14 results about "Tumour tissue" patented technology

The present invention provides multiplex assays for improved scoring of tumour tissues stained with an immune checkpoint protein such as VISTA. Methods of ranking multiple tumour tissues and of diagnosing cancer patients are also provided. The methods disclosed are also useful for identifying patient responsive to anticancer therapy.

Systems and methods for delineating tumour boundaries using a three-dimensional (3D) image stack, such as photoacoustic image slices, comprising a plurality of images. Multiple maximum intensity projections (MIPs) are derived from the stack, and level set segmentation is performed on those MIPs, to derive a boundary that bounds a region of interest (i.e., a tumour boundary). Structural and functional information is then derived for the region of interest, to analyse the tumour tissue.

A hand-held bioimpedance probe has more than four electrodes and one or more multiplexers which changeably select a subset of four electrodes, possibly in a quadrilateral shape. For each tetrapolar subset, a first pair is connected to a current source by the multiplexer and a second pair is connected to a voltage sensor, with the electrodes constituting the first and second pair changing as they are switched between a plurality of configurations. The subsets may overlap and a bioimpedance value may be generated for each subset, with a bioimpedance map being produced by superimposing quadrilaterals, coloured or shaded to indicate e.g. the average value. This may iteratively determine the path of a tissue margin and a low-pass filter may be applied e.g. using a Gaussian blur. Also disclosed is an apparatus for discriminating tissue where voltage between a second pair of electrodes as well as their individual voltages are measured.

The invention discloses a laparoscope system, comprising a control cabinet, a display is arranged on the surface of the control cabinet, the control cabinet is connected to a lens body through a line, a mirror body is arranged on one side of the lens body, an auxiliary device is arranged on the surface of the mirror body, the auxiliary device comprises a mounting ring and an ultrasonic generator, the mounting ring is fixedly connected to the surface of the mirror body, the mounting ring is composed of a circular ring and square blocks on both sides, the ultrasonic generator is arranged on one side of the mirror body, both sides of the ultrasonic generator are fixedly connected with plug blocks, the cross section of the plug blocks is L-shaped, and the surface of the mounting ring is provided with square holes. By arranging the auxiliary device, it is convenient for the auxiliary equipment to perform surgery, and normal tissue and tumor tissue, adipose tissue and gland, cystic and solid tissue, fiber bundles, fascia, blood vessels and lymphatic vessels can be effectively distinguished, the phenomenon of causing damage to some normal tissues is reduced, the situation that the operation efficiency of the equipment is low and affects the operation is reduced, and the overall practicality of the equipment is improved.

A method to assess the presence of tumour tissue in a lymph node specimen resected during surgery / biopsy using Field Cycling Relaxometry technique, corresponding system and computer program product.

The invention belongs to the technical field of medical equipment, and particularly relates to an ankle radiotherapy self-adaptive buffering body position fixing instrument which comprises a base, a controller is fixedly connected to the side wall of the base, four supporting rods are fixedly connected to the upper side wall of the base, the upper ends of the four supporting rods are fixedly connected with the same fixing base, and the same fixing base is fixedly connected with the controller. The fixing base is of a U-shaped structure, small electric push rods are fixedly connected to the left side and the right side of the fixing base correspondingly, and the movable ends of the small electric push rods penetrate through the fixing base and are connected with attaching clamping assemblies. When the ankle of a patient is subjected to radiotherapy, the foot of the patient can be fully bound, multi-direction displacement such as foot rotation, ankle translation and plantar sliding can be accurately limited, a positioning error is controlled within a radiotherapy safety threshold value, it is ensured that a target area and an irradiation field are accurately overlapped, and the situation that the dosage of tumor tissue is insufficient or normal tissue is excessively irradiated is avoided.

The invention relates to a catheter for locally treating tissue, in particular tumour tissue or other undesirable tissue types, in intravascular and intraluminal spaces for insertion into a vessel for the duration of treatment. The catheter comprises a flexible, cylindrical body (2) having a first lumen (14.1) for receiving a guidewire for guiding the catheter (1), a second lumen (14.2), and at least one third lumen (14.3) for separately introducing chemical and / or biological therapeutic agents into the tissue, wherein the cylindrical body (2) has radio-paque features. The catheter further comprises a conductive structure (6) for generating pulsed electric fields, wherein the conductive structure (6) comprises at least a first and a second structural element (8.1, 8.2). In addition, a first and a second electrical supply line (10.1, 10.2) are provided and insulated from each other. The invention further relates to a catheter system.

The present invention provides methods of producing, from malignant pleural effusion, expanded populations of tumour tissue-resident T cell memory (Trm) like CD103+CD8+ T cells based on expression of GPR183 and CXCR4 or expression of LITAF, JUNB and PI3KR1. Also provided are uses of said cells as a medicament and as a prognostic marker.

The invention discloses a tumor blood vessel blocking type light diagnosis and treatment reagent and a preparation method thereof.The preparation method comprises the steps that in the nitrogen atmosphere, aza-BODIPY molecules NBDP and a blood vessel blocking reagent 5, 6-dimethylxanthine-4-acetic acid are dissolved in a dichloromethane medium; the light diagnosis and treatment molecule NVDA is obtained through a reaction by taking NVDA as a substrate, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide) as a carboxyl activating reagent and 4-dimethylaminopyridine as a reaction catalyst. The optical diagnosis and treatment reagent NVDA nano-particles can selectively destroy tumor blood vessels and realize high-resolution blood vessel NIR-II fluorescence imaging so as to dynamically monitor the damage process of the tumor blood vessels; under the irradiation of 808 nm laser, the NVDA nanoparticles can efficiently generate I-type active oxygen species, and also show the photothermal conversion efficiency as high as 44%; the NIR-II fluorescent imaging-mediated I-type photodynamic therapy, photothermal therapy and vascular disruption combined therapy for deep tumor tissues can be used for efficiently killing tumor cells.

A segment of characteristic polypeptide antigen of a TRPV6 protein is selected to immunize mice and then screening is performed to obtain hybridoma cell lines 12CT 9.5.1, 16CT 18.1.1.2 and 16CT 4.1.1.2. The series of cells can secrete monoclonal antibodies against TRPV6 and can specifically recognize the TRPV6 protein and tumour tissue. The series of antibodies can be used to measure the level of TRPV6 in cells in an artificial or automated manner by means of immunohistochemistry (IHC), enzyme-linked immunosorbent assay (ELISA), immunofluorescence (IF), chemiluminescent immunoassay (CLIA), turbidimetric immunoassay (TIA), or western blot, are thus used in a method for diagnosing tumour tissue, and relate to the field of biological detection.

The microcatheter comprises an inner tube and an outer tube which are coaxially arranged, the outer tube wraps the inner tube, a side hole is formed in the near end of the outer tube, and the inner tube extends out of the side hole to form a forked structure; a gap is formed between the outer tube and the inner tube, and the gap and the inner tube are separated to form two-component infusion channels which are isolated from each other. According to the invention, two component liquid substances can be independently conveyed at the same time, are converged at a treatment target at the far end of the catheter and then are subjected to in-situ polymerization to form gel, so that the gel enters a finer blood vessel branch, and comprehensive and thorough embolism treatment is carried out on tumor tissues; the adjusting knob is rotated to drive the sliding block to extrude or release extrusion on the balloon, so that the total volume of the infusion channel of the outer tube is changed, and finally the flow ratio of different component liquid substances at the far end of the catheter is adjusted. The conveying micro-catheter can be used in cooperation with a conventional duplex injector, the output end of the catheter outputs liquid substances with different components at the same time, two kinds of liquid are mixed more evenly, and meanwhile the operation steps of a doctor are effectively reduced.

Apparatus for discriminating between tumour tissue and non-tumorous tissue, the apparatus comprising: a handheld bioimpedance probe having a plurality of electrodes mounted thereon, wherein the plurality of electrodes are greater than four in number; a current source configured to generate a stimulation current; a voltage sensor; one or more multiplexers coupled between the current source, the voltage sensor and the electrodes and configured to changeably select a subset of four electrodes from the plurality of electrodes, and, for each selected subset of four electrodes, to switch between a plurality of switching configurations, wherein, in each switching configuration, a first pair of the selected subset of four electrodes are connected to the current source, and a second pair of the selected subset of four electrodes are connected to the voltage sensor, the electrodes that constitute the first pair and the electrodes that constitute the second pair changing from one switching configuration to the next; and processor-controlled circuitry configured to: control the selection of the subset of four electrodes by the one or more multiplexers; control the switching configuration of the one or more multiplexers with respect to the selected subset of four electrodes; control the generation of the stimulation current by the current source and the application of the stimulation current to the first pair of electrodes of each switching configuration, such that, in use, the stimulation current flows through tissue between the first pair of electrodes; control the measurement, by the voltage sensor, of the voltage between the second pair of electrodes of each switching configuration, across the tissue; determine, based on the applied current and the measured voltages for each switching configuration, a measure of relative impedance of the tissue for each switching configuration; and supply such impedance measurements as output data to a data analyser to enable real-time discrimination of the tissue to be performed, based on the impedance measurements.

The present invention belongs to the area of materials analysis to determine the physical or chemical properties thereof, in particular real-time gas analysis for detecting tumour tissue. The invention provides a system and a method for detecting tumour tissue by means of real-time gas analysis during a surgical procedure.

A method to assign the grade to a tumour specimen resected during surgery / biopsy using by means of the Field Cycling Relaxometry technique, a corresponding system and computer program product.