Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Intracranial degradable stent and preparation/using method thereof

A technology of degradation rate and polymer degradation, which is applied in the field of intracranial degradable stents and its preparation, can solve the problems of long degradation time, slow degradation time, and influence of stents, and achieve shortened degradation time, good mechanical strength, and short heating time Effect

Inactive Publication Date: 2021-02-05
南京浩衍鼎业科技技术有限公司
View PDF5 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after the current degradable stent material is endothelialized, the degradation time is too slow, which will lead to severe inflammatory reactions and other problems, resulting in intimal hyperplasia and increasing the risk of restenosis in the later stage
And on the other hand, if late restenosis occurs, the previously implanted stent material has been degraded for too long and has not been completely degraded, which will also affect the re-implanted stent and cause certain surgical risks

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Intracranial degradable stent and preparation/using method thereof
  • Intracranial degradable stent and preparation/using method thereof
  • Intracranial degradable stent and preparation/using method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] An intracranial degradable stent, the degradable stent according to the mass ratio is high molecular weight polymer: magnetic nanoparticles: low molecular weight polymer = 75:8:17 The ratio of the prepared multi-layer composite material is used after drying A laser engraving machine engraves the degradable stent.

[0031] The material of the outer layer 1 is high molecular weight L-polylactic acid, and the material of the middle layer 2 is Fe 3 o 4 The main material is degradable magnetic nanoparticles, and the material of the inner layer 3 is low molecular weight L-lactic acid. According to needs, the degradable magnetic nanoparticles in the middle layer are heated to control the degradation period and accelerate the degradation.

[0032]The number-average molecular weight of the high-molecular-weight L-polylactic acid described in this embodiment is 800,000, and the number-average molecular weight of the low-molecular-weight L-lactic acid is 10,000.

[0033] The de...

Embodiment 2

[0039] An intracranial degradable stent, the preparation method of the degradable stent is to first mix the high molecular weight polymer mixture according to the proportion and then add it to a twin-screw extruder to obtain granulation 1; after cleaning and drying, the aforementioned low molecular weight polymer The compound mixture is mixed according to the proportion and then added to the twin-screw extruder to obtain granulation 2. After cleaning and drying, the obtained granulation 1, 2 and degradable magnetic nanoparticles are granulated according to the mass ratio. : The ratio of granulation 2=70:15:15 prepares multi-layer composite material, such as Figure 4 shown. Then perform drying treatment, and use a laser engraving machine to engrave the degradable bracket.

[0040] The polymer used in the preparation method of the degradable stent in this embodiment is polylactic acid and its copolymers. Wherein, the high-molecular-weight polymer is a mixture of poly-L-lactic...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Sizeaaaaaaaaaa
Sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses an intracranial degradable stent and a preparation / using method thereof. The degradable stent is applied to intracranial blood vessels, is made of a multilayer composite material formed by a high molecular weight degradable polymer, degradable magnetic nanoparticles and a low molecular weight degradable polymer, and has a controllable degradation period. The stent materialcontains the degradable magnetic nanoparticles, and an external alternating magnetic field is started, so that the degradable magnetic nanoparticles generate a heat effect, the inside of the stent isheated, the degradation rate of the stent is accelerated, and the degradable magnetic nanoparticles are self-degraded. Compared with the prior art, the intracranial degradable stent provided by the invention has a controllable degradation period, and the heating mode has the characteristics of controllable time and temperature and small damage to the surrounding environment. After endothelialization, the unnecessary degradation period of the stent is shortened from 24-36 months to 12-18 months, intimal hyperplasia can be reduced, and restenosis can be more effectively prevented and reduced.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to an intracranial degradable bracket and a preparation / use method thereof. Background technique [0002] Interventional technology, internal medicine technology, and surgical technology are collectively called the three major medical technologies. Compared with the latter two, interventional technology is a new technology, which is not only independent of medical and surgical technology, but also coexists with them and develops collaboratively. Interventional technology is divided into three categories: cardiac intervention, peripheral intervention and neurological intervention according to the different professional fields involved. Neurointerventional technology is mainly used to treat nervous system diseases. It is supported by the digital subtraction angiography (DSA) system, using intravascular catheter operation technology, through selective angiography, embolizati...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61F2/82A61F2/958A61L31/14A61L31/12
CPCA61F2/82A61F2/958A61L31/148A61L31/14A61L31/06A61L31/028A61F2002/9583A61F2240/002A61F2210/0076A61F2210/0004A61L2400/12
Inventor 陈鹤赵古田张伶牛朗胡雪
Owner 南京浩衍鼎业科技技术有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com