Preparation method of magnesium alloy/hydroxyapatite composite

A hydroxyapatite and nano-hydroxyapatite technology, which is applied in surgical adhesives, medical science, prostheses, etc., can solve the problem of uneven composition of magnesium alloy-hydroxyapatite composite materials, affecting performance uniformity, It is easy to produce cracks and other problems, and achieves the effect of being beneficial to exchange transportation, good mechanical properties, and accelerated healing.

Inactive Publication Date: 2014-02-26
TONGJI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, magnesium alloys also have some problems as scaffold materials for bone implants: as scaffold materials for bone tissue engineering, the degradation speed of the implant material is required to match the speed of bone tissue repair and reconstruction.
In this patent, the porous hydroxyapatite skeleton is used as the matrix material, and the magnesium alloy melt is impregnated into the pores of the hydroxyapatite under pressure. Apatite is a brittle material, which is prone to cracks and other defects under pressure, and the original pore structure will be deformed under pressure, resulting in uneven composition and structure of the finally formed magnesium alloy-hydroxyapatite composite material, which affects the performance. Uniformity

Method used

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  • Preparation method of magnesium alloy/hydroxyapatite composite

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] refer to figure 1 , the preparation of magnesium alloy / hydroxyapatite composite materials requires the following steps: 1. Preparation of nano-hydroxyapatite powder by sol-gel method; 2. Preparation of magnesium + hydroxyapatite powder; 3. Preparation of magnesium alloy / hydroxyapatite by cold pressing Limestone composite material; 4. Sintered magnesium alloy / hydroxyapatite composite material; 5. Performance testing. details as follows:

[0027] (1) Preparation of nano-hydroxyapatite powder: Ca(NO 3 ) 2 4H 2 O and P 2 o 5 Dissolve in ethanol solution with Ca / P (molar ratio) = 1.67, respectively prepare 1mol / L alcohol solution, P 2 o 5 Alcoholic solution was slowly added Ca(NO 3 ) 2 In the alcohol solution, heated in a water bath under the condition of slow magnetic stirring, the temperature is 60°C, and the time is about 2 hours, a colorless and transparent solution is obtained; the ammonia water is adjusted to pH = 11, and the stirring is continued; the aging t...

Embodiment 2

[0030] (1) Preparation of nano-hydroxyapatite powder: Ca(NO 3 ) 2 4H 2 O and P 2 o 5 Dissolve in ethanol solution with Ca / P (molar ratio) = 1.67, respectively prepare 1mol / L alcohol solution, P 2 o 5 Alcoholic solution was slowly added Ca(NO 3 ) 2 In the alcohol solution, heated in a water bath under the condition of slow magnetic stirring, the temperature was 60°C, and the time was about 2 hours to obtain a colorless and transparent solution; the ammonia water was adjusted to pH = 11, and the stirring was continued; standing still for aging treatment until the formation of Gel; put it in an oven, heat at 100°C until the alcohol is completely volatilized; grind the obtained white block into powder, and conduct vacuum heat treatment to crystallize at 800°C, keep it warm for 2 hours to obtain nano-hydroxyapatite powder .

[0031] (2) Preparation of magnesium alloy / hydroxyapatite composite material: in terms of mass fraction, after mixing evenly 80% magnesium powder and 2...

Embodiment 3

[0033] (1) Preparation of nano-hydroxyapatite powder: Ca(NO 3 ) 2 4H 2 O and P 2 o 5 Dissolve in ethanol solution with Ca / P (molar ratio) = 1.67, respectively prepare 1mol / L alcohol solution, P 2 o 5 Alcoholic solution was slowly added Ca(NO 3 ) 2 In the alcohol solution, heated in a water bath under the condition of slow magnetic stirring, the temperature was 60°C, and the time was about 2 hours to obtain a colorless and transparent solution; the ammonia water was adjusted to pH = 11, and the stirring was continued; standing still for aging treatment until the formation of Gel; put it in an oven, heat at 100°C until the alcohol is completely volatilized; grind the obtained white block into powder, and conduct vacuum heat treatment to crystallize at 800°C, keep it warm for 2 hours to obtain nano-hydroxyapatite powder .

[0034] (2) Preparation of magnesium alloy / hydroxyapatite composite material: in terms of mass fraction, after mixing 90% magnesium powder and 10% nano...

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Abstract

The invention relates to a preparation method of a magnesium alloy/hydroxyapatite composite, which comprises the steps of firstly preparing nano hydroxyapatite powder by a sol-gel process, and then uniformly mixing the magnesium powder with the nano hydroxyapatite powder; putting the mixture into a mould and performing cold pressing; putting the cold-pressing formed sample into a vacuum heat treatment furnace for sintering to obtain the magnesium alloy/hydroxyapatite composite. Compared with the prior art, in the method provided by the invention, the magnesium alloy is used as a metal matrix, the hydroxyapatite with the same chemical composition as the human skeleton and having low solubility in the human body environment is used as a reinforcing body, and the method aims at preparing a magnesium alloy/calcium phosphate composite biomedical material by use of a powder metallurgical process; the material is mainly applied to clinical medicine as a degradable endosteal fixing material, a porous bone repair material, a dental implantation material, an oral repair material, a cardiovascular stent and the like, and has broad prospects in terms of bone tissue defect repair.

Description

technical field [0001] The invention relates to a preparation method of a composite material, in particular to a preparation method of a biomedical magnesium alloy / hydroxyapatite composite material. Background technique [0002] In recent years, with the continuous deepening of bone tissue engineering research, it is of great significance to develop new bone tissue engineering materials that have good mechanical properties and can be safely degraded in vivo. Medical metal materials have high mechanical strength, good toughness, wear resistance, fatigue resistance, good stability and processing performance, and are the most widely used load-bearing implant materials in clinical practice. Metal materials that have been used clinically include stainless steel (iron-based alloy), cobalt-based alloy and titanium-based alloy. Although these medical metal materials have good comprehensive mechanical properties and excellent processing properties, they are unmatched by other materi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/04A61L27/56A61L31/02A61L24/02C22C1/10C22C1/05
Inventor 陆伟黄平
Owner TONGJI UNIV
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