252 results about "Implant material" patented technology

The invention belongs to the field of medical materials. The invention provides a porous artificial bone and a preparation method thereof, the components of the porous artificial bone comprise absorbable macromolecules and an orthopedic inorganic implant material, the mass ratio of the absorbable macromolecules to the orthopedic inorganic implant material is 1: 0.1-2, the porous artificial bone has a through porous structure, the porosity is greater than 70%, and the pore size distribution range is less than 500 [mu] m. The porous artificial bone has a pore structure and mechanical properties beneficial to bone regeneration, the pore diameter is stable, the mechanical properties are appropriate, after the porous artificial bone is implanted into a defect part, the bone volume is always increased, the increase rate of regenerated bone tissue is remarkably improved, the effect of bone conduction is effectively achieved, bone regeneration is very beneficial, and animal experiments prove that the porous artificial bone has a good application prospect. The material can be used for filling and repairing various bone defects in orthopedic surgery. The preparation method is simple, stable and effective, can be absorbed, is low in cost, has great market potential, and is simple, stable and effective compared with a conventional artificial bone preparation method at present.

The invention provides a high-strength antibacterial implant material and a preparation method thereof. The implant material comprises a composite matrix, a graphene-titanium nitride composite coating and a tantalum-silver composite coating, wherein the graphene-titanium nitride composite coating and the tantalum-silver composite coating are sequentially arranged on the surface of the composite matrix from inside to outside; wherein the graphene-titanium nitride composite coating is of a multi-layer alternating structure formed by alternately stacking graphene layers and titanium nitride layers; the tantalum content and the silver content in the tantalum-silver composite coating are in opposite gradient changes. The mechanical strength and the antibacterial property of the implant material are remarkably improved through the multi-layer alternate structure design, the hardness and the biocompatibility of the material are enhanced through the graphene-titanium nitride composite coating, and the implant material is endowed with the antibacterial property and the corrosion resistance through the tantalum-silver composite coating; the implant material has long-acting antibacterial property and biological safety while keeping high strength, so that the implant material is widely applied to the medical implant fields of orthopedics, dentistry and the like.

The invention belongs to the field of medical titanium alloy material processing, and particularly relates to a preparation method of a high-strength titanium-zirconium alloy wire. The Ti-Zr alloy comprises the following chemical components in percentage by mass: 13.5-16.5% of Zr, less than or equal to 0.10% of Fe, less than or equal to 0.10% of C, less than or equal to 0.015% of H, less than or equal to 0.6% of O, less than or equal to 0.05% of N and the balance of Ti. Firstly, a round bar blank with a certain size is obtained through the procedures of smelting, forging and drawing; and then a finished wire is prepared in the modes of temperature-controlled drawing, stress relief annealing and centerless grinding. By means of the method, the high-strength titanium-zirconium alloy wire with Rm larger than or equal to 950 MPa and A larger than or equal to 10% can be obtained, the problems that the implant material Ti-Zr alloy is low in strength and the like are solved, the high-strength titanium-zirconium alloy wire for dental products can be produced through the method, and qualified raw materials are provided for the dental implant products.

The invention provides a super-lubricity antibacterial coating material and a preparation method and application thereof, and relates to the technical field of medical implant materials, and the preparation method comprises the following steps: S1, respectively pretreating silver nanoparticles and polyethylene glycol; s2, the pretreated silver nanoparticles are placed in a first solvent, a silver nanoparticle solution is obtained, then a silane reagent and a catalyst are added, a silanization reaction is carried out, and activated silver nanoparticles are obtained; s3, placing a hydrophilic monomer in a second solvent, and then adding the activated silver nanoparticles to obtain a silver nanoparticle modified hydrophilic monomer; s4, putting the pretreated polyethylene glycol and an activating agent into a third solvent, and carrying out activating treatment to obtain an activated polyethylene glycol solution; and S5, putting the hydrophilic monomer modified by the silver nanoparticles into the activated polyethylene glycol solution to obtain the super-lubricity antibacterial coating material. When the surface of a silica gel catheter is coated with the super-lubricity antibacterial coating material, the lubricity and antibacterial property of the catheter are remarkably improved.

The invention provides a ZIF-8 gene-loaded hydrogel bone repair scaffold as well as a preparation method and application thereof, and belongs to the technical field of biomedical material manufacturing. The bone repair scaffold of the ZIF-8 gene-loaded hydrogel comprises a porous base material, hydrogel and ZIF-8 particles. The porous base material is a bone implant material; the hydrogel is sodium alginate hydrogel, the surface of the porous base material is coated with the hydrogel, and pores of the porous base material are filled with the hydrogel; the ZIF-8 particles are distributed in the hydrogel, the genes are loaded in the ZIF-8 particles, the genes are osteogenesis promoting genes, and the bone repair scaffold has multiple functions of resisting bacteria, promoting osseointegration, promoting osteogenesis and the like, so that the clinical application requirements of the bone repair scaffold are better met.

The invention discloses a multifunctional coating with a compact-porous double-layer structure on the surface of magnesium alloy and a preparation method, and belongs to the technical field of biological materials. According to the multifunctional coating, magnesium alloy serves as a substrate, a compact layer and a porous layer are sequentially stacked from the substrate to the outside, and the compact layer is composed of two-dimensional transition metal carbide / nitride, calcium silicate nanowires and a positively charged polymer. The porous layer is composed of copper-containing complex / biopolymer composite fibers, mineralized silk fibers loaded with bioactive metal ions and astragalus polysaccharide on the surface, and natural polymers. According to the multifunctional coating with the compact-porous double-layer structure prepared on the surface of the magnesium alloy, the porous layer on the surface layer has a unique porous structure, growth and proliferation of osteoblasts can be well promoted, meanwhile, the multifunctional coating has the characteristics of pressure resistance, bacteria resistance and oxidation resistance, the compact layer on the bottom layer can improve the corrosion resistance of the magnesium alloy, and the service life of the magnesium alloy is prolonged. The coating is particularly suitable for surface coating of magnesium alloy implant materials and can be used in the field of medical instruments.

The invention discloses a polyaryletherketone composite implant material and a preparation method and application thereof, and belongs to the technical field of medical materials.The preparation method of the polyaryletherketone composite implant material comprises the following steps that a carbon fiber reinforced polyaryletherketone substrate with the surface provided with a groove structure and conductivity is prepared; based on a precipitation method, a calcium compound, a magnesium compound and a phosphoric acid aqueous solution are used for preparing white calcium stone; the preparation method comprises the following steps: carrying out surface modification on the white calcium phosphate by utilizing polydopamine, so as to obtain modified white calcium phosphate; adding the modified white calcium phosphate and a degradable piezoelectric polymer into a solvent, and mixing to obtain a mixed solution; and coating a carbon fiber reinforced polyaryletherketone substrate with the mixed solution, and performing drying and annealing treatment to form a coating, thereby obtaining the polyaryletherketone composite implant material. According to the invention, the degradable piezoelectric composite coating doped with the white phosphorus calcium stone, which has piezoelectric characteristics and ion release capability, is constructed, so that double biomimetic effects of an electric signal and a chemical signal in a bone healing microenvironment are realized.

The invention belongs to the technical field of biological materials, and discloses a PEEK bone implant material of a piezoelectric catalysis biological heterojunction and a preparation method of the PEEK bone implant material, the material comprises a PEEK bone implant loaded with the biological heterojunction, the biological heterojunction is composed of BiVOO and a chalcogenide calcium compound in a molar ratio of 1-3, and the chalcogenide calcium compound is calcium sulfide, calcium selenide or calcium telluride; during preparation, the BiVO / CaX biological heterojunction is firstly prepared by a hydrothermal method or an in-situ composite method, then PEEK is sequentially subjected to acetone, ethanol and deionized water cleaning, sulfuric acid ultrasonic treatment for 5-10 minutes and dopamine modification, the biological heterojunction is in contact with the modified PEEK at 4 DEG C for 12 hours to complete loading, and improvement means can be introduced into part of schemes. The material has the acoustic catalytic antibacterial function and the bone repair promoting function, the antibacterial effect can be regulated and controlled through ultrasound, the process is simple, and the reaction condition is mild; the multi-drug-resistant bacterial infection can be dealt with, and the heterojunction loading stability and the material cell compatibility are improved.

The invention belongs to the field of dental implants, and particularly relates to a preparation method and device of a zirconium oxide implant surface osteogenesis-promoting and antibacterial zinc phosphate coating, and the preparation method of the zinc phosphate coating comprises the following steps: S4, mixing zinc oxide, phosphoric acid, nitric acid and deionized water, and adding an additive to prepare a phosphating solution; s5, putting the phosphating solution and the zirconium oxide implant into a reaction kettle, heating the reaction kettle in a baking oven at 150-230 DEG C for 3-12 hours, and taking out the zirconium oxide implant after natural cooling; and S6, carrying out ultrasonic cleaning for 1-5 minutes by adopting deionized water, and drying in a drying oven at 40-60 DEG C to finally obtain the zirconium oxide implant coated with the zinc phosphate coating. The zinc phosphate coating is prepared on the surface of the zirconium oxide dental implant by applying a hydrothermal method, and the zirconium oxide dental implant has good mechanical properties, cytocompatibility, osteogenesis performance and antibacterial performance by changing the formula of a phosphating solution and adjusting the temperature and time of a hydrothermal reaction, and has important significance for expanding clinical application of a zirconium oxide ceramic implant material in the field of oral cavities.

The invention relates to the field of metal materials, in particular to a biodegradable zinc-germanium alloy material and a preparation method thereof. According to the technical scheme, the Ge-Zn-Zn alloy comprises the following metals in percentage by mass: 1.5-4.5% of Ge and the balance of Zn, or comprises the following metals in percentage by mass: 1.5-4.5% of Ge, 0.2-0.8% of silver and the balance of Zn. The biodegradable zinc-germanium alloy material has the beneficial effects that a trace amount of germanium element is added into pure zinc, and the biodegradable zinc-germanium alloy material with relatively high mechanical property, good biocompatibility and degradability is obtained through smelting and heat treatment; besides, a trace amount of silver element can be added as required, so that the zinc-germanium alloy has higher mechanical property, proper degradation rate and better antibacterial property, has huge potential of being applied to design of novel bone implant materials and heart stents, and has wide application prospects in biodegradable materials.

The invention relates to the technical field of medical instrument manufacturing, and discloses a method for instantly forming an individualized child tracheal catheter through a 3D printing technology. The method comprises the following steps: acquiring CT (Computed Tomography) or MRI (Magnetic Resonance Imaging) body layer image data of neck and chest areas of a target child patient, wherein the data is used for reflecting anatomical structures of a throat and a trachea; importing the image data into three-dimensional reconstruction software, executing structure identification and segmentation operation, and constructing a three-dimensional model of the throat and trachea of the child patient; performing parameter modeling according to the model, and designing an individualized tracheal catheter model which is fit with the inner diameter of a target airway and is matched with the target airway in length and curvature; the model is converted into a printing data file matched with 3D printing equipment; and a biocompatible 3D printing device is called, the catheter model is printed through a medical implant material, and the solid catheter meeting the size requirement is obtained. The pediatric intubation system improves the matching degree and safety of pediatric intubation, and has good clinical practical value.

The invention discloses a traditional Chinese medicine activity activated bone growth type support implant material and a preparation method thereof, and relates to the technical field of medical materials. The traditional Chinese medicine activity activated bone growth type support implant material is composed of an organic-inorganic composite porous antibacterial scaffold and a pharmacodynamic filler, according to the invention, Co hollow spheres loaded with carbon nanotubes are cross-linked and compounded with sodium alginate, nano-hydroxyapatite and transition metal carbide nanosheets to form an organic-inorganic composite porous antibacterial scaffold, which not only has good mechanical properties and antibacterial properties, but also can stably bear more pharmacodynamic fillers and enable the pharmacodynamic fillers to be slowly released; the stability of the stent structure is further improved through the pharmacodynamic filler, the antibacterial property and the osteogenesis effect of the implant material are remarkably enhanced through the synergistic effect of the pharmacodynamic filler and the stent structure, and the excellent bone repair effect is achieved.

The invention belongs to the technical field of biological implant materials, and discloses a medical titanium alloy implant surface modification method and application, and the medical titanium alloy implant surface modification method comprises the following steps: grinding and polishing a titanium alloy surface, and then carrying out ultrasonic cleaning and drying in ethanol; the titanium alloy is placed in multi-arc ion plating equipment, high-purity tantalum serves as a target material, and a tantalum coating is deposited on the surface of the titanium alloy; the surface of the titanium alloy is coated with photoresist, and then a micropore array is formed in the surface of the tantalum coating through the photoetching technology; the titanium alloy is placed in the electrolyte, a Ti plate serves as a cathode, a Ta plate serves as an anode, and hydroxyapatite is deposited in a porous structure through electrochemical deposition; and removing the photoresist to expose the tantalum coating, ultrasonically cleaning with deionized water, and drying. The titanium alloy implant provided by the invention has excellent corrosion resistance, biocompatibility and mechanical properties, and makes up for the deficiency of a single material, so that the titanium alloy implant subjected to surface modification has wider application.

The invention provides a high-biocompatibility antibacterial composite material and a preparation method and application thereof, and relates to the technical field of medical implant materials, the preparation method comprises the following steps: S1, carrying out first activation treatment on a hydrophilic monomer to obtain an activated hydrophilic monomer; s2, performing second activation treatment on the antibacterial agent to obtain an activated antibacterial agent; s3, mixing the activated hydrophilic monomer and the activated antibacterial agent, and reacting to obtain the high-biocompatibility antibacterial composite material. The hydrophilic monomer and the antibacterial agent are respectively activated, so that the hydrophilic monomer and the antibacterial agent are respectively grafted with active groups, and the two unique active groups can be subjected to efficient chemical reaction under specific reaction conditions, so that the hydrophilic monomer and the antibacterial agent can be tightly combined together; and a brand-new composite material is formed.

The invention relates to an antibacterial and antioxidant Ti-MXene bone implant material triggered by near-infrared light and a preparation method of the Ti-MXene bone implant material. The material is composed of a pure Ti substrate and a plurality of Ti3C2TX MXene coatings which are electrostatically self-adsorbed on the pure Ti substrate, and then is crosslinked and coated by gelatin. The multi-layer Ti3C2TX MXene is combined with the surface of a metal matrix, and has excellent biocompatibility and antibacterial and antioxidant effects. According to the coating, multiple layers of Ti < 3 > C < 2 > TX MXene are stripped from an MAX phase (Ti < 3 > Al < 2 >) through hydrochloric acid etching, then a Ti sheet is soaked in alkali liquor with dispersed MXene, and titanate and MXene are subjected to electrostatic self-bonding on the surface; and the combination is further enhanced through gelatin coating. The material can realize photo-thermal antibacterial ability under the irradiation of 808nm NIR with lower power, and has good antioxidant ability and osteoblast compatibility.

The invention provides an efficient antibacterial trachea cannula and a preparation method thereof, and relates to the technical field of medical implant materials.The preparation method comprises the following steps that S1, ofloxacin is placed in a first activating agent to be subjected to first activating treatment, activated ofloxacin is obtained, and the activated ofloxacin contains amido; s2, salbutamol is placed in a second activating agent to be subjected to second activating treatment, activated salbutamol is obtained, and the activated salbutamol contains ether groups; s3, the silica gel trachea cannula is subjected to third activation treatment, an activated silica gel trachea cannula is obtained, and the surface of the activated silica gel trachea cannula contains silanol groups; s4, the activated ofloxacin and the activated salbutamol are grafted to the surface of the activated silica gel trachea cannula, and the efficient antibacterial trachea cannula is obtained. According to the invention, ofloxacin and salbutamol are respectively activated, so that the ofloxacin and the salbutamol are connected to the surface of the silica gel trachea cannula, and the trachea cannula has efficient antibacterial property and tracheal adaptability.

The invention provides hydrogel, a porous titanium / hydrogel composite implant material and a preparation method of the porous titanium / hydrogel composite implant material. The hydrogel is obtained by photo-crosslinking and curing a hydrogel precursor solution containing acrylated beta-cyclodextrin, acrylated alendronate sodium, gelatin and a chemotactic factor. The hydrogel has a porous network structure, high elastic modulus, high fatigue resistance and excellent biocompatibility, and also has the capability of recruiting bone marrow mesenchymal stem cells (BMSCs) and the capability of promoting osteogenic differentiation of the BMSCs; the porous titanium / hydrogel composite implant material prepared from the hydrogel can effectively promote the growth of new bone tissues, has excellent osseointegration capability, obviously improves the osteogenesis repair effect and the osseointegration effect, provides a new treatment approach for the repair treatment of segmental bone defects, and has important medical significance.

The present invention discloses a coating-modified ophthalmic material with improved biocompatibility and its preparation method, belonging to the field of biomedical materials. The material preparation mainly includes the following steps: (1) treating the ophthalmic material with 3,4-dihydroxybenzaldehyde to introduce aldehyde groups thereto; (2) reacting the aldehyde-group-containing ophthalmic material in step (1) with recombinant human type I collagen or human amniotic membrane extract to obtain the coating-modified ophthalmic material. While meeting the mechanical and optical property requirements of the ophthalmic material, this material significantly reduces the adhesion of proteins and macrophages, improves biocompatibility, and potentially can extend the service life of the ophthalmic material, having broad application prospects in ophthalmic implant materials.

The invention provides a bifunctional polymer stabilized calcium phosphate precursor nano-material, a preparation method thereof and application of the bifunctional polymer stabilized calcium phosphate precursor nano-material in surface modification of a PPESK coating. The bifunctional polymer stabilized calcium phosphate precursor nano-material comprises the following components according to concentration: a bifunctional polymer with the concentration of 0.05-0.2 g / mL; the concentration of PO4 < 3-> is 0.05 to 0.5 mol / L; the concentration of Ca < 2 + > is 0.05-0.5 mol / L, and the solvent is deionized water; the diameter of the calcium phosphate precursor nano material is 20 to 100 nm. The preparation method comprises the following steps: preparing a polyacrylamide block polymer by adopting free radical polymerization, and then grafting a calcium chelating agent to obtain a bifunctional polymer; combining the difunctional polymer with a calcium-phosphorus solution to prepare a difunctional polymer stabilized calcium phosphate precursor nano material; according to the invention, the polymer is endowed with calcium chelating ability and collagenous fiber binding ability, so that the material can enter the collagenous fiber to be fully mineralized, the surface of the PPESK coating is mineralized, the biocompatibility of the material is improved, the material has osteogenesis promoting ability, and the material has a wide application prospect in the aspect of bone implant materials.

The invention relates to a medical beauty implant material intelligent optimization method and system based on artificial intelligence, and the method comprises the following steps: S1, obtaining the performance parameters of different medical beauty implant materials, capturing the anatomical features of a patient through 3D scanning and MRI images, and carrying out the statistics of the personalized biological data of the patient; s2, constructing a multi-task learning model and training based on a multi-target supervised learning data set, wherein the target is to predict the performance of different implant material formulas in a medical beauty implant environment; s3, performing multi-objective optimization by adopting an NSGA-III algorithm to obtain an optimal implant material formula; s4, reconstructing a three-dimensional model of the patient by using a reverse modeling technology based on anatomical features of the patient; and S5, based on the three-dimensional model, according to the optimal implant material formula and the personalized biological data, simulating the biomechanical characteristics of the patient by utilizing finite element analysis, and outputting biocompatibility scores and suitability suggestions of the material in different implant environments. According to the method, the clinical requirements on customized design and application of the medical beauty implant material are effectively met.

This invention discloses a composite material, its preparation method, and an implant, belonging to the field of medical materials technology. The composite material is obtained by combining a piezoelectric material and a metal ion-releasing material; the metal ion-releasing material is selected from one or more of magnesium-based biodegradable alloys, iron and iron-based biodegradable alloys, and zinc and zinc-based biodegradable alloys. The composite material can adaptively generate microcurrents of varying magnitudes at different stages of patient recovery through the piezoelectric response of the piezoelectric material. These microcurrents promote intelligent degradation of the metal ion-releasing material that matches the patient's own recovery process. The resulting metal ions and the microcurrents jointly promote healing at the implantation site, which is of great significance for the development and application of implant materials.

The invention discloses a gradient degradation type personalized absorbable sternum fracture fixing plate and a preparation process, and belongs to the technical field of medical implant materials. Comprising an anatomical adaptive plate body and an integrated locking assembly, the plate body is of a partitioned structure of a middle supporting area and an edge buffering area, a gradient pore array penetrating through the thickness direction is formed in the surface of the plate body, and a hydroxyapatite-collagen composite coating is loaded on the inner wall of a pore; the plate body is made of a composite absorbable material through 3D printing forming and hot pressing post-treatment, and the composite absorbable material comprises, by weight, 60%-70% of polylactic acid-glycolic acid copolymer (PLGA, LA / GA = 75 / 25), 15%-20% of silanized magnesium alloy microwires, 5%-10% of hydroxyapatite nano-particles and 5%-10% of polycaprolactone (PCL). Space-time matching of the degradation rate and the bone healing process is achieved through the partition gradient structure, the magnesium alloy microwires enhance the mechanical property and release active ions to promote osteogenesis, and the method has the advantages of personalized adaptation, gradient degradation, bone regeneration promotion and the like.

The present invention proposes a pentahydrate octacalcium phosphate nanoflower and a preparation method thereof. Dopamine and a divalent calcium salt solution are added to a phosphate buffer solution of pH 7.5 to 7.8 to form a reaction solution. After being mixed evenly, the mixture is allowed to stand for reaction. The polymerization of dopamine and the growth of crystals are synchronized by controlling the reaction conditions. After the reaction is completed, the precipitate is separated to obtain the pentahydrate octacalcium phosphate nanoflower. The present invention controls the synchronization of dopamine polymerization and crystal growth, and induces the crystal to continue to grow around the crystal nucleus, thereby realizing a nanoflower structure. The present invention is low in cost, and the raw materials used are only phosphate buffer solution, dopamine and divalent calcium salt solution, which has a large raw material cost advantage. The pentahydrate octacalcium phosphate nanoflower produced by the present invention can be widely used in human implant materials, such as fillers or artificial dental implants that replace bones. It has good resorbability and affinity, and has made contributions to human health.

The invention belongs to the technical field of medical materials, and discloses a novel titanium-based implant material with oxygen-releasing, antibacterial and osteogenesis-promoting properties and a preparation method of the novel titanium-based implant material. The titanium-based implant material comprises a titanium substrate and calcium peroxide on the surface of the titanium substrate. The invention provides a method for modifying a compact or porous titanium-based implant material by using calcium peroxide. The characteristic that calcium peroxide reacts with water to release oxygen, hydrogen peroxide and calcium ions and the biological activity of calcium ions in the aspect of bone repair enable the titanium-based implant material to have application potential in the aspects of preventing / relieving / treating implant bacterial infection, large-size bone defect oxygen supply insufficiency and poor osseointegration.

The present invention pertains to the field of biomedical materials and specifically relates to a biofilm for repairing an abdominopelvic cavity wound surface and a preparation method therefor. The present invention provides a biofilm for repairing an abdominopelvic cavity wound surface. The biofilm comprises a first film layer and a second film layer. The thickness of the first film layer is 0.1-1 mm, and the thickness of the second film layer is 0.02-0.4 mm. The weight per unit area of the first film layer is 1.2-5 times that of the second film layer. The interlayer bonding ratio of the first film layer and the second film layer is 35%-75%. The biofilm has good mechanical-performance stability and good operability. The changes in tensile strength and peel strength after repeated soaking / drying cycles or two weeks of soaking remain within 13% compared to 4 h of soaking. The fat ratio of the two film layers is controlled again, thereby improving the ingrowth stability and the mechanical / dimensional stability of the implant material.

The invention relates to the technical field of biodegradable materials, in particular to a biodegradable alloy, a preparation method and a preparation device thereof, and the alloy comprises V, Cr, Ga, Cu, Ag, Mg and Zn elements. Wherein the mass fraction of V is 0.1%-0.6%, the mass fraction of Cr is 0.1%-0.4%, the mass fraction of Ga is 0.6%-2.36%, the mass fraction of Cu is 0.1%-2.75%, the mass fraction of Ag is 1.0%-4.0%, the mass fraction of Mg is 1.7%-3.7%, and the balance is Zn. Compared with the prior art, the Zn-based alloy can generate solution strengthening and precipitation strengthening effects by adding Ga, Cr, V and other trace elements, the mechanical property of the Zn-based alloy can be improved, the Zn-based alloy has good corrosion resistance, tensile strength, yield strength and ductility, high-energy ultrasonic melt treatment and standing heat preservation are adopted in the method, uniform alloy components can be obtained, and the method is suitable for large-scale production. Through homogenization treatment, a strengthening phase is uniformly distributed, the mechanical property is stable, and the device can be used as a medical degradable implant material, can integrate vacuum, ultrasonic and air intake, and is convenient to use.

The invention belongs to the technical field of implant materials, and discloses a porous titanium-based implant material surface calcium-phosphorus coating and a preparation method thereof. According to the method, a porous titanium-based implant material is used as a cathode, an annular platinum electrode is used as an anode, the cathode is located in the center of the annular electrode, a solution containing calcium and phosphorus is used as an electrolyte, biomimetic mineralization is carried out under the condition of pulse micro-potential, and the calcium-phosphorus coating is formed on the surface of the porous titanium-based implant material. According to the method, the biomimetic mineralization process of the surface of the beam structure in the porous titanium-based material is regulated and controlled by adopting the annular electrode and the weak electric field, migration of ions and ion groups in the porous scaffold is improved by adjusting the current of the annular electrode and combining the biomimetic mineralization process, and the porous titanium-based implant material uniformly covered with the calcium-phosphorus coating is obtained. The method is simple, and uniform covering of the calcium-phosphorus coating of the porous titanium-based implant material is achieved.

The invention provides a degradable latex catheter material and a production process thereof, and relates to the technical field of medical implant materials, the production process comprises the following steps: S1, placing an activator in a sodium alginate solution to obtain an activated sodium alginate solution; s2, activating the latex particles to obtain activated latex particles; s3, the antibacterial agent and the activated latex particles are placed in the activated sodium alginate solution for a grafting reaction, and the degradable latex catheter material is obtained. According to the preparation method, sodium alginate and latex particles are subjected to activating treatment, so that efficient grafting of sodium alginate molecules on the surfaces of the latex particles is realized, the degradability of the latex particles is remarkably improved, and the antibacterial property of the latex particles is remarkably enhanced by further introducing an antibacterial agent.

The invention provides an implanter. The implanter comprises an implanting part, a clamping part, an opening and closing assembly, a sleeve assembly and a driving part. The implantation part comprises a near end and a far end; the clamping part comprises a clamping arm and is used for clamping a material to be implanted; the opening and closing assembly comprises an unfolding arm which is arranged at the far end. The sleeve assembly sleeves the outer side of the implantation part and is used for wrapping the clamping arm, the unfolding arm and the implantation material; a first rotating piece, a second rotating piece, a third rotating piece, a first connecting piece, a second connecting piece and a third connecting piece are arranged in the driving part shell, and the first connecting piece is wound on the first rotating piece, connected with the clamping arm and used for driving the clamping arm to clamp a material to be implanted; the second connecting piece is wound around the second rotating piece and connected with the cannula assembly to drive the cannula assembly to move in the direction away from the far end, the third connecting piece is wound around the third rotating piece and connected with the unfolding arm to drive the unfolding arm to unfold, and according to the design, the structure of the implanter is simplified, operation and use are convenient, and the surgical application efficiency of the implanter is improved.

This invention discloses an artificial corneal endothelial graft based on natural degradable proteins, its preparation method, and its application, relating to the field of medical implant materials technology. Currently, artificial corneal endothelial grafts for corneal endothelial decompensation are all non-degradable synthetic polymer materials. This invention uses a natural degradable material as the substrate to prepare the graft. A material preparation stock solution is obtained by mixing a silk fibroin solution extracted from a high-salt solution with a certain proportion of glycerol. The mixed solution is then spin-coated onto a mold using a gradient method, and dried to obtain a silk fibroin film. The obtained silk fibroin film is then circumcised and placed in a mold for hot-press steam fumigation. The resulting silk fibroin film can serve as an artificial corneal endothelial graft, providing a donor source for artificial corneas and possessing potential application value in corneal transplantation.