The invention relates to an anti-collision device by combing a chiral negative Poisson's ratio structure with a honeycomb structure, and belongs to the technical field of impact protection devices. The anti-collision device comprises an anti-collision device body, wherein the anti-collision device body is internally provided with a rigid inner cushion layer, a chiral negative Poisson's ratio layer, a rigid middle cushion layer, a honeycomb layer and a rigid skin, the chiral negative Poisson's ratio layer is a chiral negative Poisson's ratio structure arranged in the in-plane direction, the honeycomb layer is a honeycomb structure arranged in the plane outer direction, the rigid inner cushion layer, the rigid middle cushion layer and the rigid skin are fixedly connected with the adjacent layers, and the outer surface of the rigid skin for the highly corrosive environment can be sprayed with an anticorrosive material. According to the anti-collision device, the characteristics of light energy absorption of a porous material and good collision resistance performance of the negative Poisson's ratio structure are fully exerted. Compared with a traditional anti-collision device, the anti-collision device has the advantages of being light in weight, good in energy absorption, capable of resisting continuous impact, and easy to repair, and can be widely applied to the field of safety protection of land and ocean building structures.