The invention discloses a minitype ornithopter wing driving mechanism with changeable wing area, and belongs to the technical field of minitype ornithopters. The minitype ornithopter wing driving mechanism comprises a machine body frame, a driving motor, a follow-up gear, a synchronizing gear as well as a front crank, a rear crank, a front connecting rod, a rear connecting rod, a fixe rocking arm, a sliding block rocking arm, a humerus, an ulna, a middle finger bone, a little finger bone, an ulna muscle tendon and a radius which are symmetrically arranged on the two sides of the machine body frame, wherein modulus and tooth number of the follow-up gear and the synchronizing gear are same, the follow-up gear and the synchronizing gear can reversely and synchronously move, and the rear crank and the rear connecting rod can drive the sliding block rocking arm to simultaneously realize fore-and-back movement in upper-down waving manner, so that a wing is driven to transform. The minitype ornithopter wing driving mechanism provided by the invention has the advantages that the structure is simple, the cost is low, the complex movements of wing waving and wing area deformation are simultaneously realized; a wing skeleton drives a patagium to slack in upward waving, and the wing area is small; the patagium is tightened in downward waving, the wing area is enlarged, and the aerodynamic efficiency and flight efficiency are further improved.