94 results about "Intracranial vascular" patented technology

A method of treating a neurological disorder (such as acute stroke) in a patient is provided. The method comprises introducing an electrical stimulation lead within the patient's head, advancing the stimulation lead within an intracranial vascular body, such as a blood vessel or ventricle, placing the stimulation lead adjacent the fastigium nucleus of the patient's brain, and stimulating the fastigium nucleus with the stimulation lead to treat the neurological disorder.

A method of treating a neurological disorder (such as acute stroke) in a patient is provided. The method comprises introducing an electrical stimulation lead within the patient's head, advancing the stimulation lead within an intracranial vascular body, such as a blood vessel or ventricle, placing the stimulation lead adjacent the fastigium nucleus of the patient's brain, and stimulating the fastigium nucleus with the stimulation lead to treat the neurological disorder.

A method of intracranial ultrasound imaging applied in detecting a cranial blood vessel having blood filled with micro-bubbles formed by an injected contrast agent and generating blood vessel images includes: (1) emitting a plurality of ultrasound signals having bandwidths to the cranial blood vessel in sequence, (2) receiving an echoed signal from a micro-bubble, (3) performing a spectral analysis on the echoed signal and extracting a low-frequency response, the bandwidth of the low-frequency response similar to the bandwidth of the ultrasound signal, and (4) calculating a location and a depth of the micro-bubble in the cranium according to the low-frequency response and generating a corresponding blood vessel image.

The invention provides intracranial vascular thrombus removal equipment comprising a thrombus remover, a guiding guide wire, a push-pull guide wire and an outer sheath pipe. The thrombus remover is connected with the push-pull guide wire, the mounted push-pull guide wire and the thrombus remover are pressed and held into the outer sheath pipe, the thrombus remover forms a pipe cavity and can be converted between a retrieving position and an unfolding position by the aid of pushing and pulling of the push-pull guide wire, the thrombus remover is retrieved into the outer sheath pipe at the retrieving position and pushed out of the outer sheath pipe at the unfolding position. The intracranial vascular thrombus removal equipment is characterized in that distribution density of spiral net ring units of the thrombus remover is different axially, the distribution is denser at the far end and relatively sparser at the near end; and / or the axially neighboring net ring units are connected through S-shaped or Z-shaped connecting ribs. According to the arrangement, the thrombus removal equipment can not only firmly fix the thrombus, but also effectively prevent microthrombus from falling off.

The invention provides a vascular thrombus retrieval machine and a thrombus retrieval device which are particularly applicable to retrieving thrombi in intracranial blood vessels. The thrombus retrieval machine comprises an outer-layer stent and an inner-layer stent. The inner-layer stent and the outer-layer stent are netted, the outer-layer stent covers the inner-layer stent, and a gap is formed between the outer-layer stent and the inner-layer stent. The vascular thrombus retrieval machine and the thrombus retrieval device have the advantages that the thrombi can be firmly fixed by the aid of the vascular thrombus retrieval machine in withdrawal procedures after being captured, accordingly, the capturing stability can be improved, the thrombi can be prevented from falling off, the problem of secondary embolism of distal blood vessels due to the fact that plaques on the walls of blood vessels and fragmental thrombus blocks are easy to fall off can be solved, and the vascular thrombus retrieval machine and the thrombus retrieval device are small in size and good in flexibility.

The invention relates to a microcatheter moulding stent used for the intracranial aneurysm embolization and a preparation method of the microcatheter moulding stent. The microcatheter moulding stent comprises a first bending part and a second bending part, wherein the first bending part is connected with the second bending part, the length of the first bending part is 3-5 mm, the length of the second bending part is 5-15 mm, the diameter of the stent is 1-1.5 mm, the length of the stent is 30-50 mm, and the first bending part and the second bending part are used for closely fitting the intracranial vascular bending and arterial aneurysm positions. According to the microcatheter moulding stent and the preparation method, the bending degree of the stent closely fits the intracranial vascular bending and arterial aneurysm shapes, so that the accurate moulding of the microcatheter is guided, therefore, the accurate placement of the microcatheter in the surgery is facilitated, and further, the operative problems including the difficulty in placement of the microcatheter, the separation of the microcatheter, the floating of a spring ring, and the like caused by poor moulding of the microcatheter in the embolism process are avoided.

The invention provides intracranial vascular thrombus removal equipment comprising a thrombus remover, a guiding guide wire, a push-pull guide wire and an outer sheath pipe. The thrombus remover is connected with the push-pull guide wire, the mounted push-pull guide wire and the thrombus remover are pressed and held into the outer sheath pipe, the thrombus remover forms a pipe cavity and can be converted between a retrieving position and an unfolding position by the aid of pushing and pulling of the push-pull guide wire, the thrombus remover is retrieved into the outer sheath pipe at the retrieving position and pushed out of the outer sheath pipe at the unfolding position. The intracranial vascular thrombus removal equipment is characterized in that a certain number of 'barbs' inclining correspondingly to the pipe wall are arranged on the inner wall of the pipe cavity of the thrombus remover. According to the arrangement, the thrombus removal equipment can firmly fix thrombus during retrieving of the thrombus after being captured to have the capture stability improved, and falling off of the thrombus can be prevented.

The invention provides a vascular thrombus retrieval machine and a thrombus retrieval device which are particularly applicable to retrieving thrombin in intracranial blood vessels. The thrombus retrieval machine is of a netted structure, can be shifted between a withdrawal position and a spreading position, and is characterized by comprising concave and / or convex structures. The vascular thrombus retrieval machine and the thrombus retrieval device have the advantages that the thrombi can be firmly fixed by the aid of the vascular thrombus retrieval machine in withdrawal procedures after being captured, accordingly, the capturing stability can be improved, the thrombi can be prevented from falling off, the problem of secondary embolism of distal blood vessels due to the fact that plaques on the walls of blood vessels and fragmental thrombus blocks are easy to fall off can be solved, and the vascular thrombus retrieval machine and the thrombus retrieval device are small in size and good in flexibility.

The present invention provides a stent for intracranial vascular therapy which can be safely held in the intracranial arteries, induces no biological reaction in the blood vessels due to galvanic corrosion or the like, and has elevated visibility under X-ray radioscopy. A stent of the present invention includes a plurality of main struts and a plurality of link struts as its constituents, wherein the stent is made of a single material having higher radiopacity than that of stainless steel, and the main struts and the link struts each have a width ranging from 100 μm to 200 μm and a thickness ranging from 50 μm to 100 μm.

The invention provides intracranial vascular thrombus removal equipment comprising a thrombus remover, a guiding guide wire, a push-pull guide wire and an outer sheath pipe. The thrombus remover is connected with the push-pull guide wire, the mounted push-pull guide wire and the thrombus remover are pressed and held into the outer sheath pipe, the thrombus remover forms a pipe cavity and can be converted between a retrieving position and an unfolding position by the aid of pushing and pulling of the push-pull guide wire, the thrombus remover is retrieved into the outer sheath pipe at the retrieving position and pushed out of the outer sheath pipe at the unfolding position. The intracranial vascular thrombus removal equipment is characterized in that distribution density of spiral net ring units of the thrombus remover is different axially, the distribution is denser at the far end and relatively sparser at the near end; and / or the axially neighboring net ring units are connected through S-shaped or Z-shaped connecting ribs. According to the arrangement, the thrombus removal equipment can not only firmly fix the thrombus, but also effectively prevent microthrombus from falling off.

The embodiment of the invention discloses an intracranial vascular image interception method and system based on a central line. The scheme comprises the steps of segmenting a three-dimensional intracranial artery blood vessel image from a received three-dimensional CTA image; Extracting a skeleton line of the target blood vessel segment from the intracranial blood vessel image to be intercepted,and selecting a starting point and a terminal point of the target blood vessel segment; Calculating the shortest path of the starting point and the ending point of the target blood vessel segment based on the skeleton line of the target blood vessel segment, and determining the center line and the radius of the target blood vessel segment; And based on the center line and the radius of the targetblood vessel segment, intercepting the target blood vessel segment of the intracranial blood vessel image. According to the scheme, the blood vessel segment image in the three-dimensional CTA image islocally captured, so that the intracranial artery blood vessel segment can be materialized, and interventional operation simulation and related teaching appliance manufacturing are facilitated.

The invention provides intracranial vascular thrombus removal equipment comprising a thrombus remover, a guiding guide wire, a push-pull guide wire and an outer sheath pipe. The thrombus remover is connected with the push-pull guide wire, the mounted push-pull guide wire and the thrombus remover are pressed and held into the outer sheath pipe, the thrombus remover forms a pipe cavity and can be converted between a retrieving position and an unfolding position by the aid of pushing and pulling of the push-pull guide wire, the thrombus remover is retrieved into the outer sheath pipe at the retrieving position and pushed out of the outer sheath pipe at the unfolding position. The intracranial vascular thrombus removal equipment is characterized in that a certain number of 'barbs' inclining correspondingly to the pipe wall are arranged on the inner wall of the pipe cavity of the thrombus remover. According to the arrangement, the thrombus removal equipment can firmly fix thrombus during retrieving of the thrombus after being captured to have the capture stability improved, and falling off of the thrombus can be prevented.

A method of treating cerebral vasospasm includes delivering at least a first blood vessel including an expandable segment to a position within a blocked or constricted portion of a vessel and transitioning the expandable segment from a collapsed configuration to an expanded configuration to dilate the vessel and to restore adequate blood flow through the vessel. The expandable segment has a pre-set outer diameter substantially equal to or less than an inner diameter of the vessel. Additionally, the expandable segment is configured to expand with a minimal amount of radial force necessary to contact and expand the inner walls of the vessel. After dilation of the vessel, the device is removed from the patient's body. If necessary, additional blood vessel dilation devices each including an expandable segment having a pre-set outer diameter greater than the previous device's expandable segment can be used in order of increasing pre-set outer diameter of the expanded segment to further dilate the blocked or constricted portion of the vessel and restore blood flow through the vessel. Once adequate blood flow through the vessel has been restored, the blood vessel dilation device is withdrawn.

Embodiments of the present application disclose a method and system for intercepting intracranial vascular images based on a centerline. The scheme includes selecting the starting point and the endingpoint of the target vessel segment from the intracranial vessel image to be intercepted; calculating a spherical center of the largest inward ball in the target blood vessel segment according to thestart point and the end point of the target blood vessel segment, connecting the start point and the end point, the spherical center determining a centerline and a radius of the target blood vessel segment; intercepting the target vessel segment of the intracranial vessel image based on the centerline and radius of the target vessel segment. This scheme realizes the local interception of the intracranial vascular image, which is convenient for the physicalization of intracranial artery, the simulation of interventional operation and the manufacture of related teaching equipment.

The present invention relates to methods of treating ischemia-related conditions by administering to a patient in need of such methods certain thiosemicarbazone compounds. Preferred embodiments of the present invention relates to methods of treating specific ischemia-related conditions, including but not limited to Alzheimer's disease, Parkinson's disease, Coronary artery bypass graft surgery, Global cerebral ischemia due to cardiac arrest, focal cerebral infarction, cerebral hemorrhage, hemorrhage infarction, hypertensive hemorrhage. hemorrhage due to rupture of intracranial vascular abnormalities, subarachnoid hemorrhage due to rupture of intracranial arterial aneurysms, hypertensive encephalopathy, carotid stenosis or occlusion leading to cerebral ischemia, cardiogenic thromboembolism, spinal stroke and spinal cord injury, diseases of cerebral blood vessels: e.g., atherosclerosis, vasculitis, Macular degeneration, myocardial infarction, cardiac ischemia and superaventicular tachyarrhytmia.

The invention discloses a processing method for reconstructing a blood vessel three-dimensional model based on 2D-DSA images. The method comprises the following steps of: S1, collecting 2D-DSA imagesbased on a normal position angle and a side position angle, and constructing a sparse blood vessel point cloud based on the collected 2D-DSA images; S2, performing preprocessing based on the constructed sparse blood vessel point cloud so as to obtain a point cloud sheet and a standard result, taking the obtained point cloud sheet, the standard result and a known intracranial blood vessel data setas a training set, inputting the training set into a PU-GCN deep learning network for training, and obtaining a trained PU-GCN deep learning network; and S3, obtaining a to-be-reconstructed sparse point cloud of a to-be-reconstructed 2D-DSA image based on the step S1, inputting the to-be-reconstructed sparse point cloud into the trained PU-GCN deep learning network, outputting the to-be-reconstructed sparse point cloud to obtain a to-be-reconstructed dense point cloud, and obtaining a blood vessel three-dimensional model based on the to-be-reconstructed dense point cloud. In addition, the invention further discloses a processing system.

A simple analysis method for the cerebral circulation hemo-dynamics includes such steps as dividing brain into front left, front right and back parts according to the cerebral Wills ring, creating the network model of equivalent circuit of hemo-dynamic units and relative control equation, finding out their blood flow, filled blood amount and pre-compensation and calculating their hemo-dynamic parameters such as critical pressure, dynamic resistance, etc. Its instrument is also disclosed.

The invention relates to a low thrombogenic intracranial vascular woven stent and a processing method thereof. The low thrombogenic intracranial vascular woven stent comprises a cylindrical tubular net-shaped structure body, wherein the net-shaped structure body comprises a plurality of woven wires which are woven with one another to form a coherent mesh structure (3), and the woven wires comprisewarp wires (1) and weft wires (2); the warp wires and the weft wires are intersected to form weaving points, and the weaving points comprise positive weaving points (4) and negative weaving points (5), wherein the weaving points, pressed above the weft wires (2), of the warp wires (1) are the positive weaving points (4), and the weaving points, pressed below the weft wires (2), of the warp wires(1) are the negative weaving points (5); and the woven wires are selected from one or more than two metal wires, and a heat treatment oxide layer is removed from the surface of at least one metal wire. The treatment method disclosed in the invention comprises the steps of corrosion treatment and passivation treatment, and the low thrombogenic intracranial vascular woven stent obtained through treatment of the treatment method is not prone to causing thrombus.

The invention relates to an intracranial vascular pincers type thrombus take-out device in the field of medical apparatuses. When a vascular thrombus take-out support is bent, the side face of the near end of the vascular thrombus take-out support is bent to form a first large mesh hole; a second large mesh hole is formed in a unit mesh opposite to the first large mesh hole, and the area of the second large mesh hole is larger than the area of the unit mesh; the vascular thrombus take-out support is matched and provided with a plurality of developing marks. A conveying system comprises a conveying guide wire, a protection sheath, a miniature guide pipe, a guiding guide pipe, a front Y-type valve and a rear Y-type valve. The conveying guide wire is connected with the near end of the vascular thrombus take-out support. The vascular thrombus take-out support is arranged in the protection sheath. The protection sheath is connected with the tail portion of the miniature guide pipe through the rear Y-type valve. The front portion of the miniature guide pipe is directly connected with the guiding guide pipe through the front Y-type valve. By means of the thrombus take-out device, the problems of breakage and escape of thrombi in the capturing and take-out process by means of an existing thrombus take-out device and technology can be solved, the sliding and rolling probability of thrombi stably clamped by pincers is remarkably reduced, and the operative successful rate is increased.

The invention discloses a method for quickly establishing an intracranial blood vessel simulation three-dimensional model based on transfer learning. The method comprises the following steps: collecting a bright blood image group and an enhanced black blood image group of an intracranial blood vessel part; preprocessing each bright blood image and the corresponding enhanced black blood image to obtain a first bright blood image and a first black blood image; performing image registration on the first bright blood image by using mutual information based on Gaussian distribution sampling and a registration method of an image pyramid; utilizing a maximum intensity projection method to obtain MIP images in all directions from the registered bright blood image groups; taking the MIP image as atarget domain, taking the fundus blood vessel image as a source domain, and obtaining a two-dimensional blood vessel segmentation image by using a transfer learning method; performing back projectionsynthesis on the two-dimensional blood vessel segmentation images in the three directions to obtain first three-dimensional blood vessel body data; and obtaining an intracranial blood vessel simulation three-dimensional model by utilizing the second three-dimensional blood vessel body data corresponding to the registered bright blood image group. According to the method, the whole state of the intracranial blood vessel can be simply, conveniently, quickly and visually obtained clinically.

The invention discloses an intracranial blood vessel image fusion method. The method comprises the following steps: acquiring a bright blood image and a black blood image of an intracranial blood vessel; taking the black blood image as a reference image and the bright blood image as a floating image, performing coordinate transformation on the bright blood image, and performing interpolation processing on the bright blood image by adopting a nearest neighbor interpolation method; calculating the similarity between the bright blood image and the black blood image after interpolation processingby using similarity measurement; finding the optimal similarity measurement by using a search strategy, and stopping iteration when the similarity measurement is optimal; according to the space transformation matrix, carrying out coordinate transformation on the bright blood image when similarity measurement is optimal, and obtaining a first registration image; extracting the same scanning area inthe black blood image according to the scanning area of the bright blood image in the first registration image to obtain a second registration image; and adopting a PCA analysis image fusion algorithm to perform image fusion on the two images in the second registration image. According to the scheme, a doctor can be assisted in accurate intracranial disease diagnosis.

The invention discloses a drug balloon which comprises a balloon body, the outer surface of the balloon body is coated with a drug coating, the drug coating comprises a first component and a second component, the first component comprises polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), a photoinitiator and a first solvent, and the second component comprises a second solvent and a third solvent. The second component comprises a cell proliferation inhibition drug, a drug carrier and a second solvent; the cell proliferation inhibition drug is one or more of rapamycin, rapamycin and derivatives thereof, paclitaxel and derivatives thereof, the drug carrier is one or more of amphipathic high-molecular compounds, the balloon has the advantages of being good in balloon lubricity, low in drug delivery loss rate, high in bioavailability and the like, and compared with other similar products, the balloon has the advantages of being good in balloon lubricity, low in drug delivery loss rate, high in bioavailability and the like. The medicine is more suitable for patients with intracranial atherosclerosis with high intracranial blood vessel tortuosity degree and small narrow blood vessel diameter, and has a remarkable curative effect.

The invention discloses a method for measuring arteriosclerosis of 4D time-resolved dynamic magnetic resonance imaging without injecting contrast agent, which is based on the current clinical demand and combines the non-invasive application of magnetic resonance angiography technology at present. By using dynamic magnetic resonance angiography (dMRA) technique synchronized with the cardiac cycle,changes in arterial blood flow at the peak of systole and early diastole are obtained, and changes in arterial blood pressure are measured, and the ratio of intracranial vascular compliance is definedby the ratio (Vascular Compliance), quantitative information about arteriosclerosis can be obtained and used for the evaluation of intracranial arteriosclerosis.

The invention relates to a blood vessel wall image segmentation method and device, computer equipment and a storage medium. The method comprises the following steps: acquiring an intracranial blood vessel wall image of three-dimensional black blood T1 weighted magnetic resonance; performing lumen segmentation on the intracranial vascular wall image to obtain a three-dimensional vascular lumen segmentation result; extracting a center line according to the three-dimensional blood vessel cavity segmentation result, and carrying out re-cutting perpendicular to the center line to obtain a two-dimensional blood vessel wall cross section image; and segmenting the two-dimensional blood vessel wall cross section image to obtain a blood vessel cavity area and an outer tube wall area. The three-dimensional lumen in the magnetic resonance image is firstly segmented, then the two-dimensional lumen is segmented on the two-dimensional blood vessel wall cross section image according to the three-dimensional lumen segmentation result, and the accuracy and the segmentation efficiency of blood vessel wall image segmentation are improved through accurate segmentation of the lumen and the lumen.

The invention discloses an intracranial blood vessel comprehensive image generation method, which comprises the steps of obtaining a plurality of image pairs to be registered of intracranial blood vessels, and preprocessing a bright blood image and an enhanced black blood image in each image pair to obtain a first bright blood image and a first black blood image of the image pair; selecting a partof preprocessed image pairs as test image pairs; performing image registration on the first bright blood image and the first black blood image in each test image pair by adopting a registration method based on mutual information and an image pyramid to obtain a rotation matrix corresponding to the first bright blood image in the test image pair after registration; obtaining the mean value of therotation matrixes of all the test image pairs; utilizing the mean value of the rotation matrix to perform coordinate transformation on the first bright blood images in other preprocessed image pairs except the test image pair, and finishing image registration to obtain a plurality of registered image pairs; and fusing the two images in the registered image pair to obtain an intracranial vessel comprehensive image.

The invention discloses a method for establishing an intracranial vessel simulation three-dimensional stenosis model based on transfer learning. The method comprises the following steps: acquiring a bright blood image group and an enhanced black blood image group of an intracranial vessel; performing image registration by using a registration method based on mutual information and an image pyramidto obtain a registered bright blood image group; utilizing the registered bright blood image group to obtain an MIP image in each direction; obtaining a two-dimensional blood vessel segmentation image based on the MIP image as a target domain and a fundus blood vessel image; synthesizing the two-dimensional blood vessel segmentation images in the three directions by using a back projection methodto obtain first three-dimensional blood vessel body data; obtaining an intracranial blood vessel simulation three-dimensional model by utilizing the second three-dimensional blood vessel body data corresponding to the registered bright blood image group; and for each section of blood vessel in the model, obtaining a numerical value of a target parameter representing the stenosis degree of the section of blood vessel, and marking the intracranial blood vessel simulation three-dimensional model by utilizing the numerical value of the target parameter to obtain a simulated three-dimensional intracranial vessel stenosis analysis model.

The invention discloses an intracranial degradable stent and a preparation / using method thereof. The degradable stent is applied to intracranial blood vessels, is made of a multilayer composite material formed by a high molecular weight degradable polymer, degradable magnetic nanoparticles and a low molecular weight degradable polymer, and has a controllable degradation period. The stent materialcontains the degradable magnetic nanoparticles, and an external alternating magnetic field is started, so that the degradable magnetic nanoparticles generate a heat effect, the inside of the stent isheated, the degradation rate of the stent is accelerated, and the degradable magnetic nanoparticles are self-degraded. Compared with the prior art, the intracranial degradable stent provided by the invention has a controllable degradation period, and the heating mode has the characteristics of controllable time and temperature and small damage to the surrounding environment. After endothelialization, the unnecessary degradation period of the stent is shortened from 24-36 months to 12-18 months, intimal hyperplasia can be reduced, and restenosis can be more effectively prevented and reduced.

The invention discloses an intracranial vascular thrombus extractor. The intracranial vascular thrombus extractor comprises a thrombus extracting support, developing elements, a conveying catheter, a storage tube and a conveying guide wire. The thrombus extracting support comprises branches, a far end and an integral framework. One ends of the branches are fixedly connected with the thrombus extracting support into a whole, and the other ends of the branches are free ends. The developing elements are arranged on the thrombus extracting support, and the number of the developing elements is at least two. According to the intracranial vascular thrombus extractor, the whole thrombus extracting support can be developed, the branches are arranged on the thrombus extracting support, the developing elements are arranged on the branches, the developing effect is enhanced, a surgeon can rapidly and accurately position the thrombus extracting support in the operation process, the situation that a blood vascular wall is damaged due to the fact that the shaking amplitude of the thrombus extracting support is too large is avoided, and the problems that the support is inaccurate in positioning, the thrombus extracting time is too long, and thrombus falls off are solved.

The invention discloses a method for establishing an enhanced three-dimensional model for intracranial angiography. The method comprises the following steps: acquiring a bright blood image group, a black blood image group and an enhanced black blood image group of an intracranial blood vessel part; preprocessing each image pair to obtain a first bright blood image and a first black blood image; for each first bright blood image, taking the corresponding first black blood image as a reference, and performing image registration by using mutual information based on Gaussian distribution sampling and a registration method of an image pyramid to obtain a registered bright blood image group; carrying out flow empty artifact elimination operation to obtain an artifact elimination enhanced black blood image group; subtracting corresponding images in the artifact elimination enhanced black blood image group and the black blood image group to obtain K contrast enhanced images; establishing a blood three-dimensional model and a blood vessel three-dimensional model of blood boundary expansion by using the registered bright blood image group; establishing a contrast enhancement three-dimensional model by utilizing the K contrast enhancement images; obtaining an intracranial angiography enhanced three-dimensional model based on the blood three-dimensional model, the blood vessel three-dimensional model and the angiography enhanced three-dimensional model.