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56 results about "Yellow fever" patented technology

A viral infection characterized by high fever and jaundice.

Purine monophosphate prodrugs for treatment of viral infections

The present invention is directed to compounds, compositions and methods for treating or preventing viral infections using nucleoside analog monophosphate prodrugs. More specifically, HCV, Norovirus, Saporovirus, Dengue virus, Chikungunya virus and Yellow fever in human patients or other animal hosts. The compounds are certain 2,6-diamino 2-C-methyl purine nucleoside monophosphate prodrugs and modified prodrug analogs, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HCV, Norovirus, Saporovirus, Dengue virus, Chikungunya virus and Yellow fever. This invention teaches how to modify the metabolic pathway of 2,6-diamino 2′-C-methyl purine and deliver nucleotide triphosphate(s) to polymerases at heretofore unobtainable therapeutically-relevant concentrations.
Owner:COCRYSTAL PHARMA INC

Pyrimidine nucleosides and their monophosphate prodrugs for treatment of viral infections and cancer

The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, cytomegalovirus (CMV), herpes viruses (HSV-1, HSV-2), Dengue virus, Yellow fever, or HBV in human patients or other animal hosts. The compounds are certain N4-hydroxycytidine nucleosides derivatives, modified monophosphate and phosphonates prodrugs analogs, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1, HIV-2, HCV, Norovirus, Saporovirus, cytomegalovirus (CMV), herpes viruses (HSV-1, HSV-2), Dengue virus, Yellow fever, and HBV.
Owner:EMORY UNIVERSITY

Compositions comprising pathogen-associated molecular patterns and antigens and methods of use thereof

Compositions comprise at least a portion of an antigen and at least a portion of a flagellin that lacks a hinge region. Compositions, fusion proteins and polypeptides comprise at least a portion of at least one pathogen-associated molecular pattern and at least a portion of at least one viral protein. The viral protein of the compositions, fusion proteins and polypeptides of the invention are flaviviral proteins, including a West Nile flaviviral protein, a Dengue flaviviral protein, a Langat flaviviral protein, a Kunjin flaviviral protein, a Murray Valley encephalitis flaviviral protein, a Japanese encephalitis flaviviral protein, a Tick-borne encephalitis flaviviral protein, a Yellow fever flaviviral protein and a hepatitis C flaviviral protein. The compositions, fusion proteins and polypeptides are used to stimulate an immune response and protective immunity in a subject.
Owner:VAXINNATE

Purine nucleoside monophosphate prodrugs for treatment of cancer and viral infections

The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV in human patients or other animal hosts. The compounds are certain 6-substituted purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1, HIV-2, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV.
Owner:EMORY UNIVERSITY

Fluorescence quantitative polymerase chain reaction (PCR) new method for detecting multiple viruses of yellow fever, dengue fever and epidemicencephalitis B and multiple virus detection PCR system

The invention discloses a fluorescence quantitative polymerase chain reaction (PCR) new method for detecting multiple viruses of yellow fever, dengue fever and epidemicencephalitis B and multiple virus detection PCR system consisting of primers, probes, a Premix Ex Taq reaction solution and a sterilized Tris buffer. With good singularity and high sensitivity, three pairs of primers and probes are very suitable for simultaneously detecting viruses of yellow fever, dengue fever and epidemicencephalitis B. And there is no cross reaction between the primers and probes and several other entomophily hemorrhagic fever viruses, such as Marburg virus and Rift Valley fever virus.
Owner:CHINESE ACAD OF INSPECTION & QUARANTINE

Purine monophosphate prodrugs for treatment of viral infections

The present invention is directed to compounds, compositions and methods for treating or preventing viral infections using nucleoside analog monophosphate prodrugs. More specifically, HCV, Norovirus, Saporovirus, Dengue virus, Chikungunya virus and Yellow fever in human patients or other animal hosts. The compounds are certain 2,6-diamino 2-C-methyl purine nucleoside monophosphate prodrugs and modified prodrug analogs, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HCV, Norovirus, Saporovirus, Dengue virus, Chikungunya virus and Yellow fever. This invention teaches how to modify the metabolic pathway of 2,6-diamino 2'-C-methyl purine and deliver nucleotide triphosphate(s) to polymerases at heretofore unobtainable therapeutically-relevant concentrations.
Owner:RFS PHARMA +1

Marburg and Ebola dual-virus fluorescent quantitative PCR (Polymerase Chain Reaction) detection method and system

The invention discloses Marburg and Ebola dual-virus fluorescent quantitative PCR (Polymerase Chain Reaction) detection method and system, wherein the detection system comprises primers, probes, a Premix EX Taq reaction solution and sterilizing Tris water. As two pairs of primers and probes have very good specificity, the detection system has high sensitivity and is suitable for simultaneously detecting Marburg and Ebola viruses without having cross reaction with other kinds of hemorrhagic fever arbovirus, such as yellow fever, dengue and rift valley fever.
Owner:CHINESE ACAD OF INSPECTION & QUARANTINE

Artemisinin with Berberine Compositions and Methods of Making

An all-natural herbal composition and methods of preparing the same are provided. The novel Artemisinin Combination Therapy (ACT) consists of artemisinin and its derivatives and berberine, the two active substances mixed with various selected excipient compounds to form a single pill, tablet or capsule for treatment and prevention of malaria, dengue fever, yellow fever, dysentery, Lyme disease, babesiosis, progressive multifocal leukoencephalopathy, Helicobacter Pylori, and colitis, in adults and children. A tablet or pill for children is formulated to be chewable.
Owner:U S PHYTOTHERAPY

Element fabric health-improving protective clothing capable of killing and repelling mosquitoes

The invention relates to element fabric health-improving protective clothing capable of killing and repelling mosquitoes, which belongs to the technical field of the production of healthy textile multifunctional textile fabric clothing. More than 360 types of mosquitoes are recorded in China. The mosquitoes are fond of sucking blood of warm-blooded animals, infect malaria, filariasis, yellow fever, dengue, epidemic encephalitis B and even H1N1 flu and threaten human health. The element fabric health-improving protective clothing, which is produced by performing nanometered disposal on mixed materials of a plurality of trace elements needed by a human body, a broad-spectrum powerful silver antibacterial agent, an anti-mosquito finishing agent SCJ-951, mosquito-killing pyrethrin and the like and adding the mixture into spinning solution of cotton, flax, fur, polypropylene fiber, polyamide fiber, acrylic fiber and the like, kills and repels mosquitoes and improves health.
Owner:陈欣荣

Process for producing yellow fever attenuated live vaccine by using SPF chicken embryo cells

InactiveCN108452298AViral antigen ingredientsAntiviralsVirus CultivationCell factory
The invention belongs to the field of biological products, and particularly relates to a process for producing a yellow fever attenuated live vaccine by using SPF chicken embryo cells. According to the process, a 17D attenuated vaccine strain provided by WHO is used, and is subjected to passage adaptation by using chicken embryo cells to prepare virulent seeds, chicken embryo cells cultured by cell factory are inoculated as matrix cells for virus culture, culture is performed, the virus solution is collected, sterilization is performed, a gelatin-free protection agent is added, and freeze drying is performed to prepare the finished product vaccine. According to the present invention, the efficacy index of vaccine meets the WHO standard, other quality test standards meet the requirement ofthe Pharmacopoeia of the People's Republic of China Volume 3 (2015 edition), and the product is used for preventing yellow fever infection.
Owner:无锡鑫连鑫生物医药科技有限公司

Hcv inhibitors

The present invention relates to compounds that are useful in the treatment of viruses belonging to Flaviviridae, including flaviviruses, pestiviruses, and hepaciviruses. The invention includes compounds useful for the treatment or prophylaxis of dengue fever, yellow fever, West Nile virus, and HCV.
Owner:SMITHKLINE BECKMAN CORP

Flavivirus virus like particle

The present application provides a virus like particle comprising one or more flavivirus structural proteins, and a composition or vaccine comprising thereof, its use in the prevention or treatment of flavivirus infection. The flavivirus structural protein contains at least one amino acid alteration in the envelope region. Examples of flavivirus contains dengue virus.
Owner:VLP THERAPEUTICS LLC

Hcv inhibitors

The present invention relates to compounds that are useful in the treatment of viruses belonging to Flaviviridae, including flaviviruses, pestiviruses, and hepaciviruses. The invention includes compounds useful for the treatment or prophylaxis of dengue fever, yellow fever, West Nile virus, and HCV.
Owner:SMITHKLINE BECKMAN CORP

Compositions comprising pathogen-associated molecular patterns and antigens and their use to stimulate an immune response

Compositions comprise at least a portion of an antigen and at least a portion of a flagellin that lacks a hinge region. Compositions, fusion proteins and polypeptides comprise at least a portion of at least one pathogen-associated molecular pattern and at least a portion of at least one viral protein. The viral protein of the compositions, fusion proteins and polypeptides of the invention are flaviviral proteins, including a West Nile flaviviral protein, a Dengue flaviviral protein, a Langat flaviviral protein, a Kunjin flaviviral protein, a Murray Valley encephalitis flaviviral protein, a Japanese encephalitis flaviviral protein, a Tick- borne encephalitis flaviviral protein, a Yellow fever flaviviral protein and a hepatitis C flaviviral protein. The compositions, fusion proteins and polypeptides are used to stimulate an immune response in a subject.
Owner:VAXINNATE

Use of dipeptide analogue

ActiveCN103585616ADipeptide ingredientsAntiviralsDiseaseWest Nile Virus Infection
The invention discloses use of a dipeptide analogue, and particularly relates to use of compounds in formulas (I) and (II), a stereisomer or a pharmaceutically acceptable salt thereof in pharmaceutical aspects. The compounds shown in the formulas (I) and (II) can be utilized as drugs for treating and preventing a disease caused by a dengue fever virus, and simultaneously can become the drugs for treating and preventing the disease caused by other flaviviruses, such as a yellow fever disease, hepatitis c, Japanese encephalitis, forest encephalitis, a disease caused by west nile virus infection, or aids caused by a human immunodeficiency virus (HIV) and the like.
Owner:NANJING TECH UNIV

Hcv inhibitors

The present invention relates to compounds that are useful in the treatment of viruses belonging to Flaviviridae, including flaviviruses, pestiviruses, and hepaciviruses. The invention includes compounds useful for the treatment or prophylaxis of dengue fever, yellow fever, West Nile virus, and HCV.
Owner:SMITHKLINE BECKMAN CORP

Insect repellent and insecticide composition

The invention discloses an insect repellent and insecticide composition. The insect repellent and insecticide composition comprises (a) lemon grass oil (citronella oil), (b) p-menthyl-3, 8-diol, (c) vanillin and (d) a transport medium, wherein the mass ratio of p-menthyl-3, 8-diol to lemon grass oil (citronella oil) is 10 to 2:1. The insect repellent and insecticide composition reduces the limitation of the existing product based on the known natural ingredients. Through the synergism of two or more insect repellent materials, the unique formula can produce additional benefits and superior effects. The research results show that the novel composition can effectively repel mosquitoes and has a strong repellent effect. The formula containing lemongrass oil (citronella oil) and p-menthyl-3, 8-diol can effectively resist mosquito-borne malarial mosquito and Aedes aegypti transmitting dengue fever and yellow fever.
Owner:黄珊珊

Yellow fever antigen near infrared fluorescence detection kit and application thereof

The invention relates to the technical field of biologics and in particular relates to a yellow fever antigen near infrared fluorescence detection kit and application thereof. The invention provides the yellow fever antigen near infrared fluorescence detection kit which comprises a reagent strip, wherein the reagent strip is positioned on a back plate; the reagent strip comprises a sample pad, a glass cellulose membrane marked by using an immunofluorescence probe, a nitrocellulose membrane coated by an LP antibody, and water absorption paper in sequence from a sample feeding end. By adopting the detection kit provided by the invention, urea or sputum of a patient can be adopted as a detection sample, and with the reference to the detection kit and a near-infrared fluorescence detection technique, specific and dissoluble LP antigen in a patient specimen can be rapidly and accurately detected.
Owner:JIANGSU WISE SCI & TECH DEV

Yellow fever antigen near-infrared fluorescence detection kit

The invention relates to the field of biotechnology, particularly to a yellow fever antigen near-infrared fluorescence detection kit and uses thereof, and provides a yellow fever antigen near-infraredfluorescence detection kit, which comprises a reagent strip positioned on a back plate, wherein the reagent strip sequentially comprises a sample pad, a glass cellulose membrane labeled with an immunofluorescent probe, a nitrocellulose membrane coated with a LP antibody, and water absorption paper from a sample adding end. According to the present invention, the detection kit can rapidly and accurately detect the specific and soluble LP antigen in the patient specimen by using the urine or sputum of the patient as the detection sample and combining with the near-infrared fluorescence detection technology.
Owner:ZHENJIANG XIANCHUANG BIOTECH CO LTD
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