198 results about "Implant material" patented technology

The invention provides a high-strength antibacterial implant material and a preparation method thereof. The implant material comprises a composite matrix, a graphene-titanium nitride composite coating and a tantalum-silver composite coating, wherein the graphene-titanium nitride composite coating and the tantalum-silver composite coating are sequentially arranged on the surface of the composite matrix from inside to outside; wherein the graphene-titanium nitride composite coating is of a multi-layer alternating structure formed by alternately stacking graphene layers and titanium nitride layers; the tantalum content and the silver content in the tantalum-silver composite coating are in opposite gradient changes. The mechanical strength and the antibacterial property of the implant material are remarkably improved through the multi-layer alternate structure design, the hardness and the biocompatibility of the material are enhanced through the graphene-titanium nitride composite coating, and the implant material is endowed with the antibacterial property and the corrosion resistance through the tantalum-silver composite coating; the implant material has long-acting antibacterial property and biological safety while keeping high strength, so that the implant material is widely applied to the medical implant fields of orthopedics, dentistry and the like.

The invention provides a ZIF-8 gene-loaded hydrogel bone repair scaffold as well as a preparation method and application thereof, and belongs to the technical field of biomedical material manufacturing. The bone repair scaffold of the ZIF-8 gene-loaded hydrogel comprises a porous base material, hydrogel and ZIF-8 particles. The porous base material is a bone implant material; the hydrogel is sodium alginate hydrogel, the surface of the porous base material is coated with the hydrogel, and pores of the porous base material are filled with the hydrogel; the ZIF-8 particles are distributed in the hydrogel, the genes are loaded in the ZIF-8 particles, the genes are osteogenesis promoting genes, and the bone repair scaffold has multiple functions of resisting bacteria, promoting osseointegration, promoting osteogenesis and the like, so that the clinical application requirements of the bone repair scaffold are better met.

The invention discloses a polyaryletherketone composite implant material and a preparation method and application thereof, and belongs to the technical field of medical materials.The preparation method of the polyaryletherketone composite implant material comprises the following steps that a carbon fiber reinforced polyaryletherketone substrate with the surface provided with a groove structure and conductivity is prepared; based on a precipitation method, a calcium compound, a magnesium compound and a phosphoric acid aqueous solution are used for preparing white calcium stone; the preparation method comprises the following steps: carrying out surface modification on the white calcium phosphate by utilizing polydopamine, so as to obtain modified white calcium phosphate; adding the modified white calcium phosphate and a degradable piezoelectric polymer into a solvent, and mixing to obtain a mixed solution; and coating a carbon fiber reinforced polyaryletherketone substrate with the mixed solution, and performing drying and annealing treatment to form a coating, thereby obtaining the polyaryletherketone composite implant material. According to the invention, the degradable piezoelectric composite coating doped with the white phosphorus calcium stone, which has piezoelectric characteristics and ion release capability, is constructed, so that double biomimetic effects of an electric signal and a chemical signal in a bone healing microenvironment are realized.

The invention belongs to the technical field of biological materials, and discloses a PEEK bone implant material of a piezoelectric catalysis biological heterojunction and a preparation method of the PEEK bone implant material, the material comprises a PEEK bone implant loaded with the biological heterojunction, the biological heterojunction is composed of BiVOO and a chalcogenide calcium compound in a molar ratio of 1-3, and the chalcogenide calcium compound is calcium sulfide, calcium selenide or calcium telluride; during preparation, the BiVO / CaX biological heterojunction is firstly prepared by a hydrothermal method or an in-situ composite method, then PEEK is sequentially subjected to acetone, ethanol and deionized water cleaning, sulfuric acid ultrasonic treatment for 5-10 minutes and dopamine modification, the biological heterojunction is in contact with the modified PEEK at 4 DEG C for 12 hours to complete loading, and improvement means can be introduced into part of schemes. The material has the acoustic catalytic antibacterial function and the bone repair promoting function, the antibacterial effect can be regulated and controlled through ultrasound, the process is simple, and the reaction condition is mild; the multi-drug-resistant bacterial infection can be dealt with, and the heterojunction loading stability and the material cell compatibility are improved.

The invention relates to the technical field of medical instrument manufacturing, and discloses a method for instantly forming an individualized child tracheal catheter through a 3D printing technology. The method comprises the following steps: acquiring CT (Computed Tomography) or MRI (Magnetic Resonance Imaging) body layer image data of neck and chest areas of a target child patient, wherein the data is used for reflecting anatomical structures of a throat and a trachea; importing the image data into three-dimensional reconstruction software, executing structure identification and segmentation operation, and constructing a three-dimensional model of the throat and trachea of the child patient; performing parameter modeling according to the model, and designing an individualized tracheal catheter model which is fit with the inner diameter of a target airway and is matched with the target airway in length and curvature; the model is converted into a printing data file matched with 3D printing equipment; and a biocompatible 3D printing device is called, the catheter model is printed through a medical implant material, and the solid catheter meeting the size requirement is obtained. The pediatric intubation system improves the matching degree and safety of pediatric intubation, and has good clinical practical value.

The invention discloses a traditional Chinese medicine activity activated bone growth type support implant material and a preparation method thereof, and relates to the technical field of medical materials. The traditional Chinese medicine activity activated bone growth type support implant material is composed of an organic-inorganic composite porous antibacterial scaffold and a pharmacodynamic filler, according to the invention, Co hollow spheres loaded with carbon nanotubes are cross-linked and compounded with sodium alginate, nano-hydroxyapatite and transition metal carbide nanosheets to form an organic-inorganic composite porous antibacterial scaffold, which not only has good mechanical properties and antibacterial properties, but also can stably bear more pharmacodynamic fillers and enable the pharmacodynamic fillers to be slowly released; the stability of the stent structure is further improved through the pharmacodynamic filler, the antibacterial property and the osteogenesis effect of the implant material are remarkably enhanced through the synergistic effect of the pharmacodynamic filler and the stent structure, and the excellent bone repair effect is achieved.

The invention belongs to the technical field of biological implant materials, and discloses a medical titanium alloy implant surface modification method and application, and the medical titanium alloy implant surface modification method comprises the following steps: grinding and polishing a titanium alloy surface, and then carrying out ultrasonic cleaning and drying in ethanol; the titanium alloy is placed in multi-arc ion plating equipment, high-purity tantalum serves as a target material, and a tantalum coating is deposited on the surface of the titanium alloy; the surface of the titanium alloy is coated with photoresist, and then a micropore array is formed in the surface of the tantalum coating through the photoetching technology; the titanium alloy is placed in the electrolyte, a Ti plate serves as a cathode, a Ta plate serves as an anode, and hydroxyapatite is deposited in a porous structure through electrochemical deposition; and removing the photoresist to expose the tantalum coating, ultrasonically cleaning with deionized water, and drying. The titanium alloy implant provided by the invention has excellent corrosion resistance, biocompatibility and mechanical properties, and makes up for the deficiency of a single material, so that the titanium alloy implant subjected to surface modification has wider application.

The invention relates to an antibacterial and antioxidant Ti-MXene bone implant material triggered by near-infrared light and a preparation method of the Ti-MXene bone implant material. The material is composed of a pure Ti substrate and a plurality of Ti3C2TX MXene coatings which are electrostatically self-adsorbed on the pure Ti substrate, and then is crosslinked and coated by gelatin. The multi-layer Ti3C2TX MXene is combined with the surface of a metal matrix, and has excellent biocompatibility and antibacterial and antioxidant effects. According to the coating, multiple layers of Ti < 3 > C < 2 > TX MXene are stripped from an MAX phase (Ti < 3 > Al < 2 >) through hydrochloric acid etching, then a Ti sheet is soaked in alkali liquor with dispersed MXene, and titanate and MXene are subjected to electrostatic self-bonding on the surface; and the combination is further enhanced through gelatin coating. The material can realize photo-thermal antibacterial ability under the irradiation of 808nm NIR with lower power, and has good antioxidant ability and osteoblast compatibility.

The invention provides hydrogel, a porous titanium / hydrogel composite implant material and a preparation method of the porous titanium / hydrogel composite implant material. The hydrogel is obtained by photo-crosslinking and curing a hydrogel precursor solution containing acrylated beta-cyclodextrin, acrylated alendronate sodium, gelatin and a chemotactic factor. The hydrogel has a porous network structure, high elastic modulus, high fatigue resistance and excellent biocompatibility, and also has the capability of recruiting bone marrow mesenchymal stem cells (BMSCs) and the capability of promoting osteogenic differentiation of the BMSCs; the porous titanium / hydrogel composite implant material prepared from the hydrogel can effectively promote the growth of new bone tissues, has excellent osseointegration capability, obviously improves the osteogenesis repair effect and the osseointegration effect, provides a new treatment approach for the repair treatment of segmental bone defects, and has important medical significance.

The invention provides a bifunctional polymer stabilized calcium phosphate precursor nano-material, a preparation method thereof and application of the bifunctional polymer stabilized calcium phosphate precursor nano-material in surface modification of a PPESK coating. The bifunctional polymer stabilized calcium phosphate precursor nano-material comprises the following components according to concentration: a bifunctional polymer with the concentration of 0.05-0.2 g / mL; the concentration of PO4 < 3-> is 0.05 to 0.5 mol / L; the concentration of Ca < 2 + > is 0.05-0.5 mol / L, and the solvent is deionized water; the diameter of the calcium phosphate precursor nano material is 20 to 100 nm. The preparation method comprises the following steps: preparing a polyacrylamide block polymer by adopting free radical polymerization, and then grafting a calcium chelating agent to obtain a bifunctional polymer; combining the difunctional polymer with a calcium-phosphorus solution to prepare a difunctional polymer stabilized calcium phosphate precursor nano material; according to the invention, the polymer is endowed with calcium chelating ability and collagenous fiber binding ability, so that the material can enter the collagenous fiber to be fully mineralized, the surface of the PPESK coating is mineralized, the biocompatibility of the material is improved, the material has osteogenesis promoting ability, and the material has a wide application prospect in the aspect of bone implant materials.

The invention relates to a medical beauty implant material intelligent optimization method and system based on artificial intelligence, and the method comprises the following steps: S1, obtaining the performance parameters of different medical beauty implant materials, capturing the anatomical features of a patient through 3D scanning and MRI images, and carrying out the statistics of the personalized biological data of the patient; s2, constructing a multi-task learning model and training based on a multi-target supervised learning data set, wherein the target is to predict the performance of different implant material formulas in a medical beauty implant environment; s3, performing multi-objective optimization by adopting an NSGA-III algorithm to obtain an optimal implant material formula; s4, reconstructing a three-dimensional model of the patient by using a reverse modeling technology based on anatomical features of the patient; and S5, based on the three-dimensional model, according to the optimal implant material formula and the personalized biological data, simulating the biomechanical characteristics of the patient by utilizing finite element analysis, and outputting biocompatibility scores and suitability suggestions of the material in different implant environments. According to the method, the clinical requirements on customized design and application of the medical beauty implant material are effectively met.

This invention discloses a composite material, its preparation method, and an implant, belonging to the field of medical materials technology. The composite material is obtained by combining a piezoelectric material and a metal ion-releasing material; the metal ion-releasing material is selected from one or more of magnesium-based biodegradable alloys, iron and iron-based biodegradable alloys, and zinc and zinc-based biodegradable alloys. The composite material can adaptively generate microcurrents of varying magnitudes at different stages of patient recovery through the piezoelectric response of the piezoelectric material. These microcurrents promote intelligent degradation of the metal ion-releasing material that matches the patient's own recovery process. The resulting metal ions and the microcurrents jointly promote healing at the implantation site, which is of great significance for the development and application of implant materials.

The invention discloses a gradient degradation type personalized absorbable sternum fracture fixing plate and a preparation process, and belongs to the technical field of medical implant materials. Comprising an anatomical adaptive plate body and an integrated locking assembly, the plate body is of a partitioned structure of a middle supporting area and an edge buffering area, a gradient pore array penetrating through the thickness direction is formed in the surface of the plate body, and a hydroxyapatite-collagen composite coating is loaded on the inner wall of a pore; the plate body is made of a composite absorbable material through 3D printing forming and hot pressing post-treatment, and the composite absorbable material comprises, by weight, 60%-70% of polylactic acid-glycolic acid copolymer (PLGA, LA / GA = 75 / 25), 15%-20% of silanized magnesium alloy microwires, 5%-10% of hydroxyapatite nano-particles and 5%-10% of polycaprolactone (PCL). Space-time matching of the degradation rate and the bone healing process is achieved through the partition gradient structure, the magnesium alloy microwires enhance the mechanical property and release active ions to promote osteogenesis, and the method has the advantages of personalized adaptation, gradient degradation, bone regeneration promotion and the like.

The present invention pertains to the field of biomedical materials and specifically relates to a biofilm for repairing an abdominopelvic cavity wound surface and a preparation method therefor. The present invention provides a biofilm for repairing an abdominopelvic cavity wound surface. The biofilm comprises a first film layer and a second film layer. The thickness of the first film layer is 0.1-1 mm, and the thickness of the second film layer is 0.02-0.4 mm. The weight per unit area of the first film layer is 1.2-5 times that of the second film layer. The interlayer bonding ratio of the first film layer and the second film layer is 35%-75%. The biofilm has good mechanical-performance stability and good operability. The changes in tensile strength and peel strength after repeated soaking / drying cycles or two weeks of soaking remain within 13% compared to 4 h of soaking. The fat ratio of the two film layers is controlled again, thereby improving the ingrowth stability and the mechanical / dimensional stability of the implant material.

The invention belongs to the technical field of implant materials, and discloses a porous titanium-based implant material surface calcium-phosphorus coating and a preparation method thereof. According to the method, a porous titanium-based implant material is used as a cathode, an annular platinum electrode is used as an anode, the cathode is located in the center of the annular electrode, a solution containing calcium and phosphorus is used as an electrolyte, biomimetic mineralization is carried out under the condition of pulse micro-potential, and the calcium-phosphorus coating is formed on the surface of the porous titanium-based implant material. According to the method, the biomimetic mineralization process of the surface of the beam structure in the porous titanium-based material is regulated and controlled by adopting the annular electrode and the weak electric field, migration of ions and ion groups in the porous scaffold is improved by adjusting the current of the annular electrode and combining the biomimetic mineralization process, and the porous titanium-based implant material uniformly covered with the calcium-phosphorus coating is obtained. The method is simple, and uniform covering of the calcium-phosphorus coating of the porous titanium-based implant material is achieved.

The invention provides an implanter. The implanter comprises an implanting part, a clamping part, an opening and closing assembly, a sleeve assembly and a driving part. The implantation part comprises a near end and a far end; the clamping part comprises a clamping arm and is used for clamping a material to be implanted; the opening and closing assembly comprises an unfolding arm which is arranged at the far end. The sleeve assembly sleeves the outer side of the implantation part and is used for wrapping the clamping arm, the unfolding arm and the implantation material; a first rotating piece, a second rotating piece, a third rotating piece, a first connecting piece, a second connecting piece and a third connecting piece are arranged in the driving part shell, and the first connecting piece is wound on the first rotating piece, connected with the clamping arm and used for driving the clamping arm to clamp a material to be implanted; the second connecting piece is wound around the second rotating piece and connected with the cannula assembly to drive the cannula assembly to move in the direction away from the far end, the third connecting piece is wound around the third rotating piece and connected with the unfolding arm to drive the unfolding arm to unfold, and according to the design, the structure of the implanter is simplified, operation and use are convenient, and the surgical application efficiency of the implanter is improved.

This invention discloses an artificial corneal endothelial graft based on natural degradable proteins, its preparation method, and its application, relating to the field of medical implant materials technology. Currently, artificial corneal endothelial grafts for corneal endothelial decompensation are all non-degradable synthetic polymer materials. This invention uses a natural degradable material as the substrate to prepare the graft. A material preparation stock solution is obtained by mixing a silk fibroin solution extracted from a high-salt solution with a certain proportion of glycerol. The mixed solution is then spin-coated onto a mold using a gradient method, and dried to obtain a silk fibroin film. The obtained silk fibroin film is then circumcised and placed in a mold for hot-press steam fumigation. The resulting silk fibroin film can serve as an artificial corneal endothelial graft, providing a donor source for artificial corneas and possessing potential application value in corneal transplantation.

The application relates to a nano cerium oxide reinforced biological magnesium alloy and a preparation method thereof, and belongs to the technical field of medical implant material preparation. The biological magnesium alloy is composed of a magnesium matrix, an aluminum-cerium phase and nano cerium oxide, and the preparation method is as follows: (1) nano cerium oxide and AZ61 magnesium alloy powder are mixed by ball milling under an argon atmosphere according to a designed proportion to obtain uniformly dispersed mixed powder; and (2) the above mixed powder is used as raw material to prepare the nano cerium oxide reinforced biological magnesium alloy by using a selective laser melting technology under an argon atmosphere. In the application, part of the nano cerium oxide is reduced into cerium by magnesium, the cerium combines with aluminum in the matrix to form an aluminum-cerium phase, magnesium-aluminum phase precipitation is inhibited, and micro-galvanic corrosion can be inhibited; meanwhile, the remaining nano cerium oxide falls off into a degradation product film after the magnesium matrix is degraded, the compactness of the product film is increased, the invasion of an erosion liquid is blocked, and the degradation resistance of the magnesium alloy is improved in a synergistic manner by inhibiting galvanic corrosion and increasing the compactness of the degradation product film.

The present invention relates to a bio-orthogonal, biodegradable hydrogel for sustained drug delivery, a method for preparing a bio-orthogonal, biodegradable hydrogel, the use thereof as an implantable material in the treatment of disease, and a method for preparing the same. As well as kits for preparing the hydrogels in situ at a treatment site and methods of treatment using the hydrogels or kits, such as for the treatment of ocular diseases.

The present invention provides an antibacterial and anti-sticking latex catheter and a preparation method thereof, which relates to the technical field of medical implant materials. The method comprises the following steps: S1: placing vinyl pyrrolidone, an unsaturated carboxylic acid monomer, and an initiator in a first solvent to obtain polyvinyl pyrrolidone with a carboxyl side chain; S2: placing the polyvinyl pyrrolidone with a carboxyl side chain, an activator, and a catalyst in a second solvent to obtain activated polyvinyl pyrrolidone; S3: placing the antibacterial agent and the activated polyvinyl pyrrolidone in a third solvent to obtain quaternary ammonium salt group-grafted polyvinyl pyrrolidone; S4: performing an activation treatment on latex particles to obtain activated latex particles; S5: placing the quaternary ammonium salt group-grafted polyvinyl pyrrolidone and the activated latex particles in a fourth solvent to obtain antibacterial and anti-sticking latex particles; and S6: melting and extruding the antibacterial and anti-sticking latex particles to form an antibacterial and anti-sticking latex catheter. The hydrophilicity and antibacterial properties of the latex catheter are effectively improved.

The application provides a medical biological magnesium alloy material containing trace light rare earth elements, which comprises: Nd 1.0-5.0%, Ag 0.5-1.8%, Pr 0.15-0.65%, Pm 0.15-0.65%, and the balance is Mg. The application also provides a preparation method of the medical biological rare earth magnesium alloy material and application thereof. The medical biological rare earth magnesium alloy material provided by the application has excellent mechanical properties, uniform degradation performance and processing performance by adding appropriate alloying elements Nd, Ag, Pm and Pr which meet a certain relationship formula and using a specific preparation method, and can meet the requirements of being used as a medical implant material and being processed into related medical devices; the medical biological rare earth magnesium alloy material has excellent biological safety and biocompatibility, and also has the biological functions of inhibiting and killing bacteria, resisting inflammation and resisting infection, and can also activate cells, promote tissue repair and wound healing.

A process for debonding carrier and device wafer assemblies comprises providing a carrier wafer assembly and a device wafer assembly that comprises a substrate, and a device layer on the substrate. The device layer has at least one semiconductor device formed therein, and the substrate has a planar implantation zone of implant material below the device layer. The carrier wafer assembly is bonding to the device layer of the device wafer assembly with an adhesive. The substrate is annealed to weaken the substrate along the planar implantation zone. A main portion of the substrate above the planar implantation zone is separated from the device wafer assembly to form a thinned device wafer assembly. A residual portion of the substrate is removed from the thinned device wafer assembly to form a precursor.

In certain embodiments, the present disclosure provides methods of treating diseased or damaged tissue in a patient. In some forms the methods comprise introducing a photocurable composition to the diseased or damaged tissue, the photocurable composition comprising a photoactivatable metal ligand complex, a matrix forming polymer, and an electron acceptor. Such methods may further comprise irradiating the photocurable composition through a tissue portion to induce a photocrosslinking reaction forming crosslinks between individual polymers of the matrix forming polymer within the photocurable composition.

The application discloses a bone-integrative degradable silica gel support for treating bone nonunion and a preparation method thereof, and relates to the technical field of medical implant materials.The preparation method comprises the following steps: hydrogen-containing silicone oil and allyl glycidyl ether are subjected to a hydrosilylation reaction under the action of a platinum catalyst to generate silicone oil containing an epoxy group, then the epoxy group is subjected to ring-opening under the action of a catalyst to obtain silicone oil containing a phosphate group in a side chain; carboxyl-terminated polylactic acid-glycolic acid copolymer is mixed with the silicone oil containing the phosphate group in the side chain, and a condensation reaction is carried out under the action of a condensing agent and a catalyst to obtain a PLGA-P-PDMS-PLGA triblock copolymer; the triblock copolymer, a reactive diluent, a photoinitiator and inorganic reinforcing fillers are mixed to obtain 3D printing slurry; and the printing slurry is printed into a designed bone-integrative support according to set printing parameters by using a light-curing 3D printing technology.The application endows the material with intrinsic osteogenic activity, and realizes the unification of bioactivity, shape memory function and mechanical support.

The invention discloses bioactive porous high-density polyethylene foam and a preparation method thereof, and belongs to the technical field of medical implant materials. The preparation method comprises the following steps: (1) mixing high-density polyethylene powder and template particles, carrying out hot press molding, ultrasonically removing the template particles in a solvent, and finally washing and drying to obtain porous high-density polyethylene foam; and (2) sequentially soaking and modifying the porous high-density polyethylene foam in a hydrophilic improver, a biological active agent and an antibacterial agent, and drying to obtain the porous high-density polyethylene foam. The preparation method disclosed by the invention is simple, and the obtained bioactive high-density polyethylene foam with the porous structure has good biological activity, hydrophilicity and excellent mechanical properties, is beneficial to cell adhesion, material exchange, fibroblast ingrowth and angiogenesis, can be used as a craniomaxillofacial non-bearing area bone defect repair material, and has wide application prospects. And the method has a huge practical application prospect.

The invention relates to the technical field of preparation of natural polysaccharides for in-vivo implantation, and particularly discloses a preparation method of low-molecular-weight oxidized sodium alginate and application of the low-molecular-weight oxidized sodium alginate as a biological cross-linking agent. The preparation method of the low-molecular-weight oxidized sodium alginate comprises the steps that a sodium alginate solution is prepared, after calcium coagulation acidification and neutralization pretreatment, a sodium periodate solution is added for an oxidation reaction, after the reaction is completed, modified activated carbon is added for adsorption and carbon removal, then the oxidized sodium alginate solution is obtained, and an MOFs structural layer is loaded in the modified activated carbon; dialyzing the oxidized sodium alginate solution, and freeze-drying to obtain purified oxidized sodium alginate; and carrying out gamma irradiation treatment on the purified oxidized sodium alginate to obtain the sodium alginate. The oxidized sodium alginate prepared by the preparation method of the low-molecular-weight oxidized sodium alginate is relatively low in harmful impurity content and relatively high in safety, the molecular weight is about 2000, and the oxidized sodium alginate has excellent cross-linking performance when being used as a biological cross-linking agent for an in-vivo implant material.

The invention relates to the technical field of biomedical materials. The invention discloses a Schiff base-sulfonated hyaluronic acid light-cured microsphere as well as a preparation method and application thereof. The microspheres are prepared by condensing DL-lysine and paeonol to generate Schiff base, then conjugating the Schiff base with sulfonated hyaluronic acid through a carbodiimide chemical method, and finally molding by adopting a microfluidic technology and carrying out ultraviolet curing. The metal chelation characteristic of Schiff base is combined with the precise structure regulation advantage of the microspheres, and the prepared microspheres show an excellent synergistic effect when applied to the surfaces of implant materials such as degradable magnesium alloy, iron alloy and zinc alloy: the corrosion resistance of a base material can be remarkably improved, an effective protective layer is formed, and the service life of the microspheres is prolonged. Meanwhile, the compound has multiple biological functions of promoting endothelial cell proliferation, inhibiting excessive proliferation of smooth muscle cells and regulating and controlling macrophages to be polarized to anti-inflammatory phenotypes, and has a wide application prospect in the biomedical fields of intravascular stents, bone fixing instruments and the like.

The invention relates to the technical field of titanium alloy materials, and discloses a modified titanium-based implant material based on a pericarpium citri reticulatae extract and a preparation method and application of the modified titanium-based implant material. The preparation method of the modified titanium-based implant material based on the pericarpium citri reticulatae extract comprises the steps that a nano-porous structure is introduced to the surface of a titanium material, and the titanium material with the nano-porous structure is prepared; a polydopamine layer is attached to the surface of the titanium material with the nano-porous structure, and the titanium material attached with the polydopamine layer is prepared; and mounting hesperetin and / or naringenin on the surface of the titanium material attached with the polydopamine layer to prepare the modified titanium-based implant material based on the pericarpium citri reticulatae extract. The nano-porous structure is introduced to the surface of the titanium material, the polydopamine layer is further attached to the surface of the titanium material, and more hesperetin and / or naringenin are / is mounted to the surface of the titanium material through the multi-bonding effect of the nano-porous structure and the polydopamine layer; the biological functions of resisting bacteria, resisting inflammation and promoting angiogenesis and osseointegration are realized.

The application provides a controllable degradation medical orthopedic magnesium-ceramic glass composite stent and a preparation method thereof. The preparation method comprises the following steps: mixing a magnesium alloy powder and a ceramic glass powder; printing a composite material stent by using a laser powder bed melting technology; and performing surface treatment on the composite material stent, and then performing high polymer coating surface treatment, so that the controllable degradation medical orthopedic magnesium-ceramic glass composite stent is obtained; wherein the magnesium alloy is a Mg-Y-Gd-Zr magnesium alloy; and the ceramic glass is selected from hydroxyapatite, beta-tricalcium phosphate, bioglass, ZrO2 and the like. The stent structure suitable for bone defect model construction is prepared by using the laser powder bed melting technology, the surface treatment technology is used for realizing the regulation and control of the mechanics and biological activity of the stent, the magnesium-ceramic glass composite stent with good hydrophilicity, controllable degradation, high strength and good bone conduction is successfully prepared, and the urgent needs of the stent material for long-term mechanical support, controllable degradation and good osteogenic induction effect of the medical orthopedic implant material can be met.

The invention discloses a natural polymer polyelectrolyte microsphere as well as a preparation method and application thereof, the microsphere is of a covalent and non-covalent double-crosslinking network structure formed by crosslinking natural polymer and polyelectrolyte, and the modification degree of the crosslinked natural polymer is 1.0-50.0%; the natural polymer is a compound containing more than two carboxyl groups or amino groups or a combination of the carboxyl groups and the amino groups; and the polyelectrolyte is a compound containing more than two carboxyl groups or amino groups or a combination of the carboxyl groups and the amino groups. The preparation method comprises the following steps: S1, dissolving a natural polymer and a polyelectrolyte in a water phase to generate an electrostatic complex; s2, adding enzyme into the electrostatic complex and incubating to form microspheres; and S3, adding a condensing agent and / or a cross-linking agent, removing the unreacted condensing agent and / or cross-linking agent, and sterilizing to obtain the natural polymer polyelectrolyte microspheres. The microsphere can be used as an embolism agent in an interventional technology or a separation and purification medium of protein, antibodies and drugs or a cell and drug carrier system, or as an implant material for orthopedics, surgery, ophthalmology and medical beauty.