Degradable biomedical Mg-Zn-Zr-Nd alloy material and preparation method thereof

A biomedical and alloy material technology, applied in medical science, surgery, etc., can solve the problems of fast corrosion rate of magnesium alloy, insufficient mechanical properties, and no consideration of material biocompatibility, etc., to achieve good mechanical properties and processing properties, preparation The method is simple and avoids the effect of premature failure

Active Publication Date: 2018-01-09
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are also the following problems: (1) the release of toxic metal ions or particles due to corrosion causes inflammatory reactions; (2) the elastic modulus is much higher than that of human bone, which produces a large "stress shielding" for local bone tissue "effect", which may lead to the possibility of degeneration or even atrophy of natural bone function; (3) These materials are biologically inert materials, which are difficult to degrade in the body. Patient pain and psychological burden
However, the degradable magnesium alloys that have been developed still have the following problems in clinical practice: (1) The biocompatibility of materials is not considered when designing components, such as the Al element in the AZ series alloys has neurotoxicity, which can easily lead to Alzheimer's disease; ( 2) The corrosion rate of magnesium alloy is too fast, it is difficult to ensure the mechanical integrity during the service period, and it has failed before the body is cured; (3) The mechanical properties are insufficient, especially the plastic deformation ability is poor

Method used

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  • Degradable biomedical Mg-Zn-Zr-Nd alloy material and preparation method thereof
  • Degradable biomedical Mg-Zn-Zr-Nd alloy material and preparation method thereof
  • Degradable biomedical Mg-Zn-Zr-Nd alloy material and preparation method thereof

Examples

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Effect test

Embodiment 1

[0024] The degradable biomedical Mg-Zn-Zr-Nd alloy material in this example is prepared from the following components according to the mass percentage: Zn 1.8%, Zr 0.6%, Nd 0.1%, and the rest are Mg and unavoidable impurity elements .

[0025] Concrete preparation steps are as follows:

[0026] (1) Weigh the raw materials according to the proportioning ratio. The above-mentioned raw materials adopt high-purity magnesium alloy (Mg≥99.99%), high-purity zinc ingot (Zn≥99.995%), Mg-30% Zr master alloy (Zr: 29.6%, impurity content 0.008%, The balance is Mg) and Mg-30% Nd master alloy (Nd: 29.2%, the impurity content is 0.005%, and the balance is Mg). The above raw materials are smelted in a vacuum induction furnace under the protection of argon, and kept at 780°C 20 minutes, after the above raw materials are all melted, stir for 2 minutes, then cool down to 740°C and refine for 8 minutes, after refining, raise the temperature to 750°C and let it stand for 6 minutes, and cast it in...

Embodiment 2

[0031] The degradable biomedical Mg-Zn-Zr-Nd alloy material in this example is prepared from the following components according to the mass percentage: Zn 2.0%, Zr 0.5%, Nd 0.3%, and the rest are Mg and unavoidable impurity elements .

[0032] Concrete preparation steps are as follows:

[0033] (1) Weigh the raw materials according to the proportioning ratio. The above-mentioned raw materials adopt high-purity magnesium alloy (Mg≥99.99%), high-purity zinc ingot (Zn≥99.995%), Mg-30% Zr master alloy (Zr: 29.6%, impurity content 0.008%, The balance is Mg) and Mg-30% Nd master alloy (Nd: 29.2%, the impurity content is 0.005%, and the balance is Mg). The above raw materials are smelted in a vacuum induction furnace under the protection of argon, and kept at 780°C 20 minutes, after the above raw materials are all melted, stir for 2 minutes, then cool down to 740°C and refine for 8 minutes, after refining, raise the temperature to 750°C and let it stand for 6 minutes, and cast it in...

Embodiment 3

[0038] The degradable biomedical Mg-Zn-Zr-Nd alloy material in this example is prepared from the following components according to the mass percentage: Zn 1.9%, Zr 0.6%, Nd 0.7%, and the rest are Mg and unavoidable impurity elements .

[0039] Concrete preparation steps are as follows:

[0040] (1) Weigh the raw materials according to the proportioning ratio. The above-mentioned raw materials adopt high-purity magnesium alloy (Mg≥99.99%), high-purity zinc ingot (Zn≥99.995%), Mg-30% Zr master alloy (Zr: 29.6%, impurity content 0.008%, The balance is Mg) and Mg-30% Nd master alloy (Nd: 29.2%, the impurity content is 0.005%, and the balance is Mg). The above raw materials are smelted in a vacuum induction furnace under the protection of argon, and kept at 790°C 25min, after the above raw materials are melted, stir for 3min, then cool down to 750°C and refine for 10min, after refining, raise the temperature to 760°C and let stand for 8min, then cast into ingot at 720°C;

[0041]...

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Abstract

The invention discloses a degradable biomedical Mg-Zn-Zr-Nd alloy material and a preparation method thereof. Magnesium alloy comprises, by mass, 1-3% of Zn, 0.5-1% of Zr, 0.1-1.5% of Nd, and the balance Mg and inevitable impurities. The preparation method comprises the specific steps of raw material smelting, casting forming, homogenizing treatment, hot extrusion and artificial ageing treatment, and the biomedical magnesium alloy bar material meeting the service requirements under the biological fluid environment is obtained. According to the degradable biomedical Mg-Zn-Zr-Nd alloy material and the preparation method thereof, the alloy elements harmless to human bodies are added into the magnesium alloy, the alloy is non-poisonous to the human bodies after being degraded in the human bodies, is excellent in mechanical property, has good mechanical performance and machining performance, is good in corrosion resistance, can be completely degraded in the biological fluid environment and can also ensure the appropriate corrosion rate so that early failure can be avoided. The degradable biomedical Mg-Zn-Zr-Nd alloy material is simple in preparation method, low in production cost and suitable for being made into a cardiovascular stent, a bone nail and other medical materials.

Description

technical field [0001] The invention belongs to the technical field of biomedical magnesium alloy materials, and in particular relates to a degradable biomedical Mg-Zn-Zr-Nd alloy material and a preparation method thereof. Background technique [0002] At present, metal implant materials widely used clinically include stainless steel, titanium alloy, cobalt-chromium alloy, etc. The advantages of these materials are that they have good mechanical properties and corrosion resistance, and can maintain structural stability in vivo for a long time. However, there are also the following problems: (1) the release of toxic metal ions or particles due to corrosion causes inflammatory reactions; (2) the elastic modulus is much higher than that of human bone, which produces a large "stress shielding" for local bone tissue "effect", which may lead to the possibility of degeneration or even atrophy of natural bone function; (3) These materials are biologically inert materials, which are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C23/04C22C23/06C22C1/03C22F1/06A61L31/02
Inventor 宋仁伯蔡长宏汪孪祥黄良
Owner UNIV OF SCI & TECH BEIJING
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