The invention provides a method for preparing a high-strength high-density isotropic graphite material. According to the method, pitch mesocarbon micro bead (MCMB) powder of which the D50 is larger than 20 micrometers, and the volatile content is less than 7 percent is taken as a raw material, and the high-strength high-density isotropic graphite material is prepared by adopting the self-sintering process that the raw material powder is added into an organic solvent of pitch, the solvent is removed, the powder is pressed, a green briquette is formed through isostatic compaction, roasting and carbonization are performed, and graphitization is performed. According to the method, an organic solvent method is utilized to disperse bitumastic cement, so as to realize the modification on MCMB powder with large size and low volatile matter, the original shapes and sizes of the MCMB particles are basically kept after modification, good self sinterability is realized, and the finally obtained graphite is fine and uniform in structure, high in density and excellent in mechanical property. The pitch of the dispersed and modified MCMB is distributed uniformly, the inner stress of the green briquette in the isostatic compaction step is more uniformly distributed, and balanced expansion and shrinkage in the working procedures of roasting and graphitization are realized, and therefore, a product is not liable to crack, and the yield reaches not less than 90 percent.