The invention provides application of a reagent for detecting pathogenicity and/or susceptibility genes of sudden cardiac death in preparing a product for diagnosing the sudden cardiac death. The reagent can capture various pathogenicity and/or susceptibility genes of the sudden cardiac death and can be used for detecting 116 related genes at most. By means of the reagent and the product containing the reagent, the causes of sudden cardiac death patients can be explained, the risk and danger factors of suffering from the sudden cardiac death are evaluated, references are provided for moleculargenetic diagnosis of diseased individuals, general investigation of high-risk populations, screening of onset-of-illness high-risk populations in family members and corresponding genetic counseling and prenatal diagnosis intervention, and the incidence of the sudden cardiac death is expected to be reduced. Meanwhile, a probe set, a chip and a kit have the advantages of high efficiency, many detection sites, high accuracy, convenient operation, high specificity and sensitivity, fastness, high practicability and low cost.