A Chinese medicine composition for treating chronic heart failure and its preparation method and application

Abstract

The present invention discloses a Chinese medicine composition for treating chronic heart failure, wherein the Chinese medicine composition comprises the following raw materials: 45-55 parts of raw astragalus, 10-18 parts of epimedium, 10-18 parts of scutellaria, 10-18 parts of tiliaceus, 10-18 parts of tuckahoe, 10-18 parts of stir-fried atractylodes, 10-18 parts of acanthopanax, 10-18 parts of salvia miltiorrhiza, 9-12 parts of ophiopogon, and 9-12 parts of cassia twig. The present invention also discloses a preparation method for providing the above-mentioned Chinese medicine composition, and the application of the above-mentioned Chinese medicine composition in the preparation of a drug for treating chronic heart failure. The Chinese medicine composition of the present invention can inhibit and delay the development of myocardial remodeling, block a vicious cycle, and reduce the mortality rate of patients with heart failure.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular, relates to a traditional Chinese medicine composition for treating chronic heart failure, and application of the traditional Chinese medicine composition. Background Art

[0002] Heart failure is a clinical syndrome caused by abnormal cardiac structure or function. Potential heart failure is the main cause of heart failure. Hypertension, hyperlipidemia, coronary artery disease, etc. accelerate cardiovascular aging and are specific risk factors for heart failure.

[0003] At present, the common treatment for chronic heart failure is to reduce the ventricular load. Most modern treatment models focus on improving the neuroendocrine disorders caused by the renin-angiotensin-aldosterone system and the sympathetic nervous system. With the deepening of the understanding of the pathophysiological mechanism of chronic heart failure in clinical treatment, the treatment methods have gradually changed from a single improvement of hemodynamics to a comprehensive and diverse biological adjustment.

[0004] At present, the treatment goal of chronic heart failure is no longer satisfied with improving the quality of life and clinical symptoms of patients, but is committed to reversing ventricular remodeling from the root, inhibiting the development and blocking the vicious cycle. However, most heart failure treatment drugs have differences in basic pathophysiology and treatment targets, and cannot improve the final outcome of heart failure. The mortality and hospitalization rates of heart failure are still high in the world. Western medicine is mainly angiotensin-converting enzyme inhibitors and β-receptor blockers in clinical treatment. Patients are more likely to have adverse events when taking Western medicine, such as cough, respiratory tract and urinary tract infections, hypotension, dyspnea, headache, gastrointestinal symptoms, etc. Although modern medical research provides miRNA and gene biological adjustment technology in experiments to prevent the occurrence of adverse events, there is still a long way to go before it can be applied in clinical practice. The currently commonly used traditional Chinese medicine Qishen Yiqi Drop Pills use modern technology to extract the active ingredients from Astragalus, Salvia miltiorrhiza, Panax notoginseng, and Dalbergia odorifera to improve chronic heart failure caused by myocardial ischemia and delay ventricular remodeling. Previous studies have shown that Astragalus and Salvia miltiorrhiza are the main drugs for the treatment of cardiovascular diseases and are often used in the diagnosis and treatment of chronic heart failure. However, due to different prescriptions and drug combinations, the efficacy is also different. However, adverse reactions such as blood pressure fluctuations may occur after taking it, which still needs further exploration in clinical practice. In addition, the main function of Qishen Yiqi Drop Pills is to promote blood circulation and relieve pain, improve pain symptoms, and its effect on ventricular remodeling is still under discussion.

[0005] The existing Qishen Granules are composed of six Chinese herbs: Astragalus, Salvia, Honeysuckle, Scrophularia, Licorice, and Aconite. They promote angiogenesis, regulate myocardial energy metabolism, and improve chronic heart failure. Among them, improper use of Aconite can easily cause toxic side effects and adverse reactions, and is highly toxic in clinical applications. Summary of the invention

[0006] In view of the shortcomings and deficiencies in the prior art, the purpose of the present invention is to provide a Chinese medicine composition for treating chronic heart failure, inhibiting and delaying the development of myocardial remodeling, blocking the vicious cycle, and reducing the mortality rate of patients with heart failure.

[0007] The present invention also aims to provide a method for preparing the above-mentioned Chinese medicine composition.

[0008] The present invention also aims to provide the use of the above-mentioned Chinese medicine composition in the preparation of medicines for treating chronic heart failure.

[0009] The technical solution of the present invention is as follows:

[0010] A traditional Chinese medicine composition for treating chronic heart failure, characterized in that the traditional Chinese medicine composition is prepared from raw drugs in the following proportions: 20-60 parts of raw astragalus, 9-21 parts of epimedium, 9-21 parts of scutellaria baicalensis, 9-21 parts of tiliac cristae, 9-21 parts of poria, 9-21 parts of stir-fried atractylodes, 9-21 parts of acanthopanax senticosus, 9-21 parts of salvia miltiorrhiza, 6-18 parts of ophiopogon japonicus, and 6-18 parts of cassia twig.

[0011] Furthermore, the Chinese medicine composition is prepared by raw materials in the following proportions: 45-55 parts of raw astragalus, 10-18 parts of epimedium, 10-18 parts of scutellaria baicalensis, 10-18 parts of tiliac cristata, 10-18 parts of poria, 10-18 parts of stir-fried atractylodes, 10-18 parts of acanthopanax senticosus, 10-18 parts of salvia miltiorrhiza, 9-12 parts of ophiopogon japonicus, and 9-12 parts of cinnamon twig.

[0012] Furthermore, the Chinese medicine composition is prepared by raw materials including the following proportions: 50 parts of raw astragalus, 15 parts of epimedium, 15 parts of scutellaria, 15 parts of tiliac cristata, 15 parts of poria, 15 parts of stir-fried atractylodes, 15 parts of acanthopanax, 15 parts of salvia miltiorrhiza, 10 parts of ophiopogon, and 10 parts of cassia twig.

[0013] Furthermore, the dosage form of the Chinese medicine composition is any one of a decoction piece, a decoction, a granule, a Chinese medicine ointment, and a honey pill.

[0014] Furthermore, the dosage form of the Chinese medicine composition is a decoction or granules.

[0015] A method for preparing a Chinese medicine composition for treating chronic heart failure, wherein the Chinese medicine composition is a decoction, and the preparation method thereof is as follows:

[0016] Weigh the above raw materials according to the ratio, remove impurities, wash, sun-dry or bake, and set aside;

[0017] The treated raw materials are soaked in water for 20 to 30 minutes, boiled over high heat for the first time at 60 to 80° C. for 10 to 15 minutes, and 150 to 200 ml of the medicinal liquid is poured out; warm water is added for a second decoction at a temperature of 50 to 60° C., 150 to 200 ml of the medicinal liquid is poured out, and the two medicinal liquids are mixed to obtain the water decoction.

[0018] A method for preparing a Chinese medicine composition for treating chronic heart failure, wherein the Chinese medicine composition is a granule, and the preparation method thereof is as follows:

[0019] Weigh the above raw materials according to the ratio, remove impurities, wash, sun-dry or bake, and mix for later use;

[0020] The Chinese medicine composition granules are obtained by sequentially crushing, primary grinding and secondary grinding;

[0021] Preparation: Add the above-mentioned Chinese medicine composition granules into water at 40-50°C and dissolve for 10 minutes to obtain the granules.

[0022] A method for preparing a Chinese medicine composition for treating chronic heart failure, wherein the Chinese medicine composition is a Chinese medicine ointment, and the preparation method thereof is as follows:

[0023] Weigh the above raw materials according to the ratio, remove impurities, wash, sun-dry or bake, and set aside;

[0024] Crush into powder, filter through a 100-mesh filter to obtain a mixture for later use;

[0025] Soak in water for 8-10 hours, boil over high heat, and then simmer for 2 hours over low heat; simmer twice at a temperature range of 80-100° C., filter after simmering, and combine the filtrate; then add 10% of its weight of auxiliary materials and mix and concentrate to a thick paste with a density of 1.5-1.6, which is the Chinese medicine ointment.

[0026] Use of any of the above-mentioned Chinese medicine compositions in the preparation of medicines for treating chronic heart failure.

[0027] Use of any of the above-mentioned Chinese medicine compositions in the preparation of a medicine for treating edema symptoms caused by chronic heart failure.

[0028] Use of any of the above-mentioned Chinese medicine compositions in the preparation of a drug for treating symptoms of chest tightness, shortness of breath and fatigue caused by chronic heart failure.

[0029] Compared with the prior art, the advantages of the present invention are as follows:

[0030] The Chinese medicine composition of the present invention, i.e., the Qishen Zhenxin prescription, uses raw Radix Astragali and Epimedium as monarch drugs, wherein a large dose of Radix Astragali can supplement the Qi of the lungs and spleen and is biased upward, while Epimedium warms and nourishes the Yang of the liver and kidneys and is positioned downward, and the two are used together, so that the fire of the gate of life is helped, the spleen and earth are warmed, the heart Yang is replenished, and the five internal organs are at peace, and the functions of invigorating Qi and strengthening the body, warming the kidney and raising Yang are achieved. Semen scutellariae, Poria cocos, stir-fried Atractylodes macrocephala, Salvia miltiorrhiza, and Acanthopanax senticosus are ministerial drugs, so as to promote blood circulation and remove blood stasis and promote diuresis and reduce swelling, wherein Semen scutellariae can relieve the lungs and promote diuresis to clear the upper source of water, while Poria cocos and Atractylodes macrocephala can strengthen the spleen and promote diuresis and have the meaning of cultivating soil and controlling water, so as to treat the central region, and the monarch and minister depend on each other, and Epimedium can help kidney Yang and play the role of transforming Qi and promoting water, so as to treat the lower jiao, and the lungs, spleen, and kidneys are treated together, so that the three jiaos are smooth and water and drink can be transformed. It is also said that "long-term illness will lead to more blood stasis" and "blood will become water if it is not smooth". Therefore, in diuresis, it is necessary to activate blood circulation and remove blood stasis. Salvia miltiorrhiza tastes bitter and belongs to the heart and liver meridians. It can activate blood circulation and remove blood stasis to dredge the meridians. "Qi is the leader of blood, and blood is the mother of qi". In the process of blood circulation, it is also necessary to promote qi. Therefore, Ciwujia is added to replenish qi and strengthen the body, taking into account the five internal organs and activating blood circulation. The combination of the two can attack and supplement at the same time, and benefit without hurting the body. Assisted with cinnamon twig to warm yang, transform qi and promote diuresis, "Ben Jing Shu Zheng" once said: "There are six ways to use it: to harmonize the camp, to promote yang, to promote diuresis, to lower qi, to remove blood stasis, and to tonify the middle. It has the greatest effect and the widest application". One medicine has many uses. One is to help Poria cocos and Atractylodes macrocephala warm yang and strengthen the spleen to relieve water, and the other is to help the main medicine warm the heart yang and treat its root. Because phlegm and blood stasis turn into heat for a long time, steaming and burning body fluids, or in the late stage of the disease, the true yin is deficient, the vital energy is seriously damaged, and the diarrhea is excessive, which consumes body fluids secretly, so Ophiopogon japonicus is used to nourish yin and produce body fluids, protect yin body fluids, so as to achieve the purpose of promoting water without damaging yin, and nourishing yin without hindering evil. From the perspective of the meridians of the drugs, this prescription focuses on the heart and kidney, and takes into account the lung, spleen, and liver meridians; from the analysis of nature and taste, the drug is mild, neither warm nor dry; the drugs are matched, and the qi, blood, and water are balanced.

[0031] Astragalus has the effects of diuresis and lowering blood pressure, reducing pulmonary artery pressure and right cardiac preload, dilating peripheral resistance vessels, lowering arterial pressure, and thus improving cardiac function.

[0032] Epimedium can inhibit the strength and heart rate of isolated right atrial muscle. This effect has no M receptor stimulatory and calcium antagonistic effects, and can shift the dose-effect curve of isoproterenol (ISO 7-10mol / L) on the positive frequency effect to the right in parallel. This study provides a theoretical basis for the clinical treatment of coronary heart disease and angina pectoris with Epimedium.

[0033] The seeds of the Chinese clematis have a cardiotonic effect. They can enhance myocardial contractility, slow down heart rate, increase heart output and reduce venous pressure for a weak heart.

[0034] Salvia miltiorrhiza has the effects of scavenging free radicals, anti-inflammatory, antioxidant, inhibiting platelet aggregation, and dilating blood vessels.

[0035] Poria and Atractylodes macrocephala have been proven to have the function of enhancing hematopoiesis and promoting diuresis.

[0036] Acanthopanax can slow down the heart rate, reduce myocardial oxygen consumption and myocardial oxygen consumption index, reduce myocardial oxygen utilization rate, lower blood pressure, reduce the scope of myocardial infarction, and protect myocardial ischemia.

[0037] The whole prescription focuses on the heart and kidney, and takes into account the lung, spleen, and liver meridians; from the analysis of nature and taste, the medicinal properties are mild, neither warm nor dry; the medicines are matched, and the qi, blood, and water are balanced. The whole prescription has monarch, minister, assistant, and envoy, yin and yang are coordinated, the medicinal effects are superimposed, and there is a clear degree, and it takes into account both deficiency and excess, and uses both tonification and purgation. It treats qi, blood, and water at the same time, tonifies deficiency without restraining evil, and attacks excess without hurting the body, and plays the role of invigorating qi and warming yang, activating blood circulation and promoting water excretion, and protecting yin and fluid, which is very consistent with the mechanism changes of heart failure.

[0038] The Chinese medicine composition of the present invention, namely the Qishen Zhenxin Recipe, has the functions of improving the overall or even local heart structure at an early stage, reversing ventricular remodeling, improving myocardial cell function, preventing myocardial fibrosis, etc. in the treatment of chronic heart failure, and has high safety in clinical use.

[0039] On this basis, compared with other existing prescriptions, the Chinese medicine composition of the present invention can also play the role of strengthening the heart and promoting urination, promoting blood circulation and promoting diuresis, and protecting yin and fluid, thereby improving the clinical symptoms and cardiac function of patients, and at the same time improving the quality of life of patients and the prognosis. DETAILED DESCRIPTION

[0040] The present invention will be further described below in conjunction with the embodiments.

[0041] Example 1-N Preparation of the Chinese medicine composition of the present invention

[0042] Embodiment 1:

[0043] The weight ratio of the raw materials of the (Chinese medicine composition) Qishen Zhenxin Fang of the present embodiment is: 50 parts of raw astragalus, 15 parts of epimedium, 15 parts of scutellaria, 15 parts of poria, 15 parts of stir-fried atractylodes, 15 parts of Acanthopanax, 15 parts of Salvia miltiorrhiza, 10 parts of Ophiopogon japonicus, and 10 parts of cinnamon twig.

[0044] The Qishen Zhenxin prescription of the present embodiment is a water decoction, and its preparation method is as follows:

[0045] 1. Weigh the above raw materials according to the above ratio, remove impurities, wash, and dry in the sun or in an oven.

[0046] 2. Soak the medicine in drinking water for 20 to 30 minutes. After boiling over high heat, decoct it at 60-80℃ for 10 to 15 minutes. Pour out 150 to 200 ml of the liquid medicine, add appropriate amount of warm water, and decoct it for the second time at a temperature range of 50-60℃. Pour out 150 to 200 ml of the liquid medicine and mix the two liquid medicines.

[0047] 3. Take once in the morning and evening, 150-200ml each time.

[0048] Embodiment 2:

[0049] The weight ratio of the raw materials of the (Chinese medicine composition) Qishen Zhenxin Fang of the present embodiment is: 20 parts of raw astragalus, 9 parts of epimedium, 9 parts of scutellaria, 9 parts of poria, 9 parts of stir-fried atractylodes, 9 parts of Acanthopanax, 9 parts of Salvia miltiorrhiza, 6 parts of Ophiopogon japonicus, and 6 parts of cinnamon twig.

[0050] The Qishen Zhenxin prescription of this embodiment is a granule, and its preparation method is as follows:

[0051] Weigh the above raw materials according to the above ratio, remove impurities, wash, sun-dry or bake, and mix for later use;

[0052] The Chinese medicine composition granules are obtained by sequentially crushing, primary grinding and secondary grinding;

[0053] Preparation: Add the above-mentioned Chinese medicine composition granules into water at 40-50°C and dissolve for 10 minutes to obtain the granules.

[0054] Embodiment 3:

[0055] The weight ratio of the raw materials of the (Chinese medicine composition) Qishen Zhenxin Fang of the present embodiment is: 60 parts of raw astragalus, 21 parts of epimedium, 21 parts of scutellaria, 21 parts of poria, 21 parts of stir-fried atractylodes, 21 parts of Acanthopanax, 21 parts of Salvia miltiorrhiza, 18 parts of Ophiopogon japonicus, and 18 parts of cinnamon twig.

[0056] The Qishen Zhenxin prescription of this embodiment is a traditional Chinese medicine ointment. Its preparation method is as follows:

[0057] Weigh the above raw materials according to the ratio, remove impurities, wash, dry in the sun or bake, and set aside.

[0058] Crush it into powder, filter it through a 100-mesh filter to obtain a mixture for later use.

[0059] Add 1500ml of drinking water and soak for 8 hours, boil over high heat, and then simmer for 2 hours; simmer twice, adding 1000ml and 800ml of water each time, and simmering for 2 hours and 1 hour respectively; filter after simmering, and combine the filtrate. Then add 10% of its weight of donkey-hide gelatin, sucrose and honey auxiliary materials, mix and concentrate to a thick paste with a density of 1.5-1.6.

[0060] How to take Chinese medicine ointment: Take it once in the morning and evening, each time with 50-100 ml of warm water.

[0061] Embodiment 4:

[0062] The weight ratio of the raw materials of the (Chinese medicine composition) Qishen Zhenxin Fang of the present embodiment is: 45 parts of raw astragalus, 10 parts of epimedium, 10 parts of scutellaria, 10 parts of tiliac cristae, 10 parts of poria, 10 parts of stir-fried atractylodes, 10 parts of acanthopanax, 10 parts of salvia miltiorrhiza, 9 parts of ophiopogon, and 9 parts of cinnamon twig.

[0063] The Qishen Zhenxin prescription of the present embodiment is a Chinese medicine pill, and its preparation method is as follows:

[0064] Weigh the above raw materials according to the ratio, remove impurities, wash, sun-dry or bake, and set aside;

[0065] Grinding: take the fine powder of Chinese medicine after the medicinal materials are crushed, add an appropriate amount of adhesive or other auxiliary materials, and make it into a spherical or quasi-spherical dosage form. The adhesive includes water, honey, wine, vinegar, and medicinal juice, and can be made into different types of pills, such as water pills, honey pills, water-honey pills, wax pills, etc.

[0066] Clinical trials:

[0067] 1. Case selection

[0068] A total of 60 patients with heart failure due to Yang deficiency and blood stasis were selected, with 30 cases in each group (there were no significant differences in gender, age, disease course, etc.).

[0069] 2. Grouping and Dosing

[0070] According to the patients' wishes, they were divided into the Qishen Zhenxin prescription group and the conventional Western medicine treatment group, forming two cohorts exposed to two different treatment methods.

[0071] The control group only took conventional western medicine drugs, and the treatment group took the Qishen Zhenxin Fang decoction of Example 1 on the basis of taking conventional western medicine drugs.

[0072] (I) Both groups of patients received standardized anti-heart failure treatment according to the 2021 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure, which should include one or more of the following drugs unless there are contraindications:

[0073] (1) ARNI (or ACEI / ARB), β-blockers, aldosterone receptor antagonists, SGLT2 inhibitors (drug dosage determined according to guidelines).

[0074] (2) According to the guidelines, other cardiovascular drugs are allowed to be used according to the condition: digitalis, diuretics, nitrates, warfarin, calcium antagonists, antiplatelets, and statins.

[0075] (II) Treatment course: 12 weeks

[0076] (III) Combined medication

[0077] Except for the experimental drugs, the combined use of any Chinese medicine or Chinese patent medicine with similar ingredients and effects to the Qishen Zhenxin Formula is prohibited during the observation period.

[0078] 3. Results

[0079] The effect of the Chinese medicine composition of the present invention was explained by comparing the results of cardiac ultrasound, Minnesota Heart Failure Quality of Life Scale, and 6-min walking distance test (6MWT) between the two groups of patients before and after treatment.

[0080] Table 1 Comparison of walking distance in 6-minute test between two groups

[0081]

[0082] Note: The two groups were compared before treatment, P>0.05, which is comparable; the two groups were compared before and after treatment ** P<0.01; after treatment, the two groups were compared. ## P<0.01.

[0083] The 6-minute walk test is an exercise test used to assess aerobic capacity and endurance. The 6-minute walk test can be used to determine the patient's cardiac function status and exercise tolerance. The experimental results show that the Chinese herbal composition has the function of significantly improving the patient's exercise tolerance.

[0084] Table 2 Comparison of Minnesota Quality of Life Scale scores between the two groups

[0085]

[0086]

[0087] Note: The two groups were compared before treatment, P>0.05, which is comparable; the two groups were compared before and after treatment ** P<0.01; after treatment, the two groups were compared. ## P<0.01.

[0088] Table 2 classifies the patients according to the degree of influence of heart failure on their daily activities. The results show that after treatment with the Chinese medicine composition, the patients' quality of life was significantly improved compared with the conventional treatment group.

[0089] Table 3 Comparison of echocardiographic parameters between the two groups

[0090]

[0091] Note: The two groups were compared before treatment, P>0.05, which is comparable; the two groups were compared before and after treatment ** P<0.01; P>0.05, no statistical difference was found between the two groups after treatment.

[0092] Echocardiography intuitively reveals the ability of the Chinese herbal composition to reverse ventricular remodeling.

[0093] Table 4 Comparison of NYHA cardiac function classification between the two groups

[0094]

[0095] Note: Before treatment, the NYHA classification of the two groups was compared by rank-sum test, Z=-0.162, P=0.871, P>0.05; after treatment, the NYHA classification of the two groups was compared by rank-sum test, Z=-1.581, P=0.114, P>0.05.

[0096] Table 5 Comparison of efficacy between the two groups in NYHA cardiac function classification

[0097]

[0098]

[0099] Note: Comparison between the two groups, Z = -2.321, P = 0.020, * P<0.05.

[0100] The NYHA classification categorizes the impairment of cardiac function according to the degree of activity that induces heart failure symptoms. The final scale shows that the patient's heart failure condition has been effectively improved.

[0101] Table 6 NT-proBNP level and efficacy Comparison of NT-proBNP levels in the two groups P50 (P25, P75)

[0102]

[0103] Note: Before treatment, the two groups were compared by rank sum test, Z = -0.377, P = 0.706, P > 0.05, which were comparable; before and after treatment, the treatment group was compared with Z = -4.372, P = 0.000, P < 0.01; before and after treatment, the control group was compared with Z = -4.372, P = 0.000, P < 0.01; after treatment, the two groups were compared with Z = -1.219, P = 0.197, P > 0.05, which showed no statistical difference.

[0104] Table 7 Comparison of NT-proBNP efficacy between the two groups

[0105]

[0106] Note: Comparison between the two groups, by chi-square test, P=0.029, P<0.05.

[0107] The above results show that the Chinese medicine composition of the present application has obvious therapeutic effect on patients with heart failure due to yang deficiency and blood stasis syndrome.

[0108] In addition, two typical cases are listed below for reference. Case 1:

[0109] Patient Zhang, male, 82 years old, suffered from "chest tightness and shortness of breath intermittently for 2 years, aggravated with fatigue for 4 months", and the main clinical manifestation was chest tightness and shortness of breath. Admission echocardiography showed: LAD 47mm LVDd 65mm EF 13%. During the period, moderate pitting edema of both lower limbs, chest tightness and shortness of breath aggravated with limb fatigue. Appetite is OK, sleep is restless at night, and dreams are many. Purple tongue with thin yellow fur, and stringy pulse. Chinese medicine diagnosis: heart failure, treatment of conventional oral heart failure treatment drugs. Oral administration of the Chinese medicine composition decoction provided in Example 1. After treatment, the patient's lower limb edema was alleviated, chest tightness was improved compared with before, shortness of breath and fatigue were improved, and the symptoms were stable. Echocardiography showed: LAD 41mm LVDd 68mm EF 20%. The results show that the Chinese medicine composition liquid provided by the present invention can effectively alleviate the symptoms of lower limb edema in patients with heart failure, indicating that the Chinese medicine composition liquid provided by the present invention has a good therapeutic effect on chest tightness, shortness of breath and fatigue caused by heart failure. This shows that the drug is effective and has no obvious toxic side effects.

[0110] Case 2:

[0111] Patient Zhu, male, 75 years old, had "chest tightness and shortness of breath intermittently for more than 6 years, and then recurred with shortness of breath for 2 months". Six years ago, chest tightness and shortness of breath appeared without obvious cause, aggravated after activity, and improved after rest. The patient still has chest tightness and shortness of breath intermittently, which is obvious after activity and relieved after rest, general fatigue, and mild edema of both lower limbs. Poor appetite and sleep, frequent urination at night, and regular bowel movements. Pale red tongue with little coating. Laboratory examination showed: myocardial pentavalent: cTnl 0.033ng / ml, myoglobin 38.4ng / ml CK-MB 0.5ng / ml, NT-proBNP 2390pgml. Traditional Chinese medicine diagnosis: heart failure, treatment with oral conventional heart failure treatment drugs. Oral administration of the Chinese medicine composition decoction provided in Example 1. After one week, the patient's chest tightness and shortness of breath improved, there was no edema in both lower limbs, the symptoms improved, and the condition was stable. The results show that the Chinese medicine composition liquid provided by the present invention can effectively alleviate the symptoms of lower limb edema in patients with heart failure, indicating that the Chinese medicine composition liquid provided by the present invention has a good therapeutic effect on chest tightness, shortness of breath and fatigue caused by heart failure. It shows that the drug is effective and has no obvious toxic and side effects.

[0112] The above embodiments are only for illustrating the technical idea of ​​the present invention, and cannot be used to limit the protection scope of the present invention. Any changes made on the basis of the technical solution in accordance with the technical idea proposed by the present invention shall fall within the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating chronic heart failure, characterized in that: The Chinese medicine composition is prepared from the following raw materials in the following weight ratio: 50 parts of raw astragalus, 15 parts of epimedium, 15 parts of scutellaria, 15 parts of tiliac cristata, 15 parts of poria, 15 parts of stir-fried atractylodes, 15 parts of acanthopanax, 15 parts of salvia miltiorrhiza, 10 parts of ophiopogon, and 10 parts of cassia twig; the dosage form of the Chinese medicine composition is any one of a decoction, a granule, a Chinese medicine ointment, and a honey pill.

2. A Chinese medicine composition for treating chronic heart failure according to claim 1, characterized in that: The dosage form of the Chinese medicine composition is water decoction or granules.

3. The method for preparing a Chinese medicine composition for treating chronic heart failure according to claim 1, characterized in that: The Chinese medicine composition is a water decoction, and its preparation method is as follows: Weigh the above raw materials according to the ratio, remove impurities, wash, sun-dry or bake, and set aside; Soak the treated raw materials in water for 20 to 30 minutes, decoct for the first time for 10 to 15 minutes, pour out 150 to 200 ml of the liquid medicine; then add warm water, decoct for the second time, pour out 150 to 200 ml of the liquid medicine, mix the two liquid medicines to obtain the water decoction.

4. The method for preparing a Chinese medicine composition for treating chronic heart failure according to claim 1, characterized in that: The Chinese medicine composition is a Chinese medicine ointment, and its preparation method is as follows: Weigh the above raw materials according to the ratio, remove impurities, wash, sun-dry or bake, and set aside; Crush into powder, filter through a 100-mesh filter to obtain a mixture for later use; Soak in water for 8-10 hours, boil over high heat, and then simmer for 2 hours over low heat; simmer twice more, filter after simmering, and combine the filtrate; then add 10% of its weight of auxiliary materials and mix and concentrate to a thick paste with a density of 1.5-1.6, which is the Chinese medicine ointment.

5. Use of the Chinese medicine composition according to any one of claims 1-2 in the preparation of a medicament for treating chronic heart failure with yang-qi deficiency and blood stasis syndrome.

6. Use of the Chinese medicine composition according to any one of claims 1 to 2 in the preparation of a medicine for treating edema symptoms caused by chronic heart failure.

7. Use of the Chinese medicine composition according to any one of claims 1-2 in the preparation of a drug for treating chest tightness, shortness of breath and fatigue symptoms caused by chronic heart failure.

Images