242 results about "Attachment site" patented technology

The invention relates to leadless cardiac pacemakers (LBS), and elements and methods by which they affix to the heart. The invention relates particularly to a secondary fixation of leadless pacemakers which also include a primary fixation. Secondary fixation elements for LBS's may either actively engage an attachment site, or more passively engage structures within a heart chamber. Active secondary fixation elements include a tether extending from the LBS to an anchor at another site. Such sites may be either intracardial or extracardial, as on a vein through which the LBS was conveyed to the heart, the internal or external surface thereof. Passive secondary fixation elements entangle within intraventricular structure such as trabeculae carneae, thereby contributing to fixation of the LBS at the implant site.

A method and apparatus for performing mitral valve chordal repair on a patient include attaching at least one filament to a mitral valve leaflet and to a papillary muscle. A first end of a filament can be attached to the mitral valve leaflet and the length of the filament can be adjusted by adjusting the tension of the filament in a catheter. The second end of the filament can be attached to an attachment site.

A bone milling instrument is disclosed for creating a shaped cavity from an initial cavity in a bone, the bone milling instrument comprising a reference frame, a centering member at the distal end of the reference frame, a registration surface for engaging a portion of the initial cavity, and an attachment site provided proximally of the registration surface, a guidance support member, an attachment mechanism at the first end of the guidance support member, and a constrained pathway extending between the ends of the guidance support member; a shuttle having a first connection element configured for positionably attaching the shuttle to the guidance support member, and a second connection element configured to provide a rotational coupler; and a cutting device having a cutting portion configured at a distal end thereof, and an attachment portion provided at a proximal end.

Creating an anastomosis, or the surgical formation of a passage between two normally distinct vessels or lumens, is enhanced by an applier that introduces a ring device without the need for a separate anvil to form a hollow rivet shaped attachment. Moreover, the ring device may be advantageously formed in a cylindrical shape from molded polymer material or stamped from sheet metal with proximal and distal rings connected by proximal and distal arms that respectively form hinged, ring shaped so appose tissue walls. A center ring or portion sits in the attachment site. The applier causes actuating by moving the rings relative to one another. A latching mechanism locks the rings in the actuating state.

Conductive polymers having a star structure comprising a central core with multiple attachment sites and conjugated charge transporting arms radiating therefrom. The cores are derived from hyperbranched polymers, dendrimers, or other molecules with a multiplicity of attachment sites. The arms are derived from conjugated oligomers and polymers such as polythiophene, polyaniline or polyphenylene. The subject polymers allow assembly of the macromolecules in all three dimensions in the solid state. A ramification of the compact assembly is the realization of highly reflective, smooth coatings simply applied from solution. A preferred embodiment having a 1,3,5 hyperbranched polyphenylene core and poly (3-hexylthiophene) arms provides lustrous reflective gold coatings.

A system for delivering magnetic stimulation to a subject that has a magnetic stimulation coil, a power source, and a patient-positioning device is provided. The magnetic stimulation coil is movably connected to patient-positioning device for fixably positioning the magnetic stimulation coil to stimulate a region of a subject and electrically connected to the power source. A cooling system maintains the magnetic stimulation coil between a temperature of about 5° C. and about 40° C. during operation of the coil for a period of at least 90 minutes. An attachment site for a second magnetic stimulation coil is provided, and the second magnetic stimulation coil is optionally movably connected to the patient-positioning device for positioning the second magnetic stimulation coil independently of the first magnetic stimulation coil to provide a combination delivery of magnetic stimulation to a second region of the subject.

A method for preparing water-stable semiconductor nanocrystal complexes that can be stably coupled to tertiary molecules using a self-assembled coating of diblock polymers. The diblock polymers have hydrophilic ends containing hydrophilic functional groups and hydrophobic ends containing hydrophobic functional groups. The diblock polymers are assembled around a semiconductor nanocrystal having a lyophilic surface outer layer. The diblock polymers are further crosslinked via bridging molecules that link adjacent diblock polymers through the hydrophilic functional groups of the hydrophilic ends of the diblock polymers to form a semiconductor nanocrystal complex. The functional groups present on the outer surface of the amphiphilic diblock polymer may serve as attachment sites for coupling tertiary molecules to the semiconductor nanocrystal complex.

Described herein are nasal respiratory devices including an attachment site for a sensors and sensor adapters for securing at least a portion of a sensor to a nasal respiratory device. Sensor adapters typically have a body frame having at least two regions: an attachment region for securing the sensor adapter to the nasal respiratory device; and a sensor connector region for securing a sensor across from an outlet of the nasal respiratory device.

Apparatus and methods for use in measurement of applied load at a chainring assemblage of a pedal powered device are provided. The apparatus includes a link adapted for interposition between a chainring attachment site located on a conventional chainring mount, or spider, and a corresponding chainring attachment locale at a conventional chainring. The link has a geometry and/or material composition selected to accommodate measurement of load exhibited between the attachment site and the corresponding chainring attachment locale. Means for measuring the load exhibited thereby is associated with the link.

Heterodimeric polypeptide conjugates exhibiting FSH activity, comprising a dimeric polypeptide comprising an FSH-.alpha. subunit and an FSH-.beta. subunit, wherein at least one of the FSH-.alpha. and FSH-.beta. subunits differs from the corresponding wildtype subunit in that at least one amino acid residue acid residue comprising an attachment group for a non-polypeptide moiety has been introduced or removed, and having at least one non-polypeptide moiety bound to an attachment group of at least one of said subunits are provided. Preferably, at least one attachment group, e.g., an N- or O-glycosylation site or an attachment site for a polymer molecule such as polyethylene glycol, has been introduced, e.g., at an N-terminal. The polypeptide conjugates exhibit improved properties, in particular an increased half-life, compared to human FSH.

Creating an anastomosis, or the surgical formation of a passage between two normally distinct vessels or lumens, is enhanced by an applier that introduces a ring device without the need for a separate anvil to form a hollow rivet shaped attachment. Moreover, the ring device may be advantageously formed in a cylindrical shape from molded polymer material or stamped from sheet metal with proximal and distal rings connected by proximal and distal arms that respectively form hinged, ring shaped so appose tissue walls. A center ring or portion sits in the attachment site. The applier causes actuating by moving the rings relative to one another. A latching mechanism locks the rings in the actuating state.

Articles and methods for growing or analyzing tissues and organs using bioreactors or other devices and components are provided. In some embodiments, a bioreactor is configured to provide a growth chamber having one or more inlets, outlets, sensors, organ attachment sites, and/or organ identifiers.