9 results about "Resorption" patented technology

The present invention relates to a biosensor that enables the detection of biomarkers related to bone metabolism through saliva samples. This biosensor, which uses a saliva sampling method and offers an economical and user-friendly solution by adopting a non-invasive approach, can detect biomarkers related to bone formation and resorption such as Procollagen Type I N-terminal Propeptide (PINP) and β-C- terminal Telopeptide (β-CTX) in saliva with high sensitivity. The present invention increases patient comfort while also providing rapid analysis, making the diagnosis and treatment processes of diseases related to bone metabolism more efficient.

A medical device can include a first anchor for attachment to a first bone fragment and a second anchor for attachment to a second bone fragment. The second anchor attachment can be coupled to the first anchor via a compression element between the first anchor and the second anchor. The medical device can include a resorbable element maintaining the first anchor and the second anchor at a first distance. The resorbable element can be configured to at least partially resorb after insertion into a patient. After the resorbable element is at least partially sorbed, the compression element forces the first anchor and / or the second anchor to translate such that the first anchor and the second anchor are at a second distance, thereby compressing the first bone fragment and the second bone fragment.

Certain aspects of the present disclosure provide a flexible scaffold implant comprising a plurality of layered structures, the plurality of layered structures comprising: a first layered structure having a three-dimensional (3D) shape and formed from a bioresorbable material, and a second layered structure conforming to the corresponding 3D shape of the first layered structure and formed from the bioresorbable material. The first layered structure is arranged in proximity to the second layered structure. The first layered structure is configured to dissolve for resorption at a different rate than the second layered structure based on design elements of the first layered structure and the second layered structure. The plurality of layered structures are flexible.

This invention discloses the application of an inhibitor of transcription factor C / EBPβ in the preparation of a drug for treating postmenopausal osteoporosis. This invention also discloses the application of transcription factor C / EBPβ in screening drugs that reduce postmenopausal FSH levels, wherein the drugs inhibit the expression of transcription factor C / EBPβ. Furthermore, this invention discloses the application of compounds #11a and CF3CN in the preparation of a drug for treating postmenopausal osteoporosis. This invention reveals for the first time that the C / EBPβ-AEP pathway participates in promoting FSHβ synthesis in a menopausal model. By reducing the transcription factor activity of C / EBPβ, it can reduce FSH expression at the pituitary gland, promote osteogenic differentiation, inhibit osteoclast resorption, and effectively alleviate PMOP symptoms. Compounds #11a and CF3CN can effectively achieve both anti-bone resorption and bone formation-promoting functions, achieving coupled treatment of PMOP.

The invention relates to the technical field of biological treatment of bone metabolic diseases, and discloses an application of a bone-strengthening and blood-generating oral liquid in preparation of a medicine for treating osteoporotic fracture.The application includes the steps that when the medicine is prepared, active components in the bone-strengthening and blood-generating oral liquid are combined with a Wnt signal transduction complex in osteoblasts in a targeted mode, and the bone-strengthening and blood-generating oral liquid is obtained; the phosphorylation activity of glycogen synthase kinase-3 is inhibited, so that-catenin enters a nucleus, Runx2 expression is started, and the synthesis rate of the N-terminal propeptide of the type I procollagen is increased; according to the method, a positive anabolism window is established in an original callus formation period of fracture healing by constructing an osteogenesis and osteoclast activity two-way decoupling biological regulation mechanism, so that a positive anabolism effect is achieved, and a positive anabolism effect is achieved. Bone metabolism pathological deviation in an osteoporosis state is corrected, secondary absorption of callus is inhibited while high osteogenic activity is maintained, and biomechanical fracture load of bones after fracture healing is improved.

The absorbable bone nail comprises an end cover structure at the top, the lower portion of the end cover structure is connected with a main body part which is in a cone frustum shape and gradually contracts from top to bottom, the bottom of the main body part is connected with a cylindrical extension section, and the tail end of the extension section is connected with a conical end part. The diameter of the upper bottom of the cone-frustum-shaped main body part is the same as that of the end cover structure; the diameter of the bottom surface of the cone-shaped end part is the same as that of the extension section; wherein the end cover structure, the main body part, the extension section and the end part are coaxially arranged and adopt an integrally formed structure made of an allogeneic bone; the cone-frustum-shaped main body part is wide in upper part and narrow in lower part, is consistent with the diameter of the end cover, is gradually attached to a bone tissue during implantation, the contact area is gradually increased, the main body part is fully embedded when the bottom of the end cover is attached to the surface of an alveolar bone, the resistance is suddenly increased, and a doctor is helped to accurately judge the depth. The end cover and the main body part are equal to be coaxial and are in a symmetrical and regular shape, inclination can be prevented when the device is implanted along the preset axis, observation is facilitated, and accuracy is improved. The allogeneic bone is of an integrated structure, and the physical strength, the biocompatibility and the absorbability are all considered. The bone material can be absorbed by a human body, and can induce osteoblasts to form new bones on the premise of ensuring a supporting effect, so that fusion substitution is realized. And slow absorption is realized in an induced osteogenesis process, so that secondary operation taking-out is avoided, and reabsorption and reconstruction of soft and hard tissues caused by secondary operation are prevented.

The application relates to the field of artificial intelligence medical image processing technology and discloses a three-dimensional intelligent jaw bone absorption rate dynamic change monitoring method based on CBCT. CBCT data is used for three-dimensional image analysis, a deep learning model is used to automatically segment teeth, tooth enamel, maxillary bones and mandibular bones, the enamel-dentin junction and the top base of periodontal bone defects are automatically identified, the position of tooth root tips is automatically located, and the local bone absorption rate is calculated.

Certain aspects of the present disclosure provide a flexible scaffold implant comprising a plurality of layered structures, the plurality of layered structures comprising: a first layered structure having a three-dimensional (3D) shape and formed from a bioresorbable material, and a second layered structure conforming to the corresponding 3D shape of the first layered structure and formed from the bioresorbable material. The first layered structure is arranged in proximity to the second layered structure. The first layered structure is configured to dissolve for resorption at a different rate than the second layered structure based on design elements of the first layered structure and the second layered structure. The plurality of layered structures are flexible.