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Sol-gel process for the functionalisation of a surface of a solid substrate

A solid matrix, sol technology, applied in the sol-gel field, can solve problems such as very complex development, and achieve the effects of limited duration, reduced cost, and reduced energy consumption

Inactive Publication Date: 2007-08-01
COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The methods used to prepare monolayers exhibit the following disadvantages: aggressive and / or toxic organic solvents such as aromatic solvents, alkanes or chlorinated solvents are often employed
[0021] Mixtures of organic and inorganic organosilylation precursors consist of a large number of ingredients: their formulations are very complex to develop in order to obtain layers of controlled and reproducible thickness

Method used

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  • Sol-gel process for the functionalisation of a surface of a solid substrate
  • Sol-gel process for the functionalisation of a surface of a solid substrate
  • Sol-gel process for the functionalisation of a surface of a solid substrate

Examples

Experimental program
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Effect test

Embodiment 1

[0159] In this example, epoxy-functional and A thick layer around 100 nm in thickness, where the matrix was cleaned and prepared by washing (or stripping) in sodium hydroxide (Brown method).

[0160] A solution of (5,6-epoxyhexyl)triethoxysilane (EHTEOS) in ethanol in the presence of triethylamine (TEA) and water was deposited on the substrate.

[0161] The content of EHTEOS in the solution was 2.5% by weight. The ratio of the contents of water and ethanol was 0.18% by weight (water / ethanol).

[0162] The relative amounts of ingredients are specified by two parameters: H=[H 2 O] / [EHTEOS]=1 and T=[TEA] / [EHTEOS]=1, where [X] represents the molar concentration of the bulk X.

[0163] The solution was matured for at least 3 days at 22°C with gentle agitation.

[0164] Deposition is performed by spin coating at ambient temperature (at a rate of 200 to 3000 rpm, eg 700 rpm) to produce a wet layer. The contact time between the matrix and the liquid solution is 1 to several secon...

Embodiment 2

[0168] In this example, thick layers with a thickness of about 100 nm and containing aldehyde functional groups were prepared on a glass substrate (thin flakes of commercially available float glass) by the sol-gel method according to the invention.

[0169] Substrates prepared as in Example 1 (set with a Thick layer of epoxy functional group) in order to open the epoxy ring and form diol, then use NaIO 4 The diol was oxidatively sheared (stirred at ambient temperature for 1 hour, rinsed with deionized water for 5 minutes, then centrifuged dry) to generate aldehyde functional groups.

Embodiment 3

[0171] Will NH 2 Modified oligonucleotides (20 bases (20mers)) were deposited and immobilized on the support prepared in Example 1. Through a pressure-type automatic device in an aqueous solution (0.3MNa 2 HPO 4 ) for deposition.

[0172] The resulting oligonucleotide probes were hybridized to a complementary target labeled with the CY3 fluorophore. Fluorescence measurements were performed with an Axon Genepix scanner.

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Abstract

The invention relates to a sol-gel process for the functionalisation of a surface of a solid substrate in order to provide said surface with chemical functions that can react with chemical or biological molecules, i.e. chemical functions that can immobilise, attach, graft biological or chemical molecules. The invention can be used, for example, in the preparation of chemical and biological sensors, such as for the production of chips comprising DNA, oligonucleotides, sugars, peptides and small organic molecules.

Description

technical field [0001] The present invention relates to a sol-gel method for functionalizing the surface of a solid substrate. [0002] The technical field of the invention can be defined as the field of functionalization of solid substrate surfaces in order to provide surfaces with chemical functional groups capable of reacting with chemical or biological molecules, in other words to provide surfaces with chemical functional groups , the chemical functional group is capable of immobilizing, attaching or grafting biological or chemical molecules. [0003] The invention can be applied, for example, in the preparation of chemical and biological sensors, especially in the production of DNA chips, oligonucleotide chips, sugar chips, peptide chips and chips for small organic molecules. [0004] The invention can also be applied to the preparation of fluidic microsystems whose walls need to be functionalized. Background technique [0005] In order to graft, immobilize and attach...

Claims

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Application Information

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IPC IPC(8): B01J19/00B05D1/18C40B40/06C40B40/10C40B40/12C40B60/14G01N33/543
CPCB01J2219/00677B01J2219/00691G01N33/54353C40B40/06B01J2219/00725B01J2219/00722B82Y40/00B01J2219/00644B01J2219/00387C40B40/12B01J2219/00497B01J2219/00641B01J2219/00659B05D1/185B01J2219/00596B82Y30/00B01J2219/00378C40B40/10B01J19/0046B01J2219/00527C40B60/14B01J2219/00731
Inventor 纪尧姆·德拉皮埃尔弗朗索瓦丝·维内菲利普·佩贡
Owner COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
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