289 results about "Aortic valve" patented technology

Apparatus and methods are described including delivering a left-ventricular assist device to a subject's aorta. The device including a distal-tip element that defines a straight proximal portion, and a curved distal portion, the curved distal portion defining first and second curves with an elongated straight portion between the first and second curves. The distal-tip element is centered with respect to the aortic valve using the curved distal portion of the distal-tip element, to thereby guide the device through the subject's aortic valve atraumatically. A pump pumps blood through from the subject's left ventricle to the subject's aorta. Other applications are also described.

Apparatus and methods are described including delivering a left-ventricular assist device to a subject's left ventricle. A tube is positioned such that a proximal portion of the tube traverses an aortic valve of the subject, and a distal portion of the tube is disposed within a left ventricle of the subject. A pump pumps blood through the tube from the subject's left ventricle to the subject's aorta such as to cause the proximal portion of the tube to be maintained in an open state, and to cause at least a portion of the tube to become curved. Other applications are also described.

The invention relates to the technical field of heart blood pumps, in particular to a passive ventricular auxiliary circulation device. Comprising a motor body shell, a stator and a rotor are arranged in the motor body shell, and one of the stator and the rotor comprises a coil; the axial flow channel shell is sleeved; the upper end of the axial flow channel shell is configured to face the aortic valve to the lower part of the ventricle, and a power supply configured to be operably coupled to the coil; and the controller is configured to be operated and coupled to the power supply to select and control the power supply to change the rotor to a certain rotating speed in a manual selection mode, then the rotor keeps working in a certain rotating speed mode, and corresponding auxiliary pressure output by the fluid outlet interface is configured at a different rotating speed. The device is controlled to be in a rotating speed state, and when systolic pressure smaller than normal systolic pressure is provided for cardiac pulsation of a heart failure patient, the normal systolic pressure is provided when the systolic pressure and auxiliary pressure are overlapped together, so that the heart failure patient maintains the normal systolic pressure.

The present invention discloses a presettable artificial biological aortic valve which comprises a valve seat (1), a valve leaflet stent (2) and three valve leaflets (3), wherein the valve seat (1) is a one-way limiting expandable annular metal seat; the head end of each seat body unit (4) is sequentially provided with a first rivet (7), a limiting protrusion (6) and a first long circular groove (5) from the outside to the inside; the tail end of each seat body unit (4) is sequentially provided with a second long circular groove (8), a second limiting hole (10) and a first limiting hole (9) matched with the limiting protrusion (6), and a second rivet (11) matched with the first long circular groove (5). The presettable artificial biological aortic valve has an original preset state and a normal use state after one-way limiting expansion.

In some embodiments, a method includes providing a prosthetic heart valve including a collapsible and expandable stent having struts and a valve assembly coupled to the stent, the valve assembly having a plurality of leaflets and a cuff, providing a delivery device including a catheter extending between a proximal end and a distal end, an inflatable balloon, a handle coupled to the catheter, and a memory for storing data disposed within the handle, recording at least one of part-to-part noise factors and process variation factors and storing it in the memory, calculating an adjusted inflation parameter based on the at least one of part-to-part noise factor and process variation factor, advancing the delivery device to a native aortic valve of a patient while the prosthetic heart valve is disposed about the inflatable balloon, and inflating the balloon according to the adjusted inflation parameter.

The present disclosure relates to the field of medical device technology, and specifically to a cardiac outflow tract valved patch, which includes a sinus wall support sheet and a valve leaflet; the lower edge of the valve leaflet is arc-shaped, and the lower edge of the valve leaflet is connected to the sinus wall support sheet, and a valve pocket is formed between the valve leaflet and the sinus wall support sheet; between the upper edge of the valve leaflet and the lower edge of the valve leaflet, an upper edge arm protrudes from the outside of the valve leaflet, and the end of the upper edge arm is used to connect to the sinus wall support sheet. After the heart is repaired with the cardiac outflow tract valved patch in this scheme, as the size of the cardiac outflow tract increases, the extension of the upper edge arm increases accordingly, so that the size of the opening of the valve pocket formed between the valve leaflet and the sinus wall support sheet also increases accordingly, thereby ensuring that the aortic valve will not be incompletely closed.

The invention provides an adjustable structure, comprising: a variable catheter provided with a projecting portion; the protruding part comprises an outer protruding side and an inner protruding side, and the protruding height of the outer protruding side is larger than the protruding height of the inner protruding side. The invention further provides a guide wire assisted transvalvular device comprising the adjustable structure. The transverse position of the far end of the variable catheter is controlled by adjusting the protruding height, so that the valve crossing device can be stably fixed to the aortic valve opening, a guide wire located in the adjusting pipe can conveniently and smoothly cross the aortic valve opening, and preparation is made for a subsequent TAVA operation.

The present application relates to the field of medical devices, and specifically to an aortic valve auxiliary prosthesis for preventing regurgitation, comprising: a main body, which is configured to remain in place in the aorta at the surgical site; and three auxiliary leaflet segments configured to cooperate with the three free segments of the native leaflets of the aortic valve; the three auxiliary leaflet segments are fixed to the main body. The present invention allows the original native leaflets to be retained, and when the native valve is closed, the purpose of improving the prevention of regurgitation is achieved by overlapping and covering the free segments of the native valve, with significant therapeutic effects and stronger targeting. Since the native valve is retained, most of the impact force of blood when flowing is still on the native valve, the reliability requirements for the fixed positioning of the main body are low, and the morphological changes to the native valve are smaller.

Disclosed herein are representative embodiments of methods, apparatus, and systems used to deliver a prosthetic heart valve to a deficient valve. In one embodiment, for instance, a support structure and an expandable prosthetic valve are advanced through the aortic arch of a patient using a delivery system. The support structure is delivered to a position on or adjacent to the surface of the outflow side of the aortic valve (the support structure defining a support-structure interior). The expandable prosthetic valve is delivered into the aortic valve and into the support-structure interior. The expandable prosthetic heart valve is expanded while the expandable prosthetic heart valve is in the support-structure interior and while the support structure is at the position on or adjacent to the surface of the outflow side of the aortic valve, thereby causing one or more native leaflets of the aortic valve to be frictionally secured between the support structure and the expanded prosthetic heart valve.

The limiting expandable aortic valve pipeline comprises an aortic valve preliminary pipeline attached with a collagen fiber coating, and the aortic valve preliminary pipeline comprises a proximal pipeline, a valve connecting pipe and a telecentric pipeline. The invention also discloses a preparation method thereof. The limiting expandable aortic valve pipeline provided by the invention is used for replacing an aortic artificial blood vessel and a Bentall type operation of an aortic valve, and after the artificial bioprosthetic valve declines, the limiting expandable aortic valve pipeline provided by the invention provides a condition for embedding the artificial bioprosthetic valve with the same size as an original valve in an interventional manner, so that the limiting expandable aortic valve pipeline can be used for replacing the Bentall type operation of the aortic valve and the artificial bioprosthetic valve. In this way, after the bioprosthetic valve declines, the valve with the same size as the original valve can be placed in an interventional mode, and the patient does not need to open the chest to replace the bioprosthetic valve with the same size.

The invention relates to the technical field of medical image processing, in particular to an aortic valve automatic segmentation method based on a multi-temporal CTA image. The method comprises the following steps: identifying a laminar flow dark area and a vortex bright area on a cross section of an aortic sinus area; according to the first feature size of the laminar flow dark area and the second feature size of the vortex bright area, the valve leaflet-sinus wall spacing is determined; determining a first deviation index according to the change trend of the valve leaflet-sinus wall spacing in the cardiac cycle; determining a second deviation index according to a difference characteristic between the CT value of the laminar flow dark area and the CT value of the eddy current bright area; if the first deviation index and the second deviation index both exceed the corresponding threshold values, judging that the data is in a to-be-corrected time phase; correcting the spacing by using the correction weight calculated by the second deviation index; and extracting key parameters of each time phase on the longitudinal section, and associating the corrected valve leaflet-sinus wall spacing to construct a valve three-dimensional dynamic model, thereby facilitating the three-dimensional dynamic model to output more accurate valve motion data.

The invention discloses an aortic valve function evaluation device which comprises a processor and a memory, and the memory stores programs or instructions capable of running on the processor. When the program or the instruction is executed by the processor, the following steps are realized: acquiring a first echocardiogram of a target object corresponding to a final systole and a second echocardiogram of a target object corresponding to a final diastole in a cardiac cycle, and acquiring medical record data of the target object; determining a first mask pattern corresponding to the first echocardiogram and a second mask pattern corresponding to the second echocardiogram according to the first echocardiogram, the second echocardiogram and an aortic valve segmentation model; determining an aortic valve morphological index of the target object according to the first mask pattern and the second mask pattern; determining aortic valve functional indexes of the target object according to the medical record data of the target object; and determining and outputting an aortic valve function evaluation result of the target object according to the first mask pattern, the second mask pattern, the aortic valve morphological index and the aortic valve functional index.

The invention belongs to the technical field of cell mechanics biology experiment devices for health and rehabilitation engineering, and relates to a microfluidic device for endothelialization evaluation of a tissue engineering valve, which comprises a microfluidic chip, peripheral equipment, a signal acquisition and processing system and a feedback system. The biomechanical principle and the micro-fluidic chip technology are ingeniously combined, the control system, the mechanical loading device and the micro-fluidic chip are connected, a micro-fluidic endothelial cell culture cavity and a peripheral system are constructed, real-time accurate control over aortic valve blood flow is achieved through the PID control system, and the system is suitable for large-scale popularization and application. Shear stress applied to a tissue engineering valve endothelial cell culture area is generated, so that the real stress condition of the tissue engineering valve endothelial cells is simulated, and the method is used for analyzing and researching the influence rule of mechanical loading on the tissue engineering valve endothelial cells.

Methods for determining likelihood of thrombosis based on patient-specific anatomic, valve, and flow parameters are disclosed herein. Such methods are used to select a transcatheter aortic valve that decreases likelihood of thrombosis after TAVR procedures. The methods correlate a number of fluid flow and geometric parameters such as stasis volume, neo-sinus volume, kinematic viscosity, dynamic viscosity, heart rate, the circulation, ejection time, velocity of the main jet, wall shear stress, total kinetic energy in the neo sinus volume, width of the neo-sinus, height or depth of the neo-sinus, the angle between the velocity direction and the stent of the transcatheter valve, the distance from the tip of the leaflet perpendicular to the leaflet edge and intersecting the sinotubular junction, and the cross-sectional area of the neo-sinus taken from a longitudinal or axial perspective. Such parameters are used to derive empirical or semi-empirical mathematical models to determine the likelihood of thrombosis.

Devices, systems and methods for filtering embolic particles that may be generated from a medical procedure including protection of the major branching vessels from the aorta, and catches and filters emboli that may be generated during the TAVR procedure. The filter devices disclosed herein form an improved seal against the vessel wall that is activated by flowing blood. Devices described herein also allow for the closing of the ends of the filter device after capture of emboli, providing further security against accidental loss of emboli post capture.

A non-invasive diagnostic system assesses the optimal timing for aortic valve replacement (AVR) by quantifying left-ventricular Frank-Starling reserve before irreversible myocardial damage occurs. The system (i) acquires left-ventricular ejection time (LVET) and other systolic-time intervals from optical or vibrational sensors positioned on the patient, (ii) induces a reversible preload change—e.g., passive leg raise or posture transition—to create a controlled venous-return increment, (iii) processes the paired baseline and post-maneuver waveforms to extract systolic time interval metrics, and (iv) analyzes the ΔLVET / Δpreload relationship against historical or population references. A diminished LVET response signals loss of contractile reserve, enabling timely AVR while myocardial changes remain reversible. The platform integrates measurement hardware, a data-processing engine, a data-analysis module, and a reporting interface, and may be configured as a wrist, ring, chest, or ear sensor. The method can be implemented at point-of-care without operator-dependent imaging or invasive monitoring.

The invention provides a stepped ventricle auxiliary circulating pump device, relates to the technical field of heart blood pumps, and provides a structure that a heart blood pump is arranged in a heart chamber and below an aortic valve or a pulmonary valve, and a stepped motor and an axial flow channel are designed on the basis, so that a blood flow channel is formed between the motor and the axial flow channel; the blocking influence of the size of the motor above the aortic valve or the pulmonary valve on the blood circulation process can be effectively avoided, and the amount of blood pumped out of the aortic valve or the pulmonary valve is effectively increased.

An assessment of basal cardiac fitness uses noninvasively obtained physiological measures to determine the presence of a basal physiological state and cardiometric measures to determine cardiac fitness. In the presence of preload independence and cardiac vagal control, cardiometric signals are acquired that are sensitive to cardiac function and include information indicative of the opening and closing of the individual's aortic valve. The cardiometric signals are analyzed by a cardiac fitness assessment system for the determination of basal cardiac fitness. The invention assures preload independence through the assessment of observational physiological parameters or the use of physiological parameters obtained following alterations in venous return. The invention assures the presence of cardiac vagal control by assessment of measured parameters, including the presence of respiratory sinus arrhythmia. The resulting test is specific for cardiac function without dependencies on physical activities associated with heart rate elevation or respiratory capabilities.

The application discloses an aortic valve guide wire and a use method thereof, which comprises a head section, a transition section and a support section connected in sequence along an axial direction; the head section is composed of a polymer and further comprises a deformation capsule, at least one closed unit embedded in the head section, and an internal sealing electric field sensitive viscoelastic fluid; a mesh cable is arranged on the surface of the deformation capsule and extends to the transition section; the transition section and the support section are provided with a conductive film on the surface, and the conductive film is connected with the mesh cable and used for applying a non-uniform electric field to the deformation capsule to generate a regional viscosity difference and drive the head section to bend in a direction.The electric field sensitive viscoelastic fluid built in the head section generates a regional viscosity difference under the action of the non-uniform electric field, and the difference is converted into a directional bending moment through the synergistic effect of the mesh cable and the conductive film, so that the head of the guide wire can quickly respond to an external electric signal and accurately deflect.

The application discloses a guide wire transvalvular guide device for aortic valve replacement surgery, comprising: an inner tube providing a guide wire channel, the distal end of the inner tube being a guide wire outlet; the multiple far-end bags are isolated from one another, and the far-end bags are sequentially arranged on the periphery of the inner tube in the circumferential direction; the outer tube is slidably arranged on the periphery of the inner tube in a sleeving mode, and the far-end bag can be stored to adapt to interventional delivery; the inner tube and the outer tube are controlled by the control handle, a plurality of near-end bags are arranged in the control handle, and the near-end bags and the far-end bags are communicated in a one-to-one correspondence mode and are loaded with fluid; the driving sleeve and the rotating sleeve are arranged on the peripheries of all the near-end bags in a sleeving mode, an extrusion part protruding inwards in the radial direction is arranged in the driving sleeve, and when the driving sleeve rotates, the extrusion part acts on the near-end bags and enables the far-end bag exposed out of the outer tube to deform so as to change the pointing direction of the guide wire outlet. Through mutual linkage of the far-end bag and the near-end bag, the guide wire outlet direction is accurately adjusted, the interventional delivery and release performance is optimized, and the operation efficiency and convenience are improved.

According to the arteriosclerosis detection method and device, the upper arm blood pressure is obtained based on the heart and ankle vascular index CAVI; systolic pressure Ps and diastolic pressure Pd are obtained; calculating to obtain a pulse pressure difference delta P, wherein the pulse pressure difference delta P = systolic pressure Ps-diastolic pressure Pd; measuring to obtain the distance Lca from the heart aortic valve to the ankle; measuring to obtain the time difference Tca of the pulse wave propagating from the heart to the ankle; a heart and ankle vascular index CAVI is obtained through calculation according to the following formula; # imgabs0 # is used for measuring and obtaining a pulse wave starting point time point TA1 of the ankle; measuring a pulse starting point TA2 of brachial artery pulse waves, and calculating TA1 to TA2 to obtain a time difference Tba; measuring to obtain a heart sound signal of cardiac pulsation, and obtaining a time difference T2 between a second heart sound and a first incision of the brachial artery; the time difference Tca is equal to the sum of the time difference Tba and the time difference T2. At least three blood pressure measuring devices and at least three electrocardio detection electrodes are arranged; the heart sound detection module is in electric signal connection with the heart sound detection sensor through a signal line; the heart sound detection sensor is used for being placed at the heart position of a detected person to obtain heart sound signals.

The invention discloses a valve stent, an aortic valve and a mitral valve, and the valve stent comprises a valve stent which is of a latticed annular stent structure formed by cutting a metal tube; the outer frame is of a latticed or semi-latticed annular support structure formed by cutting a metal pipe, the outer frame wraps the outer side of the valve frame and is connected with the valve frame, and a first positioning unit is integrally formed on the outer frame; the first positioning unit comprises a plurality of supporting legs arranged in the circumferential direction of the outer frame, and the supporting legs are obtained by outwards bending and forming two adjacent edges in the grids or half grids of the outer frame in the circumferential direction, so that when the outer frame is implanted into the implantation position of the inner side of the autologous valve leaflet, the first positioning unit can be supported on the inner side of the autologous valve ring; the valve support is limited to move in the direction opposite to the heart blood flow direction. When the valve support is anchored through the outer support, the valve support provided with the outer support can still have the small radial size, and the implanting difficulty of the valve and the requirement for a conveying system are lowered.

The subject of the invention is a delivery system for delivering a self-expanding endoluminal prosthesis to the patient's ascending aorta and aortic valve, the system comprising: - an inner tube (33), extending along a longitudinal Y axis of the delivery system (100), from an atraumatic distal tip (27) to a handle (37); - a metal tube (32), slide-fitted on the inner tube (33), and extending from the internal space of the distal tip (27) to a handle (37); - an outer tubular catheter shaft (22) slide-fitted on the metal tube (32), the catheter shaft (22) is brought out from the handle (37) and is terminated by a capsule (20), containing inside the radially compressed on the metal tube (32), self-expanding endoluminal prosthesis (1) having defined construction and covered at least partially by a coating (16), - the capsule (20) has closed position when is closed by the tip (27) and has open position when the capsule (20) and the tip (27) are displaced relative to each other; wherein the distal part of the metal tube (32) is equipped with receiving means (41, 42) on which the distal locking means (7) of prosthesis (1) are removably embedded and blocked in the inner space of the tip (27) and the delivery system (100) comprises also removable holding means (45, 45') retaining the proximal locking means (9) of the prosthesis (1), so that when the capsule (20) is in its fully open position, the prosthesis (1) is still maintained partially compressed, holding its crimping length.

The present invention relates to compounds, pharmaceutical compositions, combined preparations, and dosage regimens for treating, inhibiting the progression, and preventing cardiovascular calcification, and in particular, coronary calcification, aortic artery calcification, and aortic valve calcification comprising inositol phosphates. In a particular aspect the disclosure provides a dosage regimen for treating, inhibiting the progression, or preventing cardiovascular calcification comprising the administration of about 200 mg to about 700 mg of myo-inositol hexaphosphate per administration.

The present invention provides methods and systems that provide for reliable, convenient, and noninvasive assessment of hydration status. The methods and apparatuses can use the temporal sequence of the aortic value opening and closing along with the user's body position to derive parameters that determine the hydration status of the user. The user can use this information to make near-term lifestyle changes that can improve physical performance, health, and general wellbeing.

The invention relates to a prosthetic heart valve (100) for an endoprosthesis (1) used in the treatment of a stenotic cardiac valve and / or a cardiac valve insufficiency. The prosthetic heart valve (100) comprises of a plurality of leaflets (102), which consist of a natural and / or synthetic material and have a first opened position for opening the heart chamber and a second closed position for closing the heart chamber, the leaflets (102) being able to switch between their first and second position in response to the blood flow through the heart. In addition, the prosthetic heart valve (100) comprises a leaflet support portion (103), consisting of biological and / or synthetic material for mounting of the prosthetic heart valve (100) to a stent (10), and a bendable transition area (104) which forms a junction between the leaflets (102) and the leaflet support portion (103), the transition area (104) progressing essentially in a U-shaped manner similar to a cusp shape of a natural aortic or pulmonary heart valve for reducing tissue stresses during opening and closing motion of the leaflets (102). The invention further relates to an endoprosthesis (1) comprising a prosthetic heart valve (100) and a stent (10).

A catheter device is disclosed comprising; an elongate sheath (503) with a lumen and a distal end for positioning at a heart valve (6), an embolic protection device (200) for temporarily positioning in the aortic arch for deflection of embolic debris from the ascending aorta to the descending aorta, said embolic protection device is connectable to a transluminal delivery unit (130) extending proximally from a connection point (131), and having: a frame with a periphery, a blood permeable unit within said periphery for preventing embolic particles from passing therethrough with a blood flow downstream an aortic valve into side vessels of said aortic arch to the brain of a patient, and at least one tissue apposition sustaining unit (300, 350) extending from said catheter, into said aortic arch, and being attached to said embolic protection device at a sustaining point (502), for application of a stabilization force offset to said connection point at said embolic protection device, such as at said periphery, and for providing said stabilization force towards an inner wall of said aortic arch, away from said heart, and in a direction perpendicular to a longitudinal extension of said periphery, when said catheter device is positioned in said aortic arch, such that tissue apposition of said periphery to an inner wall of said aortic arch is supported by said force for improving stability and peripheral sealing. In addition related methods are disclosed.

A catheter assembly for retaining a prosthetic valve as the prosthetic valve is guided to a point of delivery within a patient is provided with radioscopic markers. The markers are distributed within the catheter assembly such that an observer may discern a rotational orientation of the assembly from a radioscopic image of the assembly within the patient. Delivery of the prosthetic valve may include aligning the markers with the commissures of the prosthetic valve and radioscopic observation of the location or movement of the markers to rotationally align the prosthetic valve with a native valve within the patient, such as by aligning the commissures of the prosthetic valve with the commissures of the native valve.

Various arrangements for measuring blood pressure using radar are presented herein. Radio frequency (RF) signals may be emitted and RF reflection signals can be received in response. The RF reflection signals can be analyzed at a first distance range and a second distance range to identify a first time of a pulse pressure wave at an aortic valve of a user and a second time of the pulse pressure wave at an extremity of the user, respectively. A pulse transmit time (PTT) of the pulse pressure wave from the aortic valve of the user to the extremity of the user using the first time and the second time can be determined. Using the PTT, a blood pressure of the user can then be determined.

An adjustable structure, comprising: a variable catheter (101) and an adjustment tube (103), wherein the variable catheter (101) is provided with a protrudable portion (102), which comprises an outer protruding side (1023) and an inner protruding side (1024), the height by which the outer protruding side (1023) can protrude being greater than the height by which the inner protruding side (1024) can protrude. A guidewire-assisted transvalvular device (100) comprising an adjustable structure. The lateral position of the distal end of the variable catheter (101) is controlled by means of adjusting the protruding height, so that the guidewire-assisted transvalvular device (100) can be stably fixed at the aortic valve orifice, making it convenient for a guidewire located inside the adjustment tube (103) to smoothly cross the aortic valve orifice so as to prepare for a subsequent TAVR procedure.