Preparations for tissue restoration containing atrial diuretic hormone and family molecules as active ingredients; method of restoring tissue using the preparation; agents for growing, restoring, promoting growth of hair and agents for promoting restoration of skin tissue and cardiac muscle tissue containing atrial diuretic hormone family molecules as active ingredients; method of growing, restoring, promoting growth of hair by using the agents; and method of promoting restoration of skin tissue and cardiac muscle tissue

Abstract

[Summary][Object]To develop a preparation and a treatment method effective for improving a state of a bald hear, promoting hair growth, and restoring injuredskin tissues, supporting tissues, and cardiac muscle.[Solution]A preparation containing atrial diuretic hormone family molecules are used for restoration and regeneration of a tissue and an organ. The preparation is used for growing hairs and / or for improving and restoring failures of skin, mucosa, and subcutaneous tissue such as bed bore, rough and dry skin, burn injuries, necrosis, and psoriasis, and also for improving cardiac muscle failures.

Description

BACKGROUND OF THE INVENTION[0001]1. Field of the Invention[0002]The present invention relates to techniques for restoration of living biological tissues or promoting cell proliferation as well as to agents for growing, extending, promoting growth of hair or for restoring skin lesions and a method of promoting restoration of skin lesions.[0003]2. Description of the Related Art[0004]Recently, efforts have been becoming increasingly active in the field of medical techniques for regenerating a part of or particular cells of human tissues or organs for the purpose to supplement or restore the tissues or organs suffering from heavy diseases or destructive injures or lesions and regarded as difficult to be functionally restored.[0005]Efforts and trials for regenerative medical techniques are still in the stage of animal experiments, and the techniques for regenerating human tissues have been put into practical use still only in the field of cultured skin.[0006]In the methods now under deve...

AI Technical Summary

Benefits of technology

[0024]Actions of the preparations according to the present invention for fibrogenesis or for regenerating and activating thin cardiac muscle appear within several weeks after administration thereof, and a thickness of the cardiac muscle starts increasing in about 3 months after administration of the drugs with the contractility becoming higher. Therefore, the preparations according to the present invention are clearly more effective as compared to known preparations such as those acting to the catecholamine or renin-angiotensin system or digitalis preparations, and also the action mechanism of the preparations according to the present invention are different from that of the known preparations as described above.

[0057]In a female patient of 49 years old who received operation for removing lentigo on the entire facial surface by the laser method, ANP was administered at a dose of 0.1 to 5 μg (with an isotonic aqueous solution at a dose of 0.01 ml to 0.5 ml) twice a day to wounds caused by the surgical operation or areas around the wounds on the left haft of the patient's face, and the result was compared to wounds on the right side half of the patient's face. As a result, the patient's subcutaneous tissue was reformed in the left side half facial surface clearly earlier as compared to the right side half facial surface, and in one week after start of administration, most of the wounds were closed in the left side by administration of ANP, while craters were still present in the right side and the subcutaneous tissue was directly observed (FIG. 1). In addition, at the sites where ANP was administered, the patient's flesh rose less and the surgical traces were less remarkable as compared to the portions not having received the surgical operation. Furthermore, tension of skin was observed more clearly in the left side facial area as a whole as compared to that in the right side, and smoothness of the facial skin in the left side was improved.Example 3

Problems solved by technology

Recently, efforts have been becoming increasingly active in the field of medical techniques for regenerating a part of or particular cells of human tissues or organs for the purpose to supplement or restore the tissues or organs suffering from heavy diseases or destructive injures or lesions and regarded as difficult to be functionally restored.

However, the problem in the prior art is that divided cells are hardly regenerated.

In other words, in the case of highly diving cells / tissues in a living body such as central nerves, heart, or kidney, once injured, the cells or the tissues are hardly regenerated by any conventional technique.

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