28 results about "Cardiovascular stent" patented technology

This invention relates to a cardiovascular stent loading sheath and a retraction system for an advancing stent sheath. The cardiovascular stent loading sheath, through the deformation-sealing opening of a deformable element disposed on the sheath tube, achieves the purpose of sealing the sheath opening after stent deployment. This ensures that when the loading sheath retracts across the stent, the sheath end opening does not snag on the stent, effectively preventing stent displacement and reducing surgical risks.

The application discloses an experimental device for in-vitro simulation degradation of cardiovascular stents, and relates to the technical field of biomedical experimental devices, comprising a box body, a water bath mechanism, a temperature controller, a heating component, a temperature measuring component, a degradation mechanism, a deposition mechanism, a pulsatile pump and a driving mechanism, wherein the degradation mechanism comprises a shunt component, a loading connecting plate, a sliding block, a collection component and a plurality of degradation functional assemblies; the driving mechanism is connected with the bottom of the sliding block; the pulsatile pump comprises a pump body and a piston push rod; one side of the pump body is provided with an opening; the piston push rod is slidingly installed in the pump body through the opening; and the driving mechanism is connected with one side of the piston push rod. The driving mechanism is used for driving the sliding block and the piston push rod to synchronously perform periodic reciprocating motion. The experimental device can synchronously simulate the periodic action of a blood vessel wall and blood pulsation on the cardiovascular stent, realizes real-time simulation of the stent degradation environment, and improves the accuracy of experimental results.

The present invention discloses a bioresorbable cardiovascular stent (100). The bioresorbable cardiovascular stent (100) comprising at least one strut (104) (110) connecting the plurality of rhombus-shaped cells (102) in both the longitudinal directions and the circumferential directions and each strut (104) (110) provided with a consistent thickness (108) and width (106). The stent (100) maintains a uniform thickness (108) throughout its length, and featuring struts (104, 110) with consistent thickness (108). The stent (100) is manufactured by using a micro-injection molding process with a single sprue-less hot runner gate. The bioresorbable cardiovascular stent (100) is configured to maintain structural integrity, biocompatible properties, improve radial stiffness to (612 kPa / mm) and radial strength to (225 kPa).

The invention relates to a cardiovascular stent with a double-ultrasonic positioning function, which adopts an ultrasonic positioning principle to position plaques in blood vessels, and comprises a catheter assembly, a balloon component and a vascular stent, the balloon component is arranged at the far end of the catheter assembly, the vascular stent is arranged on the outer side of the balloon component, and the balloon component is arranged on the outer side of the balloon component through special design of a built-in catheter. The balloon catheter has an ultrasonic positioning and imaging function and a double-ultrasonic positioning function, the imaging function in coronary vessels can be achieved on the premise of reducing use of contrast agents and X-rays, accurate positioning of the balloon is achieved, accurate release of the stent is completed, the problem that part of patients are intolerant to the contrast agents is solved, and the balloon catheter has the advantages of being simple in structure and convenient to use. By optimizing the combination mode of the ultrasonic sensor and the intravascular stent, the accuracy and safety of the operation are improved, and a new solution is provided for percutaneous coronary intervention and treatment of cardiovascular diseases.

The invention discloses a cardiovascular stent coating capable of rapidly reconstructing endothelium and releasing nitric oxide for a long time, a preparation method and a stent. The cardiovascular stent coating comprises a dopamine / hexamethylenediamine-copper coating and multiple functional substances combined with the dopamine / hexamethylenediamine-copper coating, and the multiple functional substances comprise an NO precursor, endothelial polysaccharide with the anticoagulation characteristic and growth factors capable of specifically adhering EC. The cardiovascular stent coating provided by the invention is grafted with various functional substances such as endothelial polysaccharide, growth factors capable of specifically adhering EC, NO precursors and the like, so that the defects of low NO yield, poor anticoagulation effect, incapability of quickly promoting re-endothelialization in an early stage and the like of a traditional coating are favorably improved. According to the invention, the cardiovascular stent is endowed with various functions of adhering EC, increasing anticoagulation, providing enough NO under the condition of existence or absence of an endogenous NO donor and the like, so that rapid reendothelialization is promoted, thrombosis and restenosis are prevented, and the long-term curative effect and safety of the cardiovascular stent are finally improved.

The present application relates to the technical field of metallurgical and plastic processing of biomaterials, and provides a biodegradable zinc alloy thin-walled microtube and a preparation method and application thereof.The present application uses zinc and zinc intermediate alloy as raw materials, prepares a zinc alloy hollow ingot through vacuum melting and pouring casting, and then prepares the biodegradable zinc alloy thin-walled microtube through hot spinning-drawing.The alloying elements in the obtained thin-walled microtube include one, two or three of Mg, Mn, Cu and Ti, and the total mass fraction of the alloying elements is not more than 0.5%.The preparation method provided by the present application has a short process flow and low cost, and the mechanical properties, degradation performance and surface quality of the obtained thin-walled microtube can completely meet the processing and service requirements of cardiovascular stents, and thus has a wide application prospect.

The utility model discloses a cutting tool for a cardiovascular stent tectorial membrane. The cutting tool comprises a bottom plate, a pressing plate is arranged above the bottom plate; the bottom plate is hinged to one side of the pressing plate and is used for pressing a film laminating sheet; a plurality of slotted holes are formed in the pressing plate, so that the upper end of the film covering sheet is communicated with the outside, and the pressed film covering sheet is cut at the slotted holes through a cutter; when the cutting tool is used for cutting cardiovascular stent membranes of different specifications, a cutter is directly used for cutting along the slotted hole of the pressing plate in the using process of the cutting tool, a ruler does not need to be used for marking scribed lines of different specifications on the whole membrane piece, the process is simplified, time is saved, the situation that the ruler needs to be used for comparison is avoided, and the production efficiency is improved. And the situation that scratches are easily caused when a cutter is used for cutting along the scribed lines is avoided, and the production safety coefficient is improved.

The invention discloses a targeted drug release type cardiovascular stent system for preventing vascular restenosis, and belongs to the technical field of interventional medical instruments. Comprising a stent skeleton matched with a coronary artery lumen, a micro-fluidic drug storage bin assembly integrally embedded in the stent skeleton, an intelligent driving assembly correspondingly assembled in a micro-fluidic channel and a targeted release mechanism arranged in the stent skeleton, the micro-fluidic drug storage bin assembly comprises a plurality of independently sealed drug storage bins and corresponding micro-fluidic channels, and the intelligent driving assembly achieves sequential unlocking according to the vascular repair stage through a Venturi tube, a body temperature response type diameter adjusting piece, a sequential degradation sealing piece and an elastic self-reset blocking sealing piece, dynamically adjusts the drug release amount along with the body temperature gradient, and achieves the purpose of repairing the blood vessel. And the liquid medicine is directionally released to a diseased region through the array microtube. The full-period staged precise drug delivery can be realized, the unbalance and unexpected release of the drug are avoided, and the effect and clinical reliability of the stent for preventing the vascular restenosis are improved.

The medical implant antibacterial cobalt-based alloy has the mass percentage composition of Cr: 17-18, Mn: 10.5-11.5, Fe: 22-23.5, W: 4-5, N: 0.1-0.2, Mo: 1.5-1.9, Nb: 0.7-0.85, Zr: 0.05-0.11, Cu: 2.5-3.0, and the balance of Co and inevitable impurities. The alloy has excellent mechanical and processing properties, can be widely applied to the preparation of orthopedic implants, oral implant systems, cardiovascular stents and other medical devices, can effectively reduce the infection risk of implanted devices, and can obviously reduce the corresponding cost of the devices.

The present invention provides a photopolymerisable composition for 4D printing, comprising an acrylated polyol (AOPO) derived from a natural oil, such as olive oil, and acrylic acid as a comonomer. The composition is used in a solvent-free digital light processing (DLR) method to fabricate high-resolution, multifunctional objects. The resulting 4D printed objects are biocompatible, hemocompatible, and cytocompatible. They exhibit excellent temperature- responsive shape memory properties activated near body temperature, inherent antimicrobial activity against both gram-negative and gram-positive bacteria, and tuneable mechanical properties suitable for soft tissue engineering. Furthermore, the composition can be loaded with therapeutic agents, such as progesterone, to form biodegradable objects capable of sustained, controlled drug release. These properties make the material ideal for medical implants, cardiovascular stents, and drug delivery devices.

The present invention discloses a bioresorbable cardiovascular stent (100). The bioresorbable cardiovascular stent (100) comprising at least one strut (104) (110) connecting the plurality of rhombus-shaped cells (102) in both the longitudinal directions and the circumferential directions and each strut (104) (110) provided with a consistent thickness (108) and width (106). The stent (100) maintains a uniform thickness (108) throughout its length, and featuring struts (104, 110) with consistent thickness (108). The stent (100) is manufactured by using a micro-injection molding process with a single sprue-less hot runner gate. The bioresorbable cardiovascular stent (100) is configured to maintain structural integrity, biocompatible properties, improve radial stiffness to (612 kPa / mm) and radial strength to (225 kPa).

The invention discloses a metal-doped diamond-like carbon film on the surface of a magnesium-based material and a preparation method and application of the metal-doped diamond-like carbon film. The preparation method of the metal-doped diamond-like carbon film on the surface of the magnesium-based material comprises the following steps that (1) the magnesium-based material is selected and subjected to forming treatment; (2) carrying out surface pretreatment on the magnesium matrix material; and (3) preparation of the metal-doped diamond-like carbon film: a pulse arc source and plasma immersion ion implantation composite technology is adopted, and the prepared metal-doped, especially copper-doped diamond-like carbon film reduces the corrosion rate of a magnesium-based material in simulated body fluid by more than one order of magnitude; the binding force, antibacterial property and corrosion resistance are comprehensively superior to those of unmodified and conventional diamond-like coatings, and reliable guarantee is provided for safe and long-acting application of the degradable magnesium alloy in the medical fields of orthopedic implantation, cardiovascular stents and the like and in severe service environments of aerospace, ocean engineering and the like.

1. The name of the design product: balloon forming machine. 2. The use of the design product: for processing and manufacturing balloon for cardiovascular stent. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

This invention belongs to the field of medical materials technology, specifically relating to a bioresorbable corrosion-resistant magnesium alloy cardiovascular stent and its preparation method. This invention, through multi-element microalloying design, introduces specific types and amounts of alloying elements (such as Zn, Ca, Sr, Mn, and Nd) to synergistically regulate the electrode potential and microstructure of the alloy while ensuring biocompatibility. It also provides matching precision plastic processing and post-processing techniques. Through grain refinement, texture optimization, and surface modification, excellent radial support strength is achieved while simultaneously realizing controllable degradation rate and uniform degradation pattern. The results of the embodiments show that the corrosion reaction of the magnesium alloy cardiovascular stent of this invention occurs uniformly, solving the key problem of uniform degradation of biodegradable magnesium alloy stents.

The invention discloses a stent coating and a preparation method thereof.The preparation method comprises the steps that firstly, dopamine is used for conducting chemical crosslinking on the surface of a stent, and an amino-rich surface is provided for subsequent grafting; then grafting p-azidobenzoic acid on the surface of the polydopamine by adopting an amidation reaction, and finally, firmly grafting the lipidosome to the surface of the material through a covalent grafting reaction of an azido group on the p-azidobenzoic acid and cycloalkyne on the lipidosome, so as to construct the multifunctional intravascular stent coating with anti-inflammatory and endothelial protection effects at the same time. The coating can adapt to long-term physiological functions required by the cardiovascular stent, and the lasting intravascular stent coating provides a solution strategy for complications such as stent restenosis and advanced thrombus.

The invention discloses a poly (trimethylene carbonate-co-lactide) copolymer capable of accurately regulating and controlling the monomer proportion and a preparation method and application thereof.The copolymer is formed by polymerizing trimethylene carbonate and L-lactide, trimethylene carbonate, lactide and stannous octoate are subjected to high-strength purification and impurity removal, a reaction system is pretreated, and the poly (trimethylene carbonate-co-lactide) copolymer is obtained. A high-molecular-weight PTLA series material with the molecular weight of about 550 kDa is synthesized by adopting a ring-opening copolymerization method, and random copolymers with different block lengths and distribution are constructed by accurately controlling the molar ratio of TMC to LA. According to the invention, the high-molecular-weight material is degraded in 28 days to keep the stable form, and the problem that the traditional low-molecular-weight material is easy to deform is solved; a degradation product is free of accumulation of acidic substances and excellent in biocompatibility; a wide-range degradation period of 30-685 days can be obtained through composition regulation and control, and the different requirements of orthopedic fixation (rapid degradation), cardiovascular stent (long-term maintenance) and the like are met.

The invention belongs to the technical field of medical materials, and particularly relates to a coating with anticoagulation and endothelialization promotion functions and a preparation method and application thereof. In the preparation method of the coating, 2-methacryloyloxyethyl phosphorylcholine molecules are utilized to construct a bionic anti-fouling biological coating, a phosphorylcholine coating is prepared through a thermal initiation free radical reaction and a silane coupling agent polymerization reaction, and biological macromolecules and specific targeting functional polypeptides are introduced. The invention further discloses the coating prepared according to the method and application of the coating in preparation of surfaces of implanted and interventional instruments in contact with blood. The coating disclosed by the invention has a synergistic effect of double functions of anticoagulation and endothelialization promotion, and can be applied to cardiovascular intervention instruments such as artificial blood vessels, cardiovascular stents and left auricle occluders, so that the clinical requirement of long-term biocompatibility of the cardiovascular instruments is met.

The invention discloses an MXene and everolimus composite coating and a preparation method and application thereof.The preparation method comprises the steps that MXene nanosheets and everolimus are compounded through hydrogen bonds and pi-pi stacking, the maximum drug loading capacity is 44.4%, and the MXene and everolimus composite coating is further blended with a degradable polymer to prepare the coating, the mass ratio of the MXene and everolimus compound to the degradable polymer is (1: 5)-(1: 15). An in-vitro experiment shows that the coating has a two-phase slow release characteristic, antioxidant activity and efficient antibacterial performance. A biological safety test shows that the hemolysis rate of a coating leaching solution is smaller than or equal to 4.1% + / -0.9%, the endothelial cell survival rate is 87.6% + / -3.8%, the problems of biotoxicity, process and infection of a traditional coating are solved from the source of materials, the coating is suitable for cardiovascular stent surface modification, and the risks of restenosis, oxidative stress and bacterial infection are jointly solved.

A cardiovascular stent comprising: an active mechanical metamaterial, comprising: first and second electrically conductive components disposed relative to each other to act as opposite electrodes to induce contact electrification; wherein the first and second electrically conductive components, along with a dielectric component serving as a skeleton of the active mechanical metamaterial, form a lattice of snapping curved semicircular-shaped segments, wherein each of the snapping curved semicircular-shaped segments has an elastic snap-through instability mechanism; and wherein the lattice comprises periodic repeatable parallel rows of the snapping curved semicircular-shaped segments.

The cardiac vascular stent comprises a catheter, a guide mechanism is arranged in the catheter, an expansion mechanism is connected to the guide mechanism in a sliding mode, and a taking-out mechanism is installed on the expansion mechanism; the guide wire is inserted into the top of a cardiac vessel from a radial artery, the catheter is inserted into the vessel through guiding of the guide wire, the trachea provided with the taking-out mechanism is inserted into the cardiac vessel along the inside of the catheter, the air bag is moved to a cardiac stent through imaging equipment, and air is input into the air inlet head to expand the air bag for a certain distance. The distance between the flexible metal plate and the heart stent is reduced, the electromagnet controller is started to magnetize the flexible connecting piece, the flexible metal plate also magnetizes at the moment, the flexible metal plate sucks the stent on the inner wall of the blood vessel, the trachea is pulled to enable the heart stent to enter the catheter, and damage of the heart stent to the blood vessel is reduced. When the heart stent is completely pulled out from the inside of the catheter, the heart stent is taken out, and the vascular elasticity and follow-up treatment of a patient are protected.

A method for preparing a poly(thioctic acid)-copper coating (poly(TA-Cu)) on a surface of a cardiovascular stent material includes: grinding a cardiovascular stent material with sandpaper until the surface of the cardiovascular stent material is flat and smooth, rinsing the cardiovascular stent material with deionized water and anhydrous ethanol in sequence, and drying the cardiovascular stent material to obtain a pre-treated cardiovascular stent material; dissolving thioctic acid in an alcoholic solvent, adding anhydrous copper chloride to a mixed solution of thioctic acid and the alcoholic solvent, stirring the mixed solution, to yield a precursor solution; treating the pre-treated cardiovascular stent material with the precursor solution, and drying, thus forming a poly(thioctic acid)-copper coating on the surface of the pre-treated cardiovascular stent material. The concentration of thioctic acid in the alcoholic solvent is 0.1-0.3 g / mL, and the molar ratio of anhydrous copper chloride to thioctic acid monomer is 1:100-5000.

The invention discloses a magnesium alloy surface MGO-MFP5 composite coating and a preparation method and application thereof. The preparation method comprises the steps that a magnesium alloy is ground, cleaned, subjected to sodium hydroxide alkaline etching pretreatment and subjected to ultraviolet sterilization, and then the surface of the magnesium alloy is coated with a mussel adhesion protein solution through a trace drop deposition method to form the MGO-MFP5 composite coating. According to the preparation method, the MgO thin film is formed on the surface of the magnesium alloy through alkali etching, then MFP5 is stably adhered to the surface of the magnesium alloy through the chemical adsorption effect between Dopa molecules of mussel adhesion protein and MgO to form the MgO-MFP5 composite coating, the process is simple, operability is high, the application range is wide, and the obtained composite coating has good biocompatibility, can promote cell proliferation and can be used for preparing the magnesium alloy composite coating. Meanwhile, the antibacterial performance is remarkably improved, adhesion and reproduction of common pathogenic bacteria such as staphylococcus aureus and escherichia coli are inhibited, and the magnesium-based bone implant is suitable for preparing bone fixing instruments, cardiovascular stents and the like.

The application belongs to the technical field of genetic engineering, and particularly relates to a recombinant collagen type III with endothelialization promotion and low platelet adhesion, a preparation method and application thereof. The recombinant collagen type III retains a functional site in human natural collagen type III for promoting endothelial cell combination, and a key site for platelet combination is directionally replaced to reduce platelet adhesion, and the amino acid sequence is designed as a repeatable unit to enhance functional activity. The recombinant collagen can be expressed in a host cell through genetic engineering and purified to obtain. The obtained recombinant collagen type III has the characteristics of promoting endothelialization and reducing the risk of thrombosis, and is suitable for cardiovascular stent coating, artificial blood vessels and other blood contact instruments, and can be used as an active ingredient in the preparation of vascular repair or antithrombotic drugs.

The invention belongs to the technical field of genetic engineering, and particularly relates to endothelialization-promoting and low-platelet-adhesion recombinant III-type collagen as well as a preparation method and application thereof. The recombinant III-type collagen retains functional sites for promoting endothelial cell binding in human natural III-type collagen, key sites for platelet binding are directionally replaced to reduce platelet adhesion, and an amino acid sequence is designed as a repeatable unit to enhance functional activity. The recombinant collagen can be obtained by expression and purification in host cells through genetic engineering means. The obtained recombinant III-type collagen has the characteristics of promoting endothelialization and reducing the risk of thrombosis, is suitable for cardiovascular stent coatings, artificial blood vessels and other blood contact instruments, and can also be used as an active component to be applied to vascular repair or preparation of antithrombotic drugs.

The application discloses a cardiovascular stent delivery device and belongs to the technical field of medical devices, which comprises a control handle, and a locking component is arranged on the left side of the control handle; the locking component comprises a balloon fixedly connected to the left end of an inner core pipe; a mesh metal pipe is slidably sleeved outside the balloon; a plurality of limiting grooves are formed in the outer surface of the balloon; and a limiting block is slidably connected to the inside of each limiting groove; and recesses are formed in the opposite surfaces of the upper and lower corresponding two limiting blocks. The limiting block is arranged to limit the unreleased mesh metal pipe, so that the mesh metal pipe is prevented from being dislocated or separated; the limiting block can continuously apply stable extrusion force to the mesh metal pipe, so that the mesh metal pipe is prevented from being displaced due to factors such as balloon filling during the releasing process, and in turn, the stent is prevented from being displaced or separated, the accuracy of the stent releasing is ensured, and meanwhile, the contractility of the limiting block can ensure the quick assembly of the mesh metal pipe and the stability of the mesh metal pipe after installation.

The present application belongs to the technical field of blood contact materials, and relates to a vascular stent coating based on phase transition lysozyme film loading copper ions and heparin. The preparation method of the coating comprises the following steps: S1, loading a phase transition lysozyme coating on the surface of a base material of a vascular stent; S2, immersing the base material obtained in step S1 into a copper-containing solution for not less than 4 hours to obtain a copper-loaded coating; and S3, finally immersing the base material covered with the copper-loaded coating obtained in step S2 into an activated heparin solution to obtain a coating jointly loading copper ions and heparin. The cardiovascular stent coating prepared by the present application and loading copper ions and heparin on the phase transition lysozyme film can have long-term stability and continuously release copper ions for 14 days, has good blood compatibility and cell compatibility, and can be used for constructing a surface modification coating of a multifunctional cardiovascular material with antithrombosis and endothelialization.

This invention relates to the field of medical material manufacturing technology, and more specifically, to a photothermally controllable antibacterial titanium alloy implant and its preparation method. The implant substrate is titanium or a titanium alloy, and its surface is activated by alkaline heat treatment. Polydopamine and copper ions are polymerized in situ at room temperature to coat the implant substrate surface. The implant obtained by this invention has no significant toxicity to osteoblasts, excellent biocompatibility, and combines multiple functions such as synergistic antibacterial activity, high hydrophilicity, osteopromoting properties, photothermally controllable properties, and safe sustained release. It can be widely applied in medical implantation fields such as orthopedic implants, bone fixation devices, and cardiovascular stents, providing a safe, efficient, and feasible new solution for effectively addressing key issues such as clinical infection and poor osseointegration in medical titanium alloys.