135 results about "Implant material" patented technology

The invention discloses a polyaryletherketone composite implant material and a preparation method and application thereof, and belongs to the technical field of medical materials.The preparation method of the polyaryletherketone composite implant material comprises the following steps that a carbon fiber reinforced polyaryletherketone substrate with the surface provided with a groove structure and conductivity is prepared; based on a precipitation method, a calcium compound, a magnesium compound and a phosphoric acid aqueous solution are used for preparing white calcium stone; the preparation method comprises the following steps: carrying out surface modification on the white calcium phosphate by utilizing polydopamine, so as to obtain modified white calcium phosphate; adding the modified white calcium phosphate and a degradable piezoelectric polymer into a solvent, and mixing to obtain a mixed solution; and coating a carbon fiber reinforced polyaryletherketone substrate with the mixed solution, and performing drying and annealing treatment to form a coating, thereby obtaining the polyaryletherketone composite implant material. According to the invention, the degradable piezoelectric composite coating doped with the white phosphorus calcium stone, which has piezoelectric characteristics and ion release capability, is constructed, so that double biomimetic effects of an electric signal and a chemical signal in a bone healing microenvironment are realized.

The invention belongs to the technical field of biological materials, and discloses a PEEK bone implant material of a piezoelectric catalysis biological heterojunction and a preparation method of the PEEK bone implant material, the material comprises a PEEK bone implant loaded with the biological heterojunction, the biological heterojunction is composed of BiVOO and a chalcogenide calcium compound in a molar ratio of 1-3, and the chalcogenide calcium compound is calcium sulfide, calcium selenide or calcium telluride; during preparation, the BiVO / CaX biological heterojunction is firstly prepared by a hydrothermal method or an in-situ composite method, then PEEK is sequentially subjected to acetone, ethanol and deionized water cleaning, sulfuric acid ultrasonic treatment for 5-10 minutes and dopamine modification, the biological heterojunction is in contact with the modified PEEK at 4 DEG C for 12 hours to complete loading, and improvement means can be introduced into part of schemes. The material has the acoustic catalytic antibacterial function and the bone repair promoting function, the antibacterial effect can be regulated and controlled through ultrasound, the process is simple, and the reaction condition is mild; the multi-drug-resistant bacterial infection can be dealt with, and the heterojunction loading stability and the material cell compatibility are improved.

The invention provides hydrogel, a porous titanium / hydrogel composite implant material and a preparation method of the porous titanium / hydrogel composite implant material. The hydrogel is obtained by photo-crosslinking and curing a hydrogel precursor solution containing acrylated beta-cyclodextrin, acrylated alendronate sodium, gelatin and a chemotactic factor. The hydrogel has a porous network structure, high elastic modulus, high fatigue resistance and excellent biocompatibility, and also has the capability of recruiting bone marrow mesenchymal stem cells (BMSCs) and the capability of promoting osteogenic differentiation of the BMSCs; the porous titanium / hydrogel composite implant material prepared from the hydrogel can effectively promote the growth of new bone tissues, has excellent osseointegration capability, obviously improves the osteogenesis repair effect and the osseointegration effect, provides a new treatment approach for the repair treatment of segmental bone defects, and has important medical significance.

The invention relates to a medical beauty implant material intelligent optimization method and system based on artificial intelligence, and the method comprises the following steps: S1, obtaining the performance parameters of different medical beauty implant materials, capturing the anatomical features of a patient through 3D scanning and MRI images, and carrying out the statistics of the personalized biological data of the patient; s2, constructing a multi-task learning model and training based on a multi-target supervised learning data set, wherein the target is to predict the performance of different implant material formulas in a medical beauty implant environment; s3, performing multi-objective optimization by adopting an NSGA-III algorithm to obtain an optimal implant material formula; s4, reconstructing a three-dimensional model of the patient by using a reverse modeling technology based on anatomical features of the patient; and S5, based on the three-dimensional model, according to the optimal implant material formula and the personalized biological data, simulating the biomechanical characteristics of the patient by utilizing finite element analysis, and outputting biocompatibility scores and suitability suggestions of the material in different implant environments. According to the method, the clinical requirements on customized design and application of the medical beauty implant material are effectively met.

This invention discloses a composite material, its preparation method, and an implant, belonging to the field of medical materials technology. The composite material is obtained by combining a piezoelectric material and a metal ion-releasing material; the metal ion-releasing material is selected from one or more of magnesium-based biodegradable alloys, iron and iron-based biodegradable alloys, and zinc and zinc-based biodegradable alloys. The composite material can adaptively generate microcurrents of varying magnitudes at different stages of patient recovery through the piezoelectric response of the piezoelectric material. These microcurrents promote intelligent degradation of the metal ion-releasing material that matches the patient's own recovery process. The resulting metal ions and the microcurrents jointly promote healing at the implantation site, which is of great significance for the development and application of implant materials.

The invention discloses a gradient degradation type personalized absorbable sternum fracture fixing plate and a preparation process, and belongs to the technical field of medical implant materials. Comprising an anatomical adaptive plate body and an integrated locking assembly, the plate body is of a partitioned structure of a middle supporting area and an edge buffering area, a gradient pore array penetrating through the thickness direction is formed in the surface of the plate body, and a hydroxyapatite-collagen composite coating is loaded on the inner wall of a pore; the plate body is made of a composite absorbable material through 3D printing forming and hot pressing post-treatment, and the composite absorbable material comprises, by weight, 60%-70% of polylactic acid-glycolic acid copolymer (PLGA, LA / GA = 75 / 25), 15%-20% of silanized magnesium alloy microwires, 5%-10% of hydroxyapatite nano-particles and 5%-10% of polycaprolactone (PCL). Space-time matching of the degradation rate and the bone healing process is achieved through the partition gradient structure, the magnesium alloy microwires enhance the mechanical property and release active ions to promote osteogenesis, and the method has the advantages of personalized adaptation, gradient degradation, bone regeneration promotion and the like.

The present invention pertains to the field of biomedical materials and specifically relates to a biofilm for repairing an abdominopelvic cavity wound surface and a preparation method therefor. The present invention provides a biofilm for repairing an abdominopelvic cavity wound surface. The biofilm comprises a first film layer and a second film layer. The thickness of the first film layer is 0.1-1 mm, and the thickness of the second film layer is 0.02-0.4 mm. The weight per unit area of the first film layer is 1.2-5 times that of the second film layer. The interlayer bonding ratio of the first film layer and the second film layer is 35%-75%. The biofilm has good mechanical-performance stability and good operability. The changes in tensile strength and peel strength after repeated soaking / drying cycles or two weeks of soaking remain within 13% compared to 4 h of soaking. The fat ratio of the two film layers is controlled again, thereby improving the ingrowth stability and the mechanical / dimensional stability of the implant material.

The invention belongs to the technical field of implant materials, and discloses a porous titanium-based implant material surface calcium-phosphorus coating and a preparation method thereof. According to the method, a porous titanium-based implant material is used as a cathode, an annular platinum electrode is used as an anode, the cathode is located in the center of the annular electrode, a solution containing calcium and phosphorus is used as an electrolyte, biomimetic mineralization is carried out under the condition of pulse micro-potential, and the calcium-phosphorus coating is formed on the surface of the porous titanium-based implant material. According to the method, the biomimetic mineralization process of the surface of the beam structure in the porous titanium-based material is regulated and controlled by adopting the annular electrode and the weak electric field, migration of ions and ion groups in the porous scaffold is improved by adjusting the current of the annular electrode and combining the biomimetic mineralization process, and the porous titanium-based implant material uniformly covered with the calcium-phosphorus coating is obtained. The method is simple, and uniform covering of the calcium-phosphorus coating of the porous titanium-based implant material is achieved.

The invention provides an implanter. The implanter comprises an implanting part, a clamping part, an opening and closing assembly, a sleeve assembly and a driving part. The implantation part comprises a near end and a far end; the clamping part comprises a clamping arm and is used for clamping a material to be implanted; the opening and closing assembly comprises an unfolding arm which is arranged at the far end. The sleeve assembly sleeves the outer side of the implantation part and is used for wrapping the clamping arm, the unfolding arm and the implantation material; a first rotating piece, a second rotating piece, a third rotating piece, a first connecting piece, a second connecting piece and a third connecting piece are arranged in the driving part shell, and the first connecting piece is wound on the first rotating piece, connected with the clamping arm and used for driving the clamping arm to clamp a material to be implanted; the second connecting piece is wound around the second rotating piece and connected with the cannula assembly to drive the cannula assembly to move in the direction away from the far end, the third connecting piece is wound around the third rotating piece and connected with the unfolding arm to drive the unfolding arm to unfold, and according to the design, the structure of the implanter is simplified, operation and use are convenient, and the surgical application efficiency of the implanter is improved.

This invention discloses an artificial corneal endothelial graft based on natural degradable proteins, its preparation method, and its application, relating to the field of medical implant materials technology. Currently, artificial corneal endothelial grafts for corneal endothelial decompensation are all non-degradable synthetic polymer materials. This invention uses a natural degradable material as the substrate to prepare the graft. A material preparation stock solution is obtained by mixing a silk fibroin solution extracted from a high-salt solution with a certain proportion of glycerol. The mixed solution is then spin-coated onto a mold using a gradient method, and dried to obtain a silk fibroin film. The obtained silk fibroin film is then circumcised and placed in a mold for hot-press steam fumigation. The resulting silk fibroin film can serve as an artificial corneal endothelial graft, providing a donor source for artificial corneas and possessing potential application value in corneal transplantation.

The application relates to a nano cerium oxide reinforced biological magnesium alloy and a preparation method thereof, and belongs to the technical field of medical implant material preparation. The biological magnesium alloy is composed of a magnesium matrix, an aluminum-cerium phase and nano cerium oxide, and the preparation method is as follows: (1) nano cerium oxide and AZ61 magnesium alloy powder are mixed by ball milling under an argon atmosphere according to a designed proportion to obtain uniformly dispersed mixed powder; and (2) the above mixed powder is used as raw material to prepare the nano cerium oxide reinforced biological magnesium alloy by using a selective laser melting technology under an argon atmosphere. In the application, part of the nano cerium oxide is reduced into cerium by magnesium, the cerium combines with aluminum in the matrix to form an aluminum-cerium phase, magnesium-aluminum phase precipitation is inhibited, and micro-galvanic corrosion can be inhibited; meanwhile, the remaining nano cerium oxide falls off into a degradation product film after the magnesium matrix is degraded, the compactness of the product film is increased, the invasion of an erosion liquid is blocked, and the degradation resistance of the magnesium alloy is improved in a synergistic manner by inhibiting galvanic corrosion and increasing the compactness of the degradation product film.

The present invention relates to a bio-orthogonal, biodegradable hydrogel for sustained drug delivery, a method for preparing a bio-orthogonal, biodegradable hydrogel, the use thereof as an implantable material in the treatment of disease, and a method for preparing the same. As well as kits for preparing the hydrogels in situ at a treatment site and methods of treatment using the hydrogels or kits, such as for the treatment of ocular diseases.

The application provides a medical biological magnesium alloy material containing trace light rare earth elements, which comprises: Nd 1.0-5.0%, Ag 0.5-1.8%, Pr 0.15-0.65%, Pm 0.15-0.65%, and the balance is Mg. The application also provides a preparation method of the medical biological rare earth magnesium alloy material and application thereof. The medical biological rare earth magnesium alloy material provided by the application has excellent mechanical properties, uniform degradation performance and processing performance by adding appropriate alloying elements Nd, Ag, Pm and Pr which meet a certain relationship formula and using a specific preparation method, and can meet the requirements of being used as a medical implant material and being processed into related medical devices; the medical biological rare earth magnesium alloy material has excellent biological safety and biocompatibility, and also has the biological functions of inhibiting and killing bacteria, resisting inflammation and resisting infection, and can also activate cells, promote tissue repair and wound healing.

The application discloses a bone-integrative degradable silica gel support for treating bone nonunion and a preparation method thereof, and relates to the technical field of medical implant materials.The preparation method comprises the following steps: hydrogen-containing silicone oil and allyl glycidyl ether are subjected to a hydrosilylation reaction under the action of a platinum catalyst to generate silicone oil containing an epoxy group, then the epoxy group is subjected to ring-opening under the action of a catalyst to obtain silicone oil containing a phosphate group in a side chain; carboxyl-terminated polylactic acid-glycolic acid copolymer is mixed with the silicone oil containing the phosphate group in the side chain, and a condensation reaction is carried out under the action of a condensing agent and a catalyst to obtain a PLGA-P-PDMS-PLGA triblock copolymer; the triblock copolymer, a reactive diluent, a photoinitiator and inorganic reinforcing fillers are mixed to obtain 3D printing slurry; and the printing slurry is printed into a designed bone-integrative support according to set printing parameters by using a light-curing 3D printing technology.The application endows the material with intrinsic osteogenic activity, and realizes the unification of bioactivity, shape memory function and mechanical support.

The invention discloses bioactive porous high-density polyethylene foam and a preparation method thereof, and belongs to the technical field of medical implant materials. The preparation method comprises the following steps: (1) mixing high-density polyethylene powder and template particles, carrying out hot press molding, ultrasonically removing the template particles in a solvent, and finally washing and drying to obtain porous high-density polyethylene foam; and (2) sequentially soaking and modifying the porous high-density polyethylene foam in a hydrophilic improver, a biological active agent and an antibacterial agent, and drying to obtain the porous high-density polyethylene foam. The preparation method disclosed by the invention is simple, and the obtained bioactive high-density polyethylene foam with the porous structure has good biological activity, hydrophilicity and excellent mechanical properties, is beneficial to cell adhesion, material exchange, fibroblast ingrowth and angiogenesis, can be used as a craniomaxillofacial non-bearing area bone defect repair material, and has wide application prospects. And the method has a huge practical application prospect.

The invention relates to the technical field of preparation of natural polysaccharides for in-vivo implantation, and particularly discloses a preparation method of low-molecular-weight oxidized sodium alginate and application of the low-molecular-weight oxidized sodium alginate as a biological cross-linking agent. The preparation method of the low-molecular-weight oxidized sodium alginate comprises the steps that a sodium alginate solution is prepared, after calcium coagulation acidification and neutralization pretreatment, a sodium periodate solution is added for an oxidation reaction, after the reaction is completed, modified activated carbon is added for adsorption and carbon removal, then the oxidized sodium alginate solution is obtained, and an MOFs structural layer is loaded in the modified activated carbon; dialyzing the oxidized sodium alginate solution, and freeze-drying to obtain purified oxidized sodium alginate; and carrying out gamma irradiation treatment on the purified oxidized sodium alginate to obtain the sodium alginate. The oxidized sodium alginate prepared by the preparation method of the low-molecular-weight oxidized sodium alginate is relatively low in harmful impurity content and relatively high in safety, the molecular weight is about 2000, and the oxidized sodium alginate has excellent cross-linking performance when being used as a biological cross-linking agent for an in-vivo implant material.

The invention relates to the technical field of biomedical materials. The invention discloses a Schiff base-sulfonated hyaluronic acid light-cured microsphere as well as a preparation method and application thereof. The microspheres are prepared by condensing DL-lysine and paeonol to generate Schiff base, then conjugating the Schiff base with sulfonated hyaluronic acid through a carbodiimide chemical method, and finally molding by adopting a microfluidic technology and carrying out ultraviolet curing. The metal chelation characteristic of Schiff base is combined with the precise structure regulation advantage of the microspheres, and the prepared microspheres show an excellent synergistic effect when applied to the surfaces of implant materials such as degradable magnesium alloy, iron alloy and zinc alloy: the corrosion resistance of a base material can be remarkably improved, an effective protective layer is formed, and the service life of the microspheres is prolonged. Meanwhile, the compound has multiple biological functions of promoting endothelial cell proliferation, inhibiting excessive proliferation of smooth muscle cells and regulating and controlling macrophages to be polarized to anti-inflammatory phenotypes, and has a wide application prospect in the biomedical fields of intravascular stents, bone fixing instruments and the like.

The application provides a controllable degradation medical orthopedic magnesium-ceramic glass composite stent and a preparation method thereof. The preparation method comprises the following steps: mixing a magnesium alloy powder and a ceramic glass powder; printing a composite material stent by using a laser powder bed melting technology; and performing surface treatment on the composite material stent, and then performing high polymer coating surface treatment, so that the controllable degradation medical orthopedic magnesium-ceramic glass composite stent is obtained; wherein the magnesium alloy is a Mg-Y-Gd-Zr magnesium alloy; and the ceramic glass is selected from hydroxyapatite, beta-tricalcium phosphate, bioglass, ZrO2 and the like. The stent structure suitable for bone defect model construction is prepared by using the laser powder bed melting technology, the surface treatment technology is used for realizing the regulation and control of the mechanics and biological activity of the stent, the magnesium-ceramic glass composite stent with good hydrophilicity, controllable degradation, high strength and good bone conduction is successfully prepared, and the urgent needs of the stent material for long-term mechanical support, controllable degradation and good osteogenic induction effect of the medical orthopedic implant material can be met.

The invention discloses a natural polymer polyelectrolyte microsphere as well as a preparation method and application thereof, the microsphere is of a covalent and non-covalent double-crosslinking network structure formed by crosslinking natural polymer and polyelectrolyte, and the modification degree of the crosslinked natural polymer is 1.0-50.0%; the natural polymer is a compound containing more than two carboxyl groups or amino groups or a combination of the carboxyl groups and the amino groups; and the polyelectrolyte is a compound containing more than two carboxyl groups or amino groups or a combination of the carboxyl groups and the amino groups. The preparation method comprises the following steps: S1, dissolving a natural polymer and a polyelectrolyte in a water phase to generate an electrostatic complex; s2, adding enzyme into the electrostatic complex and incubating to form microspheres; and S3, adding a condensing agent and / or a cross-linking agent, removing the unreacted condensing agent and / or cross-linking agent, and sterilizing to obtain the natural polymer polyelectrolyte microspheres. The microsphere can be used as an embolism agent in an interventional technology or a separation and purification medium of protein, antibodies and drugs or a cell and drug carrier system, or as an implant material for orthopedics, surgery, ophthalmology and medical beauty.

The invention discloses a magnesium-based medical material containing a CaP-CS / diamond-like carbon composite coating and a preparation method and application thereof.The magnesium-based medical material is composed of a magnesium alloy, the diamond-like carbon coating and the CaP-CS coating, the diamond-like carbon coating is attached to a magnesium alloy substrate, and the CaP-CS coating is attached to the diamond-like carbon coating. The method comprises the following steps: preparing a diamond-like coating on the surface of a magnesium alloy substrate, and soaking the diamond-like coating in a CaP-CS solution to obtain the magnesium-based medical material containing the CaP-CS / diamond-like composite coating. According to the composite coating structure, high hardness and chemical inertness of the diamond-like coating and excellent biocompatibility and osteoinductivity of the CaP-CS coating are integrated, collaborative optimization of corrosion resistance and biocompatibility of the magnesium alloy is achieved, good film-substrate binding force is achieved, and application of the magnesium alloy in the field of biomedical implant materials is promoted.

The invention discloses an additive manufacturing zirconium alloy magnetic susceptibility prediction method based on a convolutional neural network, and belongs to the technical field of material performance prediction and intelligent manufacturing. The method comprises the following steps: firstly, preparing a plurality of groups of zirconium alloy samples with different process parameters through an electron beam powder bed melting process; secondly, performing X-ray diffraction analysis on the sample to obtain normalized diffraction intensity data of each crystal face, and measuring the magnetic susceptibility of each crystal face; thirdly, constructing a convolutional neural network model, and performing model training by taking the normalized diffraction intensity data and the phase composition data as input features and the magnetic susceptibility as an output label; and finally, predicting the zirconium alloy magnetic susceptibility under unknown process parameters by using the trained model. According to the method, the CNN model reveals that the crystal orientation is a leading factor influencing the magnetic susceptibility under the condition that the material components are the same, efficient and accurate prediction of the magnetic susceptibility of the zirconium alloy is realized, and a new way is provided for design and optimization of an MRI compatible implant material.

The application discloses a kind of polyaryletherketone composite implant materials and preparation method and application, and belongs to medical material technical field, wherein, the preparation method of the polyaryletherketone composite implant material includes the following steps: preparation surface has recess structure and the carbon fiber reinforced polyaryletherketone base of conductivity;Based on precipitation method, white brushite is prepared using calcium compound, magnesium compound and phosphoric acid aqueous solution;White brushite is surface modified using polydopamine, to obtain modified white brushite;Modified white brushite is mixed with degradable piezoelectric polymer into solvent, to obtain mixed solution;Mixed solution is coated on carbon fiber reinforced polyaryletherketone base, after drying, annealing treatment, form coating, to obtain polyaryletherketone composite implant material.The application constructs white brushite doped degradable piezoelectric composite coating with piezoelectric characteristics and ion release capacity simultaneously, realizes the dual bionics of electric signal and chemical signal in bone healing microenvironment.

The invention relates to a method including box boriding process to improve some mechanical properties such as hardness, corrosion resistance and wear and to provide 100% antibacterial properties to AISI 316L quality stainless steels, which are among the most widely used and known metals in terms of biocompatibility as implant materials. The invention relates to AISI 316L type biomaterial having 100% antibacterial properties according to antibacterial tests with Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 29213 bacteria.

This invention relates to the field of metal matrix composite material preparation technology, specifically to a zinc-based alloy composite material and its preparation method, particularly applicable to the field of biodegradable biomedical implant materials. The zinc-based alloy composite material comprises a zinc alloy matrix and nano-reinforcing particles. The zinc alloy matrix is ​​composed of Zn, Cu, and Li; wherein the mass percentage of Cu in the zinc alloy matrix is ​​1-2 wt%, and the mass percentage of Li in the zinc alloy matrix is ​​0.1-0.9 wt%; the volume percentage of the nano-reinforcing particles in the zinc alloy matrix is ​​<2.5 vol%; the particle size of the nano-reinforcing particles is <100 nm, and the nano-reinforcing particles are uniformly dispersed in the zinc alloy matrix. The invention also relates to the preparation and application of the above-mentioned zinc-based alloy composite material. This invention solves the problems of unstable microstructure and difficulty in balancing strength and ductility in existing zinc-copper-lithium alloys, thus improving the mechanical properties of the zinc-copper-lithium alloy system.

A high-strength porous metal implant material comprises a three-dimensional interconnected porous structure with a porosity of 55-90%, and two or more reinforcing elements distributed at the edge of the porous structure. The reinforcing elements are integrally formed and seamlessly bonded to each other and to the porous material. The reinforcing element structure of the porous metal implant material improves the material's mechanical strength. Its porous structure promotes bone tissue ingrowth into the porous metal's pores, facilitates osteoblast adhesion, differentiation, and growth, enhances the integration of the implant with bone, and achieves long-term biological fixation of the implant to human tissue. The thickness of the reinforcing elements, their positional distribution, or their volume percentage within the overall material can be adjusted according to the stress or mechanical performance requirements of the bone repair or bone defect site, thereby enabling the production of bone filling and implant materials that meet the different mechanical strength requirements of various locations.

The application discloses a traditional Chinese medicine active activated bone growth type support implant material and a preparation method thereof, and relates to the technical field of medical materials.The traditional Chinese medicine active activated bone growth type support implant material is composed of an organic-inorganic composite porous antibacterial support and a medicinal efficacy filler.Co hollow spheres loaded with carbon nanotubes, sodium alginate, nano-hydroxyapatite and transition metal carbide nanosheets are cross-linked and compounded to form the organic-inorganic composite porous antibacterial support, which not only has good mechanical properties and antibacterial properties, but also can stably bear more medicinal efficacy fillers and slowly release the medicinal efficacy fillers, and the medicinal efficacy fillers further improve the stability of the support structure.The synergistic effect of the two can significantly enhance the antibacterial property and osteogenesis of the implant material, and excellent bone repair effect is achieved.

The application provides a preparation method of a polyarylether medical material with a hydrogel coating on the surface, which comprises the following steps: firstly, treating a polyarylether sheet by plasma to endow the sheet with reactive functional groups; and then, spin-coating a hydrogel precursor solution onto the surface of the polyarylether sheet treated by plasma, and curing the sheet in an ultraviolet curing box to obtain a polyarylether medical material with a hydrogel coating on the surface; the hydrogel precursor solution comprises the following components in percentage by mass: acrylic acid-N-succinimidyl ester (AAc-N-NHS) 1-5%; methacrylic anhydride modified chitosan (CSMA) 1-3%; methacrylic anhydride modified gelatin (GelMA) 4-8%; alpha-ketoglutaric acid 0.2%; and water in the rest. The hydrogel coating and the polyarylether substrate are combined by chemical bonds, the bonding force between the hydrogel coating and the substrate is enhanced, the biocompatibility of the polyarylether material is improved, the polyarylether material is endowed with antibacterial and adhesive properties, and the polyarylether material has a wide application prospect in bone implant materials.

The present application relates to the use of polysialic acid or its derivatives in anti-foreign body reaction, in particular, to a polysialic acid anti-foreign body reaction material for resisting biological contamination, for regulating macrophage phenotype to reduce inflammatory response, and for resisting foreign body reaction. The polysialic acid material includes a bulk material prepared from polysialic acid and its derivatives, or a coating material for surface modification of the material, which can resist protein adsorption, cell adhesion and adhesion of various microorganisms, can act on immune cells, such as regulating the phenotype of macrophages, thereby reducing acute and chronic inflammatory response, and has excellent anti-foreign body reaction effect as an implant material.

The application discloses a kind of biological composite material for regulating magnesium ion release by surface layer channel and preparation thereof, belong to the technical field of biomedical materials.The surface layer of the composite material is porous zinc alloy, and the core is medical magnesium alloy.The preparation method includes first using atmosphere smelting combined with nested extrusion process to obtain zinc-magnesium composite bar, then preparing porous zinc alloy surface layer on the surface of the composite bar by laser drilling.The application realizes the controllable degradation of the overall material and the controllable release of magnesium ions.The surface layer zinc alloy slows down the degradation rate of the core magnesium alloy, and the surface layer regulates the magnesium ion release dose through channel size and distribution, i.e., it achieves the use of magnesium ions to promote the bone effect and promote the initial osteogenesis of the composite implant material, and through the volume ratio design of the surface layer zinc alloy and the core magnesium alloy, the degradation rate is regulated to match the bone tissue healing process.The material has moderate mechanical properties, and the elastic modulus is similar to that of human bone.The preparation process is simple, precise, and suitable for mass production.

The application provides a MgZnCa / SnZn metal glass composite material and a preparation method thereof, and the preparation method comprises the following steps: step S1, preparing MgZnCa metal glass powder and SnZn powder; step S2, uniformly mixing the MgZnCa metal glass powder and the SnZn powder, and performing discharge plasma sintering on the obtained mixture to obtain the MgZnCa / SnZn metal glass composite material; wherein the mass ratio of the SnZn in the mixture is 40%-80%. The MgZnCa / SnZn bulk metal glass composite material obtained by the technical scheme has excellent mechanical properties, the compressive strength is more than 110MPa, and the elongation rate is more than 15%, and the processing requirements of a biomedically implantable material are reached; and the MgZnCa / SnZn bulk metal glass composite material is nontoxic, degradable, and has better corrosion resistance performance than the MgZnCa bulk metal glass alloy in both instantaneous and long-term performances.