352 results about "Implant material" patented technology

The invention belongs to the field of medical materials. The invention provides a porous artificial bone and a preparation method thereof, the components of the porous artificial bone comprise absorbable macromolecules and an orthopedic inorganic implant material, the mass ratio of the absorbable macromolecules to the orthopedic inorganic implant material is 1: 0.1-2, the porous artificial bone has a through porous structure, the porosity is greater than 70%, and the pore size distribution range is less than 500 [mu] m. The porous artificial bone has a pore structure and mechanical properties beneficial to bone regeneration, the pore diameter is stable, the mechanical properties are appropriate, after the porous artificial bone is implanted into a defect part, the bone volume is always increased, the increase rate of regenerated bone tissue is remarkably improved, the effect of bone conduction is effectively achieved, bone regeneration is very beneficial, and animal experiments prove that the porous artificial bone has a good application prospect. The material can be used for filling and repairing various bone defects in orthopedic surgery. The preparation method is simple, stable and effective, can be absorbed, is low in cost, has great market potential, and is simple, stable and effective compared with a conventional artificial bone preparation method at present.

Disclosed is a method for constructing a hydrophilic, antifouling coating on the surface of a medical implantable material. The method comprises the following steps: 1) pretreating the surface of the medical implantable material to obtain a clean surface and / or a hydrophilic active site; and 2) impregnating the medical implantable material that has been pretreated in step 1) in a precursor solution for reaction so as to obtain a reaction interface layer or a free radical reaction and / or polymerization site on the surface of the medical implantable material; and removing the medical implantable material from the solution: 3) carrying out a polymerization grafting reaction; and 4) after the reaction in step 3) is complete, performing a wash and drying, thus finishing the construction of the hydrophilic, antifouling coating on the surface of the medical implantable material. According to the present invention, an alternating-structure amino acid copolymer or a derivative thereof is used as a cross-linking agent to modify the surface of the medical implantable material, and a hydrophilic, antifouling coating is obtained. The coating has relatively good hydrophilicity and in-vivo anti-scaling properties. The hydrophilicity of the coating enables formation of a hydration layer on the surface of the material, facilitating the prevention of protein, bacteria, cells, ions, etc. from adsorption and thus achieving the anti-scaling properties.

The present invention provides a bioabsorbable photocurable composition, a bioabsorbable tissue regeneration inducing material including the same, and a transplantation method using the same. The bioabsorbable photocurable composition includes a photoreduction agent and collagen, and is applied to the top of a transplantation site filled with a transplantation material, filling the empty space at the transplantation site and covering the transplantation material. The photoreduction agent is activated by irradiation with visible light to crosslink the collagen, and the collagen crosslinked by the visible light fills the minute empty space at the transplantation site and tightly bonds with the transplantation material to fix the transplantation material.

The invention discloses a composite material, a preparation method thereof and an implant, and belongs to the technical field of medical materials. The composite material is obtained by compounding a piezoelectric material and a metal ion release material, the metal ion release material is selected from one or more of magnesium-based degradable alloy, iron and iron-based degradable alloy, and zinc and zinc-based degradable alloy. The composite material can adaptively generate micro-currents with different magnitudes at different recovery stages of a patient through piezoelectric response of a piezoelectric material, and the micro-currents promote intelligent degradation, matched with self-recovery of the patient, of a metal ion release material. And the metal ions obtained by degradation and the micro current jointly promote the healing of the implanted part, which is of great significance to the development and application of implant materials.

The invention relates to the field of hydrogel preparation, and discloses anti-scale zwitter-ion hydrogel as well as a preparation method and application thereof. The method comprises the following steps: firstly, initiating an oxazine derivative monomer to polymerize through a double-end initiator to generate dihydroxyl polyoxazine; and then, removing a side chain of the polymer to obtain the dihydroxy polypropylene imine. Then, dihydroxy polypropylene imine is selected for further reaction to generate a zwitter-ion precursor polymer, and the zwitter-ion precursor polymer is hydrolyzed to obtain the polypropylene imine zwitter-ion derivative. And finally, converting hydroxyl groups at two ends, synthesizing a zwitterionic macromolecular cross-linking agent, and carrying out polymerization cross-linking in an aqueous solution to prepare the anti-scale zwitterionic hydrogel. The hydrogel is simple in formula, is completely composed of the zwitterionic cross-linking agent, has excellent anti-scaling performance such as protein adsorption resistance, bacterial adsorption resistance and cell adsorption resistance, and is suitable for biological materials, medical devices, implant materials and cell delivery materials.

The invention provides a high-strength antibacterial implant material and a preparation method thereof. The implant material comprises a composite matrix, a graphene-titanium nitride composite coating and a tantalum-silver composite coating, wherein the graphene-titanium nitride composite coating and the tantalum-silver composite coating are sequentially arranged on the surface of the composite matrix from inside to outside; wherein the graphene-titanium nitride composite coating is of a multi-layer alternating structure formed by alternately stacking graphene layers and titanium nitride layers; the tantalum content and the silver content in the tantalum-silver composite coating are in opposite gradient changes. The mechanical strength and the antibacterial property of the implant material are remarkably improved through the multi-layer alternate structure design, the hardness and the biocompatibility of the material are enhanced through the graphene-titanium nitride composite coating, and the implant material is endowed with the antibacterial property and the corrosion resistance through the tantalum-silver composite coating; the implant material has long-acting antibacterial property and biological safety while keeping high strength, so that the implant material is widely applied to the medical implant fields of orthopedics, dentistry and the like.

The invention belongs to the field of medical titanium alloy material processing, and particularly relates to a preparation method of a high-strength titanium-zirconium alloy wire. The Ti-Zr alloy comprises the following chemical components in percentage by mass: 13.5-16.5% of Zr, less than or equal to 0.10% of Fe, less than or equal to 0.10% of C, less than or equal to 0.015% of H, less than or equal to 0.6% of O, less than or equal to 0.05% of N and the balance of Ti. Firstly, a round bar blank with a certain size is obtained through the procedures of smelting, forging and drawing; and then a finished wire is prepared in the modes of temperature-controlled drawing, stress relief annealing and centerless grinding. By means of the method, the high-strength titanium-zirconium alloy wire with Rm larger than or equal to 950 MPa and A larger than or equal to 10% can be obtained, the problems that the implant material Ti-Zr alloy is low in strength and the like are solved, the high-strength titanium-zirconium alloy wire for dental products can be produced through the method, and qualified raw materials are provided for the dental implant products.

The invention provides a super-lubricity antibacterial coating material and a preparation method and application thereof, and relates to the technical field of medical implant materials, and the preparation method comprises the following steps: S1, respectively pretreating silver nanoparticles and polyethylene glycol; s2, the pretreated silver nanoparticles are placed in a first solvent, a silver nanoparticle solution is obtained, then a silane reagent and a catalyst are added, a silanization reaction is carried out, and activated silver nanoparticles are obtained; s3, placing a hydrophilic monomer in a second solvent, and then adding the activated silver nanoparticles to obtain a silver nanoparticle modified hydrophilic monomer; s4, putting the pretreated polyethylene glycol and an activating agent into a third solvent, and carrying out activating treatment to obtain an activated polyethylene glycol solution; and S5, putting the hydrophilic monomer modified by the silver nanoparticles into the activated polyethylene glycol solution to obtain the super-lubricity antibacterial coating material. When the surface of a silica gel catheter is coated with the super-lubricity antibacterial coating material, the lubricity and antibacterial property of the catheter are remarkably improved.

The invention discloses a biomedical gradient high-entropy composite strengthened coating with an interstitial strengthening phase and a preparation method of the biomedical gradient high-entropy composite strengthened coating, the coating is prepared through a double glow plasma surface metallurgy technology, a laser cladding technology and a magnetron sputtering technology, the performance of a high-entropy alloy can be effectively improved through interstitial solid solution strengthening of the high-entropy alloy, and the coating is easy to prepare; the plasma solid-state surface metallurgy technology has the technical advantages of strong binding force, high surface modification efficiency, low cost, adaptability to various complex workpiece shapes and the like; the laser cladding technology has the advantages of high deposition rate, low coating dilution rate, high cooling rate, controllable hardness and thickness, strong adhesion between the coating and a substrate, high film-substrate bonding strength and the like; and the magnetron sputtering technology has the advantages of high deposition rate, high film layer purity, good compactness, uniform film formation, good film-substrate binding force and the like, so that the strength, hardness, wear resistance, corrosion resistance and biocompatibility of the medical implant material clinically used are improved.

The invention provides a ZIF-8 gene-loaded hydrogel bone repair scaffold as well as a preparation method and application thereof, and belongs to the technical field of biomedical material manufacturing. The bone repair scaffold of the ZIF-8 gene-loaded hydrogel comprises a porous base material, hydrogel and ZIF-8 particles. The porous base material is a bone implant material; the hydrogel is sodium alginate hydrogel, the surface of the porous base material is coated with the hydrogel, and pores of the porous base material are filled with the hydrogel; the ZIF-8 particles are distributed in the hydrogel, the genes are loaded in the ZIF-8 particles, the genes are osteogenesis promoting genes, and the bone repair scaffold has multiple functions of resisting bacteria, promoting osseointegration, promoting osteogenesis and the like, so that the clinical application requirements of the bone repair scaffold are better met.

The invention discloses a multifunctional coating with a compact-porous double-layer structure on the surface of magnesium alloy and a preparation method, and belongs to the technical field of biological materials. According to the multifunctional coating, magnesium alloy serves as a substrate, a compact layer and a porous layer are sequentially stacked from the substrate to the outside, and the compact layer is composed of two-dimensional transition metal carbide / nitride, calcium silicate nanowires and a positively charged polymer. The porous layer is composed of copper-containing complex / biopolymer composite fibers, mineralized silk fibers loaded with bioactive metal ions and astragalus polysaccharide on the surface, and natural polymers. According to the multifunctional coating with the compact-porous double-layer structure prepared on the surface of the magnesium alloy, the porous layer on the surface layer has a unique porous structure, growth and proliferation of osteoblasts can be well promoted, meanwhile, the multifunctional coating has the characteristics of pressure resistance, bacteria resistance and oxidation resistance, the compact layer on the bottom layer can improve the corrosion resistance of the magnesium alloy, and the service life of the magnesium alloy is prolonged. The coating is particularly suitable for surface coating of magnesium alloy implant materials and can be used in the field of medical instruments.

The invention relates to the technical field of titanium alloy material surface treatment processes, and particularly discloses a pickling method for a titanium alloy implant material. The pickling method of the titanium alloy implant material comprises the following steps that a pickling solution is prepared, specifically, HF, HNO3 and water are mixed according to the volume ratio of (3-10): (3-10): 120 and stirred to be uniform, and the pickling solution is obtained; and acid pickling is conducted, specifically, the titanium alloy implant material is soaked in an acid pickling solution, timing is started when the titanium alloy implant material is completely soaked in the acid pickling solution, and the acid pickling time is controlled to be 80-150 s. According to the pickling method for the titanium alloy implant material, a flaky oxide layer on the surface of the titanium alloy implant material can be effectively removed, meanwhile, the surface pitting phenomenon is reduced, and the hydrophilicity and corrosion resistance of the titanium alloy implant material are improved.

The invention relates to the field of preparation of a metal material magnesium alloy, in particular to a preparation method of a low-alloying high-strength medical magnesium alloy wire. The preparation method comprises the following steps: adding not more than 3.6% of zinc, neodymium and zirconium elements into magnesium, optimizing the composition proportion, smelting and extruding to prepare a magnesium alloy bar, preparing the magnesium alloy bar into a wire with the thickness of 0.10-0.30 mm by combining a large cold deformation process with an intermediate annealing process, and performing electric pulse treatment on the wire to finally obtain the finished wire. The strength of the low-alloying magnesium alloy wire can be remarkably improved by combining large-deformation cold deformation with an electric pulse process, good plasticity is kept, and meanwhile, the magnesium alloy wire has good biological safety and degradability, is an ideal implant material and is particularly suitable for being used in the fields of anastomosis nails and the like. In addition, the medical product can be used as line sculptures, suture lines and the like.

The invention discloses a polyaryletherketone composite implant material and a preparation method and application thereof, and belongs to the technical field of medical materials.The preparation method of the polyaryletherketone composite implant material comprises the following steps that a carbon fiber reinforced polyaryletherketone substrate with the surface provided with a groove structure and conductivity is prepared; based on a precipitation method, a calcium compound, a magnesium compound and a phosphoric acid aqueous solution are used for preparing white calcium stone; the preparation method comprises the following steps: carrying out surface modification on the white calcium phosphate by utilizing polydopamine, so as to obtain modified white calcium phosphate; adding the modified white calcium phosphate and a degradable piezoelectric polymer into a solvent, and mixing to obtain a mixed solution; and coating a carbon fiber reinforced polyaryletherketone substrate with the mixed solution, and performing drying and annealing treatment to form a coating, thereby obtaining the polyaryletherketone composite implant material. According to the invention, the degradable piezoelectric composite coating doped with the white phosphorus calcium stone, which has piezoelectric characteristics and ion release capability, is constructed, so that double biomimetic effects of an electric signal and a chemical signal in a bone healing microenvironment are realized.

The invention belongs to the technical field of biological materials, and discloses a PEEK bone implant material of a piezoelectric catalysis biological heterojunction and a preparation method of the PEEK bone implant material, the material comprises a PEEK bone implant loaded with the biological heterojunction, the biological heterojunction is composed of BiVOO and a chalcogenide calcium compound in a molar ratio of 1-3, and the chalcogenide calcium compound is calcium sulfide, calcium selenide or calcium telluride; during preparation, the BiVO / CaX biological heterojunction is firstly prepared by a hydrothermal method or an in-situ composite method, then PEEK is sequentially subjected to acetone, ethanol and deionized water cleaning, sulfuric acid ultrasonic treatment for 5-10 minutes and dopamine modification, the biological heterojunction is in contact with the modified PEEK at 4 DEG C for 12 hours to complete loading, and improvement means can be introduced into part of schemes. The material has the acoustic catalytic antibacterial function and the bone repair promoting function, the antibacterial effect can be regulated and controlled through ultrasound, the process is simple, and the reaction condition is mild; the multi-drug-resistant bacterial infection can be dealt with, and the heterojunction loading stability and the material cell compatibility are improved.

The invention belongs to the field of dental implants, and particularly relates to a preparation method and device of a zirconium oxide implant surface osteogenesis-promoting and antibacterial zinc phosphate coating, and the preparation method of the zinc phosphate coating comprises the following steps: S4, mixing zinc oxide, phosphoric acid, nitric acid and deionized water, and adding an additive to prepare a phosphating solution; s5, putting the phosphating solution and the zirconium oxide implant into a reaction kettle, heating the reaction kettle in a baking oven at 150-230 DEG C for 3-12 hours, and taking out the zirconium oxide implant after natural cooling; and S6, carrying out ultrasonic cleaning for 1-5 minutes by adopting deionized water, and drying in a drying oven at 40-60 DEG C to finally obtain the zirconium oxide implant coated with the zinc phosphate coating. The zinc phosphate coating is prepared on the surface of the zirconium oxide dental implant by applying a hydrothermal method, and the zirconium oxide dental implant has good mechanical properties, cytocompatibility, osteogenesis performance and antibacterial performance by changing the formula of a phosphating solution and adjusting the temperature and time of a hydrothermal reaction, and has important significance for expanding clinical application of a zirconium oxide ceramic implant material in the field of oral cavities.

A method for preparing a Zn—Mg—Ca—Sr alloy, in which an as-cast Zn—Mg—Ca—Sr alloy is subjected to homogenization, and a boron nitride lubricant is sprayed on a surface of the as-cast Zn—Mg—Ca—Sr alloy and an inner cavity surface of a die. The as-cast Zn—Mg—Ca—Sr alloy is put into the die, and subjected to heating and 8-pass reciprocating extrusion to obtain the desired Zn—Mg—Ca—Sr alloy with high strength and high toughness, where the extrusion speed is stagewise controlled to realize stagewise variable-extrusion speed reciprocating extrusion. This application also provides a biodegradable medical implant material including a Zn—Mg—Ca—Sr alloy prepared by such method.

The invention relates to the field of metal materials, in particular to a biodegradable zinc-germanium alloy material and a preparation method thereof. According to the technical scheme, the Ge-Zn-Zn alloy comprises the following metals in percentage by mass: 1.5-4.5% of Ge and the balance of Zn, or comprises the following metals in percentage by mass: 1.5-4.5% of Ge, 0.2-0.8% of silver and the balance of Zn. The biodegradable zinc-germanium alloy material has the beneficial effects that a trace amount of germanium element is added into pure zinc, and the biodegradable zinc-germanium alloy material with relatively high mechanical property, good biocompatibility and degradability is obtained through smelting and heat treatment; besides, a trace amount of silver element can be added as required, so that the zinc-germanium alloy has higher mechanical property, proper degradation rate and better antibacterial property, has huge potential of being applied to design of novel bone implant materials and heart stents, and has wide application prospects in biodegradable materials.

The invention discloses a magnesium-based material surface self-healing protective coating as well as a preparation method and application thereof. The magnesium-based material surface protective coating is mainly formed by crystallizing an organic corrosion inhibitor and inorganic corrosion inhibitor co-intercalated layered bimetal hydroxide LDH on the surface of a magnesium-based material. Through the innovative design of the organic and inorganic ion co-intercalation LDH coating with good biocompatibility, the coating can be quickly and effectively self-repaired after being physically damaged or chemically eroded, so that the maintenance cost can be reduced, the reliability of the material can be improved, and more efficient and more economical long-term protection on the surface of the magnesium-based material can be realized. According to the protective coating, the corrosion resistance of the magnesium-based material is greatly improved, meanwhile, the possibility is provided for application in the high-requirement fields such as medical implant materials, the protective coating is further suitable for the high-end industrial fields such as aerospace, automobiles and electronic information, a brand new material protection strategy is provided, and the protective coating is expected to lead to the new trend of the material protection technology.

The invention relates to the technical field of medical instrument manufacturing, and discloses a method for instantly forming an individualized child tracheal catheter through a 3D printing technology. The method comprises the following steps: acquiring CT (Computed Tomography) or MRI (Magnetic Resonance Imaging) body layer image data of neck and chest areas of a target child patient, wherein the data is used for reflecting anatomical structures of a throat and a trachea; importing the image data into three-dimensional reconstruction software, executing structure identification and segmentation operation, and constructing a three-dimensional model of the throat and trachea of the child patient; performing parameter modeling according to the model, and designing an individualized tracheal catheter model which is fit with the inner diameter of a target airway and is matched with the target airway in length and curvature; the model is converted into a printing data file matched with 3D printing equipment; and a biocompatible 3D printing device is called, the catheter model is printed through a medical implant material, and the solid catheter meeting the size requirement is obtained. The pediatric intubation system improves the matching degree and safety of pediatric intubation, and has good clinical practical value.

The invention discloses a traditional Chinese medicine activity activated bone growth type support implant material and a preparation method thereof, and relates to the technical field of medical materials. The traditional Chinese medicine activity activated bone growth type support implant material is composed of an organic-inorganic composite porous antibacterial scaffold and a pharmacodynamic filler, according to the invention, Co hollow spheres loaded with carbon nanotubes are cross-linked and compounded with sodium alginate, nano-hydroxyapatite and transition metal carbide nanosheets to form an organic-inorganic composite porous antibacterial scaffold, which not only has good mechanical properties and antibacterial properties, but also can stably bear more pharmacodynamic fillers and enable the pharmacodynamic fillers to be slowly released; the stability of the stent structure is further improved through the pharmacodynamic filler, the antibacterial property and the osteogenesis effect of the implant material are remarkably enhanced through the synergistic effect of the pharmacodynamic filler and the stent structure, and the excellent bone repair effect is achieved.

The invention relates to the field of metal medical implant materials, and discloses a corrosion-resistant and antibacterial magnesium alloy for a bone repair scaffold, a preparation method and application, the corrosion-resistant and antibacterial magnesium alloy for the bone repair scaffold comprises the following components in percentage by mass: 3.5-7.0% of Zn, 0.1-0.5% of Ca, 0.1-0.3% of Al, 0.05-0.1% of Cu and the balance of Mg; the invention further discloses application and a preparation method. According to the method, the corrosion resistance of the magnesium alloy implant can be remarkably improved, and meanwhile the bacteriostatic effect can be effectively achieved; the method has the advantages that individual modeling and forming processing can be conveniently carried out on the implant according to different requirements of different patients on the shape and size of the implant, meanwhile, the treatment time can be greatly shortened, the treatment cost can be greatly reduced, the recovery process of the patients is accelerated, and the method has a very wide application prospect; the laser powder bed melting technology is adopted for preparing the magnesium alloy, the method has the advantages of being short in process, high in forming precision and good in mechanical property, the method is extremely suitable for manufacturing of small-batch complex-structure high-added-value products, and the production cost and time of the complex-structure medical implant are remarkably shortened.

The invention belongs to the technical field of biological implant materials, and discloses a medical titanium alloy implant surface modification method and application, and the medical titanium alloy implant surface modification method comprises the following steps: grinding and polishing a titanium alloy surface, and then carrying out ultrasonic cleaning and drying in ethanol; the titanium alloy is placed in multi-arc ion plating equipment, high-purity tantalum serves as a target material, and a tantalum coating is deposited on the surface of the titanium alloy; the surface of the titanium alloy is coated with photoresist, and then a micropore array is formed in the surface of the tantalum coating through the photoetching technology; the titanium alloy is placed in the electrolyte, a Ti plate serves as a cathode, a Ta plate serves as an anode, and hydroxyapatite is deposited in a porous structure through electrochemical deposition; and removing the photoresist to expose the tantalum coating, ultrasonically cleaning with deionized water, and drying. The titanium alloy implant provided by the invention has excellent corrosion resistance, biocompatibility and mechanical properties, and makes up for the deficiency of a single material, so that the titanium alloy implant subjected to surface modification has wider application.

The invention provides a high-biocompatibility antibacterial composite material and a preparation method and application thereof, and relates to the technical field of medical implant materials, the preparation method comprises the following steps: S1, carrying out first activation treatment on a hydrophilic monomer to obtain an activated hydrophilic monomer; s2, performing second activation treatment on the antibacterial agent to obtain an activated antibacterial agent; s3, mixing the activated hydrophilic monomer and the activated antibacterial agent, and reacting to obtain the high-biocompatibility antibacterial composite material. The hydrophilic monomer and the antibacterial agent are respectively activated, so that the hydrophilic monomer and the antibacterial agent are respectively grafted with active groups, and the two unique active groups can be subjected to efficient chemical reaction under specific reaction conditions, so that the hydrophilic monomer and the antibacterial agent can be tightly combined together; and a brand-new composite material is formed.

The invention relates to an antibacterial and antioxidant Ti-MXene bone implant material triggered by near-infrared light and a preparation method of the Ti-MXene bone implant material. The material is composed of a pure Ti substrate and a plurality of Ti3C2TX MXene coatings which are electrostatically self-adsorbed on the pure Ti substrate, and then is crosslinked and coated by gelatin. The multi-layer Ti3C2TX MXene is combined with the surface of a metal matrix, and has excellent biocompatibility and antibacterial and antioxidant effects. According to the coating, multiple layers of Ti < 3 > C < 2 > TX MXene are stripped from an MAX phase (Ti < 3 > Al < 2 >) through hydrochloric acid etching, then a Ti sheet is soaked in alkali liquor with dispersed MXene, and titanate and MXene are subjected to electrostatic self-bonding on the surface; and the combination is further enhanced through gelatin coating. The material can realize photo-thermal antibacterial ability under the irradiation of 808nm NIR with lower power, and has good antioxidant ability and osteoblast compatibility.

The invention discloses a nickel-titanium alloy material and a preparation method and application thereof. The nickel-titanium alloy material comprises a nickel-titanium alloy body and a TiN-containing coating arranged on the surface of the body, wherein the coating is prepared by adopting a high-power pulse magnetron sputtering technology. The TiN-containing coating in the nickel-titanium alloy material is prepared through the HiPIMS technology, the obtained coating material has the remarkable characteristic of high compactness, and when the coating material is used for an implant material, the nickel element precipitation prevention effect is good. Meanwhile, the nickel-titanium alloy material has the advantages of high corrosion resistance, high binding force, low stress and the like, can be used in (non) implantable medical devices with high corrosion resistance and high compact protection requirements, and is good in application prospect.

The invention provides an efficient antibacterial trachea cannula and a preparation method thereof, and relates to the technical field of medical implant materials.The preparation method comprises the following steps that S1, ofloxacin is placed in a first activating agent to be subjected to first activating treatment, activated ofloxacin is obtained, and the activated ofloxacin contains amido; s2, salbutamol is placed in a second activating agent to be subjected to second activating treatment, activated salbutamol is obtained, and the activated salbutamol contains ether groups; s3, the silica gel trachea cannula is subjected to third activation treatment, an activated silica gel trachea cannula is obtained, and the surface of the activated silica gel trachea cannula contains silanol groups; s4, the activated ofloxacin and the activated salbutamol are grafted to the surface of the activated silica gel trachea cannula, and the efficient antibacterial trachea cannula is obtained. According to the invention, ofloxacin and salbutamol are respectively activated, so that the ofloxacin and the salbutamol are connected to the surface of the silica gel trachea cannula, and the trachea cannula has efficient antibacterial property and tracheal adaptability.

The invention provides hydrogel, a porous titanium / hydrogel composite implant material and a preparation method of the porous titanium / hydrogel composite implant material. The hydrogel is obtained by photo-crosslinking and curing a hydrogel precursor solution containing acrylated beta-cyclodextrin, acrylated alendronate sodium, gelatin and a chemotactic factor. The hydrogel has a porous network structure, high elastic modulus, high fatigue resistance and excellent biocompatibility, and also has the capability of recruiting bone marrow mesenchymal stem cells (BMSCs) and the capability of promoting osteogenic differentiation of the BMSCs; the porous titanium / hydrogel composite implant material prepared from the hydrogel can effectively promote the growth of new bone tissues, has excellent osseointegration capability, obviously improves the osteogenesis repair effect and the osseointegration effect, provides a new treatment approach for the repair treatment of segmental bone defects, and has important medical significance.

The present invention discloses a coating-modified ophthalmic material with improved biocompatibility and its preparation method, belonging to the field of biomedical materials. The material preparation mainly includes the following steps: (1) treating the ophthalmic material with 3,4-dihydroxybenzaldehyde to introduce aldehyde groups thereto; (2) reacting the aldehyde-group-containing ophthalmic material in step (1) with recombinant human type I collagen or human amniotic membrane extract to obtain the coating-modified ophthalmic material. While meeting the mechanical and optical property requirements of the ophthalmic material, this material significantly reduces the adhesion of proteins and macrophages, improves biocompatibility, and potentially can extend the service life of the ophthalmic material, having broad application prospects in ophthalmic implant materials.

The application belongs to the technical field of bone repair implant materials, and particularly relates to an antibacterial peptide functionalized bone cement as well as a preparation method and application thereof. An amino acid sequence general formula of the functional antibacterial peptide is ZUX1X2UX3X4UZ0. The antibacterial peptide functionalized bone cement takes a protease stable cationic antibacterial peptide as a functional component, is prepared by in-situ blending polymerization with a commercial bone cement, can improve the problems of high drug resistance risk, no immune regulation ability and insufficient osteogenesis activity of a traditional antibiotic-loaded bone cement, simultaneously expands an orthopedic material application scene of an Aib modified antibacterial peptide, and realizes a synergistic treatment of infection clearance, immune remodeling and bone regeneration.