39 results about "Cervical tissue" patented technology

The invention relates to the technical field of image classification, in particular to a training method and system of a cervical pathological image classification model based on multiple modes. The method comprises the following steps: acquiring a cervical tissue image and carrying out tissue structure segmentation, forming a nucleus-interstitial-epithelium three-distribution framework, collecting development historical data, confirming a prediction trend of each layer, carrying out environment field simulation through the image, generating a simulated cervical environment field, and carrying out hierarchical evolution prediction on the framework. Evolution mapping images are generated according to the evolution data and classified, finally, a visual basic model is obtained through combined modeling training, image-text fusion is achieved, and a cross-center deployment model system is generated. According to the method, vision-language combined modeling is realized, and the stability and controllability of the whole model structure in image space deformation modeling, semantic cross-modal alignment construction and task-level response flow scheduling are improved.

The invention discloses a cervical lesion intercellular relation modeling and analysis system based on a graph neural network, and the system comprises a medical image collection module which is used for collecting a digital image of a cervical tissue pathological section or a cervical TCT slide; the cell detection and segmentation module is used for extracting spatial position information and morphological characteristics of cells; the cell feature extraction module is used for extracting and fusing the spatial position, morphology, texture and biological marker features of the cells; the cell relation graph construction module is used for constructing a heterogeneous cell relation graph with cells as nodes and inter-cell relations as edges; the graph neural network analysis module is used for carrying out feature learning and modeling on the heterogeneous cell relation graph; the intelligent auxiliary diagnosis module is used for generating auxiliary diagnosis suggestions; and the data management and automatic control module is used for realizing automatic control and case data management of the whole process of the data. The intelligent and automatic level of cervical lesion cell analysis can be comprehensively improved, and the accuracy and efficiency of diagnosis are improved.

The invention provides a cervical tissue slice lesion diagnosis method and device based on reinforcement learning, and belongs to the technical field of medical diagnosis. The method comprises the following steps: cutting a whole slice image of a standardized cervical tissue slice to be diagnosed according to a preset cutting parameter to obtain an image block, inputting the image block into a visual encoder for feature reasoning analysis to obtain the feature of the whole slice image, calculating the hidden vector of the feature by using a reinforcement learning model, and calculating the hidden vector of the feature. According to the two-dimensional continuous coordinates corresponding to the hidden vectors, indexing of preset iterations is carried out, to-be-diagnosed image block vectors are obtained, an aggregator is used for attention weight distribution, clustering constraint is carried out according to a distribution result, global representation vectors are obtained, the global representation vectors are input into a classification head of the aggregator, and a lesion diagnosis result is output. While high sensitivity is ensured, classification accuracy and focus positioning credibility are remarkably improved, and reliable lesion level judgment is provided for clinicians.

The present invention proposes a device (100) for collecting cervical tissue samples, comprising: a sample collecting bud (10) connecting to one end of an elongated shaft (21); a holder (20) provided at the other end of the elongated shaft (21); a handle (30) enclosing the elongated shaft (21), wherein the elongated shaft (21) is slidable and rotatable within the handle (30); characterized in that: the sample collecting bud (10) is retractable into the handle (30) and extendable from the handle (30) by moving the holder (20) connected to the sample collecting bud (10) via the elongated shaft (21); wherein the sample collecting bud (10) comprises a star-shaped center cone (11) having a flat tip end, and a plurality of petal-like structures (12) surrounding the center cone (11), each of the petal-like structure (12) having an inner scraping ridge (13) and an outer scraping ridge (14).

This invention discloses a cervical tissue pathology image classification method based on a hybrid CNN-ViT architecture, relating to the fields of computer vision and deep learning. Firstly, based on the combination of CNN and ViT architectures, this invention addresses the shortcomings of existing methods in feature extraction, classification performance, and model adaptability by proposing a Linear Angle Cross-Covariance Self-Attention Module (LACCSA) and a novel activation function, ExpReLU. The LACCSA module, combining cross-covariance attention and linear angle similarity, effectively captures the dynamic relationships between global features, distinguishing subtle differences between categories and extracting common features within categories, significantly improving the accuracy of complex pathology image classification. The ExpReLU activation function enhances nonlinear expressive power, reduces the impact of data distribution shift on model performance, and optimizes computational efficiency. By combining the local feature extraction capabilities of CNNs and the global feature capture capabilities of ViTs, this invention achieves a good balance between detailed representation and global relationship modeling.

The utility model relates to medical instrument technical field discloses a kind of noninvasive cervical cerclage buckles, including flexible kit, one end of flexible kit is provided with upper connecting ring, the other end is provided with lower connecting ring, upper connecting ring inside is provided with the upper annular passage for accommodating first connecting buckle, one end of first connecting buckle enters from the side import of upper annular passage, and it is passed out from the other side export of upper annular passage by the inside of upper annular passage.The utility model is fixed on cervix by setting upper connecting ring and lower connecting ring on the upper and lower ends of flexible kit, and setting the first, second connecting buckle that can be tightened on upper and lower connecting ring, reach the purpose of bundling.Compared with cervical cerclage, it has the superiority of noninvasive, fast, without anesthesia, compared with the cervical support product on market, can provide high-quality individualized product for patient, release the compression to vaginal wall and pelvic tissue, effectively avoid the irritation and harm of operation to cervical tissue.

A cervical dilator comprises a stem comprising a partially or completely dehydrated hydrogel comprising a water-insoluble synthetic hydrophilic polymer capable of radial expansion due to absorption of water from bodily fluids. The cervical dilator softens and matures cervical tissue and dilates the cervical canal through a combination of radial hydrogel stem expansion and osmotic absorption of water from the tissue. The osmotic absorption is caused by at least one osmotically active compound, such as a water-soluble salt, polyelectrolyte, or mixtures thereof, dispersed within the hydrogel. The cervical dilator may also include a non-toxic plasticizer for the hydrogel, such as water.

The utility model discloses an adjustable exercise rehabilitation soft brace which comprises a soft brace body, a supporting soft plate is arranged on one side of the soft brace body, air holes are evenly distributed in the supporting soft plate, bandages are evenly distributed on the supporting soft plate, an adjusting mechanism is arranged in the center of one side of the supporting soft plate, and the adjusting mechanism is arranged on the other side of the supporting soft plate. A neck support is arranged above the adjusting mechanism, the dismounting and mounting mechanism is arranged at the top of the adjusting mechanism, and the bottom end of the neck support is connected with the dismounting and mounting mechanism through a mounting piece. By installing the soft brace body, the binding band, the supporting soft plate, the adjusting mechanism, the neck support, the shell, the lifting sleeve, the micro motor and the lead screw, the soft brace body is worn through the binding band, the neck of a patient is supported on the neck support, the neck support is lifted and supported, and then the cervical vertebra of the patient is pulled and fixed; and the traction degree can be automatically adjusted, so that the cervical traction device is more flexible to use.

The invention relates to the technical field of artificial intelligence, and provides a lesion risk prediction method, a lesion risk patient management system, equipment, a medium and a product, and the method comprises the steps: obtaining a risk depth feature, a risk interaction feature and an original risk feature; and inputting the risk depth feature, the risk interaction feature and the original risk feature into a lesion risk prediction model to obtain a risk prediction result of the histopathologic precancerous lesion. According to the lesion risk prediction method provided by the invention, on the basis of the practical situation that precancerous lesion samples are few, prediction comprehensiveness is enhanced through multi-feature cooperation, hidden deep features and risk interaction features in risk depth feature capture data reveal an inter-variable association mechanism, and original risk features reserve original basic data; the three are combined to break through single feature limitation, more comprehensive feature knowledge is added to the prediction model, the generalization ability and prediction precision of the prediction model are enhanced, and thus the risk prediction accuracy of cervical histopathologic precancerous lesions is improved.

Aspects described herein may include a method of diagnosing cervical cancer and pre-cancer conditions, including: utilizing a computer to extract a numerical value corresponding to an order parameter squared (S2) from image data from at least one image of cervical tissue / cells from a patient, wherein the image data includes at least one region having light regions and dark regions, and wherein S2 includes a numerical value quantifying a degree of order present in the image data, and wherein the extracted numerical value comprises a ratio of an area of the light regions to a total area; comparing the extracted numerical value to one or more predefined diagnosis ranges corresponding to stages of cervical cancer and pre-cancer conditions; and diagnosing the stage of the cervical cancer and pre-cancer conditions if the numerical value of the S2 falls within one of the predefined diagnosis ranges.

The invention relates to the technical field of hysteroscopes, and discloses a disposable hysteroscope which comprises a grab handle, a mirror rod is arranged on the grab handle, and a guide head is arranged at the end of the mirror rod; the guide head comprises an abduction lip part and a convergent neck part, a guide hole is formed in the center of the abduction lip part, the mirror rod penetrates through the guide hole, the convergent neck part is arranged on the mirror rod in a sleeving mode, the abduction lip part is in a horn shape, the narrow end of the abduction lip part is connected with the convergent neck part, and the convergent neck part makes friction contact with the mirror rod; the mirror rod is close to the guide hole, so that the open end of the abduction lip part is enlarged. According to the disposable hysteroscope, accurate centering of the disposable hysteroscope and a cervical opening can be automatically completed. When the abduction lip is in contact with the cervix uteri, the elastic petal structure can automatically adjust the angle under the interaction of the propulsive force of the mirror rod and the counter-acting force of the cervix uteri tissue until the center of the guide hole coincides with the center of the cervix uteri opening.

The invention relates to CNF-C / PVA composite hydrogel, a cervical support as well as preparation and application of the CNF-C / PVA composite hydrogel and the cervical support, the composite hydrogel is prepared from raw materials containing carboxylated nanocellulose fibers CNF-C and polyvinyl alcohol PVA through freezing and thawing cycle treatment, and the carboxyl content in the carboxylated nanocellulose fibers CNF-C is 1.7-2.5 mmol / g; the alcoholysis degree of the polyvinyl alcohol PVA is more than 98 mol%, and the polymerization degree of the polyvinyl alcohol PVA is 2200-2500. The cervical support comprises a main body part and a cavity, and the main body part is composed of CNF-C / PVA composite hydrogel. According to the invention, through a nanocellulose fiber compounding and dynamic cross-linking strategy, the mechanical property of the composite material is regulated and controlled, so that the composite material is dynamically matched with the cervical tissue of a human body, reliable supporting force can be provided, and mechanical damage to mucous membranes can be reduced.

The invention belongs to the technical field of biological medicines, and aims to solve the problems of low popularization rate, poor diagnosis sensitivity and specificity, low prediction efficiency and the like of current cervical cancer screening means. The invention provides a cervical cancer biomarker FCGR3B and an application thereof, and further provides an application of the FCGR3B as a cervical cancer diagnosis biomarker in diagnosis of cervical cancer. The biomarker is FCGR3B, and the specific expression level of the FCGR3B in cancer tissues of a cervical cancer patient is up-regulated. The fact that FCGR3B has a good diagnostic value in cervical cancer is evaluated by drawing an ROC curve, and the correlation between SELL and immune cells is analyzed by using a CIBERSORT technology. According to the research, the expression of FCGR3B in cervical cancer is obviously higher than that in normal cervical tissues. FCGR3B may become a biomarker for diagnosis of cervical cancer and a key target for treatment, and provides a new idea and reference for prevention and treatment of cervical cancer.

The invention relates to an early diagnosis reagent for cervical and gastric adenocarcinoma based on multi-marker combination and application thereof, PGC can be used as a new marker for detecting cervical and gastric adenocarcinoma, and PGC is not expressed in other cervical adenocarcinoma and tumors except cervical and gastric adenocarcinoma and normal cervical tissues, and has extremely high specificity; furthermore, the PGC can be combined with the CLDN18.2 and the HIK1083, so that the positive predicted value can be obviously improved.

The invention belongs to the technical field of biological medicines, particularly relates to tumor inhibitory escherichia coli 18 and application thereof, and more particularly relates to escherichia coli HZEc18 and application thereof. According to the present invention, the bacteria in the cervical tissue and the vaginal swab of the cervical cancer patient are subjected to in vitro culture and purification to obtain a plurality of strains having potential influence on the tumor microenvironment, and the Escherichia coli HZEc18 has strong tumor cell inhibition activity and host cell interaction, and can be used for the development of antitumor drugs.

The invention provides a cervical cancer prognosis evaluation kit based on ITM2A mRNA expression level and application of the cervical cancer prognosis evaluation kit, and belongs to the technical field of molecular detection. The kit disclosed by the invention comprises a primer pair capable of specifically amplifying a human ITM2A gene sequence; through detection of expression levels of ITM2A genes and encoded proteins in normal cervical tissues and tumor tissues, it is found that expression of ITM2A in the tumor tissues of cervical cancer patients is remarkably reduced, and a kit for prognosis judgment of cervical cancer is developed based on the discovery. The method has extremely important significance on risk assessment and prognosis prediction of cervical cancer patients.

This invention belongs to the field of biomedical technology, specifically relating to a tumor-suppressive *Escherichia coli* 18 and its uses, and more specifically to *Escherichia coli* HZ_Ec_18 and its applications. This invention obtains multiple strains with potential to influence the tumor microenvironment through in vitro culture and purification of bacteria from cervical tissue and vaginal swabs of cervical cancer patients. Among them, *Escherichia coli* HZ_Ec_18 exhibits stronger tumor cell inhibitory activity and interaction with host cells, and can be used for the development of anti-tumor drugs.

The invention provides a cervical lesion thermodynamic diagram prediction method and system based on pathological base model fine tuning, a storage medium and a program, and relates to the technical field of medical pathological diagnos.The method comprises the steps that S10, a pre-trained Prov-GigaPath tissue pathological base model is adopted to extract pathological feature vectors of a cervical tissue panoramic digital slice image; s20, executing dichotomy mapping according to the pathological feature vectors, and generating positive probabilities of the sub-regions; s30, generating a highly suspicious sub-region set according to the positive probability of each sub-region; and S40, executing five-classification prediction according to the height suspicious sub-region set, and generating lesion level probability distribution corresponding to each height suspicious sub-region. Compared with the prior art, the method has the following beneficial effects: 1, two-classification and five-classification tasks are decoupled, so that the model complexity is reduced; secondly, fine-grained distinguishing of CINI-III and canceration is achieved through a five-classification grading framework; thirdly, by embedding an uncertainty quantification mechanism, a lesion grading result and model confidence degree evaluation are synchronously output.

The utility model discloses a cervical contractor which comprises an elastic constriction piece which is suitable for being hooped on a cervical canal so as to seal a cervical opening. The elastic contraction piece comprises a lantern ring part and a holding structure, and the lantern ring part is suitable for being arranged on the cervical canal in a sleeving mode; the enclasping structure is arranged in the circumferential direction of the lantern ring part in a surrounding mode and can tighten the cervical canal. According to the cervical contractor provided by the embodiment of the utility model, the cervical contractor can be flexibly hooped on a cervical canal to realize effective sealing of a cervical orifice, so that premature delivery of a fetus is prevented. Compared with a traditional method, the operation process is greatly simplified through the design, complex suture and suture removing processes are not needed, and the infection risk and the complication occurrence rate are remarkably reduced. Meanwhile, due to the elastic characteristic, appropriate adjustment can be conducted according to natural changes of the cervix uteri, the comfort level of the pregnant woman is improved, and discomfort is reduced. In addition, by means of the non-invasive design, damage to cervical tissue is greatly reduced, and psychological burden is relieved.

The invention discloses a lactic acid bacteria bacteriostatic composition, bacteriostatic gel and application. The lactic acid bacteria bacteriostatic composition is prepared from the following raw materials in parts by weight: 15 to 30 parts of lactic acid bacteria powder, 6 to 10 parts of rhizoma bletillae extract, 2 to 6 parts of herba centellae extract, 3 to 5 parts of fructus cnidii extract, 0.8 to 1 part of polyhexamethylene biguanide hydrochloride, 8 to 16 parts of stabilizer and 8 to 14 parts of additive. The lactic acid bacteria bacteriostatic composition has obvious anti-inflammatory and bacteriostatic effects, has a remarkable treatment effect on vaginitis and cervicitis, can effectively improve pathological injuries caused by vaginitis and cervicitis and promote repair of tissue mucosa, and can also promote expression of MKP-1 in cervical tissue, so that inflammatory response is improved, and the anti-inflammatory effect is achieved. Meanwhile, inflammation infiltration of the vagina of the rat is reduced to relieve the symptom of red and swollen vulva, the vaginal flora is protected, a favorable vaginal environment is created, the lactobacillus level is recovered to be normal, and harmful pathogenic bacteria can be inhibited in a targeted manner.

The present application relates to the technical field of image classification, and more particularly to a training method and system for a cervical pathological image classification model based on multi-modal. The method comprises the following steps: obtaining cervical tissue images and performing tissue structure segmentation to form a three-distribution framework of nucleus-stroma-epithelium, collecting development history data, confirming the prediction trend of each layer, simulating an environment field through images, generating a simulated cervical environment field, and performing layered evolution prediction on the framework, generating an evolution mapping image according to the evolution data and performing classification, and finally obtaining a visual basic model through joint modeling training, realizing image-text fusion and generating a cross-center deployment model system. The present application realizes visual-language joint modeling, improves the stability and controllability of the overall model structure in image space deformation modeling, semantic cross-modal alignment construction and task-level response flow scheduling.

Described herein, the disclosure, in one aspect, relates to simulated cervical tissues composed of a gel and red-toned pigment, wherein the cervical tissue has a first face, wherein the first face includes one or more simulated lesions. Methods for constructing the simulated cervical tissue are also disclosed. Additionally, disclosed are kits composed of two or more simulated cervical tissues as described herein, wherein the simulated cervical tissues are different from each based on (1) the number of simulated lesions on each first face of each simulated cervical tissue, (2) the position of the simulated lesions on each first face of each simulated cervical tissue, or a combination thereof. The simulated cervical tissues and kits described herein are useful training tool for performing colposcopies and cam be incorporated into cervical trainers.

A closed-loop cryotherapy system and related processes are described herein. In various embodiments, the system includes a front-end probe assembly and a backend cryogenic circulating unit designed to provide effective cryotherapy treatment of cervical tissue anomalies without using consumable gases or a hard-wired stable power grid.

This invention relates to the field of photoelectric probes, specifically a multi-point photoelectric probe for cervical cancer screening instruments. It includes a probe body and a detector handle. The probe body adopts a slender, hollow tubular structure, serving as the support and wiring main body for the probe, and internally housing multiple independent optical fibers. An end-face detection section, located at the very front of the probe, is elliptical in shape and is a dedicated cervical tissue detection component. A ring-shaped detection section, fitted onto the ring-shaped side of the probe body behind the end-face detection section, is a dedicated vaginal wall tissue detection component. An adjustment section is used to adjust the orientation of the end-face detection section, expanding the detection range and ensuring that all areas of the cervix can be effectively detected. The front end of the probe body is fixedly connected to the end-face detection head, and the rear end is detachably connected to the detector handle. This multi-point photoelectric probe for cervical cancer screening instruments, through its separate dedicated design of the end-face and ring-shaped detection heads, achieves for the first time simultaneous screening of both the cervix and vaginal wall areas with a single probe insertion.

The present application relates to the technical field of medical devices, and discloses a gynecological hysteroscope surgery object-taking forceps, which comprises a forceps rod, the two ends of the forceps rod are respectively provided with a forceps head and a forceps handle, the inner side of the forceps rod is provided with a storage box and a push rod, and the outer side of the forceps rod is provided with a negative pressure assembly; one end of the push rod is connected with a movable lasso, the other end is connected with a push plate, the inside of the push rod is provided with a gas conveying channel, one end of the gas conveying channel is in communication with the inner side of the movable lasso, and the other end is connected with the negative pressure assembly; the push rod can push the movable lasso to separate from or enter the storage box, and the suction force generated by the negative pressure assembly can be transmitted to the tail end of the push rod through the gas conveying channel, so that the pre-fixing of target cervical tissue by the movable lasso and the adsorption of cut tissue by the negative pressure assembly can avoid repeated operation caused by tissue movement in the cutting process, reduce accidental damage to other surrounding tissues, reduce the risk of surgery and speed up the surgery process.

The utility model discloses a cervical lesion positioning device which comprises a positioning needle and a sleeve. The sleeve is movably arranged on the positioning needle in a sleeving mode, a plurality of piercing parts are arranged at the end, away from the tip end of the positioning needle, of the sleeve in the circumferential direction, and an inclined face is arranged at the end, close to the tip end of the positioning needle, of the sleeve. The upper end of the positioning needle extends to the outer side of the sleeve, and the upper end of the positioning needle is sleeved with a needle cap extending to the piercing part. The positioning device is simple in structure and convenient to use, sampling operation can be facilitated by puncturing the positioning device into cervical tissue, meanwhile, the cervix sampling position can be identified, and the accuracy of case detection results is improved.

The utility model discloses a kind of for cervical conization specimen's split piece device, it is related to pathological analysis technical field, including base, the position of the outside of base near upper side is threadedly connected with threaded sleeve, the upper side of threaded sleeve is rotatably connected with cutting mechanism, the outside of cutting mechanism is movably sleeved with fixed mechanism, the upper side middle part of base is movably installed with electric push rod, the cutting mechanism includes mechanism pipe, the upper side of mechanism pipe is fixedly connected with conical seat, the lower side of mechanism pipe is rotatably connected in the upper side of threaded sleeve, the upper side of electric push rod is fixedly connected with fixed rod.The utility model said a kind of for cervical conization specimen's split piece device, directly drive blade to go up by electric push rod, so that blade carries out cutting to cervical tissue, electric push makes it unnecessary to manually provide greater pressure to push blade, while electric push rod can hide blade in mechanism pipe, more safe.

The utility model relates to the field of surgical suture needles and threads, and discloses a needle and thread assembly based on cervical cerclage surgical suture, which comprises a suture line and a suture needle, the cross section of the suture line is circular, the suture line comprises a main line section, and two ends of the main line section are respectively connected with a transition section. The diameter of the transition section is gradually reduced along the extension direction; the large-diameter end of the transition section is connected with the main line section; the small-diameter end of the transition section is connected with the needle threading section; according to the scheme, the main line section serves as a main body of the suture line, the diameter of the main line section is relatively large, the section of the main line section is round, and the problem that due to the fact that the suture line is thin, tension is large, and cutting wounds of the thin line to cervical tissue are likely to happen can be solved, and particularly under the condition that suture and binding retention time is long, the thin line is likely to damage the tissue and cause infection; the needle threading section is used for being connected with a suture needle, the diameter of the needle threading section is relatively small, the needle threading section can more conveniently penetrate into a needle eye of the suture needle, and compared with a thick thread, the thin thread is easier to knot.

To provide a device for reinforcing and supporting the cervix so as to promote pregnancy period extension of a patient who has developed complications by preterm labor.SOLUTION: A medical device is for supporting a patient's cervix, such as in an event of an insufficient cervix or uterine prolapse. The device includes: a main body 102 configured for placement in a vagina; a proximal opening 104 at an upper portion of a body; and a distal opening at a lower portion of the body. A portion of the body engages and anchors the device along a vaginal wall proximate a cervical opening. An expandable cuff 108 at the proximal opening is expandable to circumscribe an exterior of the cervix. The cuff is expandable inward toward the cervix, or downward away from a uterus, or both inward and downward. The cuff may include multiple features, such as a recessed portion 110 and an enlargeable portion arranged adjacent one another, in which the recessed portion may permit blood flow to lower cervical tissue.SELECTED DRAWING: Figure 4

The application discloses a kind of long-term treatment strategy making methods for cervical cancer prevention and treatment of HPV, belong to medical information processing technical field.The method includes: obtaining the digital HPV health record containing multiple HPV typing detection results, cervical cytology history record and individual physiological characteristic parameters;Three-dimensional treatment situation cube is constructed by virus infection state subspace, cervical tissue state subspace and treatment intervention state subspace;In the cube, state backtracking and forward-looking deduction algorithm based on time axis are used, virus clearance probability field and lesion outcome probability field are calculated;High-risk persistent infection space-time region and low-risk self-healing tendency space-time region are demarcated;Current patient state is projected to the cube, if fall into high-risk region, then trigger long-term treatment strategy generation process including multiple treatment stages, output intervention opportunity, intensity and state transition condition of each stage.