249results about How to "Early treatment" patented technology

Disclosed herein is an invention that is a medical treatment method for diabetes, its comorbidities and its complications where their treatment requires lifestyle modification. The invention changes or alters lifestyle by identifying what is valuable or harmful to the health-related determinants of the pattern-of-life of a person, modifying the such determinants of health of the person as the person navigates their pattern of life, applying the resulting insights to modify the lifestyle of the person, promoting and improving therapy adherence and compliance and thereby improving the health of the person. The method is intended to prevent diabetes, to increase the early detection of diabetes, to diagnose diabetes, to delay the progression of diabetes, to reduce the severity of diabetes and to operationalize the insights from lifestyle modification through disease risk assessment, medical decision-making, comprehensive care plan management and patient outreach, engagement and retention in the care plan.

The invention discloses a remote home health care system. The home health care system comprises a fusion sorting subsystem used for receiving physical sign data parameters collected by a sensor in real time, conducting fusion sorting processing on the physical sign data parameters and diagnosing and feeding back the body condition of a user in real time according to physiological data and physiological models in a physiological model library, a resource optimization subsystem used for regularly optimizing the physiological data in a physiological database, generating an individualized physiological model for the user according to the historical physiological data in the physiological database, storing the physiological model in the physiological model library, and updating the physiological models in the physiological model library according to the latest physiological data in the physiological database and a comprehensive assessment subsystem used for predicting the physical sign change tread and the physical sign dynamic change range of the user according to the physiological data in the physiological database and the physiological models in the physiological model library and assessing the health of the user according to the physiological data and a predicating result.

The OX-40 antigen is characterized and claimed together with variants and derivatives thereof. Also described are binding agents for the antigen and the use of these in diagnosis and therapy. Examples of such use include a method for the selective depletion of activated CD4+ T-cells in vivo by using immunotoxins comprising an OX-40 antibody conjugated to a toxic molecule (such as Ricin-A chain). The administration of these specific immunotoxins is used therapeutically to deplete autoimmune reactive CD4+ T-cells which have been implicated in diseases including Multiple Sclerosis, Rheumatoid Arthritis, Sarcoidosis, and Autoimmune Uveitis as well as inflammatory bowel disease and graft-versus-host disease. This type of therapy is also beneficial for eradicating CD4+ T-cell lymphomas and alloreactive CD4+ T-cells involved with a transplantation reaction. The use of the human form of the OX-40 antibody will also help in the early diagnosis of all the diseases mentioned above.

The invention provides an early death risk assessment model establishing method and device based on ensemble learning. The method and device are used for assessing the death risk of an old multi-organfailure patient during hospitalization based on diagnosis and treatment data of the first day when the old multi-organ failure patient enters an intensive care unit. The method comprises the steps ofdata set construction, data processing and model construction and evaluation. The method comprises the following steps: acquiring three pieces of demographic information, five pieces of vital sign information, five laboratory examination indexes and two clinical indexes of a patient on the first day during living in an intensive care unit; inputting the data into a risk assessment device, and carrying out internal data preprocessing, feature calculation and model operation. Finally, the risk of adverse outcomes in the hospital of the patient can be predicted early, and doctors are helped to treat the patient as soon as possible.

The invention provides a mass spectrum model for detecting characteristic proteins of a lung cancer. The mass spectrum model comprises peaks with mass charge ratios of 4054 m/z, 2273 m/z, 4091 m/z, 3955 m/z, 3192 m/z, 3884 m/z and 5337 m/z, wherein in the model, proteins expressing the mass charge ratios of 4054 m/z, 2273 m/z, 4091 m/z, 3955 m/z, 3192 m/z, 3884 m/z and 5337 m/z are serum characteristic proteins of the lung cancer; and when the peaks with the mass charge ratios of 4054 m/z, 2273 m/z, 4091 m/z, 3955 m/z and 3192 m/z are expressed in a down regulation manner and the peaks with the mass charge ratios of 3884 m/z and 5337 m/z are expressed in an up regulation manner, a patient is indicated to be a lung cancer patient or a potential patient. The mass spectrum model can be used for early detection and screening for the lung cancer; the method is simple, easy to operate and high in accuracy; and by utilizing the mass spectrum model, a novel idea is provided for early detection and screening for the lung cancer.

The invention provides a colloidal gold test strip for detecting an IgM antibody. The IgM antibody is a specific IgM antibody for nine respiratory tract infection pathogens, and the colloidal gold test strip comprises a sample pad, a conjugate pad, a nitrocellulose film and a water absorption pad which are attached to a polyvinyl chloride base plate in sequence; the conjugate pad is a glass fiber film wrapped with a rabbit-anti-human IgM antibody-colloidal gold conjugate; the nitrocellulose film is wrapped with 9 detection lines and 1 quality control line in sequence; the 9 detection lines are respectively a mycoplasma pneumoniae recombined antigen, a chlamydia pneumoniae recombined antigen, an influenza a virus antigen, an influenza B virus antigen, a sendai virus antigen, a legionella pneumophila antigen, a Coxiella burnetii antigen, a respiratory syncytial virus antigen and an adenovirus antigen, and the quality control line is a second antibody. The invention further provides a colloidal gold test strip card comprising the colloidal gold test strip and a colloid gold kit, a preparation method of the colloidal gold test strip card, and a method for realizing detection by adopting the colloidal gold test strip, the test strip card or the kit.

The invention belongs to the technical field of medical instruments, aims to solve the problem that an existing vision test method is inconvenient and has a complex process and provides a vision test system, comprising a data server and a vision test terminal. The vision test terminal comprises a display unit, a storage unit, a processing unit, a receiving unit and a user input unit. The processing unit is connected with all of the display unit, the storage unit and the receiving unit. The user input unit is connected with the receiving unit. The storage unit is used for storing vision test questions. The processing unit is used for reading the vision test questions. The display unit is used for displaying the vision test questions. The user input unit is used for transmitting a testee's answers to the receiving unit. The processing unit transmits the testee's answers to the data server. The vision test system has few steps, the testee can finish a vision test alone, and using is very convenient.

This invention is directed to treating disease states or conditions associated with the treatment and prevention of neurodegeneration and neurodegenerative disease states, and treatment of radiation damage. The invention relates to novel phytonutrient compositions and compounds comprising L-ergothioneine and/or selenium. The invention also provides a method of administering these compositions and combinations to humans or animals in need thereof.

The invention discloses a mobile health data collection and integrated management system employing the internet + and an application method thereof. The mobile health data collection and integrated management system comprises an ID card reader, a tablet computer, an oximeter, an infrared thermometer, electrocardiogram equipment, a urine analyzer, a multifunctional glucometer, a sphygmomanometer and a portable printer; a mobile health data collection and integrated management system APP is arranged in the tablet computer and comprises health follow-up project question and answer to automatically draw a conclusion; the ID card reader, the oximeter, the tablet computer, the infrared thermometer, the electrocardiogram equipment, the urine analyzer, the multifunctional glucometer, the sphygmomanometer and the portable printer are connected with a wireless bluetooth of the tablet computer separately. According to the mobile health data collection and integrated management system employing the internet +, various small portable instruments are matched with a wireless bluetooth technology and connected with the tablet computer, comprehensive data collection can be carried out on the physical condition of a testee, and analyzing, tracking and recording of comprehensive situations of chronic diseases are facilitated.

The invention discloses mental stress assessment and high-risk population intervention system oriented to undergraduates. The mental stress assessment and high-risk population intervention system comprises a multi-mode brain function detecting device, a mobile terminal, a network server and a monitoring client-side, wherein the multi-mode brain function detecting device is connected with the mobile terminal through a Bluetooth signal, the mobile terminal is connected with the network server through a mobile internet, and the monitoring client-side is connected with the network server through the internet. The mental stress assessment and high-risk population intervention system is based on a mobile internet technology, adopts the multi-mode brain function detecting device to acquire brain blood oxygen signals and electroencephalogram signals of the undergraduates, utilizes the mobile terminal to receive the brain blood oxygen signals and electroencephalogram signals and input family mental disease histories and earlier-stage diagnosis information of the undergraduates, then uploads the data to the network server for data processing and analysis, generates corresponding diagnosis results, feeds the results back to the mobile terminal and the monitoring client-side, achieves early finding and early treatment of the mental diseases of the undergraduates and is beneficial to early warning and intervention of the mental diseases of the undergraduates.

An adhesive plaster for treatment of chaps formed around the nail of fingertip. On one face of a backing, an adhesive layer is formed, the whole shape is a substantially T-shape, and no pad is provided on this adhesive layer. The backing has a stretchability, and is preferably a non-woven fabric made of elastic fibers, and particularly preferably a non-woven fabric made of ultrafine polyurethane filaments having an average fiber diameter of from about 7 to 15 μm. By using this adhesive plaster, a fingertip having chaps formed is entirely covered closely to treat the chaps.

The present invention relates to new polyhydroxylated compounds and, in particular, to its activity as fatty acid synthase (FASN) inhibitors and to their use for the treatment of pathological states for which an inhibitor of this enzyme is indicated. The invention further relate to pharmaceutical compositions containing them and to a process for the preparation of such compounds.

The invention discloses FISH probe groups for detecting a novel coronavirus SARS-CoV-2. The probe groups comprise at least two fluorescent probe groups among a first fluorescent probe group taking anS gene as a target, a second fluorescent probe group taking an E gene as a target, a third fluorescent probe group taking an M gene as a target, a fourth fluorescent probe group taking an ORF 3a geneas a target, a fifth fluorescent probe group taking an N gene as a target, and a sixth fluorescent probe group taking an ORF 1ab gene as a target. In the at least two fluorescence probe groups, fluorescence molecules labeled by at least one fluorescence probe group have a fluorescence emission spectrum different from that of the other fluorescence probe groups. The FISH probe groups have high specificity and sensitivity, can realize positioning detection of SARS-CoV-2 in a to-be-detected sample, obtain the distribution and relative quantification conditions of the SARS-CoV-2, are an effectivesupplement for novel coronavirus nucleic acid detection, and have important clinical application value.

The present invention relates to the use of pyrido[2,3-d]pyrimidines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or combat HCV infections. In addition, the present invention relates to pyrido-[2,3-d]pyrimidines compounds per se and their use as medicines. The present invention also concerns processes for the preparation of such compounds, pharmaceutical compositions comprising them, and combinations of said compounds with other anti-HCV agents.

Methods for the detection of active lupus nephritis (LN) and worsening renal disease activity and/or active LN in patients diagnosed with systemic lupus erythematosus, using a panel of biomarkers including transferrin (Tf), ceruloplasmin (Cp), alpha-1-acid glycoprotein (AGP1), lipocalin-like prostaglandin D synthetase (L-PGDS), and urinary neutrophil gelatinase associated lipocalin (UNGAL).

The invention relates to a wearable coronary heart disease detection device which comprises a patch and a receiving terminal. The patch comprises a heart sound detection sensor, an ECG (electrocardiogram) sensor and a first PPG (program pulse generator) sensor which are used for detecting heart sound signals, ECG signals and first pulse oximeter signals. The receiving terminal receives the heart sound signals, the ECG signals and the first pulse oximeter signals wirelessly transmitted by the patch and is provided with a second PPG sensor and a processor, wherein the second PPG sensor is used for sensing second pulse oximeter signals, and the processor processes the signals to obtain coronary heart disease risk degree indexes. By the aid of the device, the coronary heart disease risk degreeindexes and the cardiovascular function status of a wearer can be acquired.

A control system for a cardiac assist device includes a sensor implantable in the body at the heart or at an implanted pump of the cardiac assist device, the sensor being for detecting motion of the pump within the body and hence being for monitoring movement of the pump, where the control system is arranged to, in use: receive signals from the sensor, the signals providing information on the movement of the pump; and to process the signals to monitor the pump speed and/or to identify pump malfunction and/or cardiac assist treatment complications.

The invention provides a mild cognitive impairment auxiliary diagnosis system and method based on brain network multi-feature analysis, and relates to the technical field of computer-aided diagnosis.The system comprises an input module, a preprocessing module, a brain network construction module, a feature extraction module, a classification diagnosis module and an output module. According to theinvention, various characteristics of a brain network and mild cognitive impairment diseases are comprehensively considered; based on rs-fMRI image data and a complex network theory, various featuresare calculated and analyzed and an extreme learning machine is used for classification, thereby achieving the auxiliary diagnosis of the mild cognitive impairment, reducing the workload for a doctor,improving the diagnosis accuracy, achieving the early discovery, early diagnosis and early treatment of the mild cognitive impairment, reducing the risk that a patient is converted into an irreversible Alzheimer's disease, and reducing the morbidity of the Alzheimer's disease.

The invention discloses a cervix uteri and vagina histocyte sample acquisition device for an HPV detection experiment, and belongs to the technical field of medical apparatuses. The cervix uteri and vagina histocyte sample acquisition device mainly comprises a cervix uteri extending element, an acquisition element and a power source device, wherein the acquisition element comprises limiting fixingframes, an acquisition adjusting rod and an acquisition head. According to the cervix uteri and vagina histocyte sample acquisition device disclosed by the invention, the vagina of a patient is expanded through the cervix uteri extending element, so that the acquisition adjusting rod can conveniently enter for histocyte acquisition, and shooting of the cervix uteri and the vagina inner wall of the patient, by a camera is clearer; when being in contact with the vaginal orifice of the patient, the cervix uteri and vagina histocyte sample acquisition device is limited by the acquisition adjusting rod, so that the situation that the patient is damaged because a cervix uteri extending air sac and supporting pinch plates are inserted too deep is avoided; through a replaceable banister brush layer on the acquisition head, histocytes in the cervix uteri and vagina of the patient are sampled, so that cross infection is avoided; shooting is performed through the micro camera on the acquisitionhead, so that the illness state of the cervix uteri and the vagina is convenient for the patient to know, the disease can be found out timely, and treating can be performed as soon as possible; and the cervix uteri and vagina histocyte sample acquisition device disclosed by the invention is simple in structure, safe and high-efficiency, convenient to operate and suitable for wide popularization.

The invention relates to a coronary vessel segmentation method based on an attention mechanism and a full convolutional neural network. The segmentation method comprises the following steps of 1, obtaining the input data for neural network training; 2, training a three-dimensional full convolutional network model integrated with the attention mechanism by utilizing the input data; 3, performing the coronary vessel preliminary prediction segmentation on an actual patient image by using the trained three-dimensional full convolutional network model; and 4, performing iterative optimization on the preliminary prediction segmentation result through a traditional algorithm, and obtaining a final coronary vessel segmentation result. Compared with the prior art, the method has the advantages of good segmentation result definition, high accuracy and the like.

The Energy Field and Target Correlation System automatically correlates the characteristics of target particles and a living organism to compute the characteristics of an energy field that is applied to a living organism to activate the target particles which are bound to or consumed or taken up by invasive agents in the living organism to produce detectable effects which can be used to treat the invasive agents. The energy field must be crafted to properly control the response and localize the extent of the illumination. The System automatically selects a set of energy field characteristics, including: field type, frequency, field strength, duration, field modulation, repetition frequency, beam size, and focal point. The determined energy field characteristics then are used to activate field generators to generate the desired energy field.

A process of detection of the causative agent of Johne's disease (Mycobacterium avium subsp. paratuberculosis) (MAP) by detecting shedding of surface protein of MAP. A preferred way is use of surface enhanced Raman Spectroscopy. The system of detecting MAP shedding of protein provides early detection and diagnosis, and therefore allows early treatment for Johne's disease in ruminant animals.

A biosensor for diagnosing acute myocardial infarction and its manufacturing method, the biosensor includes a high electron mobility transistor, a device isolation layer and a biomolecular layer that can specifically recognize the acute myocardial infarction marker cardiac troponin, wherein the high The biomolecular layer is fixed on the grid of the electron mobility transistor. The present invention combines ultra-sensitive high electron mobility transistors with immunoassay technology to quickly detect ultra-trace biomarkers of acute myocardial infarction in serum, with a lower detection limit of 1 femtogram per milliliter, which is better than the commonly used chemiluminescence immunoassay method in clinical practice. 1000 times higher; the response time is less than 10 seconds, which is more than 100 times faster than the commonly used clinical optical detection methods. The invention can realize synchronous testing of dry method and wet method, has very obvious advantages in device detection sensitivity, response speed and portability, can realize real-time detection and is easy to operate.

The present invention provides microRNAs for assessing the status of pancreatic cancer in a subject, and provides methods, kits, and biochips for detecting said microRNAs.