic acid ionic salt has a structural formula as shown in formula I. Tranexamic acid and mandelic acid undergo reaction and bonding to form a supramolecular salt. The skin permeability of mandelic acid can be effectively improved and less irritation is caused to the skin while the efficacy of mandelic acid is well maintained.