3 results about "Oligonucleotide chip" patented technology

Methods for monitoring circannual rhythms and / or determining birth period by detecting DNA methylation and oligonucleotide arrays therefor.

Methods and systems for detecting MSI are provided. Also provided are methods for enriching human genomic DNA for microsatellite loci. Additionally, an oligonucleotide array for detecting MSI is provided. In some embodiments, the method for detecting MSI comprises detecting sequencing reads from a sample for a plurality of microsatellite loci; determining a metric for repeat length distribution (RLD) for each microsatellite locus; comparing the metric to a threshold value for the microsatellite locus; quantifying the number of microsatellite loci having an RLD metric exceeding the threshold value; and comparing the number of microsatellite loci having an RLD metric exceeding the threshold value to a microsatellite instability (MSI) proportion threshold.

The invention relates to a gene chip for screening influenza virus and detecting drug resistance. A preparation method of the gene chip comprises the following steps: preparing a universal primer, preparing a subtype nucleic acid typing probe and a drug-resistant probe, preparing an oligonucleotide chip, establishing an RT-PCR (Reverse Transcription-Polymerase Chain Reaction) system and establishing a hybridization system. The gene chip prepared by the invention can be used for simultaneously discriminating five subtypes of influenza A viruses, including influenza A H1N1, seasonal H1N1, seasonal H3N2, avian H5N1 and swine H1N1 influenza viruses, and can be used for prompting the tamiflu resistance condition of the influenza A viruses. The gene chip has the advantages of rapidness, accuracy, high flux and high specificity, and can provide guidance for monitoring, clinical diagnosis and treatment of influenza viruses.