Degradable multi-layer Mg/Zn composite material for medical use and preparation method thereof

A layered composite material and composite material technology, which are applied in the field of medical degradable multi-layer Mg/Zn composite materials and their preparation, can solve the problems of accelerated corrosion failure of the magnesium layer, and achieve good biocompatibility, excellent mechanical properties, Solve the effect of insufficient comprehensive performance

Active Publication Date: 2020-07-28
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The structural design of the multi-layer magnesium clad layer enables corrosion to develop laterally in the magnesium clad layer, prevents strong galvanic corrosion between the zinc layer and the magnesium layer, effectively protects the structural integrity of the zinc base layer, and solves the problem of accelerated corrosion of the magnesium layer failure problem

Method used

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  • Degradable multi-layer Mg/Zn composite material for medical use and preparation method thereof
  • Degradable multi-layer Mg/Zn composite material for medical use and preparation method thereof
  • Degradable multi-layer Mg/Zn composite material for medical use and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Design of multilayer Mg / Zn composites.

[0031] Magnesium cladding with the symbol Mg i (i=1~3) means that the zinc-based layer uses the symbol Zn j (j=1 to 3) means. The billet assembly method is one of the following four types:

[0032] ①Mg 1 / Mg 2 / Mg 3 / Zn 1 ;

[0033] ②Mg 1 / Mg 2 / Mg 3 / Zn 1 / Mg 3 / Mg 2 / Mg 1 ;

[0034] ③ Mg 1 / Mg 2 / Mg 3 / Zn 1 / Zn 2 / Zn 3 ;

[0035] ④Mg 1 / Mg 2 / Mg 3 / Zn 1 / Zn 2 / Zn 3 / Mg 3 / Mg 2 / Mg 1 ;

[0036] Mg i (i=1~3) The selection of materials is: pure magnesium, WE43, AZ91, Mg-(0.5~2)Ca, Mg-(0.5~6)Zn, Mg-(0.5~4)Cu, etc.

[0037] Zn j (j=1~3) The selection of materials is: pure zinc, Zn-(0.1~0.8)Li, Zn-(0.1~0.6)Mn-(0.01~0.1)Mg, Zn-(0.1~0.6)Mn-(0.05 ~0.3)Li, Zn-0.1Mg-0.02Ca, Zn-(0.01~20)Au, Zn-(0.5~2)Cu, Zn-(0.05~0.1)Mg-(0.5~4)Ag, Zn-( 0.01~0.2) Mg, etc.

[0038] Mg i (i=1~3) has a thickness of 0.5~1mm, that is, the total thickness of the magnesium clad layer in the billet is 1.5~3mm; Zn j (j...

Embodiment 2

[0041] Example 2: Preparation of multilayer Mg / Zn composite material and characterization of interfacial bonding state.

[0042] For the Mg / Zn composite material in Example 1, the preparation process route is: surface treatment → billet assembly → single pass large deformation hot rolling composite.

[0043] Use sandpaper, grinding wheel, wire brush or laser to polish the composite magnesium and zinc plates to remove the pollution layer and increase the surface roughness. Then the magnesium plate and the zinc plate to be compounded are stacked in order according to the sequence of Example 1 to form blanks. Put the billets in a heating furnace, preheat at 150-380°C for 1-60 minutes, and immediately carry out single-pass rolling after taking out, with a reduction of 40%-90%, to complete the compounding. After rolling, the thickness of the clad plate is 0.2-9mm.

[0044] Using a scanning electron microscope (SEM, Zeiss Merlin, Germany) equipped with an X-ray energy spectrometer...

Embodiment 3

[0046] Embodiment 3: Corrosion performance test of multilayer Mg / Zn composite material.

[0047] For the magnesium-zinc composite material prepared according to Example 2, the elastic modulus of the composite material measured according to the national standard GB / T 22315-2008 "Metallic Materials Elastic Modulus and Poisson's Ratio Test Method" is 45-60GPa. In this embodiment, the corrosion performance test is carried out according to ASTM G31-1972 (2004) "Standard Practice for Lab Immersion Corrosion Testing of Metals". The corrosion medium is simulated body fluid, and the temperature is maintained at 36.5 ± 0.5 ° C. The simulated body fluid is replaced every 24 hours. Soaked for 15-30 days. The test results show that the corrosion develops horizontally layer by layer on the surface of the inventive composite material, and the longitudinal corrosion speed is slow. As in Example 1, the design of the multi-layer magnesium cladding effectively prevents the longitudinal penetrat...

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Abstract

The invention provides a multi-layer Mg / Zn laminated composite material for medical use and a preparation method thereof. The composite material comprises composite layers and base layers, wherein thecomposite layers are made of pure magnesium or magnesium alloy; and the base layers are made of a corrosion-resistant, high-strength and high-plasticity zinc alloy for medical use. The magnesium composite layers are arranged in an ordered manner according to self-corrosion potential, so that corrosion laterally develops layer by layer and strong galvanic corrosion between the magnesium layers andthe zinc layers is prevented. In addition, through the magnesium composite layers, the composite material has a lower elasticity modulus than zinc, and the stress shielding effect is effectively mitigated. The composite material has good biocompatibility of the magnesium and excellent mechanical property of the zinc. When implants, such as a bone screw, a bone plate and a stent prepared from thecomposite material play a medical role after being implanted, the zinc base layer bears more than 50% of load. In the early stage after implantation, the magnesium composite layers are in direct contact with bone tissues and promote the growth and healing of the bone tissues or recirculate blood as cardiovascular stents. Finally, the composite material is completely degraded in vivo, and the complete degradation time is 8-18 months.

Description

technical field [0001] The invention belongs to the field of medical metals, in particular to a medical degradable multilayer Mg / Zn composite material and a preparation method thereof. Background technique [0002] In recent years, degradable biomedical materials have received extensive attention. It can be degraded by itself after serving in the body, and it does not need to be taken out by secondary surgery, which not only avoids the pain caused by re-operation to patients, but also reduces the medical expenses of patients. Among the existing medical degradable materials, magnesium and zinc are representative. They are essential trace elements for the human body, and the degradation products are harmless to the human body and can be metabolized and excreted. [0003] The standard electrode potential of zinc is -0.763V, which is higher than -2.372V of magnesium and lower than -0.447V of iron. It has moderate electrochemical activity and a degradation rate that matches the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/04A61L31/12A61L31/02A61L27/58A61L27/54A61L31/16A61L31/14C21D9/00C22C18/00C22C18/02C22C23/00C22C23/04C22F1/06C22F1/16C22F3/00
CPCA61L27/047A61L27/54A61L27/58A61L31/022A61L31/148A61L31/16A61L2300/412A61L2400/18A61L2420/00C21D9/0081C22C18/00C22C18/02C22C23/00C22C23/04C22F1/06C22F1/165C22F3/00
Inventor 石章智游明乐刘雪峰陈虹廷
Owner UNIV OF SCI & TECH BEIJING
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