Preparations for tissue restoration containing atrial diuretic hormone and family molecules as active ingredients; method of restoring tissue using the preparation; agents for growing, restoring, promoting growth of hair and agents for promoting restoration of skin tissue and cardiac muscle tissue containing atrial diuretic hormone family molecules as active ingredients; method of growing, restoring, promoting growth of hair by using the agents; and method of promoting restoration of skin tissue and cardiac muscle tissue

Abstract

[Summary]

[Object]

To develop a preparation and a treatment method effective for improving a state of a bald hear, promoting hair growth, and restoring injuredskin tissues, supporting tissues, and cardiac muscle.

[Solution]

A preparation containing atrial diuretic hormone family molecules are used for restoration and regeneration of a tissue and an organ. The preparation is used for growing hairs and/or for improving and restoring failures of skin, mucosa, and subcutaneous tissue such as bed bore, rough and dry skin, burn injuries, necrosis, and psoriasis, and also for improving cardiac muscle failures.

Description

BACKGROUND OF THE INVENTION[0001]1. Field of the Invention[0002]The present invention relates to techniques for restoration of living biological tissues or promoting cell proliferation as well as to agents for growing, extending, promoting growth of hair or for restoring skin lesions and a method of promoting restoration of skin lesions.[0003]2. Description of the Related Art[0004]Recently, efforts have been becoming increasingly active in the field of medical techniques for regenerating a part of or particular cells of human tissues or organs for the purpose to supplement or restore the tissues or organs suffering from heavy diseases or destructive injures or lesions and regarded as difficult to be functionally restored.[0005]Efforts and trials for regenerative medical techniques are still in the stage of animal experiments, and the techniques for regenerating human tissues have been put into practical use still only in the field of cultured skin.[0006]In the methods now under deve...

AI Technical Summary

Benefits of technology

[0024]Actions of the preparations according to the present invention for fibrogenesis or for regenerating and activating thin cardiac muscle appear within several weeks after administration thereof, and a thickness of the cardiac muscle starts increasing in about 3 months after administration of the drugs with the contractility becoming higher. Therefore, the preparations according to the present invention are clearly more effective as compared to known preparations such as those acting to the catecholamine or renin-angiotensin system or digitalis preparations, and also the action mechanism of the preparations according to the present invention are different from that of the known preparations as described above.

[0025]Actions of the preparations according to the present invention for curing injuries after surgery are characterized in that the rapidness of restoration of a tissue at an operated section in the early stage as well as of closure of the operated section and fewer traces of operated portions are more excellent as compared to those at a naturally cured portion. Especially, early closure of an operated section is very effective for restoration of tissue deficits by external injuries such as gangrene caused by the arteriosclerosis oblitarans or open bone fracture and for treatment of bed bore caused by long term confinement to bed. The actions were demonstrated by testing with cultured cells, and are clearly different from the blood flow dependency, and therefore the direct effects for restoration and proliferation of target cells are useful for regeneration and restoration of various types of tissues and organs.

[0026]The physiological activity of the preparations according to the present invention to hairs start appearing within several weeks after administration thereof, and head hairs start increasing in one month after the administration, and therefore it seems that the efficacy of the preparations is clearly higher than that of known preparations such as minoxidil or adenosine. Also, because such factors of hairs such as flexibility, elasticity, and thickness are improved, usefulness of the preparations according to the present invention is higher as compared to that of existing hair-growth drugs. The effects of the preparations over human skin are also demonstrated by the facts that the capped skin and rough and dry skin hardly appears after domestic works using water, and that an injury is cured within a short period of time after administration of the preparations according to the present invention. These facts clearly show and demonstrate usefulness of the preparations according to the present invention as active ingredients of drugs for external use to a human skin or cosmetics.

[0027]In the testing using cultured cells, it was demonstrated that, in a group of cells having various failures, the repair ability achieved when the ANP was administered was clearly higher as compared to that when a control was used, that cell colonies and cell sequence networks were formed only when the ANP was administered, which experimentally supports the effects of the NP family molecules for restoration, regeneration, and induction of tissues. Furthermore, the fact that the ANP modified expression of growth factors such as BMP2 suggested roles of the ANP family molecules each as an adjuster for effects of the known growth factors. This fact suggests that, even in regeneration or restoration of cells or tissues achieved by growth factors which can hardly be supplied from the outside, the ANP family molecules can induce regeneration or restoration of the cells or tissues by adjusting the internal mechanism of a living body for producing and activating the growth factors. In addition, it was also demonstrated in the testing that the ANP family molecules also improves the expression levels of a factor relating to a cell cycle (cyclin D1), a cell type-specific protein (KRT15), and epimorphin, and this fact suggests that the ANP family molecules can induce restoration of cells and tissues at an accelerating pace to original characters of the cells and tissues. Actually, it was demonstrated in clinical tests that cracked skin and incision wounds were more quickly restored when the ANP was administered as compared to that achieved when the ANP was not administered, and also glaze, tension, and moist feeling of skin were excellent, which is incidental to a result of the testing using cultured cells.

Problems solved by technology

Recently, efforts have been becoming increasingly active in the field of medical techniques for regenerating a part of or particular cells of human tissues or organs for the purpose to supplement or restore the tissues or organs suffering from heavy diseases or destructive injures or lesions and regarded as difficult to be functionally restored.

However, the problem in the prior art is that divided cells are hardly regenerated.

In other words, in the case of highly diving cells / tissues in a living body such as central nerves, heart, or kidney, once injured, the cells or the tissues are hardly regenerated by any conventional technique.

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