23 results about "Resorption" patented technology

The preservation number of the bacterial strain is CGMCC (China General Microbiological Culture Collection Center) NO.33629, the preservation date of the bacterial strain is February 24, 2025, the preservation classification of the bacterial strain is Lactobacillus sakei, and the preservation unit of the bacterial strain is China General Microbiological Culture Collection Center. The strain provided by the invention can reduce the concentration of blood uric acid, relieve kidney inflammation caused by hyperuricemia, improve the protein level of a kidney uric acid excretion channel and reduce the expression level of uric acid resorption protein.

The invention discloses a multifunctional bone peptide compound and application thereof in prevention and treatment of osteoporotic osteoarthritis, and relates to the technical field of bone peptides. The multifunctional bone peptide compound is prepared from the following raw materials: giant salamander bone meal, bovine bone articular cartilage powder, bovine bone meal, sturgeon bone meal, oyster bone meal, deer-horn glue powder, calcium chloride and fructo-oligosaccharide. According to the multifunctional bone peptide compound disclosed by the invention, the composite aggregate is subjected to enzymolysis step by step by using the compound enzyme, the bone peptide and calcium ions are compounded through a chelation reaction, the absorbability of calcium is improved, one part of the bone peptide in the composite bone peptide has a function of promoting osteoblast activity, and the other part of the bone peptide possibly has a function of inhibiting overactivity of osteoclasts; part of the bone peptide has an anti-inflammatory effect, can regulate bone metabolism, repair articular cartilage and relieve inflammatory response, and can improve the effect of the bone peptide product in the aspects of preventing and treating osteoporosis, osteoarthritis and other diseases.

The present invention relates to a biosensor that enables the detection of biomarkers related to bone metabolism through saliva samples. This biosensor, which uses a saliva sampling method and offers an economical and user-friendly solution by adopting a non-invasive approach, can detect biomarkers related to bone formation and resorption such as Procollagen Type I N-terminal Propeptide (PINP) and β-C- terminal Telopeptide (β-CTX) in saliva with high sensitivity. The present invention increases patient comfort while also providing rapid analysis, making the diagnosis and treatment processes of diseases related to bone metabolism more efficient.

A medical device can include a first anchor for attachment to a first bone fragment and a second anchor for attachment to a second bone fragment. The second anchor attachment can be coupled to the first anchor via a compression element between the first anchor and the second anchor. The medical device can include a resorbable element maintaining the first anchor and the second anchor at a first distance. The resorbable element can be configured to at least partially resorb after insertion into a patient. After the resorbable element is at least partially sorbed, the compression element forces the first anchor and / or the second anchor to translate such that the first anchor and the second anchor are at a second distance, thereby compressing the first bone fragment and the second bone fragment.

The utility model discloses a back suction device and water purification equipment. The resorption device comprises a shell and an elastic isolation piece, the shell is provided with a cavity, the elastic isolation piece is arranged in the cavity and divides the cavity into a first cavity body and a second cavity body, and the elastic isolation piece is used for deforming under the action of external force and restoring to the original state under the action of the elastic force of the elastic isolation piece. The size of the first cavity and the size of the second cavity can be changed; wherein the first cavity and the second cavity are respectively used for communicating different water paths of the water purification equipment; when the elastic separator deforms under the action of external force, the volume of the first cavity becomes smaller. And when the elastic separator recovers to the original state under the action of self elasticity, the volume of the first cavity is increased. The back suction device provided by the utility model is simple in structure, convenient to install and low in cost.

Collagen matrices of varying charge and cross-linking density are disclosed, and methods for preparing such collagen matrices. The cross-linking methods for collagen impart charge and allow for variable cross-linking density within the collagen device. Such variable cross-linking density imparts variable collagen resorption time, and the variable charge allows sequestering and then releasing therapeutics in a controlled manner. The techniques may be used to impact in vitro mineralization via the charged collagen platform by its interaction with rhBMP-2. The techniques can be used to create a positively charged collagen skin substitute that resists infection and supports wound closure.

Collagen matrices of varying charge and cross-linking density are disclosed, and methods for preparing such collagen matrices. The cross-linking methods for collagen impart charge and allow for variable cross-linking density within the collagen device. Such variable cross-linking density imparts variable collagen resorption time, and the variable charge allows sequestering and then releasing therapeutics in a controlled manner. The techniques may be used to impact in vitro mineralization via the charged collagen platform by its interaction with rhBMP-2. The techniques can be used to create a positively charged collagen skin substitute that resists infection and supports wound closure.

Certain aspects of the present disclosure provide a flexible scaffold implant comprising a plurality of layered structures, the plurality of layered structures comprising: a first layered structure having a three-dimensional (3D) shape and formed from a bioresorbable material, and a second layered structure conforming to the corresponding 3D shape of the first layered structure and formed from the bioresorbable material. The first layered structure is arranged in proximity to the second layered structure. The first layered structure is configured to dissolve for resorption at a different rate than the second layered structure based on design elements of the first layered structure and the second layered structure. The plurality of layered structures are flexible.

This invention discloses the application of an inhibitor of transcription factor C / EBPβ in the preparation of a drug for treating postmenopausal osteoporosis. This invention also discloses the application of transcription factor C / EBPβ in screening drugs that reduce postmenopausal FSH levels, wherein the drugs inhibit the expression of transcription factor C / EBPβ. Furthermore, this invention discloses the application of compounds #11a and CF3CN in the preparation of a drug for treating postmenopausal osteoporosis. This invention reveals for the first time that the C / EBPβ-AEP pathway participates in promoting FSHβ synthesis in a menopausal model. By reducing the transcription factor activity of C / EBPβ, it can reduce FSH expression at the pituitary gland, promote osteogenic differentiation, inhibit osteoclast resorption, and effectively alleviate PMOP symptoms. Compounds #11a and CF3CN can effectively achieve both anti-bone resorption and bone formation-promoting functions, achieving coupled treatment of PMOP.

The utility model provides a porous screw. The porous screw comprises a screw body and a Piezo agonist. The screw body comprises a threaded shaft section and a pore shaft section, external threads are arranged on the outer wall of the threaded shaft section, and at least one medicine carrying hole body is formed in the outer wall of the pore shaft section; the Piezo agonist is arranged at the medicine carrying hole body of the threaded shaft section and / or the pore shaft section of the screw body, and when the screw body is installed on a human body, the Piezo agonist is used for inhibiting bone resorption of the human body. According to the porous screw provided by the invention, the hole shaft section on the screw body is provided with the medicine carrying hole body, so that the screw body is of a porous structure, and compared with a bone nail of a compact structure in the prior art, the screw body of the porous structure has lower rigidity and can reduce stress shielding, so that bone resorption can be inhibited. In addition, the bone resorption can be further inhibited through the Piezo1 agonist arranged on the screw body.

The invention relates to the technical field of biological treatment of bone metabolic diseases, and discloses an application of a bone-strengthening and blood-generating oral liquid in preparation of a medicine for treating osteoporotic fracture.The application includes the steps that when the medicine is prepared, active components in the bone-strengthening and blood-generating oral liquid are combined with a Wnt signal transduction complex in osteoblasts in a targeted mode, and the bone-strengthening and blood-generating oral liquid is obtained; the phosphorylation activity of glycogen synthase kinase-3 is inhibited, so that-catenin enters a nucleus, Runx2 expression is started, and the synthesis rate of the N-terminal propeptide of the type I procollagen is increased; according to the method, a positive anabolism window is established in an original callus formation period of fracture healing by constructing an osteogenesis and osteoclast activity two-way decoupling biological regulation mechanism, so that a positive anabolism effect is achieved, and a positive anabolism effect is achieved. Bone metabolism pathological deviation in an osteoporosis state is corrected, secondary absorption of callus is inhibited while high osteogenic activity is maintained, and biomechanical fracture load of bones after fracture healing is improved.

Implants including non-resorbable frameworks and resorbable components, as well as methods of use thereof are disclosed. The embodiments include different combinations of a non-resorbable framework (in some case structural and in other cases non-structural), and a resorbable component embedded within and / or around the framework (again, in some cases structural and in other cases non-structural). The disclosed implants provide an efficient means of providing structural support for the vertebral bodies post-implantation, as well as encouraging resorption of the implant and fusion of the associated vertebral bodies without negative side effects and / or failure, such as subsidence of the implant or cracking / fracturing of a portion of the implant when implanted.

Implants with fillable reservoirs have been developed that are suitable for rhinoplasty, breast reconstruction, ear reconstruction, and replacement, reconstruction or repair of other soft tissues. The implants can be filled with graft material prior to implantation. The implants are preferably made from resorbable polymers, can be tailored to provide different geometries, mechanical properties and resorption rates in order to provide more consistent surgical outcomes. The implants preferably have an interconnected network of unit cells with microporous outer layers and optionally some or all of the unit cells having at least one macropore in their outer layers. The implants can be loaded by injection with microfat, collagen, DCF, cells, bioactive agents, and other augmentation materials, prior to implantation.

A program stored in a non-transitory computer-readable medium of the present disclosure causes a computer to execute: acquiring intraoral three-dimensional data that represents a tooth of a subject person and periodontium of the tooth; and calculating a gingival state index value of the subject person, an alveolar bone resorption index value of the subject person, or both thereof as a state index value of the subject person by using the intraoral three-dimensional data. The gingival state index value of the subject person is an index value related to a state of a gingival of the subject person. The alveolar bone resorption index value of the subject person is an index value related to resorption of an alveolar bone of the subject person. The state index value is an index value related to a state of teeth of the subject person.

The invention discloses a PLGA microsphere-PCL / GelMA composite scaffold based on neurotrophic factor (NGF) slow release as well as a preparation method and application of the PLGA microsphere-PCL / GelMA composite scaffold. According to the composite scaffold, NGF-loaded PLGA microspheres are embedded into a PCL skeleton and a GelMA hydrogel matrix, and a three-phase composite system with mechanical support, biological factor sustained release and cell adhesion functions is constructed. In-vitro experiments show that the NGF-loaded composite scaffold can significantly promote osteogenic differentiation of dental pulp stem cells, which shows that the activity of alkaline phosphatase is improved, the formation of mineralized nodules is increased, and the expression of osteogenic related genes RUNX2, ALPL, COL1A1 and BGLAP is up-regulated. When the composite stent is applied to a rat skull critical defect model in vivo, new bone formation and vascular nerve regeneration are remarkably promoted. Mechanism research shows that regulation and control of osteogenesis and bone resorption are realized by activating a PI3K / AKT signal channel. The composite stent is suitable for repairing complex bone defects in areas with rich nerves and blood vessels, and has a good clinical application prospect.

Disclosed is a bioresorbable implant with enhanced bone ingrowth and tissue integration utilizing an inside-out resorption mechanism and a method to manufacture a bioresorbable implants for use in osteotomies and bone-soft tissue reconstruction surgeries. The bioresorbable implant includes a polymer A (e.g., an aliphatic polymer matrix) and / or poly(propylene fumarate)), a carbohydrate B (e.g., a bioresorbable natural carbohydrate filler) and a ceramic C. The implant may be a porous scaffold structures with suitable porosity, pore size, pore interconnectivity, and mechanical properties for enhanced osteoblast penetration and bone formation to fabricate tissue integrating bioresorbable implants. The implant may be shaped as wedges, bone void fillers, and soft tissue fixation implant like screws, rods and / or anchors. In some embodiments, the implant may be a putty.

The absorbable bone nail comprises an end cover structure at the top, the lower portion of the end cover structure is connected with a main body part which is in a cone frustum shape and gradually contracts from top to bottom, the bottom of the main body part is connected with a cylindrical extension section, and the tail end of the extension section is connected with a conical end part. The diameter of the upper bottom of the cone-frustum-shaped main body part is the same as that of the end cover structure; the diameter of the bottom surface of the cone-shaped end part is the same as that of the extension section; wherein the end cover structure, the main body part, the extension section and the end part are coaxially arranged and adopt an integrally formed structure made of an allogeneic bone; the cone-frustum-shaped main body part is wide in upper part and narrow in lower part, is consistent with the diameter of the end cover, is gradually attached to a bone tissue during implantation, the contact area is gradually increased, the main body part is fully embedded when the bottom of the end cover is attached to the surface of an alveolar bone, the resistance is suddenly increased, and a doctor is helped to accurately judge the depth. The end cover and the main body part are equal to be coaxial and are in a symmetrical and regular shape, inclination can be prevented when the device is implanted along the preset axis, observation is facilitated, and accuracy is improved. The allogeneic bone is of an integrated structure, and the physical strength, the biocompatibility and the absorbability are all considered. The bone material can be absorbed by a human body, and can induce osteoblasts to form new bones on the premise of ensuring a supporting effect, so that fusion substitution is realized. And slow absorption is realized in an induced osteogenesis process, so that secondary operation taking-out is avoided, and reabsorption and reconstruction of soft and hard tissues caused by secondary operation are prevented.

The present invention pertains to the technical field of biomedicine, and relates to isopaucifloral F phosphate compounds and pharmaceutical uses thereof. It has been confirmed through experiments that said isopaucifloral F phosphate compounds and pharmaceutically acceptable salts thereof have effects on the bone remodeling process by exerting their anti-osteoporosis efficacy through a dual-mode mechanism of action of promoting osteogenesis and reducing osteoclast resorption, have the characteristics of high bioavailability, stable metabolism and good safety, and can be used to prepare a new generation of anti-osteoporosis drugs.

The application relates to the field of artificial intelligence medical image processing technology and discloses a three-dimensional intelligent jaw bone absorption rate dynamic change monitoring method based on CBCT. CBCT data is used for three-dimensional image analysis, a deep learning model is used to automatically segment teeth, tooth enamel, maxillary bones and mandibular bones, the enamel-dentin junction and the top base of periodontal bone defects are automatically identified, the position of tooth root tips is automatically located, and the local bone absorption rate is calculated.

Certain aspects of the present disclosure provide a flexible scaffold implant comprising a plurality of layered structures, the plurality of layered structures comprising: a first layered structure having a three-dimensional (3D) shape and formed from a bioresorbable material, and a second layered structure conforming to the corresponding 3D shape of the first layered structure and formed from the bioresorbable material. The first layered structure is arranged in proximity to the second layered structure. The first layered structure is configured to dissolve for resorption at a different rate than the second layered structure based on design elements of the first layered structure and the second layered structure. The plurality of layered structures are flexible.

The present invention provides a medicinal and edible composition for preventing and treating osteoporosis and a preparation method thereof. The raw materials of the medicinal and edible composition are: 15-24 parts of Rehmannia root, 12-15 parts of Cornus officinalis, 12-20 parts of Chinese yam, 15-20 parts of Astragalus root, 3-10 parts of Chinese angelica root, and 10-20 parts of Eucommia ulmoides leaves; the medicinal and edible composition of the present invention increases osteoprotegerin, reduces type I collagen C-terminal peptide and tartrate-resistant acid phosphatase, thereby promoting osteoblast differentiation, inhibiting osteoclast resorption, regulating bone metabolism balance, increasing femoral maximum load, and improving bone density and bone strength. The medicinal and edible composition of the present invention is highly safe and can be developed into medicines, health products, or functional foods for the prevention and treatment of osteoporosis.

The invention relates to the technical field of medical instruments, and discloses a thrombus extraction and protection device which comprises a delivery part and a thrombus extraction part, the delivery part comprises a metal tube and a catheter, the thrombus extraction part comprises a resorption part and a thrombus breaking part, the near end of the resorption part is connected with the far end of the catheter, and the near end of the thrombus breaking part is fixedly connected with the far end of the metal tube. A metal core wire is movably sleeved with the metal tube, and the metal core wire extends from the near end to the back suction part at the far end in the axial direction of the metal tube and then is movably connected with the bolt breaking part and the bolt blocking part in sequence. The far end of the back suction piece is of a horn mouth structure; the bolt breaking piece is of a structure with two closed ends, and the metal core wire sequentially penetrates through the center of the near end and the center of the far end of the bolt breaking piece. The plug blocking piece is of a structure with two closed ends, and the metal core wire sequentially penetrates through the center of the near end and the center of the far end of the plug blocking piece. According to the invention, firm thrombus inlaying and destroying are realized through active intervention of an operator, a tiny thrombus capturing function is realized, and the method has important significance for breaking through the clinical application bottleneck of an ADVANCE technology and improving the treatment effect of acute ischemic stroke.