29 results about "Arterial aneurysms" patented technology

A computer-implemented method of predicting a status of an embolization procedure on an aneurism, includes: receiving (S110) projection image data (110) representing temporal blood flow in a region of the anatomy including the aneurism during the embolization procedure; inputting (S120) the received projection image data (110) into a neural network (120) trained to predict temporal blood flow (130), wherein the neural network (120) is trained to predict temporal blood flow (130) using training data (140) representing temporal blood flow in a region of the anatomy that does not include an aneurism; and in response to the inputting (S120): generating (S130) an output (160) indicative of the status of the embolization procedure based on the predicted temporal blood flow.

The present invention relates to a system for predicting the effectiveness of cerebral aneurysm surgery. According to the present invention, the system for predicting the effectiveness of cerebral aneurysm surgery comprises: an input unit for receiving a blood vessel image including an aneurysm in a subject; a model generation unit for generating a pre-surgery 3D model and a post-surgery 3D model of blood vessels including the aneurysm; a simulation unit for performing a 3D blood flow computational fluid dynamics (CFD) simulation for the same blood flow condition on the pre-surgery 3D model and the post-surgery 3D model of the blood vessels; and an index calculation unit for calculating hemodynamic improvement indices before and after surgery, including an inflation force reduction ratio (IFR), a shear force reduction ratio (SFR), and a pressure-drop reduction ratio (PDR), on the basis of simulation results of the pre-surgery 3D model and the post-surgery 3D model.

This invention provides a balloon catheter comprising a catheter, a balloon, and a limiting element. The balloon is positioned distal to or near the distal end of the catheter. The limiting element is located on the outer side of the balloon, and at least a portion of the limiting element is capable of radial movement or radial deformation to drive the balloon to move radially inward. The balloon catheter provided by this invention allows physicians to adjust the limiting element to contact the balloon and deform it, ensuring that a portion of the balloon remains firmly attached to the blood vessel. This reduces the risk of balloon displacement, prevents the balloon from losing its function of dilating blood vessels or blocking aneurysms due to displacement, and improves the stability and reliability of balloon implantation. Simultaneously, it allows another portion of the balloon to no longer be tightly attached to the blood vessel wall, creating a gap to form a fluid channel, allowing a small amount of blood to flow between the two ends of the balloon, ensuring blood supply to distal organs, reducing surgical complications, reducing pressure on patients and physicians, and increasing the success rate of surgery.

Devices and methods for treatment of a patient's vasculature including occluding aneurysms and blood vessels are described. The device includes a self-expanding resilient permeable shell having a radially constrained state and an expanded state with an axially shortened configuration. The permeable shell may be a single layer of braided elongate filaments having first and second ends that are secured at the proximal end of the permeable shell. The devices may also include permeable shells made of woven braided mesh having a variable mesh density, i.e., the average size of pores in one region are a different than the average size of pores in another region. Devices and methods of using the device to treat a cerebral aneurysm are also described.

Embodiments described herein relate to a shunt for treating an aortic aneurysm and a robotic insertion system for implanting the shunt. In some embodiments, the shunt may include a central portion, an arterial sealing structure, and a venous sealing. In some embodiments, the venous sealing structure may have a lateral length in its deployed configuration, and the arterial sealing structure having a lateral length in its deployed configuration that is greater than the lateral length of the venous sealing structure. The shunt may be advanced robotically in a delivery configuration through a venous puncture site of a vein to access an arterial puncture site of the artery, and then deployed, thereby enabling blood flow through the shunt from the artery to the vein.

The utility model relates to the technical field of vascular intervention, in particular to a stent far-end anchoring near-end mechanical balloon auxiliary dense net stent which comprises a far-end anchoring stent, a stent conveying micro catheter, a conveying micro guide wire, a near-end dense net stent and a near-end mechanical balloon. The far-end anchoring support, the near-end dense net support and the near-end mechanical balloon share a transmission micro guide wire. A common micro guide wire guides a stent conveying micro catheter to reach the far end of a target blood vessel, after the common micro guide wire is withdrawn, a far-end anchoring stent, a near-end mechanical balloon and a near-end dense net stent which are folded in advance are fed into the stent conveying micro catheter along a guide sheath tube, a near-end conveying guide wire of a pushing system reaches the position of the target blood vessel, and the far-end anchoring stent is released. By means of the supporting and pulling effects of the far-end anchoring support on the conveying micro guide wire, the near-end dense net support is assisted to smoothly pass through the neck of the huge aneurysm, and the near-end mechanical balloon is used for unfolding assistance to assist the near-end dense net support to be smoothly unfolded and formed when the near-end dense net support is bent.

The present disclosure provides a whole blood, protein-based diagnostic test for presence and evaluation of aneurysm status. Further, the present disclosure relates to methods of treating aneurysms.

The invention relates to an implant (1) for the treatment of arteriovenous malformations, in particular aneurysms (2), wherein the implant (1) can be introduced in a compressed state to a destination in the blood vessel system of a patient by means of a microcatheter (3) and a secondary structure is imprinted on the implant (1) by means of which it assumes an expanded state upon release from the microcatheter (3), wherein the implant (1) is detachably connected to an insertion aid (5) via a release point (4) and, in the expanded state, has a base body (6) which is constructed from struts (16), wherein the struts (16) are at least partially connected to one another at intersection points, so that spaces (11) are formed between the struts (16), wherein, in the expanded state, the struts (16) extend radially outwards at the proximal end of the base body (6) and, further along, axially in a distal direction and radially inwards.such that a bulging of the base body (6) results, wherein the base body (6) has a zone at its distal end where the struts (16) are not connected to each other. The implant (1) according to the invention is able to adapt well to the shape of the respective aneurysm (2).

Implant for blood vessels, for influencing blood flow in the area of ​​aneurysms (A), wherein the implant (1) has a wall formed by isolated filaments (2, 2') that are joined to form a round braid, wherein the round braid is an endless braid cut to size, adopts an elongated shape with a reduced diameter in an implantation catheter (11) and expands at the implantation point, adapting to the diameter of the vessel and increasing the surface coverage, wherein the filaments (2, 2') of the round braid have shape memory characteristics, characterized in that the round braid is adjusted such that, when the stretching forces that bring the round braid to the elongated shape disappear, it extends to such an extent that, in the area of ​​an aneurysm neck where the vessel has a larger vessel diameter compared to the adjacent healthy vessel section,It adopts a greater surface coverage compared to the adjacent healthy vessel section.

The invention relates to an intracranial aneurysm in-vitro amplification model blood circulation experiment system and method, and the system comprises an intracranial aneurysm in-vitro amplification model, a peristaltic pump, a liquid storage tank, a flow detection part and a pressure detection part, one end of the pump pipe is connected with an outlet of the liquid storage tank, the other end of the pump pipe is connected with an inlet of the intracranial aneurysm in-vitro amplification model, and an outlet of the intracranial aneurysm in-vitro amplification model is connected with an inlet of the liquid storage tank to form an extracorporeal circulation path. The experimental method comprises the steps of model and boundary condition zooming, blood flow simulation system construction, in-vitro patient specificity model and circulation path establishment, real-time monitoring and data acquisition. On the premise of meeting a flow similarity criterion, amplification construction of a patient specific aneurysm model, accurate simulation of physiological pulsating blood flow and systematic monitoring of key hemodynamic parameters can be realized; therefore, an in-vitro experiment platform which is more reliable and closer to the physiological state is provided for hemodynamic research of intracranial aneurysm.

A therapeutic drug useful for the treatment of aneurysms is provided. The pharmaceutical composition for the treatment and / or prevention of aneurysms comprises at least one of the following drugs as an active ingredient(s): i) drugs targeting platelet-derived growth factor receptor β (PDGFRβ); ii) drugs that inhibit the function of desmoyokin (AHNAK); and iii) drugs that inhibit signaling enhanced by mutations in PDGFRβ or AHNAK.

The present invention relates to the field of medical device technology, and more specifically, to a semi-covered stent, a delivery system, and an operating method, wherein the semi-covered stent comprises a tubular stent, a coating provided on the tubular stent and covering only a portion of the surface of the tubular stent, a first developing member provided at both ends of the tubular stent, and a second developing member provided at the edge and / or middle of the coating. The purpose of the present invention is to overcome the deficiency that the current covered stents are all completely covered in the circumferential direction, and the membrane on the stent affects the blood flow of normal blood vessels when treating aneurysms at bifurcated blood vessels. The coated side of the semi-covered stent of the present invention can effectively prevent blood from flowing into the aneurysm, and the uncoated side will not affect the blood flow of normal blood vessels. It has a better therapeutic effect on the treatment of aneurysms at bifurcated blood vessels and reduces the occurrence of postoperative embolism.

Disclosed herein are devices having an inner core comprising a biomatrix; and an outer scaffold comprising a biocompatible polymer. Also disclosed herein are methods for supporting a blood vessel and / or for treating or preventing an aneurysm by disposing a device having an inner core comprising a biomatrix; and an outer scaffold comprising a biocompatible polymer on an outer surface of a blood vessel of a subject. The bioengineered scaffolds of the present disclosure can limit the progression of vessel dilation while maintaining the biochemical characteristics of the vessel wall. Furthermore, the disclosed devices provide a minimally invasive alternative to conventional graft replacement, making the device suitable for patients having comorbidities.

The invention discloses a photo-crosslinking preparation and a medical device, and relates to the technical field of blood vessel treatment. The photo-crosslinking preparation comprises a photosensitizer, an active oxygen scavenger and a photosensitive enhancer, the mass ratio of the photosensitizer to the active oxygen scavenger is (1: 0.01)-(1: 100), and the mass ratio of the photosensitive enhancer to the photosensitizer is (1: 0.01)-(1: 120). According to the photo-crosslinking preparation disclosed by the invention, collagen and elastin in a blood vessel wall can be induced to be rapidly combined and form a stent in situ by exciting the photosensitizer, so that healing and repairing of blood vessels are realized; according to the present invention, with the active oxygen scavenging agent, the active oxygen can be eliminated so as to reduce vascular cell damage, reduce aneurysm formation risk, reduce thrombosis formation risk and inflammatory response, and effectively maintain the smooth blood vessel, and in addition, the photosensitizer can be prevented from being affected by the active oxygen scavenging agent so as to avoid the problem that the blood vessel cross-linking effect is reduced through the photosensitizer;

The application belongs to the field of biological medicine and medical imaging technology, and relates to a rapid full-automatic intracranial aneurysm auxiliary detection post-processing system and method. The system comprises an image preprocessing module, an image adaptive threshold classification module, an automatic blood vessel seed point searching module, a blood vessel segmentation module, a blood vessel center line extraction, segmentation and classification module, an aneurysm enhancement module, an aneurysm screening module and an aneurysm display module. The application can be used for full-automatic detection of three common medical image data (MRI, CT and 3D-DSA) intracranial aneurysms, and has high processing speed.

The application relates to the technical field of medical image processing, and discloses an intracranial aneurysm recognition method and system based on a brain CT. The method obtains a brain CT image sequence, adopts an anisotropic diffusion filtering algorithm for pretreatment to suppress noise and retain blood vessel edge details. Subsequently, a region growing algorithm is used to segment an intracranial blood vessel region, and a skeletonization algorithm is used to extract a blood vessel center line to calculate curvature and diameter changes. Finally, based on curvature anomaly and diameter ratio analysis, combined with a multi-scale sliding window and a blood vessel topological structure verification, automatic recognition of intracranial aneurysms is realized, and the accuracy and reliability of diagnosis are improved.

Provided herein is a method of treating a defect in the vasculature of a patient, including delivering to the defect a gellable composition comprising a first modified extracellular matrix (ECM) component and a second modified ECM component.

A device for treating aneurysms and a delivery method are described, comprising a permeable shell having an open distal end, an internal compressible mesh structure having a lumen, and an external constraint surrounding at least a portion of the internal compressible mesh structure. The external constraint may have variable stiffness. The deployed configuration of the permeable shell may be torus-shaped, with the internal compressible mesh structure disposed along the longitudinal axis of the permeable shell. The external constraint may be a coil or a hypotube. The external constraint may have a proximal portion that is stiffer than the distal portion. The stiffer proximal portion of the external constraint may attenuate hemodynamic forces at the proximal end of the permeable shell.

Medical device (2) for treating aneurysms in cerebral blood vessels, comprising a compressible and expandable lattice structure (10) made of lattice elements (11, 12, 13, 14) forming cells (15), wherein the lattice structure (10) comprises, at least in sections, a cover (16) made of an electrospun fabric, which, in an implanted state of the lattice structure (10), reduces the blood flow through the hollow body organ by means of the lattice structure (10) in the region of the cover (16), wherein the lattice structure (10) is formed with a taper (23) in a central region (20), and wherein at least the central region (20) comprises the cover (16), wherein the cover (16) has a porosity with pores having a size of at most 750 µm 2 and on an area of ​​100,000 µm 2 at least 15 pores with a size of at least 30 µm 2and wherein the cover (16) has a blood-permeable and a blood-impermeable area.

A non-occlusive blood restricting device is provided for delivery by a microcatheter and for treating a vascular malformation. The blood restricting device includes a wire that include first and second sections. The first section is configured to be coiled into a first coil when deployed within the vascular malformation. The first coil includes a spiral or sequence of loops, the spiral or sequence of loops having a gradually decreasing diameter. The first coil is configured to line a neck, a wall, or the neck and the wall of the vascular malformation so as to at least partially cover an orifice of the vascular malformation. The second section is configured to be deployed within a blood vessel, adjacent the vascular malformation. The second section is configured to form a second coil, circumferentially lining a wall of the blood vessel. Other embodiments are also described.

An implantable medical device for bypassing an aneurysm, comprising a first stent having a first diameter; a second stent positioned at least partially within the first stent, the second stent having a second diameter, the second diameter being smaller than the first diameter such that an intermediate space is defined between the first stent and the second stent when in a deployed configuration; and a graft coupled to the first stent and to the second stent, the graft defining a lumen through the second stent, wherein the lumen is configured to allow blood flow therethrough, and wherein the graft is configured to limit blood flow between the first stent and the second stent.

The present disclosure provides a whole blood, protein-based diagnostic test for presence and evaluation of aneurysm status. Further, the present disclosure relates to methods of treating aneurysms.

Systems and methods for repairing aneurysms (e.g., abdominal aortic aneurysms) are provided. The systems and methods provide a stent graft system having a first stent and a main graft body, where the main graft body is configured to be inserted through a blood vessel into a target blood vessel. In some examples, the first stent and the main graft body may be in a substantially end-to-end configuration. In some examples, the stent graft systems and methods are configured for use in a single arterial puncture hole or incision, such as in a blood vessel having a diameter less than or equal to the femoral artery diameter of the same patient or subject.

The present disclosure provides a whole blood, protein-based diagnostic test for presence and evaluation of aneurysm status. Further, the present disclosure relates to methods of treating aneurysms.

The invention provides an aneurysm clip storage device which comprises a box body, a plurality of groups of mounting grooves are formed in the box body, a storage unit is slidably arranged in each group of mounting grooves, each storage unit comprises a storage shell slidably arranged in the corresponding mounting groove, and a control rod is slidably arranged at the end, located in the box body, of each storage shell. A clamping mechanism connected with the control rod is arranged in the containing shell, sliding of the control rod is converted into transverse clamping or clamping releasing of the aneurysm clamp through the clamping mechanism, a pressing mechanism connected with the control rod is further arranged in the containing shell, and sliding of the control rod is converted into pressing or pressing releasing of the aneurysm clamp through the pressing mechanism. According to the device, the aneurysm clamp can be automatically released and fixed in multiple directions in the opening and closing process, the aneurysm clamp does not need to be manually released after the device is opened, the aneurysm clamp does not need to be manually fixed after the aneurysm clamp is placed, the precious treatment time of medical staff is saved, and the operation efficiency is effectively improved.

A medical guide wire for improved blood vessel navigation (i.e., to a blood clot, aneurism or hemorrhagic stroke) includes a wire having a curved distal tip, a shaft covering at last part of the wire, and a coil affixedly covering a portion of the wire proximal to the distal tip and distal to the shaft. Moving the shaft linearly toward the coil compresses the coil and rotates the distal tip. A microcatheter includes a tube having a braided distal portion that is foldable axially. The braided distal portion may comprise a mixture of thicker and thinner strands. When a mechanism triggers the folding, the braided portion's outer diameter increases. The mechanism may be an actuator on the guide wire, which when pulled, exerts axial pressure (directly or indirectly) against a braided portion's distal end. A blood clot nearby may be caught and the microcatheter removed with the blood clot.

This invention discloses a biomarker combination and its screening method, relating to the field of biotechnology. The biomarker combination includes lactate, glutamine, arginine, and 3-methylpentenoic acid, applied to assess the rupture risk of cerebral aneurysms. The screening method for the biomarker combination involves: collecting metabolic fingerprints from serum of patients with cerebral aneurysms and healthy controls using nanoparticle-enhanced laser desorption / ionization mass spectrometry; and performing machine learning to screen the biomarker combination. This invention utilizes nanoparticle-enhanced laser desorption / ionization mass spectrometry to screen lactate, glutamine, arginine, and 3-methylpentenoic acid as metabolic biomarkers, and uses these biomarkers to assess the rupture risk of cerebral aneurysms. Significant differences were observed between the low-risk and high-risk groups (P < 0.05).

To provide a device that can more effectively treat aneurysms, or other malformations such as malformations of arteries, veins, or dura mater within blood vessels. [Solution] The device includes a catheter having a catheter body 120, a light-emitting element 130 located at the distal end of the catheter body, and a fluid conduit connectable to a fluid source. The fluid conduit is configured to discharge fluid from the fluid source through the conduit and out from the distal end of the catheter body. A spacing member 150 is located at the distal end of the catheter body and can move between a flattened shape and an expanded shape. In the expanded shape, the spacing member is positioned around the light-emitting element. The spacing member transmits and / or semi-transmits at least partially the light emitted from the light-emitting element. The device is configured to be at least partially inserted into a body lumen, to discharge fluid into the body lumen, and to emit light from the light-emitting element to illuminate the inner wall of the body lumen.