23 results about "Cardiopulmonary bypass time" patented technology

A composition useful for priming a heart-lung bypass machine is provided. The composition contains polyethylene glycol polymers (PEG) with a molecular weight of 18,000-100,000 Da at a concentration of 5-30% w / v; and water, wherein the PEG with a molecular weight of 18,000-100,000 Da is dissolved or dispersed in said water. The composition may further include PEG with a molecular weight of 1,000-10,000 Da at a concentration of 1-30% w / v dissolved or dispersed in said water. Methods for priming a heart-lung bypass machine and treating cardiopulmonary bypass injury are also provided.

Customizable and intuitive user interfaces are provided for medical systems and devices, such as cardiopulmonary bypass systems, perfusion systems, extracorporeal circulation apparatus, and heart-lung machines, that allow easy access to critical patient data to facilitate blood perfusion, as well as monitoring and adjusting various physiological parameters of the patient and extracorporeal blood flow circuit during procedures such as cardiopulmonary bypass and extracorporeal membrane oxygenation (ECMO).

A method for performing a robotic-assisted orthotopic heart transplant includes forming a working port subareolarly by a mini-thoracotomy at a working intercostal space, forming additional ports for robotic arms, and arranging robotic arms through the ports. A first robotic arm with first forceps extends through a second port lateral to a mid-clavicular line, while second and third robotic arms containing an imaging device and second forceps operate through the working port. A fourth robotic arm with scissors or needle holder extends through a third port proximal to an anterior axillary line. The method includes cannulating for cardiopulmonary bypass, opening the pericardium, cross-clamping the aorta, removing the native heart, and performing sequential anastomoses of the donor heart including the left atrium, pulmonary artery, aorta, inferior vena cava, and superior vena cava.

The present disclosure describes, in part, arterial cannula systems for extracorporeal membrane oxygenation and cardiopulmonary bypass provides pulsatile blood flow and selective flow distribution. The cannula comprises a multi-lumen structure including a central lumen for blood flow, dedicated lumens for helium delivery, a distal orifice for body perfusion, and proximal orifices for limb perfusion. An inflatable cuff positioned between the distal and proximal orifices modulates blood flow through rapid inflation and deflation cycles achieved in milliseconds using helium gas. An external control console with microcontrollers and customized software automates the inflation-deflation cycles based on physiological inputs including ECG, arterial pressure, and tissue oxygenation. The system restores physiologically effective pulsatile flow, prevents limb ischemia, reduces thrombus formation risk, and can provide ECG-synchronized flow modulation to facilitate native cardiac ejection, potentially eliminating the need for separate left ventricular venting during mechanical circulatory support.

The present invention relates to the field of medical diagnosis technology, and particularly to a method and system for detecting acute kidney injury based on missing data. The present invention obtains the preoperative creatinine abnormality degree according to the difference in serum creatinine data between the patient to be tested and similar patients during the preoperative analysis period, and obtains the initial postoperative creatinine abnormality degree according to the change rate and prominence of the serum creatinine data at each moment during the postoperative analysis period of the patient to be tested; based on the difference between the preoperative creatinine abnormality degree and the initial postoperative creatinine abnormality degree, and the difference between the blood loss and the blood transfusion volume, the final postoperative creatinine abnormality degree is obtained, and the acute kidney injury of the patient to be tested is detected by combining the preoperative creatinine abnormality degree and the total urine volume during the postoperative analysis period. The present invention reduces the influence of cardiopulmonary bypass on the postoperative serum creatinine abnormality degree according to the changes in the serum creatinine abnormality degree before and after surgery and the difference between the blood loss and the blood transfusion volume, and combines the preoperative creatinine abnormality degree and the urine volume to improve the accuracy of detecting acute kidney injury in the patient to be tested.

This application provides a data processing method for predicting neurocognitive disorders in patients undergoing cardiopulmonary bypass surgery. This method obtains physiological monitoring data from a target patient during cardiopulmonary bypass, then uses a preset neurocognitive disorder prediction model to determine a neurocognitive disorder prediction feature value based on the physiological monitoring data. When the neurocognitive disorder prediction feature value is determined to be greater than a preset feature threshold, the method outputs neurocognitive disorder warning information, thereby predicting the risk of neurocognitive disorders in patients undergoing cardiopulmonary bypass surgery and providing early warning.

A blood pump-oxygenator system for increasing perfusion and oxygen level in a patient comprises a blood flow inlet and outlet forming a circuit operable as a cardiopulmonary bypass system for extracorporeal processing of blood, a first blood pump and first oxygenator. The first blood pump conveys blood through the circuit from the patient into the blood flow inlet, through the first oxygenator and out of the blood flow outlet back into the patient. The system further comprises a second blood pump and second oxygenator. The second blood pump conveys blood through the circuit from the patient into the inlet, through the second oxygenator and out of the outlet back into the patient. A pump control unit controls the first and second pumps to increase or decrease blood flow rate through the respective oxygenator to vary a ratio of flow rates of blood through the first and second oxygenators.

The utility model discloses an extracorporeal circulation puncture suite which comprises a dilator, a puncture accessory and a suture accessory, and the dilator used for blood vessel dilation, the puncture accessory used for puncture and the suture accessory used for fixing a pipeline are sealed in a packaging bag body after being sterilized through ethylene oxide. The dilator is provided with dilation heads for dilating blood vessels continuously in a staged mode, and the number of the dilation heads on the dilator can be adjusted. The extracorporeal circulation puncture kit has the advantages that the multi-stage dilator with the adjustable dilation head in the extracorporeal circulation puncture kit is used for performing staged continuous dilation on blood vessels, repeated replacement of the dilator is avoided, the risk of infection of a patient is reduced while the operation efficiency is improved, and due to the staged continuous dilation, intubation tubes of different specifications are high in universality and high in practicability. Due to the design that the hydrophilic coating and the hardening material are additionally arranged on the guide wire, the surface of the guide wire is smoother, puncture catheterization is smoother and more accurate, due to the arrangement of the suture accessory, the problems of intubation fixing and skin wound suture are solved in a clinical one-stop mode, and the preparation workload of clinical operations is reduced.

The application relates to a blood temperature regulating device, method and cardiopulmonary bypass system. The device comprises a semiconductor refrigeration device in contact with a blood pipeline to be regulated in temperature. A current sensor is electrically connected with the semiconductor refrigeration device and used for collecting working current. A temperature sensor is arranged on the blood pipeline and used for collecting the actual temperature of the blood pipeline. A temperature control circuit is electrically connected with the semiconductor refrigeration device and used for providing working current for the semiconductor refrigeration device. A control module is used for determining a target voltage according to the actual temperature and a target temperature of the blood pipeline. The actual voltage of the semiconductor refrigeration device is determined according to the working current, and the temperature control circuit is controlled to adjust the amplitude and direction of the working current according to the actual voltage and the target voltage of the semiconductor refrigeration device. In summary, the device of the application regulates the temperature of the blood pipeline twice, ensures that the temperature of the blood pipeline is consistent with the target temperature, and improves the accuracy of temperature regulation of the blood pipeline.

To optimize intraoperative visualization of the mitral valve during intraoperative assessment of valvular regurgitation, a device according to the present invention provides an alternative method of filling the LV. The device can also provide direct coronary ostial and standard antegrade aortic root cardioplegia. A novel cannula is used in conjunction with the heart-lung machine during open-heart surgery. The device described herein features an additional port with extension tubing to be advanced through the aortic valve in a retrograde manner, resulting in an extended piece of tubing sitting in the left / right ventricle or coronary ostia. This new tubing can deliver cardioplegia or saline into the coronary ostia (cardioplegia) or left / right ventricle (saline). The coronary ostia are perfused thereafter with cardioplegia in standard fashion. The left / right ventricle may be distended with known pressure and / or volume, allowing the surgeon to assess the mitral valve in a hands-free and more physiologic loaded manner.

A balloon occlusive aortic cannula having a hollow cannula and an inflation lumen having a distal end and an expandable element surrounding the hollow cannul and having an exterior surface. The expandable element is disposed on the distal end of the inflation lumen. The expandable element having a micro surface texture formed on the exterior surface. The micro surface texture having a plurality of surface features configured to engage an aortic wall and form a fluidic seal therebetween during a cardiopulmonary bypass procedure.

Circulatory failure generates hypoxia and leads to accumulation of reductive species in tissue and circulatory failure monitoring tools are needed but rare. Cardiopulmonary bypass (CPB) is known to promote brief circulatory failure during its initiation. In the present study, the Inventors demonstrate a correlation between whole blood redox potential and circulatory failure during (CPB). They made a prospective study with 17 patients eligible for cardiac surgery with cardiopulmonary bypass. They demonstrated a frank reduction of the whole blood redox potential during circulatory failure during the initiation of CPB. They also demonstrated that they were able to classify patients in 3 groups, one of them presenting an unfavorable post-operative outcome. Accordingly, the present invention relates to a method of diagnosing acute circulatory failure in a patient comprising determining the level of redox potential in a sample obtained from said patient, wherein the level of redox potential indicates whether the patient suffers or not from an acute circulatory failure.

The blood pump-oxygenator system (1; ,...; 10) comprises at least one blood pump (11), at least one oxygenator (20, 21), a blood inlet (80) and a blood outlet (90) connected together to form a circuit operable as a cardiopulmonary bypass system suitable for extracorporeal treatment of patient blood, wherein the first blood pump (11) is configured to deliver blood through the circuit from the patient (P) to the blood inflow port (80), through the oxygenator (20, 21) and out of the blood outflow port (90) back into the patient (P). The system (1; ,...; the device (10) further comprises a recirculation loop (100) arranged between the blood inlet (80) and the blood outlet (90), where the recirculation loop (100) houses a first blood pump (11) and an oxygenator (20, 21), where the first blood pump (11) is configured to circulate at least a portion of the blood in the loop through the recirculation loop (100) such that the blood passes through the oxygenator (20, 21) multiple times, and where the first blood pump (11) is configured to circulate at least a portion of the blood in the loop through the recirculation loop (100). Blood is repeatedly subjected to an exchange of O2 and CO2 in oxygenators (20, 21). At least one first valve (31) is provided between the recirculation loop (100) and the blood flow outlet (90) and is configured to control an amount of blood flowing through the recirculation loop (100).

This image is intended to show the predetermined pressures in the blood circuit through which the patient's blood circulates in a cardiopulmonary bypass machine. In the upper section, the pressures at points located from left to right on the blood withdrawal side (upstream) to the blood infusion side (downstream) of the circuit are displayed, and in the lower section, the differential pressure between each point is displayed. The differential pressure display in the lower section is positioned midway between the two point pressure displays in the upper section, allowing the user to visually confirm which points the differential pressure represents.

The application discloses a cardiopulmonary bypass system, comprising: a consumable kit comprising a pre-charging device and an extracorporeal circulation line; and the control host is detachably connected with the consumable sleeve bag, the control host is further provided with a power output part, and after the consumable sleeve bag and the control host are assembled, the power output part is in butt joint with the pre-filling device and can be used for controlling the pre-filling device to conduct pipeline pre-filling on the extracorporeal circulation pipeline. By arranging the pre-charging device in the consumable sleeve bag, the extracorporeal circulation pipeline can be directly pre-charged and is driven by the control host, automatic control over pipeline pre-charging of the extracorporeal circulation pipeline can be achieved, the operation procedures of operators are simplified, and the pre-charging efficiency and safety are improved.

Apparatus (20) is provided for use with an extracorporeal membrane oxygenation (ECMO) or cardiopulmonary bypass (CPB) machine. The apparatus (20) includes a venous cannula (22), which has a proximal end (24) and a distal tip (26), and is shaped so as to define (a) a blood-drainage lumen (28) through the venous cannula (22), and (b) at or near the distal tip (26), one or more openings (30) between the blood-drainage lumen (28) and outside the venous cannula (22). A connector (36) is coupled to the proximal end (24) of the venous cannula (22) in fluid communication with the blood-drainage lumen (28), and is configured to be coupled to the ECMO or CPB machine. A fluid-tight distal balloon (38) is coupled to the venous cannula (22) near the distal tip (26) of the venous cannula (22). An external proximal balloon (40) is configured to be disposed outside a subject's body. A balloon-connection lumen (42) couples the distal balloon (38) in fluid communication with the external proximal balloon (40). Other embodiments are also described.

The present disclosure provides a solution for assisting cardiac circulation of a subject. In one aspect of the present disclosure, the new solution replaces the common practice of implementing a cannula of left ventricular assist device (LVAD) to the left ventricle (LV) through a large opening made in the apex of the LV, which has some disadvantages such as requirement of sternotomy, making a hole in an already very weak left ventricle, requirement of cardiopulmonary bypass, etc.The solution of the present disclosure suggests introducing the inflow cannula, namely the cannula / tube that suctions blood from the heart, through an opening made in the left atrium appendage (LAA) and guiding it through the left atrium (LA) and the mitral valve (MV) into the LV to be positioned therein. The inflow cannula is designed to allow suction of blood along various portions of its length that are intended to be positioned within the heart, namely along portions that are positioned in the LV, LA and optionally the LAA.The blood that is suctioned by the inflow cannula flows into a mechanical circulatory support device to be pumped therefrom, via an outflow cannula and into the aorta, thereby allowing supply of oxygenated blood to the entire body. Optionally, the outflow cannula can be coupled to the descending aorta and not to the ascending aorta as commonly done in the cases of LVAD implementations.A second aspect of the present disclosure provides a new solution for overcoming right ventricle failure by withdrawing blood from a first portion of the pulmonary artery and streaming blood to a second portion of the pulmonary artery, the second portion is downstream the first portion, namely more proximal to the lungs. The two solutions may be carried out by a similar surgical procedure, such as left thoracotomy. If the two solutions of the present disclosure are used together, they form a total artificial heart solution.

A blood pump-oxygenator system comprises at least one blood pump, an oxygenator, inflow and outflow cannulas, connected to form a closed series circuit operable as a cardiopulmonary bypass system for extracorporeal processing of the patient's blood. The blood pump conveys blood through the circuit from the patient into the inflow cannula, through the oxygenator and out of the outflow cannula back into the patient. A manifold is connected between the inflow and outflow cannulas so blood passes through the manifold, wherein the manifold accommodates the blood pump and the oxygenator to form a recirculation loop configured to recirculate at least part of the blood in the circuit so the blood passes over the oxygenator multiple times. An extra blood pump is positioned at the outflow cannula to deliver a set volume to the patient, controllable independently from the blood pump that circulates the blood in the manifold including the oxygenator.

A system and method for reducing gas bubbles, including gaseous microemboli (GME) during cardiopulmonary bypass (CPB) by the use of an oxygenator with venous blood bypass and a filter in the venous blood bypass is provided.

A blood pump-oxygenator system comprises at least one blood pump, an oxygenator, inflow and outflow cannulas, connected to form a closed series circuit operable as a cardiopulmonary bypass system for extracorporeal processing of the patient's blood. The blood pump conveys blood through the circuit from the patient into the inflow cannula, through the oxygenator and out of the outflow cannula back into the patient. A manifold is connected between the inflow and outflow cannulas so blood passes through the manifold, wherein the manifold accommodates the blood pump and the oxygenator to form a recirculation loop configured to recirculate at least part of the blood in the circuit so the blood passes over the oxygenator multiple times. An extra blood pump is positioned at the outflow cannula to deliver a set volume to the patient, controllable independently from the blood pump that circulates the blood in the manifold including the oxygenator.

The present disclosure describes, in part, arterial cannula systems for extracorporeal membrane oxygenation and cardiopulmonary bypass provides pulsatile blood flow and selective flow distribution. The cannula comprises a multi-lumen structure including a central lumen for blood flow, dedicated lumens for helium delivery, a distal orifice for body perfusion, and proximal orifices for limb perfusion. An inflatable cuff positioned between the distal and proximal orifices modulates blood flow through rapid inflation and deflation cycles achieved in milliseconds using helium gas. An external control console with microcontrollers and customized software automates the inflation-deflation cycles based on physiological inputs including ECG, arterial pressure, and tissue oxygenation. The system restores physiologically effective pulsatile flow, prevents limb ischemia, reduces thrombus formation risk, and can provide ECG-synchronized flow modulation to facilitate native cardiac ejection, potentially eliminating the need for separate left ventricular venting during mechanical circulatory support.

A blood pump-oxygenator system comprises a blood pump, oxygenator, blood flow inlet, and blood flow outlet forming a circuit operable as a cardiopulmonary bypass system for extracorporeal processing of the patient's blood, wherein the first blood pump conveys blood through the circuit from the patient into the blood flow inlet, through the oxygenator and out of the blood flow outlet back into the patient. The system further comprises a recirculation loop between the blood flow inlet and blood flow outlet that accommodates the first blood pump and oxygenator, wherein the first blood pump circulates at least part of the blood in the circuit through the recirculation loop such that blood passes through the oxygenator multiple times and is repeatedly subject to exchange of O2 and CO2 within the oxygenator. A valve between the recirculation loop and blood flow outlet controls an amount of blood flowing through the recirculation loop.

The application discloses a method for controlling the tightness of left and right heart pressure in cardiopulmonary bypass, which comprises the following steps: installing a peristaltic pump at the left and right heart inlets of a cardiopulmonary bypass device in an isolated environment; connecting a liquid inlet pump to the liquid inlet of the peristaltic pump and connecting a liquid outlet pump to the liquid outlet of the peristaltic pump; finally, setting a first pressure measuring structure and a second pressure measuring structure on the sides of the liquid inlet pump and the liquid outlet pump, respectively, away from the peristaltic pump, and adjusting the pressure of the liquid inlet pump and the liquid outlet pump to be-20mmHg. The negative pressure of the liquid inlet pump is adjusted through the first pressure measuring structure, and the negative pressure of the liquid outlet pump is adjusted through the second pressure measuring structure, so as to achieve the purpose of quantitative adjustment. The adjustment method is accurate, fast and reliable, and can effectively avoid the risk of reduction of pump blood volume, insufficient blood supply, direct interruption of blood circulation, damage of blood components, hemolysis, gas embolism and other risks caused by the "suction collapse" or "suction failure" of the pipe connected with the peristaltic pump.