51 results about "Cardiovascular stent" patented technology

The invention relates to the technical field of cardiovascular stents, in particular to an alloy cardiovascular stent and a surface coating process thereof. The preparation method comprises the following steps: performing electrolytic polishing, washing and drying on a magnesium alloy intravascular stent, immersing the magnesium alloy intravascular stent into a sodium hydroxide solution for alkali heat treatment, and washing and drying to obtain a pretreated magnesium alloy intravascular stent; immersing the pretreated magnesium alloy intravascular stent into a dopamine solution for reaction to obtain a polydopamine modified magnesium alloy intravascular stent; preparing a polymer coating on the surface of the polydopamine modified magnesium alloy intravascular stent by using a physical spraying method to obtain a polymer modified magnesium alloy intravascular stent; and immersing the polymer modified magnesium alloy intravascular stent into the nanoparticle solution, and carrying out ultraviolet irradiation, washing and drying to obtain the polymer modified magnesium alloy intravascular stent. The corrosion resistance of the magnesium alloy intravascular stent is improved, the degradation rate of the stent in vivo is effectively reduced, and the stent surface is endowed with good biocompatibility.

The present invention belongs to the field of cardiovascular stent processing technology, and relates to a processing method for a medical titanium alloy coronary artery drug-coated stent. The chemical composition and mass percentage of the titanium alloy are: Mn 5.0% to 14.0%, Fe≤0.30%, O≤0.16%, N≤0.01%, H≤0.001%, and the remainder is Ti. The present invention adopts a vacuum consumable arc furnace to melt the alloy ingot, and after forging and hot rolling, a titanium alloy rod is obtained, and then mechanical perforation, peeling, centerless grinding, cold rolling, cold drawing and straightening are performed to obtain a finished titanium alloy capillary, and a metal stent is prepared by microsecond fiber laser engraving, vacuum heat treatment and electrochemical polishing. Subsequently, a drug solution is sprayed on the outer surface of the metal stent using a sprayer, and dried in a clean environment, thereby preparing a titanium alloy coronary artery drug-coated stent.

Provided is a biosynthesis-based preparation method for a structural material of the human body. A polypeptide of the present application contains the structure of a C-terminal region of (repeating unit)n or (repeating unit)n-; the repeating unit contains an amino acid sequence as shown in SEQ ID NO. 1. Recombinant type V humanized collagen prepared in the present application has high activity in promoting cell adhesion, and does not cause an immune response when applied to the human body; moreover, the preparation method is novel, allows for large-scale production of the recombinant type V humanized collagen, and is widely used in the preparation of structural materials of the human body. The application field includes preparation of high-end medical devices, such as biological dressings, human body biomimetic materials, plastic-beauty materials, organoid culture, cardiovascular stents, coatings, tissue injection filling, ophthalmic materials, gynecological biomaterials, nerve repair and regeneration, liver tissue and vessel repair and regeneration, and 3D printing of artificial organ biomaterials.

This invention relates to a cardiovascular stent loading sheath and a retraction system for an advancing stent sheath. The cardiovascular stent loading sheath, through the deformation-sealing opening of a deformable element disposed on the sheath tube, achieves the purpose of sealing the sheath opening after stent deployment. This ensures that when the loading sheath retracts across the stent, the sheath end opening does not snag on the stent, effectively preventing stent displacement and reducing surgical risks.

The application discloses an experimental device for in-vitro simulation degradation of cardiovascular stents, and relates to the technical field of biomedical experimental devices, comprising a box body, a water bath mechanism, a temperature controller, a heating component, a temperature measuring component, a degradation mechanism, a deposition mechanism, a pulsatile pump and a driving mechanism, wherein the degradation mechanism comprises a shunt component, a loading connecting plate, a sliding block, a collection component and a plurality of degradation functional assemblies; the driving mechanism is connected with the bottom of the sliding block; the pulsatile pump comprises a pump body and a piston push rod; one side of the pump body is provided with an opening; the piston push rod is slidingly installed in the pump body through the opening; and the driving mechanism is connected with one side of the piston push rod. The driving mechanism is used for driving the sliding block and the piston push rod to synchronously perform periodic reciprocating motion. The experimental device can synchronously simulate the periodic action of a blood vessel wall and blood pulsation on the cardiovascular stent, realizes real-time simulation of the stent degradation environment, and improves the accuracy of experimental results.

The present invention discloses a bioresorbable cardiovascular stent (100). The bioresorbable cardiovascular stent (100) comprising at least one strut (104) (110) connecting the plurality of rhombus-shaped cells (102) in both the longitudinal directions and the circumferential directions and each strut (104) (110) provided with a consistent thickness (108) and width (106). The stent (100) maintains a uniform thickness (108) throughout its length, and featuring struts (104, 110) with consistent thickness (108). The stent (100) is manufactured by using a micro-injection molding process with a single sprue-less hot runner gate. The bioresorbable cardiovascular stent (100) is configured to maintain structural integrity, biocompatible properties, improve radial stiffness to (612 kPa / mm) and radial strength to (225 kPa).

The invention relates to a cardiovascular stent with a double-ultrasonic positioning function, which adopts an ultrasonic positioning principle to position plaques in blood vessels, and comprises a catheter assembly, a balloon component and a vascular stent, the balloon component is arranged at the far end of the catheter assembly, the vascular stent is arranged on the outer side of the balloon component, and the balloon component is arranged on the outer side of the balloon component through special design of a built-in catheter. The balloon catheter has an ultrasonic positioning and imaging function and a double-ultrasonic positioning function, the imaging function in coronary vessels can be achieved on the premise of reducing use of contrast agents and X-rays, accurate positioning of the balloon is achieved, accurate release of the stent is completed, the problem that part of patients are intolerant to the contrast agents is solved, and the balloon catheter has the advantages of being simple in structure and convenient to use. By optimizing the combination mode of the ultrasonic sensor and the intravascular stent, the accuracy and safety of the operation are improved, and a new solution is provided for percutaneous coronary intervention and treatment of cardiovascular diseases.

The invention relates to a withdrawing system for a cardiovascular stent loading sheath and an advancing stent sheath. According to the cardiovascular stent loading sheath, the opening is sealed through deformation of the deformable piece arranged on the sheath tube, the purpose of sealing the opening of the sheath tube after the stent is released is achieved, the opening in the sheath end cannot be hung on the stent when the loading sheath retreats to cross the stent, displacement of the stent is effectively prevented, and the surgical risk is reduced.

Example systems, methods, and apparatus are disclosed herein for a design and fabrication of patient-specific stimuli-responsive cardiovascular stents for coronary artery spasm treatment to eliminate post-surgical interventions. The stimuli-responsive material may be a magnetically-induced shape memory nanoparticle such as Hematite dispersed in PLA. Such Hematite may be at a concentration of 10 wt % to 20 wt %.

The invention discloses a cardiovascular stent coating capable of rapidly reconstructing endothelium and releasing nitric oxide for a long time, a preparation method and a stent. The cardiovascular stent coating comprises a dopamine / hexamethylenediamine-copper coating and multiple functional substances combined with the dopamine / hexamethylenediamine-copper coating, and the multiple functional substances comprise an NO precursor, endothelial polysaccharide with the anticoagulation characteristic and growth factors capable of specifically adhering EC. The cardiovascular stent coating provided by the invention is grafted with various functional substances such as endothelial polysaccharide, growth factors capable of specifically adhering EC, NO precursors and the like, so that the defects of low NO yield, poor anticoagulation effect, incapability of quickly promoting re-endothelialization in an early stage and the like of a traditional coating are favorably improved. According to the invention, the cardiovascular stent is endowed with various functions of adhering EC, increasing anticoagulation, providing enough NO under the condition of existence or absence of an endogenous NO donor and the like, so that rapid reendothelialization is promoted, thrombosis and restenosis are prevented, and the long-term curative effect and safety of the cardiovascular stent are finally improved.

The present application relates to the technical field of metallurgical and plastic processing of biomaterials, and provides a biodegradable zinc alloy thin-walled microtube and a preparation method and application thereof.The present application uses zinc and zinc intermediate alloy as raw materials, prepares a zinc alloy hollow ingot through vacuum melting and pouring casting, and then prepares the biodegradable zinc alloy thin-walled microtube through hot spinning-drawing.The alloying elements in the obtained thin-walled microtube include one, two or three of Mg, Mn, Cu and Ti, and the total mass fraction of the alloying elements is not more than 0.5%.The preparation method provided by the present application has a short process flow and low cost, and the mechanical properties, degradation performance and surface quality of the obtained thin-walled microtube can completely meet the processing and service requirements of cardiovascular stents, and thus has a wide application prospect.

The invention discloses a preparation method of a ternary developable NiTiTa shape memory alloy, which is characterized in that Ni, Ti and Ta metal particles are adopted as raw materials, and are sequentially subjected to vacuum arc melting, homogenization treatment, hot rolling, solution treatment and annealing treatment to form the shape memory alloy. According to the NiTiTa alloy, the developing property is improved, meanwhile, excellent mechanical property and biocompatibility are kept, and the NiTiTa alloy is suitable for medical instruments such as orthopedic implants and cardiovascular stents and particularly has wide application prospects in scenes (such as postoperative tracking and fault diagnosis) needing precise image guidance. According to the technical scheme, the functionality and applicability of the material are remarkably expanded, and an innovative solution is provided for development of intelligent medical materials.

The utility model discloses a cutting tool for a cardiovascular stent tectorial membrane. The cutting tool comprises a bottom plate, a pressing plate is arranged above the bottom plate; the bottom plate is hinged to one side of the pressing plate and is used for pressing a film laminating sheet; a plurality of slotted holes are formed in the pressing plate, so that the upper end of the film covering sheet is communicated with the outside, and the pressed film covering sheet is cut at the slotted holes through a cutter; when the cutting tool is used for cutting cardiovascular stent membranes of different specifications, a cutter is directly used for cutting along the slotted hole of the pressing plate in the using process of the cutting tool, a ruler does not need to be used for marking scribed lines of different specifications on the whole membrane piece, the process is simplified, time is saved, the situation that the ruler needs to be used for comparison is avoided, and the production efficiency is improved. And the situation that scratches are easily caused when a cutter is used for cutting along the scribed lines is avoided, and the production safety coefficient is improved.

The invention discloses a targeted drug release type cardiovascular stent system for preventing vascular restenosis, and belongs to the technical field of interventional medical instruments. Comprising a stent skeleton matched with a coronary artery lumen, a micro-fluidic drug storage bin assembly integrally embedded in the stent skeleton, an intelligent driving assembly correspondingly assembled in a micro-fluidic channel and a targeted release mechanism arranged in the stent skeleton, the micro-fluidic drug storage bin assembly comprises a plurality of independently sealed drug storage bins and corresponding micro-fluidic channels, and the intelligent driving assembly achieves sequential unlocking according to the vascular repair stage through a Venturi tube, a body temperature response type diameter adjusting piece, a sequential degradation sealing piece and an elastic self-reset blocking sealing piece, dynamically adjusts the drug release amount along with the body temperature gradient, and achieves the purpose of repairing the blood vessel. And the liquid medicine is directionally released to a diseased region through the array microtube. The full-period staged precise drug delivery can be realized, the unbalance and unexpected release of the drug are avoided, and the effect and clinical reliability of the stent for preventing the vascular restenosis are improved.

The medical implant antibacterial cobalt-based alloy has the mass percentage composition of Cr: 17-18, Mn: 10.5-11.5, Fe: 22-23.5, W: 4-5, N: 0.1-0.2, Mo: 1.5-1.9, Nb: 0.7-0.85, Zr: 0.05-0.11, Cu: 2.5-3.0, and the balance of Co and inevitable impurities. The alloy has excellent mechanical and processing properties, can be widely applied to the preparation of orthopedic implants, oral implant systems, cardiovascular stents and other medical devices, can effectively reduce the infection risk of implanted devices, and can obviously reduce the corresponding cost of the devices.

The present invention provides a photopolymerisable composition for 4D printing, comprising an acrylated polyol (AOPO) derived from a natural oil, such as olive oil, and acrylic acid as a comonomer. The composition is used in a solvent-free digital light processing (DLR) method to fabricate high-resolution, multifunctional objects. The resulting 4D printed objects are biocompatible, hemocompatible, and cytocompatible. They exhibit excellent temperature- responsive shape memory properties activated near body temperature, inherent antimicrobial activity against both gram-negative and gram-positive bacteria, and tuneable mechanical properties suitable for soft tissue engineering. Furthermore, the composition can be loaded with therapeutic agents, such as progesterone, to form biodegradable objects capable of sustained, controlled drug release. These properties make the material ideal for medical implants, cardiovascular stents, and drug delivery devices.

The present invention discloses a bioresorbable cardiovascular stent (100). The bioresorbable cardiovascular stent (100) comprising at least one strut (104) (110) connecting the plurality of rhombus-shaped cells (102) in both the longitudinal directions and the circumferential directions and each strut (104) (110) provided with a consistent thickness (108) and width (106). The stent (100) maintains a uniform thickness (108) throughout its length, and featuring struts (104, 110) with consistent thickness (108). The stent (100) is manufactured by using a micro-injection molding process with a single sprue-less hot runner gate. The bioresorbable cardiovascular stent (100) is configured to maintain structural integrity, biocompatible properties, improve radial stiffness to (612 kPa / mm) and radial strength to (225 kPa).

The invention discloses a cardiovascular stent cleaning device and method, and belongs to the technical field of cleaning devices. The cardiovascular stent cleaning device comprises a water tank, a discharging port is formed in the bottom of the water tank, a blocking mechanism for blocking the discharging port is arranged at the discharging port, a conical material guide plate is arranged below the water tank and located under the discharging port, and a conveying mechanism for conveying a stent is arranged outside the material guide plate. A drying mechanism for drying the support is arranged in the material guiding plate, an ultrasonic structure for cleaning the support is arranged in the water tank, and a power mechanism for driving the drying mechanism, the conveying mechanism and the ultrasonic structure to rotate is arranged below the material guiding plate. And a drain pipe for draining water in the water tank is arranged at the discharge hole of the water tank. By means of the cardiovascular stent cleaning device and method, the problems that an existing vascular stent is low in cleaning efficiency and cannot be dried in time, and secondary pollution is easily caused can be solved.

The utility model discloses cardiovascular stent tube cutting equipment which comprises a working table, a two-dimensional motion platform is arranged on one side of the outer wall of the top end of the working table, a lining assembly is arranged on one side of the two-dimensional motion platform and comprises a shell and a V-shaped plate, the shell is fixed to the outer wall of the top end of the working table, and the V-shaped plate is fixed to the shell. The V-shaped plates are connected to the inner wall of the shell in a sliding mode, the two V-shaped plates are oppositely arranged, fixing plates are detachably connected to the outer walls of the V-shaped plates, two-way threaded rods are arranged on the two sides of each V-shaped plate, and the fixing plates are in threaded fit with the two-way threaded rods. According to the bushing assembly, the V-shaped plates, the bidirectional threaded rods and the fixing plates are arranged, and the distance between the two V-shaped plates is adjusted, so that the friction loss between the metal cylinders and the V-shaped plates can be compensated, the conditions of abrasion, looseness and the like are prevented, the service life of the bushing assembly product is prolonged, and meanwhile, the positioning of the metal cylinders with different diameters can be realized.

The invention relates to the fields of biomaterials, tissue engineering and regenerative medicine. More specifically, it relates to biomaterial substrates having precise surface properties and the use thereof to enhance the attachment and ingrowth of ePTFE sleeved stents with the blood vessel wall. The specific physicochemical properties stimulate smooth muscle cell attachment and spreading that enables the stent to be biologically fixated in a very intimate fashion. This biological fixation prevents migration, infection, and aneurysm progression.

The invention discloses a metal-doped diamond-like carbon film on the surface of a magnesium-based material and a preparation method and application of the metal-doped diamond-like carbon film. The preparation method of the metal-doped diamond-like carbon film on the surface of the magnesium-based material comprises the following steps that (1) the magnesium-based material is selected and subjected to forming treatment; (2) carrying out surface pretreatment on the magnesium matrix material; and (3) preparation of the metal-doped diamond-like carbon film: a pulse arc source and plasma immersion ion implantation composite technology is adopted, and the prepared metal-doped, especially copper-doped diamond-like carbon film reduces the corrosion rate of a magnesium-based material in simulated body fluid by more than one order of magnitude; the binding force, antibacterial property and corrosion resistance are comprehensively superior to those of unmodified and conventional diamond-like coatings, and reliable guarantee is provided for safe and long-acting application of the degradable magnesium alloy in the medical fields of orthopedic implantation, cardiovascular stents and the like and in severe service environments of aerospace, ocean engineering and the like.

1. The name of the design product: balloon forming machine. 2. The use of the design product: for processing and manufacturing balloon for cardiovascular stent. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

This invention belongs to the field of medical materials technology, specifically relating to a bioresorbable corrosion-resistant magnesium alloy cardiovascular stent and its preparation method. This invention, through multi-element microalloying design, introduces specific types and amounts of alloying elements (such as Zn, Ca, Sr, Mn, and Nd) to synergistically regulate the electrode potential and microstructure of the alloy while ensuring biocompatibility. It also provides matching precision plastic processing and post-processing techniques. Through grain refinement, texture optimization, and surface modification, excellent radial support strength is achieved while simultaneously realizing controllable degradation rate and uniform degradation pattern. The results of the embodiments show that the corrosion reaction of the magnesium alloy cardiovascular stent of this invention occurs uniformly, solving the key problem of uniform degradation of biodegradable magnesium alloy stents.

The invention relates to a photostimulation response zinc-based coordination polymer as well as a preparation method and application thereof in a cardiovascular stent, and belongs to the technical field of biological medicines. The chemical formula of the photostimulation response zinc-based coordination polymer is {[Zn (OAc) 2 (tpeb)]. 2H2O} n, OAc is acetic acid, tpeb is 1, 3, 5-tri (2-(pyridine-4-yl) vinyl) benzene, and n is equal to 3000-60000. The photostimulation response zinc-based coordination polymer crystal can be subjected to photochemical [2 + 2] cycloaddition reaction under ultraviolet irradiation, and the reaction process is accompanied by strong and rapid crystal mechanical movement. The cardiovascular stent prepared from the material can be rapidly expanded according to a specified direction under ultraviolet irradiation, has a secondary illumination expansion capability, breaks through the disposable use limitation of the existing stent, and is endowed with the capability of dynamically adapting to vascular pathology / physiological changes.

The invention discloses a stent coating and a preparation method thereof.The preparation method comprises the steps that firstly, dopamine is used for conducting chemical crosslinking on the surface of a stent, and an amino-rich surface is provided for subsequent grafting; then grafting p-azidobenzoic acid on the surface of the polydopamine by adopting an amidation reaction, and finally, firmly grafting the lipidosome to the surface of the material through a covalent grafting reaction of an azido group on the p-azidobenzoic acid and cycloalkyne on the lipidosome, so as to construct the multifunctional intravascular stent coating with anti-inflammatory and endothelial protection effects at the same time. The coating can adapt to long-term physiological functions required by the cardiovascular stent, and the lasting intravascular stent coating provides a solution strategy for complications such as stent restenosis and advanced thrombus.

The cardiovascular stent imbedding low-radiation-dose radiography system comprises a supporting side frame, a standing plate is fixedly connected to the side face of the supporting side frame, a fixing sliding groove is formed in the top end of the supporting side frame, and a first fixing sleeve is fixedly installed on the side face of the supporting side frame; and a fixed panel is slidably connected into the supporting side frame in a sleeving manner. By arranging the driving adjusting assembly, the fixing panel and the supporting side frame and utilizing mutual cooperation of the driving adjusting assembly, the fixing panel and the supporting side frame, firstly, an operator holds a fixing grip and then rotates anticlockwise, and a driving gear on the side face of the first belt pulley is driven by the first belt pulley to synchronously rotate; at the moment, a driving gear is meshed to drive a fixed rack plate on one side of the back of a fixed panel to move upwards, so that a scanning area plate on the front face of the fixed panel is lifted, and on the contrary, a fixed grip can be rotated clockwise, so that the fixed panel moves downwards to be adjusted, and the flexibility of the device is improved; and the requirements of patients with different heights and types are met.

The invention provides a degradable medical 3D printing magnesium alloy cardiovascular stent and a preparation method thereof, and belongs to the technical field of human body implantation medical instruments. The medical magnesium alloy is obtained through a specific element ratio and specific preparation process parameters, the microstructure of the alloy is optimized, the yield strength, tensile strength and corrosion resistance of the magnesium alloy cardiovascular stent are improved, and then the stability of the magnesium alloy cardiovascular stent is improved. Moreover, the medical magnesium alloy is combined with a 3D printing technology, so that the shape and the size of the stent can be accurately customized according to individual requirements of patients, the implantation suitability is improved, the production period is shortened, the cost is reduced, and the production efficiency of medical materials is improved.

The invention discloses a poly (trimethylene carbonate-co-lactide) copolymer capable of accurately regulating and controlling the monomer proportion and a preparation method and application thereof.The copolymer is formed by polymerizing trimethylene carbonate and L-lactide, trimethylene carbonate, lactide and stannous octoate are subjected to high-strength purification and impurity removal, a reaction system is pretreated, and the poly (trimethylene carbonate-co-lactide) copolymer is obtained. A high-molecular-weight PTLA series material with the molecular weight of about 550 kDa is synthesized by adopting a ring-opening copolymerization method, and random copolymers with different block lengths and distribution are constructed by accurately controlling the molar ratio of TMC to LA. According to the invention, the high-molecular-weight material is degraded in 28 days to keep the stable form, and the problem that the traditional low-molecular-weight material is easy to deform is solved; a degradation product is free of accumulation of acidic substances and excellent in biocompatibility; a wide-range degradation period of 30-685 days can be obtained through composition regulation and control, and the different requirements of orthopedic fixation (rapid degradation), cardiovascular stent (long-term maintenance) and the like are met.

The invention belongs to the technical field of medical materials, and particularly relates to a coating with anticoagulation and endothelialization promotion functions and a preparation method and application thereof. In the preparation method of the coating, 2-methacryloyloxyethyl phosphorylcholine molecules are utilized to construct a bionic anti-fouling biological coating, a phosphorylcholine coating is prepared through a thermal initiation free radical reaction and a silane coupling agent polymerization reaction, and biological macromolecules and specific targeting functional polypeptides are introduced. The invention further discloses the coating prepared according to the method and application of the coating in preparation of surfaces of implanted and interventional instruments in contact with blood. The coating disclosed by the invention has a synergistic effect of double functions of anticoagulation and endothelialization promotion, and can be applied to cardiovascular intervention instruments such as artificial blood vessels, cardiovascular stents and left auricle occluders, so that the clinical requirement of long-term biocompatibility of the cardiovascular instruments is met.