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152 results about "Burn injury" patented technology

Burn injuries can vary between relatively minor or the most traumatic type of personal injury a person can suffer. Burns can cause disfigurement, scarring, muscle damage, respiratory failure, and significant psychological harm.

Visible-near infrared spectroscopy in burn injury assessment

A non-invasive method of characterizing burn injuries using near infrared spectroscopy is described. In the method, a beam of light is emitted into the burnt tissue portion at two or more different tissue depths. The spectra are then compared using multivariate analysis to determine diagnostic regions of the spectra. This information is used to categorize the burn. In some cases, the diagnostic regions correspond to wavelengths related to the hemodynamics of the tissue portion. The spectra can also be repeated over time, thereby allowing trends and changes in the spectra to be measured. This data is in turn used to categorize the burn as either a superficial burn, partial thickness burn, deep partial burn or a full thickness burn. Once the burn has been categorized, the clinician can intervene as needed to treat the burn.
Owner:NAT RES COUNCIL OF CANADA

Synthetic apelin mimetics for the treatment of heart failure

The invention provides a synthetic polypeptide of Formula I′:or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Owner:NOVARTIS AG

Method of inhibiting factor B-mediated complement activation, and the uses thereof

The present invention discloses the method of inhibiting complement activation mediated by factor B inhibitors, that involves: (a) inhibiting factor B binding to properdin-bound C3b; (b) inhibiting the release of Bb; (c) inhibiting the activation of neutrophils, monocytes, platelets, and endothelium; or (d) inhibiting / reducing the formation of PC3bBb, C3a, C5a, and MAC. The present invention also discloses the novel use of factor B inhibitors in the treatment of various immunological disorders, resulting either primarily from direct immune responses such as rheumatoid arthritis, anaphylactic shock, myasthenia gravis, asthma, Alzheimer's disease, and the like, or secondarily from clinical conditions such as cardiopulmonary bypass inflammation, vascular stenosis and restenosis, burn injury, and the like.
Owner:NOVELMED THERAPEUTICS

An endoscope tip position visual indicator and heat management system

The present specification discloses an endoscope having a tip section equipped with multiple viewing elements. Each of the viewing elements' field of view is illuminated by a discrete illuminator, such as a LED, being operated in a flash mode. The flash mode of operation of the LEDs enable doctors to obtain a position of the endoscope tip within a patient's body from outside by viewing the light emitted by the LEDs. Since the light is emitted for short pre-defined periods of time, the heat generated by the LEDs during their periods of operation is within a safe threshold value, and does not cause any burn injury inside the patient's body.
Owner:ENDOCHOICE

Synthetic apelin mimetics for the treatment of heart failure

The invention provides a synthetic polypeptide of Formula I′:or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Owner:NOVARTIS AG

Preparation method of self-adhesive hydrogel having anti-freezing/heat-resistant performance

The invention discloses a preparation method of a self-adhesive hydrogel having anti-freezing / heat-resistant performance. The method adopts a hydrogel solvent system consisting of glycerin and a watermixed system, and powerful hydrogen-bond interaction between glycerin and water enables water to be stably immobilized in a polymer network, can destroy the formation of ice crystal lattices at a lowtemperature and prevent moisture volatilization at a high temperature, and endows the hydrogel with long-term stability, anti-freezing performance and heat resistance. Besides, synergy between polydopamine, glycerin and polymer network enhances the mechanical property of hydrogel, so that the hydrogel has high strength, high toughness and good restorability. Furthermore, the addition of the polydopamine component makes hydrogel have good adhesion, and hydrogel can be adhered to surfaces of substrates with different chemical properties. The self-adhesive hydrogel with the anti-freezing / heat-resistant performance prepared with the method can be used as a wearable dressing to protect skin from cold injury or burn injury in an extremely cold or hot environment.
Owner:SOUTHWEST JIAOTONG UNIV

Machining method for rolling bearing with ring precisely shaped by hard finishing

Disclosed is a machining method for a rolling bearing with a ring precisely shaped by hard finishing. The machining method is characterized in that an inner ring and an outer ring of the bearing are integrally precisely shaped by hard finishing or the key surface of a ring part is precisely shaped by hard finishing; the key surface comprises raceways, raceway flanges, raceway oil grooves, seal grooves, ring flanges, grooved raceway edge chamfers and the like; precise shaping by hard finishing takes the place of grinding (such as the raceways) shaping and shaping by soft finishing (such as the sealing grooves), so that technical and quality problems of limited shape design of a raceway section, grinding badness even burn injuries and the like are solved; the technical and quality problems of low machining precision, heat treatment distortion and the like existing in shaping surfaces of the sealing grooves, the grooved raceway edge chamfers and the like by soft finishing are solved by precise hard finishing, so that the surfaces of the ring can be designed according to the operating condition and can be shaped precisely in a quite high mode, and the key surface of the ring can be controlled in shape and performance, and designing and manufacturing of the high-performance rolling bearing high in sealability and reliability and the like are of great practical engineering significance.
Owner:SHANGHAI F&S BEARING TECH

Resin CBN (cubic boron nitride) grinding wheel for machining saw blade base body

The invention discloses a resin CBN (cubic boron nitride) grinding wheel for machining a saw blade base body. The resin CBN grinding wheel comprises a base body and an abrasive material layer. The abrasive material layer comprises the following raw materials in percent by volume: 15%-30% of CBN abrasive materials, 30%-45% of phenolic resin powder, 3%-6% of villiaumite grinding-aiding materials, 5%-15% of heat conduction materials, 5%-25% of metallic oxide, 2%-5% of solid lubricating materials and 4%-8% of pore forming materials. Compared with a common white corundum grinding wheel, the resin CBN grinding wheel is high in grinding amount, high in machining efficiency, long in finishing interval and low in speed of loss; and the grinding wheel changing frequency is reduced. Because the grinding wheel has high self-sharpening performance, burn injury and slow grinding of the CBN grinding wheel can be eliminated in a grinding process. On a grinding machine with low revolving speed of 1450 revolutions per minute, the CBN grinding wheel is used for replacing the common white corundum grinding wheel, and the saw blade base body can be quickly ground into a saw blade base body with the given size.
Owner:江苏赛扬精工科技有限责任公司

Comprehensive system that minimizes outbreak of operating room fires

A system for prevention of fires in operating rooms as frequently arises from electrocautery and laser systems comprising an electrocautery instrument having a shielding gas that is expelled from the distal-most end thereof to thus prevent the cautery tip spark from coming into contact with an oxygen-enriched environment that may otherwise propagate the spark into a full-fledged fire. The systems can further be coupled with oxygen sensors, alarms and mechanisms for limiting the delivery of oxygen. Additional refinements include incorporating heat sensory strips to the distal ends of oxygen delivery systems, which are in turn coupled with a thermocouple device set to turn off oxygen delivery or electrosurgical system at given levels of heat to thereby limit the extent of burn injury. Further refinements also include the use of nonflammable inserts to the tips of the oxygen delivery systems such that in the event of a fire the plastic does not catch on fire and in effect turn into a blowtorch.
Owner:GEDEBOU TEWODROS

Methods to enhance wound healing and enhanced wound coverage material

The present invention describes the incorporation of liposomal gene constructs directly into a wound to further improve wound repair, or into wound coverage and / or closure materials to enhance the functionality of the material. The present invention further describes the use of human fetal membranes (e.g., amnion) enhanced with the liposomal gene therapy as a wound coverage material in full-thickness wound repair. The enhanced fetal membranes or enhanced cadaver skin have advantages over currently used materials lacking the liposomal gene construct and are an efficient and safe approach to improve clinical outcome in patients with burn injuries.
Owner:RES DEVMENT FOUND

Methods and means for soft tissue engineering

Cellfree adipose tissue extracts, implants including the same and methods for the preparation thereof. The extracts and implants are capable of inducing adipogenesis and angiogenesis and are, thus, useful in applications including soft tissue repair and engineering and angiogenesis induction, e.g., in wound healing, treatment of burn injuries and ischemic conditions.
Owner:LINIO BIOTECH OY

Bioconjugates of synthetic apelin polypeptides

The invention provides a bioconjugates comprising a synthetic polypeptide of Formula I′ (SEQ ID NO: 1):or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein and a half-life extending moiety wherein the peptide and the half-life extending moiety are covalently linked or fuse, optionally via a linker. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the bioconjugates of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Owner:NOVARTIS AG

Chitosan-silicone dressing as well as preparation method and application thereof

The invention discloses chitosan-silicone dressing as well as a preparation method and application thereof. The chitosan-silicone dressing comprises chitosan, silicone, an organosilicone antibacterial agent and matrix. The chitosan silicone dressing is reasonable in formula, convenient to prepare, capable of effectively inhibiting various hyperplastic scars caused by burn injury, trauma, surgery, infection and the like and various wounds caused by protecting burn injury, trauma, surgery, inflection and the like, controlling wound infection, keeping wounds moist and promoting the heating of wounds; and the chitosan silicone dressing has the bacteria inhibition capability being higher than or equal to 99% for Staphylococcus aureus and Escherichia coli.
Owner:潘银根

Apparatus and method to treat a wound area

A method is disclosed to treat a patient having a wound area, such as a burn injury. The method provides a plurality of epidermal / dermal cells, and applies that plurality of epidermal / dermal cells to the wound area.
Owner:DIXON DAVID M

Liquid nutrient food

The invention provides liquid nutrient food. The liquid nutrient food is prepared from 24 types of raw materials, and nutrient elements include protein, carbohydrate, dietary fiber, multiple vitamins, multiple minerals, taurine and the like. The liquid nutrient food has the advantages that the eating is simple, the number of complications is fewer, the restoration of intestinal function is promoted, the bacteria translocation in intestinal tracts is reduced, and the like; the absorbing and utilization efficiency is very high, and the food can be quickly absorbed by a human body in a short time; rich nutrients are contained, the eating is convenient, the instant compounding is not needed, and the instant eating by brewing is realized; the taste is moderately sweet and salty, the satiety and palatability are better, and the appetite of a patient is stimulated; by not adding fat and insoluble dietary fiber, the difficulty in digestion and absorbing by intestinal tracts is relieved, the burden of gastrointestinal tract is relieved, dyspepsia is avoided, and the rehabilitation of the patient is accelerated; the liquid nutrient food is suitable for patients in wound, burn injury and post-operation anti-infectious stages from adapting by the gastrointestinal tract to restoration of normal eating.
Owner:麦孚营养科技(北京)有限公司

Water-absorbent antibacterial dressing for burn injuries and wounds and preparation method and application thereof

Provided are a water-absorbent antibacterial dressing for burn injuries and wounds and a preparation method and application thereof. The dressing is a stereoscopic reticular porous sponge, chitosan isadopted as a framework, a super absorbent polymer combined with an antibacterial agent control-released carrier is adopted as branched chains, and macromolecules or polymers of flexiblestructures areadopted as a cross-linking agent among the branched chains. The antibacterial agent control-released carrier is loaded with an antibacterial agent. The weight ratio of the chitosan to the super absorbent polymer to the antibacterial agent control-released carrier to the cross-linking agent to the antibacterial agent in the antibacterial dressing is (0.6-2):(40-60):(0.6-25):(0.1-10):(1-10). The dressing has water absorption performance, moisture retention performance, air permeability, a barrier property, a long-acting antibacterial property, a bleeding stopping function and high strength andis easy to tear off, and is a novel antibacterial compound dressing with a broad-spectrum antibacterial effect. The dressing can be prepared through a one-pot method, is simple in preparation process,low in cost, prominent in treatment effect and high in safety and has remarkable medical value and industrialization potential.
Owner:非零和(北京)投资管理有限公司

Synthetic apelin mimetics for the treatment of heart failure

The invention provides a synthetic polypeptide of Formula I′:or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Owner:NOVARTIS AG

Cyclic polypeptides for the treatment of heart failure

The invention provides a cyclic polypeptide of Formula I (SEQ ID NO: 1):X1-R-X3-X4-L-S-X7-X8-X9-X10-X11-X12-X13  Ior an amide, an ester or a salt thereof, or a bioconjugate thereof, wherein X1, X3, X4, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention or bioconjugates thereof, and their therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Owner:NOVARTIS AG

Preparation method of bacteriostatic and wound restoration promoting chitosan hydrogel dressing

The invention belongs to the field of biomedical material application, and particularly relates to a preparation method of a bacteriostatic and wound restoration promoting chitosan hydrogel dressing. According to the preparation method, firstly, chitosan is prepared into microspheres in a dispersion medium by a Pickering emulsion process; after glutaraldehyde fixation, the microspheres are uniformly dispersed into a chitosan water solution; then, glutaraldehyde crosslinking agents are used for preparing hydrogel; and through soaking and flushing by deionized water, excessive cross linking agents and certain moisture are removed to obtain the chitosan hydrogel dressing. The dressing has soft textures; the inside has the uniform three-dimensional hole structures; wound percolate and secreta can be sucked away; the chitosan microspheres loaded by the hydrogel have high-density positive charges; the bacteria growth can be inhibited; the additional addition of bacteriostatic medicine is not needed; the wound restoration can also be promoted; and the dressing can be applied to the restoration of wound and the protection of various kinds of skin wound surfaces such as burn injury, mechanical trauma, diabetic foot and pressure sores.
Owner:JIANGNAN UNIV

Isolation implement for treatment of limb surface burn injuries

The invention discloses an isolation implement for treatment of limb surface burn injuries. The isolation implement comprises a fixing mechanism, a protecting mechanism and a nursing mechanism. The fixing mechanism comprises a first fixing ring and a second fixing ring; the protecting mechanism comprises an air bag protecting sleeve in an annular structure, and the first fixing ring and the secondfixing ring are connected with two ends of the air bag protecting sleeve respectively; the nursing mechanism comprises a sterilization spraying pipe which is closely attached to an inner cavity of the air bag protecting sleeve through hook-and-loop fasteners, and one end of the sterilization spraying pipe penetrates the first fixing ring while the other end of the sterilization spraying pipe is capped. By inflation for forming the protecting sleeve, supporting and protecting can be realized, and secondary injuries caused by impact can be prevented. In addition, the isolation implement is convenient to mount, light in weight, portable and convenient to collect due to small size after deflation, and by the sterilization spraying pipe for spraying sterilization mist, breeding of germs is reduced, and infection can be prevented.
Owner:梁韦巍

Macromolecules modified with electrophilic groups and methods of making and using thereof

Described herein are macromolecules modified with electrophilic groups and methods of making and using thereof. The preparation of a thiol-reactive, electrophililic derivative of HA in order to prepare ''crosslinker-free'' hydrogels are described as well as compounds and methods that are capable of coupling two or more molecules, such as macromolecules, under mild conditions. Specifically disclosed is the introduction of reactive bromo- and iodoacetate functionalities at the hydroxyl groups that are abundantly present on the HA polymer. The ''crosslinker-free'' hydrogels described have numerous applications including, but not limited to, drug delivery, small molecule delivery, wound healing, burn injury healing, tissue regeneration / engineering, cell culturing, and bio-artificial materials.
Owner:UNIV OF UTAH RES FOUND

Device for spirally grinding back knife face of spiral drill based on electrospark wire cutting

The invention provides a device for spirally grinding a back knife face of a spiral drill based on electrospark wire cutting, which comprises a spiral drill, a rotary shaft, a ball screw nut pair, a rolling guide pair and a rack; the spiral drill is mounted at one end of the rotary shaft by a spanner three-jaw drill chuck; the other end of the rotary shaft is connected with a first step motor through a shaft coupler; the rotary shaft is mounted in a bearing seat by a bearing; a connecting plate is fixed to the bottom of the bearing seat; the ball screw nut pair is composed of a screw rod and a nut sleeved to the screw rod; the screw rod is connected to a second step motor; the nut is fixedly connected with the connecting plate; the rolling guide pair is composed of a groove arranged on a rolling guide block and a guide embedded in the groove; the rolling guide block is fixed to the bottom of the connecting plate; and the guide is fixed to the rack. The device provided by the invention has the advantages that: the device may not cause grinding burn injury of the back knife face for no grinding force, is not influenced by knife materials and knife sizes and can grind spiral drills of various conductive knife materials and sizes.
Owner:SHAANXI UNIV OF TECH

3D printer with finished product fast taking-out function

The invention discloses a 3D printer with a finished product fast taking-out function. The 3D printer comprises a 3D printer body. A pair of strip-shaped grooves is formed in the lower wall face of a printing platform of the 3D printer body. Strip-shaped sliding rails are embedded in the strip-shaped grooves. A pair of moving wheels is assembled on the strip-shaped sliding rails. Support seats are installed on the upper wall faces of the moving wheels. Bearing plates are installed on the upper wall faces of the two pairs of support seats. First strip-shaped support seats are fixed to the upper wall faces of the bearing plates. The side wall faces of the first strip-shaped support seats are provided with first grooves. First swing motors are installed in the first grooves. First support rods are installed at the driving ends of the first swing motors in a sleeved mode. Arc-shaped art knives are installed on the first support rods in a sleeving mode. The 3D printer is novel in structure and convenient to operate, and effectively helps people to take out a formed article printed by the 3D printer, taking of the finished product saves time and labor, loss of the finished product due to inconvenient taking is reduced, and meanwhile, the phenomenon of burning injury of people is reduced.
Owner:芜湖智享三维打印服务有限公司

Electronic automatic internal ignition device of cutting torch

The invention discloses an electronic automatic internal ignition device of a cutting torch. The electronic automatic internal ignition device of the cutting torch comprises a cutting torch body, a cutting nozzle and a direct current discharge device arranged on the cutting torch body. The cutting nozzle comprises a nozzle core and a nozzle cap sleeving the nozzle core. The nozzle core comprises a nozzle cap connecting threaded port, an insulator and an oxygen outlet nozzle which are connected in sequence. One electrode of the direct current discharge device is electrically connected with the oxygen outlet nozzle, the other electrode of the direct current discharge device is electrically connected with the nozzle cap, and electric sparks can be generated between the nozzle cap and the oxygen outlet nozzle. By arranging the insulator, insulation between the oxygen outlet nozzle and the cutting torch body is achieved, and the insulator serves as one electrode of the direct current discharge device. The nozzle cap serves as the other electrode of the direct current discharge device, discharge between the oxygen outlet nozzle and the nozzle cap is achieved, and electric sparks are generated for ignition. Through the ignition mode, burning injuries to an operator can be avoided, and ignition can be conducted smoothly under the condition of outdoor strong wind.
Owner:徐慕庆
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