23 results about "Embolization Therapy" patented technology

The application discloses a kind of degradable microspheres with controllable and preparation method thereof, belong to the technical field of biomedical materials.The base material of the microspheres is methacrylated gelatin, and the degradation time of the microspheres is controlled by regulating the degree of substitution of methacrylated gelatin.The microspheres are prepared by microfluidic and photopolymerization technology, and have uniform size with particle size of 10 μm to 1000 μm.The methacrylated gelatin microspheres with controllable degradation provided by the application can be used for interventional recanalization embolization therapy of substantial organ hemorrhage, realize the time sequence regulation of "hemostasis-degradation-recanalization", and have good clinical transformation value.

The invention discloses hydrogel microspheres capable of loading radioactive isotopes and a preparation method of the hydrogel microspheres. The microsphere is formed by copolymerizing a macrocyclic ligand structure, a hydrophilic monomer and a cross-linking agent, and a macrocyclic ligand is connected with a polymer main chain through a bridging structure containing p-aminobenzoic acid and aliphatic diamine and can efficiently and stably complex various radioactive isotopes. The microspheres have the characteristics of being close to water in density, good in suspension property, smooth in surface and rich in elasticity, and are easily and uniformly distributed in tumor peripheral blood vessels. The preparation method comprises the following two routes: firstly synthesizing the functional monomer and then copolymerizing, or firstly preparing the microspheres and then gradually grafting. The problems that existing microsphere nuclides are prone to falling off, high in density and poor in suspension property are effectively solved, and the microsphere is suitable for interventional radioactive embolism treatment.

The application discloses a polymer vesicle-stabilized drug-iodized oil emulsion and a preparation method and application thereof, to realize safe and efficient transarterial chemoembolization (TACE) treatment of hepatocellular carcinoma in situ. The drug-iodized oil emulsion system has the following advantages: simple preparation, convenient size adjustment, excellent stability, near-zero order and sustained controllable drug release rate, low blood drug concentration after transarterial embolization, and the retention time and retention amount of the drug in the liver are superior to those of free drug-iodized oil emulsion used in clinical treatment, the tumor can be completely eradicated, angiogenesis can be effectively inhibited, and adverse reactions can be reduced. In general, the polymer vesicle-stabilized drug-iodized oil emulsion has the advantages of high stability and sustained controllable drug release, and can greatly improve the embolization chemotherapy effect of hepatocellular carcinoma, and provide a safe and efficient TACE strategy.

Method and system for embolization treatment at a target site within a vessel using an endovascular embolization system. A microcatheter is navigated to the target site in the vessel. Embolic solution is injected into the vessel. Proximal migration in the vessel of the injected embolic solution is prevented by injecting into the vessel a glucose solution.

The application provides a high drug loading slow-release embolism microsphere with rough surface. The microsphere is composed of a double-layer core-shell structure, the core layer comprises cross-linked poly-N-isopropyl acrylamide, a polysiloxane framework and nano-clay, and the shell layer comprises cross-linked polymethyl methacrylate-N, N-dimethyl amine ethyl ester, octavinyl-POSS nanoparticles and polylactic acid macromolecules; the rough structure on the surface of the microsphere can promote the rapid and stable embolism of the microsphere in blood vessels, the core layer and the shell layer can simultaneously load a large amount of different types of anticancer drugs, and the slow-release can be sustained for 60 days, and the microsphere has significant potential in the embolism treatment field.

The invention relates to the technical field of biomedical materials, and provides zeolite polyvinyl alcohol organic-inorganic composite embolization microspheres as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing nano zeolite with a blood coagulation function through ion exchange, dispersing the nano zeolite in silicone oil to form a continuous phase, and forming W / O type liquid drops from a polyvinyl alcohol dispersed phase solution and the continuous phase containing the nano zeolite by adopting a microfluidic technology; and crosslinking and curing by using an organic acid catalyst to obtain the zeolite polyvinyl alcohol organic-inorganic composite embolism microsphere with a physical embolism function and a procoagulant function. The zeolite polyvinyl alcohol organic-inorganic composite embolism microsphere takes cross-linked polyvinyl alcohol as a matrix, nano zeolite particles with specific functions are uniformly distributed on the surface, and the zeolite polyvinyl alcohol organic-inorganic composite embolism microsphere has a physical embolism function and a procoagulant function and has a wide application prospect in the fields of tumor embolism treatment, vascular malformation embolism, hemorrhagic disease treatment and the like; and a brand-new efficient embolism treatment solution is provided for clinic.

The invention discloses an intracranial dura mater arteriovenous fistula medical image analysis method, and relates to the technical field of medical image.The method comprises the steps that a digital subtraction angiography dynamic image sequence after interventional embolization treatment is obtained; performing motion compensation on each frame of image in the dynamic image sequence; extracting a time-varying track of the signal intensity of the contrast agent from the dynamic image sequence after motion compensation; identifying a blood vessel dynamic mode based on the track of the contrast agent signal intensity changing along with time; performing dynamic enhancement processing on the blood vessel image area in the blood vessel dynamic mode according to the hemodynamic characteristics; extracting a blood vessel signal from the dynamic image under the enhancement processing; and reconstructing a three-dimensional model under the cerebrovascular network in a three-dimensional space based on the blood vessel signal. According to the method, a reliable basis is provided for a doctor to evaluate the treatment effect, judge the residual focus or recruit the collateral vessel, misdiagnosis and misjudgment are avoided, and therefore the treatment effect and safety of a patient are improved.

Materials, methods, and systems are provided that are particularly useful for embolizing, for example, a target vascular sac using microgels applied with a microrobot. The microrobot comprises a microgel based on a self-healing material for on-demand controllable aggregation, magnetic agents, such as magnetite nanoparticles, encapsulated in microgels for driving and aggregating microrobots at targeted intravascular locations under physiological blood flow and imaging agents, such as tantalum microparticles, for accurately tracking microrobots in living organisms through clinical medical devices. Related systems and methods are disclosed for delivering and guiding microrobots to accumulate and gather at targeted locations to provide on-demand and reliable embolization therapy under real-time monitoring.

The invention discloses a temperature-sensitive nanogel system based on a tirapazamine derivative, the temperature-sensitive nanogel system is composed of RTPZ, PIB nanogel and normal saline, the concentration of PIB is 25-40 mg / mL, and the concentration of RTPZ is 2-6 mg / mL. The preparation method comprises the following steps: preparing a tirapazamine derivative RTPZ; dissolving a tirapazamine derivative RTPZ and PIB nanogel in absolute ethyl alcohol, stirring until the materials are uniformly mixed, spin-drying to remove ethyl alcohol, and drying in a vacuum drying oven to obtain a mixture of PIB and RTPZ; and dissolving a mixture of PIB and RTPZ in normal saline to prepare the RTPZ temperature-sensitive nanogel system. The temperature-sensitive nanogel system disclosed by the invention is a novel embolism treatment delivery system, integrates the characteristics of novel temperature-sensitive nanogel PIB, hypoxia activation prodrug and slow release, and constructs a local, slow-release and targeted hypoxia tumor treatment system for transcatheter arterial chemoembolism.

A computer-implemented method for evaluating image data depicting a vascular structure for the purpose of automatically determining at least one arterial and / or venous access position of the vascular structure. An embolization may be carried out at at least one peripheral position of a pathological change in the region of the vascular structure by introducing a catheter via an access path which runs through the vascular structure and leads from the access position or one of the access positions to the respective peripheral position. The method includes obtaining the image data comprising a plurality of image points, wherein those image points through whose respectively associated position in the vascular structure a contrast agent flowed during the recording of the image data, or of raw images from which the image data is derived, are each assigned at least one captured item of time information relating to a time point at which the contrast agent reached the respective position, the contrast agent being administered during or before this recording and determining the at least one arterial and / or venous access position on the basis of the at least one item of time information.

This invention belongs to the fields of biomedical engineering and nanomaterials technology, and provides a drug-loadable sodium alginate / citric acid embolization microsphere with photothermal effects, its preparation method, and the drug-loaded microspheres. The invention utilizes electrostatic spraying technology to prepare drug-loadable black phosphorus nanosheets (BPNS) of sodium alginate (ALG) / sodium citrate (SC) embolization microspheres. These microspheres are then mineralized to obtain the photothermal drug-loadable sodium alginate / citric acid embolization microspheres. In vitro mineralization enhances the surface roughness of the microspheres, achieving integration of coagulation, embolization therapy, photothermal therapy, and chemotherapy. The microspheres are uniform in size, controllable, and well-dispersible, exhibiting good coagulation effects. They can be used for embolization, local chemotherapy, and local hyperthermia to achieve effective tumor treatment. The process is simple and easy to manufacture. The product exhibits good dispersibility and excellent sphericity, with a diameter between 200-300 μm. It can be used for interventional treatment of solid tumors such as liver cancer.

This invention relates to polymer microspheres supported by active metal nanoparticles, their manufacturing method, and applications, and belongs to the technical field of tumor embolization therapy. The polymer microspheres supported by active metal nanoparticles described in this invention include a polymer microsphere skeleton and active metal nanoparticles distributed inside the polymer microsphere skeleton. This invention mainly produces the target microspheres by a reversed-phase microemulsion method. The polymer microspheres supported by active metal nanoparticles produced in this invention are used in transarterial tumor embolization, embolizing tumor blood vessels and blocking nutrient supply to the tumor site, while also gradually and continuously releasing hydroxides within the epithelium to adjust the tumor microenvironment to a weakly acidic state, releasing hydrogen gas to activate the immune response, inducing hydrogen gas therapy, and amplifying the effect of embolization therapy. This demonstrates a superior combined therapeutic effect compared to embolization therapy using only polymer microspheres.

In the microsphere preparation for chemoembolization therapy and nuclear medicine imaging of tumor, and a preparation method thereof, the microsphere is formed by means of using a polyvinyl alcohol derivative as a framework material and polymerizing, crosslinking and curing same with an N-acryl amino acid monomer. The microsphere can label radionuclide iodine and can also absorb load chemotherapeutic drugs.

To provide a material for embolic arterial intervention (embolotherapy or arterial embolotherapy) and a method for preparing the material.SOLUTION: Radiopaque, bioresorbable spherical microparticles for embolization or vascular occlusion therapy are provided which comprise a copolymer of an iodo-containing, halogenated phenyl-containing unit, such as an iodinated desaminotyrosine derivative, and a rubbery component such as polyethylene glycol (PEG), polycaprolactone (PCL), polytetramethylene oxide (PTMO) or polytrimethylene carbonate (PTMC). The provided microbeads can further contain or be coated with a therapeutic agent, such as paclitaxel, for targeted delivery of the therapeutic agent.SELECTED DRAWING: Figure 3

This invention provides a vascular embolization treatment device, relating to the field of vascular embolization medical device technology. It includes a delivery tube and a spring coil. The spring coil includes a spring coil body and an end fixed to the distal end of the spring coil body. It also includes an end control mechanism and a spring coil control mechanism, with the distal end of the end control mechanism detachably connected to the proximal end of the end. The distal end of the delivery tube is detachably connected to the proximal end of the spring coil body via the spring coil control mechanism. This invention can improve the success rate of spring coil formation, avoid mis-embolization, and reduce surgical risks.

The invention provides an electrocoagulation guide wire system. The electrocoagulation guide wire system comprises a net-shaped plugging device, a conveying piece, a core wire and a leading-in sheath. The conveying part is arranged on the side wall of the core wire in a protruding mode, the core wire and the conveying part are both contained in the guiding-in sheath, at least part of the near end of the core wire protrudes out of the near end of the guiding-in sheath, the net-shaped plugging device is configured to be shrunk in the radial direction and contained in the guiding-in sheath, and the guiding-in sheath is connected to the net-shaped plugging device in a sleeving mode. The net-shaped plugging device is at least partially clamped between the inner wall of the guiding-in sheath and the side face, away from the core wire, of the conveying piece. The side face, away from the core wire, of the conveying piece is configured to generate friction interference when the net-shaped plugging device slides away from the conveying piece. The far end of the net-shaped plugging device extends into an aneurysm cavity, and the net-shaped plugging device is plugged at the aneurysm neck after being expanded in the radial direction. The far end of the core wire is configured to at least partially extend into an aneurysm cavity and form an electric loop with a power supply through blood. The electrocoagulation guide wire system can achieve the purpose of electrocoagulation embolism treatment of wide-neck aneurysm.

This invention relates to the field of tumor treatment technology, and particularly to a radioembolization microsphere, a radioembolization microsphere formulation, its preparation method, and its application. The radioembolization microsphere provided by this invention comprises radioactive particles and an organic phase containing iodized oil. The radioactive particles are coated on an interface with the organic phase containing iodized oil as its core. The radioactive particles comprise a radionuclide and an inorganic matrix, with the radionuclide immobilized in the inorganic matrix. The particle size of the radioactive particles is 0.01~10 μm; the particle size of the radioembolization microspheres is 0.01~1000 μm. Applying the radioembolization microspheres of this invention to embolization therapy can maintain long-term retention at the tumor site and reduce radiation damage to non-tumor sites. The iodine component provides X-ray imaging functionality, enabling integrated diagnosis and treatment, radioactive dose tracking, and accurate measurement of radiation dose.

Method and system for embolization treatment at a target site within a vessel using an endovascular embolization system. A microcatheter is navigated to the target site in the vessel. Embolic solution is injected into the vessel. Proximal migration in the vessel of the injected embolic solution is prevented by injecting into the vessel a glucose solution.

The invention provides a tumor targeted therapy system combining an energy field with embolism microspheres, which is applied to the field of tumor therapy instruments, and is characterized in that an energy enrichment material for targeting and enriching an external electric field or ultrasonic energy is loaded inside or on the surface of the embolism microspheres; therefore, TACE (Trans Arterial Chemoembolism) and energy release unit treatment are synergistically matched, on one hand, the embolism microspheres are implanted into a tumor blood supply artery in a minimally invasive catheter implantation mode in the early stage of the operation so as to block blood flow or nutrition supply of a tumor part; on the other hand, accurate focusing is carried out through an electric field / ultrasonic energy generator in the postoperative stage, normal cells are not damaged, and the microenvironment around the tumor is improved; embolism treatment and energy ablation treatment are combined for the first time, the safety and the treatment effect in the treatment process are further improved, and a new way for solid tumor treatment is opened up.

The invention provides a tumor neck opening closing component and a tumor neck opening closing device.The tumor neck opening closing component comprises a clamping piece used for clamping the edge of a tumor neck opening, the clamping piece comprises a connecting part, an intra-tumor clamping part and an extra-tumor clamping part, the intra-tumor clamping part and the extra-tumor clamping part are connected to the two opposite ends of the connecting part, the intra-tumor clamping part is used for acting on the inner wall of an aneurysm, and the extra-tumor clamping part is used for acting on the inner wall of the aneurysm; the external tumor clamping part is used for acting on the inner wall of a tumor-carrying artery; the driving piece is used for applying a driving force for gathering the connecting parts to the connecting parts; the tumor neck opening can be closed to embolize the aneurysm only by placing the tumor neck opening closing component at the tumor neck opening, other instruments do not need to be placed repeatedly, the embolism effect is good, operation is easy and convenient, and the surgical risk is small.

A disposable zero-exchange long sheath transradial artery access sheath assembly includes, but is not limited to, a needle and / or a skin cutter, and also a guide wire, a long sheath, and a dilator. The needle head is used for puncturing the skin, muscle and blood vessel wall close to the radial artery; the guide wire is used for entering blood vessels of a human body and abutting against an area near a focus; the long sheath is provided with a channel for an instrument to pass through, one end in the far-end direction is a head end for treatment, and one end in the near-end direction is one end for external operation; the dilator is in a catheter shape, movably connected to the outer portion of the guide wire in a sleeving mode and connected to a channel in the long sheath in a penetrating mode, and is used for providing a supporting basis for the near-end pipe section of the long sheath. The utility model is used for solving the defect that the current vascular embolism treatment lacks a catheter assembly combination, and avoiding the situation that in case of vasculopathy which needs to use a super-selection device, other medical devices need to be used for matching after unpacking. And the long sheath is directly matched to complete the operations of puncture and blood vessel super-selection. A puncture short sheath and a puncture guide wire are omitted.

Method for embolization treatment at a target site within a vessel using an endovascular embolization system. A microcatheter is navigated to the target site in the vessel. Via the microcatheter, only embolic solution is injected into the vessel. Aspirated fluid representing only a portion of the injected embolic solution present in the vessel is aspirated into the microcatheter to prevent the injected embolic solution present in the vessel from proximally migrating in the vessel. Alternatively, the injected embolic solution is prevented from proximal migration by occluding the vessel with the distal end of the microcatheter.