47 results about "Cervical mucus" patented technology

The invention relates to a pathological examination, in particular to a liquid-based cell preservation solution used in cytopathological examination of human cervical mucus, sputum, urine, pleural fluid, tracheal mucus and the like. It is characterized in that it is prepared from alcohols, sodium phosphate buffer, edetate disodium, sodium chloride 0.08%-0.12%, potassium chloride, formaldehyde, dithiothreitol, calcium acetate, magnesium acetate, etc. As a result, it can not only maintain the stability of the cell structure. It can reduce the agglomeration and precipitation of cell mucus and the loss of cell rupture, and can also make cells easy to stain, improve the clarity of cell preparation, facilitate the smooth progress of pathological examination, and the cost is low, which is conducive to popularization and use.

The present invention provides methods, antibodies and kits useful for detecting the presence of a fetal cell and / or fetal nucleic acids in a biological sample obtained from a maternal host. It also provides methods and kits for isolating fetal nucleic acid from maternal cervical mucus samples, and for testing or screening the isolated fetal nucleic acid for genetic abnormalities in fetuses.

An embryo transfer catheter with a protective sheath is disclosed. The use of a protective sheath shields a guide catheter from cervical mucus. The retracted open flaps of the outer protective sheath draw the mucus and blood away from the inner guide catheter. This allows an inner embryo transfer sheath to enter the uterus unobstructed. The embryo is then transferred to the uterus by means of fluid pressure with a culture medium. The protective sheath may be snap fit onto the guide catheter. The sheaths and catheters may be manufactured in a variety of lengths for individual convenience and then snap-fit onto each other for better control during an embryo implantation procedure. Other catheters and related instruments may also be manufactured with snap-on features.

Antimicrobial and contraceptive compositions and methods which prevent and / or reduce the risk of transmission of sexually transmitted diseases through sexual activity as well as prevent and / or reduce the risk of pregnancy are provided. The compositions contain (1) a matrix-forming agent, (2) a bio-adhesive agent, (3) a buffering agent, (4) optionally a humectant, (5) optionally a preservative, and (6) water; wherein the composition is suitable for application within the vagina; wherein the compositions form a semisolid matrix on contact with ejaculate (thereby trapping ejaculated microbes and spermatozoa); wherein the composition causes hardening of cervical mucus (thereby decreasing the probability of sperm entry); wherein the composition forms a bio-adhesive layer over vaginal surfaces (thereby preventing or reducing the risk of contact of STD-causing microbes with the vaginal surfaces); wherein the composition maintains an acidic vaginal pH of less than about 5 in the presence of semen ejaculated from the male; and wherein the composition does not significantly impair the natural microbiological balance within the vagina. The antimicrobial and contraceptive compositions may also contain additional antimicrobial and / or contraceptive agents (e.g., nonoxynol-9, octoxynol-9, benzalkonium chloride, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H2SO4-modified mandelic acids, povidone iodine, itraconazole, ketoconazole, metronidazole, clotrimazole, fluconazole, teraconazole, miconazole, tinidazole, iconazole, chloramphenicol, nystatin, cyclopiroxolamine, and the like).

The present invention relates to pathological examination, especially to a liquid-based cell preservation solution used in pathologically examining cells such as human cervical mucus, sputum, urine, thoracic liquid, and tracheal mucus. The liquid-based cell preservation solution is characterized by being prepared from alcohols, a sodium phosphate buffer solution, disodium ethylenediamine tetraacetate, 0.08-0.12% sodium chloride, potassium chloride, formaldehyde, dithiothreitol, calcium acetate, magnesium acetate and the like. The cell preservation solution cannot only maintain the cell structure stability and reduce the agglomerated precipitation of the cell mucus and the cell breakage loss, but also enables the cells easily to be stained, improves the clarity of the cell sheets, and facilitates smooth performance of the examination work. Moreover, the cell preservation solution is low in cost and easy to promote and use.

A method and kit for enhancing the natural fertility process. The kit includes a vaginal douche that is used prior to intercourse to enhance the sperm transportation and sustaining properties of the cervical mucous. The douche contains a balanced electrolyte solution, polysaccharides, and pH buffers. The kit also includes nutriceuticals specifically formulated for both the male and female which include amino acids, minerals, vitamins, herbs, phytoestrogens, and antioxidants along with a specified dosing regimen. A basal body temperature thermometer and chart is provided with instructions to confirm when and if ovulation will / did occur. Commercially available urinary chemical reagent strips are provided with instructions so as to predict / confirm if and when ovulation will occur. A lubricating medium will also be provided and utilized at the time of intercourse which is nonspermicidal and which contains polysaccharides which influence natural sperm motility. A detailed instruction book regarding the method and practice is provided along with dietary and lifestyle recommendations which have been shown to affect natural fertility.

The present invention includes formulations comprising synthetic vaginal fluid, synthetic cervical mucus, and, a mixture of a synthetic cervical mucus and synthetic vaginal fluid suitable for mucosal administration of at least one therapeutic agent. The formulations of the invention are useful in the treatment, prevention and control of diseases and conditions in a subject in need thereof. The present invention also includes methods of administering the formulations. Also included are methods of using the formulations in the treatment, prevention and control of diseases or conditions affecting other mucus membranes, such as the nose, throat and gastrointestinal tract.

The invention discloses a solution for sperm detection. The solution for sperm detection of the invention comprises hyaluronic acid and L-carnitine, and can be used for sperm-cervical mucus penetration tests. Thereinto, the hyaluronic acid is used as a substitute of human cervical mucus, and L-carnitine can protect sperm motility. Based on conditions that patients with oligozoospermia / asthenospermia have less sperm numbers and low sperm motility, the invention is further improved, and a sperm detection solution for patients with oligozoospermia / asthenospermia is prepared. The sperm detection solution for patients with oligozoospermia / asthenospermia has high sensitivity, and a high concentration of L-carnitine, and the L-carnitine can increase the oxidative damage resistance of sperms and protect sperm motility.

The invention provides an immune colloidal gold test card for testing high-risk type human papillomavirus. A test strip thereof consists of a back lining, a sample pad, a combining pad, an NC membrane and a water-absorbing pad; the upper middle part of the back lining is provided with the NC membrane; the two ends of the NC membrane are respectively connected with the combining pad and water-absorbing pad in a neighboring way; the sample pad is arranged above the combining pad; a gold-labelled antibody G-Ab1 is sprayed on the combining pad; the coated gold-labelled antibody G-Ab1 is the monoclonal antibody of the high-risk type human papillomaviru virus HPV16; and the NC membrane is respectively sprayed with the polyclonal antibody Ab2 of the high-risk type human papillomaviru virus HPV16 and the antibody of the gold-labelled antibody, namely the IgG antibody of a rabbit antimouse. The invention applies the technology of immune colloidal gold into the quick testing of the high-risk type human papillomaviru virus; moreover, the test strip for quick testing the high-risk type human papillomaviru virus does not need a test device, thus being convenient for the application to the clinic quick diagnosis and suitable to hospitals of various grades to screen cervical carcinoma.

A process is provided for analyzing a specimen of biological material in any of a number of biochemical or immunological tests for an analyte which involves subjecting the specimen to treatment which develops a color correlating to the amount of analyte in the specimen. According to the invention at least one defined color characteristic selected from hue angle, chroma, saturation and lightness of the developed color is measured and the results of that measurement analyzed to determine the presence or concentration of the analyte in the specimen. Particular applications are to the detection of cancerous or pre-cancerous abnormalities from the analysis of lung mucus, throat mucus, cervical mucus or seminal fluid.

The present invention provides methods and kits useful for genetic testing or screening of fetuses using nucleic acid samples isolated from cervical mucus samples of fetus hosts.

The present invention is a composition for a synthetic mucus formulation with viscosity, spinnbarkeit, and pH comparable to that reported for human cervical mucus.

The invention discloses a sperm optimizing microflow control device which comprises a slide glass provided with a buffer liquid sampling pool, a sample detection pool and a sample collecting pool, and a support substrate for supporting the slide glass, wherein a buffer liquid connection channel is arranged between the buffer liquid sampling pool and the sample detection pool; a sample acting poolis arranged inside the sample detection pool; one or more screening channels are arranged between the sample detection pool and the sample acting pool, and at least one screening channel is arranged at one side on which the sample detection pool and the sample collecting pool are connected; and a sample collecting channel is arranged between the sample detection pool and the sample collecting pool. The invention also discloses a sperm optimizing method. According to the invention, sperms having high motility and high linear motion speed are naturally screened through simulating physiological state of interaction between semen and cervix uteri mucus in the sample acting pool and utilizing the glutinousness of the cervix uteri mucus, thereby avoiding the damage of centrifugation on the sperms. The device disclosed by the invention can be used as a tool for auxiliary reproduction technology.

The invention relates to the technical field of medicines, in particular relating to a composition of 5-aminolevulinic acid and a derivative thereof as well as application thereof. The composition of the 5-aminolevulinic acid and the derivative thereof disclosed in the invention comprises an effective dose of active constituent of the 5- aminolevulinic acid and the derivative thereof, and is characterized in that the composition also comprises proteolytic enzyme which is 0.035-277U per gram of the composition. The invention simultaneously discloses the application of the composition in the preparation of medicines for treating gynecological diseases. The composition can effectively improve the influence of cervical mucus on an active constituent ALA and a derivative thereof, enhances the permeability of the active constituent ALA and the derivative thereof in the cervical part, and improves the bioavailability of the ALA and the derivative thereof. The composition not only greatly improves the effect of the ALA and the derivative thereof on treating the gynecological diseases and in particular the cervical diseases, but also ameliorates the disamenity of the patients in the traditional treating process.

A process is provided for analyzing a specimen of biological material in any of a number of biochemical or immunological tests for an analyte which involves subjecting the specimen to treatment which develops a color correlating to the amount of analyte in the specimen. According to the invention at least one defined color characteristic selected from hue angle, chroma, saturation and lightness of the developed color is measured and the results of that measurement analyzed to determine the presence or concentration of the analyte in the specimen. Particular applications are to the detection of cancerous or pre-cancerous abnormalities from the analysis of lung mucus, throat mucus, cervical mucus or seminal fluid.

The invention provides a cervical mucus swab. The cervical mucus swab comprises a swab rod and a swab head, wherein the swab head is fixed to the front end of the swab rod, and is latticed as a whole.The swab head is represented as a latticed structure, and through the liquid surface tension principle, the problem that mucus is hard to remove is solved; an elastic fusiform structure of the swab head perfectly fits an inverted pear structure of a cervical canal; and by means of a smooth fetching surface formed by the latticed structure, hard damage to cervical tissue is avoided. The cervical mucus swab is simple to operate, no professional training is needed, and a user knows how to operate the cervical mucus swab when seeing the cervical mucus swab, so that popularization is facilitated.To sum up, the cervical mucus swab is creative in design, wide in application and economic in technology, so that application and popularization are highly facilitated.

An aqueous preservation medium for the selective preservation of trophoblasts obtained in a sample of cervical mucus which permits transportation of such sample to a laboratory facility for analysis and selectively preserves fetal trophoblasts in said sample while presenting conditions that are antagonistic to many maternal cells.

The present invention provides methods and kits useful for genetic testing or screening of fetuses using nucleic acid samples isolated from cervical mucus samples of fetus hosts.

The invention discloses a rapid separation and identification kit for streptococcus agalactiae. In the kit, the following reagents are included: sheep defibering blood plate, 3% H2O2, staphylococcus aureus strains, a specific PCR (polymerase chain reaction) solution, and positive control DNA (deoxyribonucleic acid). The rapid separation and identification kit for streptococcus agalactiae provided by the invention has the following beneficial effects that bacterial morphological observation, catalase test, CAMP (cyclic adenylic acid) reaction and PCR detection are used together, so that identification procedures can be simplified, the specificity is strong, and the sensitivity is increased by more than 15%; and moreover, the identification cost is low, the time consumption is short (only needing 3 days), and streptococcus agalactiae strains can be obtained by separation and accurately identified. The kit can be used for separation and identification for the samples of the milk samples of human or dairy cows, cervical mucus, vaginal swabs and the like.

The invention discloses an intelligent detection system for prediction of the ovulatory period. The system comprises 1, a data acquisition terminal and 2, a data processing system operating on a computer system. The intelligent detection system is characterized in that a sensor of the data acquisition terminal is used for measuring information on a period change rule of electrolyte conduction characteristics including saliva, cervical mucus or other body fluids; measured information is uploaded to the data processing system for processing by means of a communication link in order to obtain information on the physiological cycle; and relevant information on the ovulatory period, the best pregnant date and natural (the safe period) family planning serve as a real-time reminder for a user. The intelligent detection system for prediction of the ovulatory period has following beneficial effects: due to the fact that the data acquisition terminal is separated from the data processing system, and a data processing unit is finished only by the computer system, cost of the terminal is reduced and size of the terminal is decreased; the intelligent detection system is easily carried; and a professional computer system is well utilized for finishing data processing, displaying and reminding functions and rendering services.

Device and method for determining a rheological property, such as viscosity or threadability, of mucus comprising a housing having a circumferential surface defining an opening for receiving a quantity of the mucus, a probe extending within the housing and having a tip for contacting at least a portion of the quantity of mucus, a displacement mechanism for displacing the tip of the probe with respect to the housing, and a measurement unit for measuring a displacement of the tip of the probe. The device and method are especially suitable for determining the rheological property of mammal cervical mucus for determining female fertility.

The invention discloses a detection method for an antisperm antibody in the cervical mucus of dairy cows, comprising the steps of: 1) taking cervical mucus of the dairy cow in estrus; 2) taking bull fistula frozen sperm, centrifuging and removing supernatant, adding EBSS (Earle's Balanced Salt Solution) suspension, laying the suspension at the bottom of a test tube in which the EBSS containing 10% fetal calf serum is pre-arranged, incubating for 45 min in an incubator, taking the supernatant; 3) adding pineapple protease liquid in the cervical mucus defrosted at room temperature and centrifuging; and 4) diluting the supernatant in the step 3) by using EBSS, adding 15 microliters of supernatant prepared in the step 2) and mixing, covering 20 microliters of paraffin oil, incubating for 30 min, wherein the number of the agglutinated sperm is recorded as N, the total number of sperms is recorded as Nz, the antisperm antibody is judged to be positive when N / Nz is more than and equal to 10%, and the antisperm antibody is judged to be negative when N / Nz is less than 10%. According to the detection method, the antisperm immune infertility cows in the dairy cows can be easily and rapidly detected.

The invention provides a pathological specimen collecting device for habitual abortion in the obstetrics and gynecology department, and relates to the technical field of medical equipment. The pathological specimen collecting device for habitual abortion in the obstetrics and gynecology department comprises a refrigerating box, wherein an electric air pump is fixedly arranged at the top end of therefrigerating box, a refrigerator is fixedly arranged at the bottom end of the interior of the refrigerating box, a partition plate is arranged at the upper end of the refrigerator, the partition plate is fixedly connected to the inner wall of the refrigerating box, a foam block is arranged at the upper end of the partition plate, a plurality of storage grooves are formed in the inner end of thefoam block, a box door is arranged on the front side of the refrigerating box, an air pipe is fixedly arranged on the side wall of the electric air pump, a guide rubber rod is connected to the end, away from the electric air pump, of the air pipe, and an air channel penetrating through a rod body is formed in the center of the inner end of the guide rubber rod. According to the pathological specimen collecting device for habitual abortion in the obstetrics and gynecology department, cervical mucus of a patient can be conveniently and rapidly collected and stored, and no large discomfort is brought to the patient.

The present invention provides one kind of medicine composition for killing sperm and treating vaginitis simultaneously. The medicine composition consists of active components comprising zedoary oil 0.5-20 wt% and hyodeoxycholic acid 0.5-20 wt% and pharmaceutically acceptable supplementary material. The medicine composition can kill sperm, change the physical and chemical properties of sperm and cervical mucus to prevent conception and kill microbes causing vaginal infection, so as to contracept and prevent and treat microbe caused viginitis.

The invention belongs to the technical field of micro-fluidic chips, and particularly relates to a bionic micro-fluidic chip for simulating a cervical microenvironment and a preparation method of the bionic micro-fluidic chip. The bionic micro-fluidic chip is provided with a sample introduction pool, a plurality of microcolumns, a screening channel and a collection pool. The plurality of microcolumns are uniformly distributed in the sample introduction pool and are used for filtering impurities in original semen to be detected. The sample introduction pool communicates with the collection pool through a plurality of screening channels which are parallel to one another. The bionic micro-fluidic chip is used for screening a large number of qualified high-quality sperms which can be directly applied to an assisted reproduction technology. The screening channel is filled with a trace hyaluronic acid solution with the function similar to that of cervical mucus and is used for simulating a cervical microenvironment. The chip disclosed by the invention can be used for screening sperms, identifying gene defect sperms and simply and quickly screening out infertility people caused by gene defects. The bionic micro-fluidic chip is simple and convenient to operate, low in cost and high in practicability.

The present invention provides for the use of oil of clove which causes instant immobilization of human spermatozoa both in presence of seminal fluid as well as in presence of female reproductive tract fluids, including uterine components and cervical mucus and also be useful for treating and / or preventing the common vaginal infections.

A process is provided for analyzing a specimen of biological material in any of a number of biochemical or immunological tests for an analyte which involves subjecting the specimen to treatment which develops a color correlating to the amount of analyte in the specimen. According to the invention at least one defined color characteristic selected from hue angle, chroma, saturation and lightness of the developed color is measured and the results of that measurement analyzed to determine the presence or concentration of the analyte in the specimen. Particular applications are to the detection of cancerous or pre-cancerous abnormalities from the analysis of lung mucus, throat mucus, cervical mucus or seminal fluid.

The present invention provides for the use of oil of clove which causes instant immobilization of human spermatozoa both in presence of seminal fluid as well as in presence of female reproductive tract fluids, including uterine components and cervical mucus and also be useful for treating and / or preventing the common vaginal infections.

A marker of fetal trophoblast cells, an identification method, a detection kit and the use thereof. The identification method comprises performing dyeing treatment on a sample containing fetal trophoblast cells with a fluorescence-labeled HK2 antibody substance, and then performing fluorescence detection, wherein HK2 positive cells are target cells. The kit comprises a fluorescence-labeled HK2 antibody substance and a cell nucleus dye. The above-mentioned technical solution can sensitively and reliably detect fetal trophoblast cells in the cervical mucus or blood samples of pregnant women in the first trimester, and especially can be used for prenatal diagnosis in early pregnancy.