The invention relates to a compound amoxicillin breast injection composition and a preparation method thereof, comprising a suspending agent, an antioxidant and a solid dispersion carrier, and a white to off-white oily suspension prepared through a special process. The invention has the advantages of simple preparation process, stable content, easy injection and the like. The composition of the present invention is compounded with amoxicillin, potassium clavulanate, and prednisolone. Compared with other amoxicillin patent preparations, it has obvious antibacterial effect on bacteria resistant to penicillins, and it is effective against Klebsiella Chromosome enzymes produced by Bacillus, Proteus vulgaris, and Bacteroides fragilis also have a strong inhibitory effect; prednisolone has anti-inflammatory and anti-allergic effects, and has a synergistic effect on bacterial infection and allergic inflammation.