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Method for measuring arteriosclerosis based on magnetic resonance imaging without contrast-enhanced scanning

A technology that enhances scanning and arteriosclerosis, and is applied in magnetic resonance measurement, measurement using nuclear magnetic resonance imaging system, and measurement of magnetic variables.

Inactive Publication Date: 2019-01-04
安影科技(北京)有限公司
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Problems solved by technology

However, this type of detection method is generally used in carotid, femoral or brachial arteries, ankle arteries, etc., and there is no way to evaluate the degree of arteriosclerosis of intracranial blood vessels.

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  • Method for measuring arteriosclerosis based on magnetic resonance imaging without contrast-enhanced scanning
  • Method for measuring arteriosclerosis based on magnetic resonance imaging without contrast-enhanced scanning
  • Method for measuring arteriosclerosis based on magnetic resonance imaging without contrast-enhanced scanning

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Embodiment Construction

[0016] specific implementation plan

[0017] Vascular compliance can be assessed using 4D dMRA technology with simultaneous sampling during the systolic and diastolic phases of the cardiac cycle. This has been confirmed by measuring internal carotid blood flow velocity using ECG-triggered time-resolved phase contrast MRI.

[0018] Such as figure 1 As shown, peak systole and early diastole were identified as a time delay, as an independent study phase. Pulsed ASL was applied at peak systolic and early diastolic phases, and ECG-triggered dMRA scans were performed at the corresponding phases. Systolic and diastolic arterial CBVs were calculated from tracer kinetic models. The tracer kinetic model is:

[0019] CBV =∫C(t)dt / ∫Ca(t)dt

[0020] C(t) = CBF • Ca(t)⊗R(t)

[0021] where Ca(t) is the concentration of the spin label in the artery, C(t) is the concentration of the spin label in a single pixel (Pixel) in the artery, and R(t) is the dwell function. C(t)=M(t)W(t)e t / T1 ...

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Abstract

The invention discloses a method for measuring arteriosclerosis of 4D time-resolved dynamic magnetic resonance imaging without injecting contrast agent, which is based on the current clinical demand and combines the non-invasive application of magnetic resonance angiography technology at present. By using dynamic magnetic resonance angiography (dMRA) technique synchronized with the cardiac cycle,changes in arterial blood flow at the peak of systole and early diastole are obtained, and changes in arterial blood pressure are measured, and the ratio of intracranial vascular compliance is definedby the ratio (Vascular Compliance), quantitative information about arteriosclerosis can be obtained and used for the evaluation of intracranial arteriosclerosis.

Description

technical field [0001] The present invention is a non-contrast-enhanced scan-based arteriosclerosis measurement method based on magnetic resonance. Water molecules in the blood are used as endogenous markers through arterial spin markers, and estimated based on cerebral blood volume, cerebral blood flow, and blood flow average transit time. Establish a quantitative tracking dynamic model to evaluate the degree of arterial vascular sclerosis by using dMRA (dynamic Magnetic Resonance Angiography) acquisitions synchronized with the systolic (Systolic) and diastolic (Distolic) phases of the cardiac cycle. Background technique [0002] Arteriosclerosis is a common high-incidence disease with a large number of patients and great social and economic pressure. However, over the years, there has been no significant progress in the measurement technology of arteriosclerosis. At present, biochemical detection, invasive detection and non-invasive detection are the main methods. [0003...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055A61B5/02G01R33/56
CPCA61B5/055A61B5/02007G01R33/5601
Inventor 王炯炯闫丽荣
Owner 安影科技(北京)有限公司
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