Full-degradable magnesium alloy and preparation method thereof

Abstract

The invention discloses a novel full-degradable magnesium alloy cardiovascular stent material. A full-degradable magnesium alloy comprises magnesium and alloy elements, wherein the weight ratio of the magnesium is not smaller than 85%, and the alloy elements include a combination of one or more of gadolinium, erbium, thulium, yttrium, neodymium, holmium and zinc. Mechanical properties of the full-degradable magnesium alloy can meet requirements of cardiovascular biological stents, in-vitro immersion corrosion tests and electrochemical corrosion tests prove that the in-vitro corrosion resistance of the full-degradable magnesium alloy is good, in-vitro cytotoxicity tests of the full-degradable magnesium alloy indicate the good biocompatibility, the degradation velocity is controllable, and the biocompatibility is good.

Description

technical field [0001] The invention relates to the field of biomaterials, more precisely a fully degradable magnesium alloy. Background technique [0002] Cardiovascular and cerebrovascular diseases have attracted widespread attention due to their high morbidity and high mortality and disability rates. Stent implantation to revascularize is an important means of clinical treatment of ischemic cardiovascular and cerebrovascular diseases. The main function of the stent in the blood vessel is to provide mechanical support and prevent the elastic recoil and negative remodeling of the blood vessel. The diseased artery usually completes the remodeling and repair of the blood vessel within 6-12 months. After this time, the stent is no longer beneficial to the human body. On the contrary, the compression and irritation of the blood vessel wall will cause a series of problems. At present, the vascular stent materials used clinically at home and abroad are mainly 316L stainless ste...

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Problems solved by technology

At present, the vascular stent materials used clinically at home and abroad are mainly 316L stainless steel, cobalt-chromium alloy, and nickel-titanium alloy. These permanent metal stents will have the following problems during the long-term implantation process: long-term endothelial dysfunction, endothelialization Delayed, procoagulant, long-term physical stimulation, local chronic inflammatory response, prolonged dual antiplatelet therapy, mechanical properties mismatch between stented blood vessels and normal blood vessels, blocked

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