35 results about "Embolization Therapy" patented technology

The application discloses a kind of degradable microspheres with controllable and preparation method thereof, belong to the technical field of biomedical materials.The base material of the microspheres is methacrylated gelatin, and the degradation time of the microspheres is controlled by regulating the degree of substitution of methacrylated gelatin.The microspheres are prepared by microfluidic and photopolymerization technology, and have uniform size with particle size of 10 μm to 1000 μm.The methacrylated gelatin microspheres with controllable degradation provided by the application can be used for interventional recanalization embolization therapy of substantial organ hemorrhage, realize the time sequence regulation of "hemostasis-degradation-recanalization", and have good clinical transformation value.

The invention discloses hydrogel microspheres capable of loading radioactive isotopes and a preparation method of the hydrogel microspheres. The microsphere is formed by copolymerizing a macrocyclic ligand structure, a hydrophilic monomer and a cross-linking agent, and a macrocyclic ligand is connected with a polymer main chain through a bridging structure containing p-aminobenzoic acid and aliphatic diamine and can efficiently and stably complex various radioactive isotopes. The microspheres have the characteristics of being close to water in density, good in suspension property, smooth in surface and rich in elasticity, and are easily and uniformly distributed in tumor peripheral blood vessels. The preparation method comprises the following two routes: firstly synthesizing the functional monomer and then copolymerizing, or firstly preparing the microspheres and then gradually grafting. The problems that existing microsphere nuclides are prone to falling off, high in density and poor in suspension property are effectively solved, and the microsphere is suitable for interventional radioactive embolism treatment.

The application discloses a polymer vesicle-stabilized drug-iodized oil emulsion and a preparation method and application thereof, to realize safe and efficient transarterial chemoembolization (TACE) treatment of hepatocellular carcinoma in situ. The drug-iodized oil emulsion system has the following advantages: simple preparation, convenient size adjustment, excellent stability, near-zero order and sustained controllable drug release rate, low blood drug concentration after transarterial embolization, and the retention time and retention amount of the drug in the liver are superior to those of free drug-iodized oil emulsion used in clinical treatment, the tumor can be completely eradicated, angiogenesis can be effectively inhibited, and adverse reactions can be reduced. In general, the polymer vesicle-stabilized drug-iodized oil emulsion has the advantages of high stability and sustained controllable drug release, and can greatly improve the embolization chemotherapy effect of hepatocellular carcinoma, and provide a safe and efficient TACE strategy.

The utility model relates to the technical field of medical instruments, in particular to a self-expanding intratumoral embolism device capable of being rotatably connected, which comprises an embolism device, the embolism device is formed by weaving metal wires with shape memory ability and good elasticity in a staggered manner, the embolism device comprises an anchoring part, a blocking part and a drainage part, and a lantern ring is further arranged at the bottom of the embolism device. The sleeve ring is used for being connected with the conveying device, the conveying device, the conveying device and the embolism device are connected through a rotating structure, the conveying device is used for conveying the embolism device into the aneurysm, and the conveying device comprises a conveying pipe. According to the device, the position of the embolism device in the aneurysm can be flexibly adjusted, the ball of the rotating structure freely rotates in the spherical groove of the conveying device, accurate control over the embolism device is achieved, it is ensured that the embolism device can be accurately released to the optimal position of the aneurysm, and the embolism treatment effect is remarkably improved.

Method and system for embolization treatment at a target site within a vessel using an endovascular embolization system. A microcatheter is navigated to the target site in the vessel. Embolic solution is injected into the vessel. Proximal migration in the vessel of the injected embolic solution is prevented by injecting into the vessel a glucose solution.

The invention discloses a tumor cell-derived drug-loaded vesicle and temperature-sensitive nanogel composition and a preparation method and application thereof, and belongs to the technical field of tumor treatment, and the composition comprises a poly-N-isopropylacrylamide-butyl methacrylate nanogel, iohexol and a drug-loaded vesicle. According to the tumor cell-derived drug-loaded vesicle and temperature-sensitive nanogel composition as well as the preparation method and the application thereof, the bioavailability of Dug (at) MPs is improved, the bioavailability of non-target visceral organs is reduced, the intra-tumor penetration distance of the drug is increased, precise cooperation of chemotherapy and interventional embolism treatment is realized, and the curative effect of the drug is improved. The medicine is far better than interventional embolism therapy or conventional interventional embolism chemotherapy, and recurrence and metastasis of tumors are effectively inhibited.

The application provides a high drug loading slow-release embolism microsphere with rough surface. The microsphere is composed of a double-layer core-shell structure, the core layer comprises cross-linked poly-N-isopropyl acrylamide, a polysiloxane framework and nano-clay, and the shell layer comprises cross-linked polymethyl methacrylate-N, N-dimethyl amine ethyl ester, octavinyl-POSS nanoparticles and polylactic acid macromolecules; the rough structure on the surface of the microsphere can promote the rapid and stable embolism of the microsphere in blood vessels, the core layer and the shell layer can simultaneously load a large amount of different types of anticancer drugs, and the slow-release can be sustained for 60 days, and the microsphere has significant potential in the embolism treatment field.

The invention relates to the technical field of biomedical materials, and provides zeolite polyvinyl alcohol organic-inorganic composite embolization microspheres as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing nano zeolite with a blood coagulation function through ion exchange, dispersing the nano zeolite in silicone oil to form a continuous phase, and forming W / O type liquid drops from a polyvinyl alcohol dispersed phase solution and the continuous phase containing the nano zeolite by adopting a microfluidic technology; and crosslinking and curing by using an organic acid catalyst to obtain the zeolite polyvinyl alcohol organic-inorganic composite embolism microsphere with a physical embolism function and a procoagulant function. The zeolite polyvinyl alcohol organic-inorganic composite embolism microsphere takes cross-linked polyvinyl alcohol as a matrix, nano zeolite particles with specific functions are uniformly distributed on the surface, and the zeolite polyvinyl alcohol organic-inorganic composite embolism microsphere has a physical embolism function and a procoagulant function and has a wide application prospect in the fields of tumor embolism treatment, vascular malformation embolism, hemorrhagic disease treatment and the like; and a brand-new efficient embolism treatment solution is provided for clinic.

The invention discloses an intracranial dura mater arteriovenous fistula medical image analysis method, and relates to the technical field of medical image.The method comprises the steps that a digital subtraction angiography dynamic image sequence after interventional embolization treatment is obtained; performing motion compensation on each frame of image in the dynamic image sequence; extracting a time-varying track of the signal intensity of the contrast agent from the dynamic image sequence after motion compensation; identifying a blood vessel dynamic mode based on the track of the contrast agent signal intensity changing along with time; performing dynamic enhancement processing on the blood vessel image area in the blood vessel dynamic mode according to the hemodynamic characteristics; extracting a blood vessel signal from the dynamic image under the enhancement processing; and reconstructing a three-dimensional model under the cerebrovascular network in a three-dimensional space based on the blood vessel signal. According to the method, a reliable basis is provided for a doctor to evaluate the treatment effect, judge the residual focus or recruit the collateral vessel, misdiagnosis and misjudgment are avoided, and therefore the treatment effect and safety of a patient are improved.

Materials, methods, and systems are provided that are particularly useful for embolizing, for example, a target vascular sac using microgels applied with a microrobot. The microrobot comprises a microgel based on a self-healing material for on-demand controllable aggregation, magnetic agents, such as magnetite nanoparticles, encapsulated in microgels for driving and aggregating microrobots at targeted intravascular locations under physiological blood flow and imaging agents, such as tantalum microparticles, for accurately tracking microrobots in living organisms through clinical medical devices. Related systems and methods are disclosed for delivering and guiding microrobots to accumulate and gather at targeted locations to provide on-demand and reliable embolization therapy under real-time monitoring.

Methods for preparing a drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. The drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. The therapeutic agent is not chemically bonded to the water-swellable polymer material. The drug-loaded microbead composition has a water content of less than 1% by weight, based on the total weight of the drug-loaded microbead composition. The drug-loaded microbead composition may be rehydrated to form an embolization composition for use in in embolization therapy.

The invention discloses an unsupervised learning 2D and 3D image registration method, and belongs to the field of computer medical image processing. According to the method, a CNN-Transform parallel network and improved projection space transformation based on a parallel projection mode are constructed, specifically, 3D TOF and 2D DSA data are obtained and preprocessed, the improved projection space transformation based on the parallel projection mode is constructed, a parallel CNN-Transform double-branch network (CTNet) is constructed, and the method is used for evaluating feature similarity, training the CTNet and achieving precise registration of the 2D DSA and the 3D TOF. The system is used for interventional operation navigation, provides three-dimensional guidance for catheter path planning and embolism treatment, is used for complex lesion assessment, and provides multi-aspect support for disease diagnosis and treatment. According to the method, global and local features can be extracted more comprehensively for feature similarity evaluation, and the registration performance is improved; the projection image is generated by adopting the improved projection space transformation based on the parallel projection mode, and the generated projection image is more matched with the TOF imaging principle.

A method of performing a radioembolization treatment includes injecting 402 a plurality of radioembolization particles into a bloodstream of a patient to treat a target tissue. Each radioembolization particle of the plurality of radioembolization particles includes a radioactive core and a radiopaque layer. The method also includes obtaining 404 an image of the target tissue and the radioembolization particles to determine 406 a dose of radioactivity delivered to the target tissue by the plurality of radioembolization particles. wherein the image is one of a computerized tomography (CT) image and an x-ray image.

The invention discloses a temperature-sensitive nanogel system based on a tirapazamine derivative, the temperature-sensitive nanogel system is composed of RTPZ, PIB nanogel and normal saline, the concentration of PIB is 25-40 mg / mL, and the concentration of RTPZ is 2-6 mg / mL. The preparation method comprises the following steps: preparing a tirapazamine derivative RTPZ; dissolving a tirapazamine derivative RTPZ and PIB nanogel in absolute ethyl alcohol, stirring until the materials are uniformly mixed, spin-drying to remove ethyl alcohol, and drying in a vacuum drying oven to obtain a mixture of PIB and RTPZ; and dissolving a mixture of PIB and RTPZ in normal saline to prepare the RTPZ temperature-sensitive nanogel system. The temperature-sensitive nanogel system disclosed by the invention is a novel embolism treatment delivery system, integrates the characteristics of novel temperature-sensitive nanogel PIB, hypoxia activation prodrug and slow release, and constructs a local, slow-release and targeted hypoxia tumor treatment system for transcatheter arterial chemoembolism.

A computer-implemented method for evaluating image data depicting a vascular structure for the purpose of automatically determining at least one arterial and / or venous access position of the vascular structure. An embolization may be carried out at at least one peripheral position of a pathological change in the region of the vascular structure by introducing a catheter via an access path which runs through the vascular structure and leads from the access position or one of the access positions to the respective peripheral position. The method includes obtaining the image data comprising a plurality of image points, wherein those image points through whose respectively associated position in the vascular structure a contrast agent flowed during the recording of the image data, or of raw images from which the image data is derived, are each assigned at least one captured item of time information relating to a time point at which the contrast agent reached the respective position, the contrast agent being administered during or before this recording and determining the at least one arterial and / or venous access position on the basis of the at least one item of time information.

This invention belongs to the fields of biomedical engineering and nanomaterials technology, and provides a drug-loadable sodium alginate / citric acid embolization microsphere with photothermal effects, its preparation method, and the drug-loaded microspheres. The invention utilizes electrostatic spraying technology to prepare drug-loadable black phosphorus nanosheets (BPNS) of sodium alginate (ALG) / sodium citrate (SC) embolization microspheres. These microspheres are then mineralized to obtain the photothermal drug-loadable sodium alginate / citric acid embolization microspheres. In vitro mineralization enhances the surface roughness of the microspheres, achieving integration of coagulation, embolization therapy, photothermal therapy, and chemotherapy. The microspheres are uniform in size, controllable, and well-dispersible, exhibiting good coagulation effects. They can be used for embolization, local chemotherapy, and local hyperthermia to achieve effective tumor treatment. The process is simple and easy to manufacture. The product exhibits good dispersibility and excellent sphericity, with a diameter between 200-300 μm. It can be used for interventional treatment of solid tumors such as liver cancer.

This invention relates to polymer microspheres supported by active metal nanoparticles, their manufacturing method, and applications, and belongs to the technical field of tumor embolization therapy. The polymer microspheres supported by active metal nanoparticles described in this invention include a polymer microsphere skeleton and active metal nanoparticles distributed inside the polymer microsphere skeleton. This invention mainly produces the target microspheres by a reversed-phase microemulsion method. The polymer microspheres supported by active metal nanoparticles produced in this invention are used in transarterial tumor embolization, embolizing tumor blood vessels and blocking nutrient supply to the tumor site, while also gradually and continuously releasing hydroxides within the epithelium to adjust the tumor microenvironment to a weakly acidic state, releasing hydrogen gas to activate the immune response, inducing hydrogen gas therapy, and amplifying the effect of embolization therapy. This demonstrates a superior combined therapeutic effect compared to embolization therapy using only polymer microspheres.

The present invention relates to a fresh wolfberry composition having the function of improving vascular embolism and a preparation method thereof, and relates to the technical field of vascular embolism treatment. The fresh wolfberry composition comprises the following components, measured by weight: 600-800 parts of fresh wolfberry fruit, 100-200 parts of fresh roxburgh fruit, and 40-80 parts of northern lily of the valley. The present invention is the first to use fresh wolfberry fruit as the main raw material, combined with appropriate amounts of fresh roxburgh fruit and northern lily of the valley as raw materials. The three ingredients work synergistically to produce a fresh wolfberry composition having the function of improving vascular embolism, providing a new approach for preventing and treating vascular embolic diseases.

Disclosed in the present application is a dual-lumen multifunctional catheter, comprising a catheter body and a Y-connector, wherein the catheter body comprises an inner-lumen tube and an outer-lumen tube, the outer-lumen tube is sleeved outside the inner-lumen tube, an annular cavity is formed between an outer wall of the inner-lumen tube and an inner wall of the outer-lumen tube, and the inner-lumen tube and the outer-lumen tube are connected at a tip part which is not completely sealed and serves as an outlet of the outer lumen. In conclusion, the present application relates to a dual-lumen multifunctional catheter, which integrates multiple functions of angiography, drug perfusion and access establishment, allows guidewire and microcatheter to pass therethrough, and does not need to repeatedly replace guidewire during angiography, thereby improving the operation convenience, shortening the operation time, and reducing the treatment cost; a shapeable structure section is further provided at one end of the catheter, has a shape that can be adjusted according to different blood vessel requirements, and is highly practical; and the catheter assists in positioning of the microcatheter, and a contrast agent and drugs can be injected through the outer lumen as needed during embolotherapy to reduce complications.

In the microsphere preparation for chemoembolization therapy and nuclear medicine imaging of tumor, and a preparation method thereof, the microsphere is formed by means of using a polyvinyl alcohol derivative as a framework material and polymerizing, crosslinking and curing same with an N-acryl amino acid monomer. The microsphere can label radionuclide iodine and can also absorb load chemotherapeutic drugs.

To provide a material for embolic arterial intervention (embolotherapy or arterial embolotherapy) and a method for preparing the material.SOLUTION: Radiopaque, bioresorbable spherical microparticles for embolization or vascular occlusion therapy are provided which comprise a copolymer of an iodo-containing, halogenated phenyl-containing unit, such as an iodinated desaminotyrosine derivative, and a rubbery component such as polyethylene glycol (PEG), polycaprolactone (PCL), polytetramethylene oxide (PTMO) or polytrimethylene carbonate (PTMC). The provided microbeads can further contain or be coated with a therapeutic agent, such as paclitaxel, for targeted delivery of the therapeutic agent.SELECTED DRAWING: Figure 3

This invention provides a vascular embolization treatment device, relating to the field of vascular embolization medical device technology. It includes a delivery tube and a spring coil. The spring coil includes a spring coil body and an end fixed to the distal end of the spring coil body. It also includes an end control mechanism and a spring coil control mechanism, with the distal end of the end control mechanism detachably connected to the proximal end of the end. The distal end of the delivery tube is detachably connected to the proximal end of the spring coil body via the spring coil control mechanism. This invention can improve the success rate of spring coil formation, avoid mis-embolization, and reduce surgical risks.

The present invention relates to polymer microspheres loaded with metal nanoparticles, a preparation method therefor, and use thereof. The present invention pertains to the technical field of tumor embolization therapy. The polymer microspheres loaded with metal nanoparticles are characterized by comprising a polymer microsphere framework and metal nanoparticles distributed in the polymer microsphere framework; the metal nanoparticles are manganese nanoparticles or iron nanoparticles; the particle size of the metal nanoparticles is 600 nm-1000 nm. The particle size of the polymer microspheres meets the requirements of embolization therapy. The polymer microspheres can embolize local blood vessels, achieving an embolization therapy effect. Due to the addition of the metal nanoparticles, the microspheres have a higher rigidity and a better embolization effect than traditional polymer microspheres. The preparation yield of the polymer microspheres loaded with metal nanoparticles of the present invention is significantly higher (2-3 times) than the yield of polymer microspheres loaded with active metal microparticles such as magnesium microparticles, the production efficiency and the production safety are higher, and the production cost is lower.

The invention provides an electrocoagulation guide wire system. The electrocoagulation guide wire system comprises a net-shaped plugging device, a conveying piece, a core wire and a leading-in sheath. The conveying part is arranged on the side wall of the core wire in a protruding mode, the core wire and the conveying part are both contained in the guiding-in sheath, at least part of the near end of the core wire protrudes out of the near end of the guiding-in sheath, the net-shaped plugging device is configured to be shrunk in the radial direction and contained in the guiding-in sheath, and the guiding-in sheath is connected to the net-shaped plugging device in a sleeving mode. The net-shaped plugging device is at least partially clamped between the inner wall of the guiding-in sheath and the side face, away from the core wire, of the conveying piece. The side face, away from the core wire, of the conveying piece is configured to generate friction interference when the net-shaped plugging device slides away from the conveying piece. The far end of the net-shaped plugging device extends into an aneurysm cavity, and the net-shaped plugging device is plugged at the aneurysm neck after being expanded in the radial direction. The far end of the core wire is configured to at least partially extend into an aneurysm cavity and form an electric loop with a power supply through blood. The electrocoagulation guide wire system can achieve the purpose of electrocoagulation embolism treatment of wide-neck aneurysm.

This invention relates to the field of tumor treatment technology, and particularly to a radioembolization microsphere, a radioembolization microsphere formulation, its preparation method, and its application. The radioembolization microsphere provided by this invention comprises radioactive particles and an organic phase containing iodized oil. The radioactive particles are coated on an interface with the organic phase containing iodized oil as its core. The radioactive particles comprise a radionuclide and an inorganic matrix, with the radionuclide immobilized in the inorganic matrix. The particle size of the radioactive particles is 0.01~10 μm; the particle size of the radioembolization microspheres is 0.01~1000 μm. Applying the radioembolization microspheres of this invention to embolization therapy can maintain long-term retention at the tumor site and reduce radiation damage to non-tumor sites. The iodine component provides X-ray imaging functionality, enabling integrated diagnosis and treatment, radioactive dose tracking, and accurate measurement of radiation dose.

The microcatheter comprises an inner tube and an outer tube which are coaxially arranged, the outer tube wraps the inner tube, a side hole is formed in the near end of the outer tube, and the inner tube extends out of the side hole to form a forked structure; a gap is formed between the outer tube and the inner tube, and the gap and the inner tube are separated to form two-component infusion channels which are isolated from each other. According to the invention, two component liquid substances can be independently conveyed at the same time, are converged at a treatment target at the far end of the catheter and then are subjected to in-situ polymerization to form gel, so that the gel enters a finer blood vessel branch, and comprehensive and thorough embolism treatment is carried out on tumor tissues; the adjusting knob is rotated to drive the sliding block to extrude or release extrusion on the balloon, so that the total volume of the infusion channel of the outer tube is changed, and finally the flow ratio of different component liquid substances at the far end of the catheter is adjusted. The conveying micro-catheter can be used in cooperation with a conventional duplex injector, the output end of the catheter outputs liquid substances with different components at the same time, two kinds of liquid are mixed more evenly, and meanwhile the operation steps of a doctor are effectively reduced.

The invention relates to a composition for use in a method of embolotherapy and / or in the preparation of therapeutic depots for use by injection comprising: a) a tri-arm copolymer of hydroxyethyl methacrylate (HEMA), 3-hydroxypropyl methacrylate (HPMA) and N-isopropyl methacrylamide (NIPAAM); and b) a contrast agent, preferably iodinated. The invention also relates to a process for preparing an embolic composition or a therapeutic depot for use by injection comprising combining a tri-arm copolymer as described above, optionally in the form of an aqueous composition, with a contrast agent and a therapeutic product, and to a kit for the preparation of said embolic composition or therapeutic depot.

Method and system for embolization treatment at a target site within a vessel using an endovascular embolization system. A microcatheter is navigated to the target site in the vessel. Embolic solution is injected into the vessel. Proximal migration in the vessel of the injected embolic solution is prevented by injecting into the vessel a glucose solution.

The invention provides a tumor targeted therapy system combining an energy field with embolism microspheres, which is applied to the field of tumor therapy instruments, and is characterized in that an energy enrichment material for targeting and enriching an external electric field or ultrasonic energy is loaded inside or on the surface of the embolism microspheres; therefore, TACE (Trans Arterial Chemoembolism) and energy release unit treatment are synergistically matched, on one hand, the embolism microspheres are implanted into a tumor blood supply artery in a minimally invasive catheter implantation mode in the early stage of the operation so as to block blood flow or nutrition supply of a tumor part; on the other hand, accurate focusing is carried out through an electric field / ultrasonic energy generator in the postoperative stage, normal cells are not damaged, and the microenvironment around the tumor is improved; embolism treatment and energy ablation treatment are combined for the first time, the safety and the treatment effect in the treatment process are further improved, and a new way for solid tumor treatment is opened up.