An anti-fatigue traditional Chinese medicine preparation and a preparation method thereof

Abstract

This invention relates to a traditional Chinese medicine preparation for combating fatigue and its preparation method. The preparation method includes: weighing each raw material according to the formula; pulverizing and sieving American ginseng to obtain American ginseng powder; mixing astragalus, eleutherococcus senticosus, styrax chinensis, jujube seed, lily bulb, licorice, and American ginseng powder, adding water and decocting to obtain a medicinal liquid; filtering and concentrating to obtain a concentrated liquid, adding distilled water to obtain a diluted liquid; adding a stabilizer to the diluted liquid, sterilizing to obtain the traditional Chinese medicine preparation. The traditional Chinese medicine preparation of this invention has a reasonable component ratio, wherein American ginseng and astragalus are the principal herbs, which invigorate qi and nourish yin, clear heat and generate fluids, and tonify qi and raise yang; styrax chinensis and eleutherococcus senticosus are the assistant herbs, which regulate qi and promote blood circulation, dispel wind and dampness, tonify the middle and benefit essence, and invigorate qi and strengthen the spleen; jujube seed and lily bulb are the adjuvant herbs, which nourish the liver and calm the mind, nourish yin and moisten the lungs, and clear the heart and calm the mind; and licorice is the guiding herb to harmonize the various herbs. The traditional Chinese medicine prescription of this invention is safe and non-toxic with mild medicinal properties. It invigorates the spleen and benefits qi without harming yin or depleting qi, and nourishes qi and blood without being greasy or cloying and hindering the stomach.

Description

Technical Field

[0001] This invention belongs to the field of biopharmaceutical manufacturing technology, specifically relating to an anti-fatigue traditional Chinese medicine preparation and its preparation method. Background Technology

[0002] With the fast pace of life and increasing pressure from all sides, the proportion of people in a sub-healthy state has risen sharply. Fatigue is a major manifestation of sub-health, a pre-disease state and a pathogenic signal, which can lead to a series of physiological changes in the body, such as sleep disorders, endocrine disorders, metabolic disorders, and immune dysfunction. If chronic fatigue is not relieved in time, it can lead to various diseases such as aging, anxiety, depression, cancer, and Parkinson's disease, seriously affecting patients' lives and work. In other words, fatigue may be the initial stage of secondary diseases.

[0003] In Western medicine, fatigue is defined as "the body's physiological processes failing to maintain their function at a specific level or an organ failing to maintain its predetermined intensity of activity." Chemical treatments for fatigue primarily involve energy supplements, but these only alleviate symptoms and long-term use may lead to adverse reactions. In the broader system of Traditional Chinese Medicine (TCM), fatigue is typically categorized under terms such as "deficiency," "depletion," or "exhaustion."

[0004] The *Suwen* (Plain Questions) chapter "On the Six Sections and Visceral Manifestations" states, "The liver is the root of exhaustion," indicating that liver dysfunction is a significant cause of fatigue. The *Lingshu* (Spiritual Pivot) chapter "On the Nine Needles" records, "The liver governs the tendons," meaning liver dysfunction affects tendon function, leading to muscle weakness, tremors, and other pathological conditions. The *Lingshu* chapter "On the Fundamental Spirit" states, "The liver stores blood, and blood houses the soul," meaning the liver regulates the body's blood volume to meet the body's needs for activity. "The liver governs the free flow of qi and blood, and regulates emotions," meaning that normal free flow ensures smooth heart function and emotional well-being. Therefore, the key to fatigue lies in the liver; liver dysfunction can impair the free flow of qi and blood, disrupting the functions of the internal organs and leading to fatigue. The spleen is the foundation of acquired constitution and the source of qi and blood production. The spleen governs the muscles and limbs. Food and water rely on the spleen's transformation into essential nutrients. When the spleen's function is healthy, the transformation of these nutrients is abundant; when it is impaired, the transformation is insufficient, resulting in weakness in the limbs and fatigue. The kidneys are the foundation of innate constitution, storing essence, governing bones and producing marrow, and serving as the driving force and source of physical strength. Sufficient kidney essence ensures marrow production and bone nourishment; deficient kidney essence leads to weakness in the limbs and soreness in the lower back and knees. The heart governs blood vessels and mental activity, regulating blood circulation, nourishing the whole body, and regulating mental activity and adaptability to the external environment. The lungs assist the heart in circulating blood, helping the heart govern blood vessels and propel blood flow within them. Thus, each of the five internal organs has its own function and hierarchy, with the liver holding a central position, and the spleen and kidneys being key to physical strength generation. Furthermore, traditional Chinese medicine has a long history of application in combating fatigue, with significant effects. It can promptly eliminate or delay the onset of exercise-induced fatigue. Traditional Chinese medicine possesses unique advantages due to its multi-component, multi-functional synergistic properties, natural and safe ingredients, and minimal adverse reactions. Summary of the Invention

[0005] The primary objective of this invention is to provide a traditional Chinese medicine preparation for relieving fatigue.

[0006] The second objective of this invention is to provide a method for preparing a traditional Chinese medicine preparation for relieving fatigue.

[0007] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0008] This invention provides a method for preparing a traditional Chinese medicine preparation for combating fatigue, comprising the following steps:

[0009] (1) Weigh each raw material according to the formula of the traditional Chinese medicine preparation and set aside;

[0010] The traditional Chinese medicine preparation comprises the following raw materials in parts by weight: American ginseng 20-25 parts, astragalus 18-23 parts, fragrant vine 10-15 parts, eleutherococcus senticosus 7-12 parts, jujube seed 5-10 parts, lily bulb 9-14 parts, and licorice 3-8 parts.

[0011] (2) First, crush the American ginseng, sieve it to obtain American ginseng powder, and set it aside; then mix the powdered astragalus, Acanthopanax senticosus, sinomenium acutum, jujube seed, lily bulb, licorice and American ginseng evenly, add water and decoct to obtain the medicinal liquid; after filtration and concentration, obtain the concentrated liquid.

[0012] (3) Add distilled water to the concentrate to obtain a diluted solution; add a stabilizer to the diluted solution and sterilize to obtain a traditional Chinese medicine preparation.

[0013] Preferably, in step (1), the traditional Chinese medicine preparation includes the following raw materials in parts by weight: 22 parts of American ginseng, 20 parts of astragalus, 12 parts of fragrant vine, 10 parts of Acanthopanax senticosus, 8 parts of jujube seed, 12 parts of lily bulb, and 5 parts of licorice.

[0014] Preferably, in step (2), the amount of water used during decoction is 8-10 times the total mass of Astragalus membranaceus, Acanthopanax senticosus, Clematis armandii, Ziziphus jujuba var. spinosa, Lilium brownii, Glycyrrhiza uralensis and Panax quinquefolius powder; the number of decoctions is 2-4 times, and the time for each decoction is 2-3 hours.

[0015] Preferably, in step (3), the stabilizer is xanthan gum and kaempferol-3-O-glucoside.

[0016] Preferably, the amount of xanthan gum added is 0.2-0.4% of the mass of the diluent; the amount of kaempferol-3-O-glucoside added is 0.2-0.4% of the mass of the diluent.

[0017] Preferably, in step (3), the diluent contains 0.4-0.6 g / mL of crude drug.

[0018] This invention provides a traditional Chinese medicine preparation for relieving fatigue, which is prepared by the aforementioned preparation method.

[0019] The properties, meridian tropism, and efficacy of each drug in the traditional Chinese medicine preparation of this invention are as follows:

[0020] American ginseng: sweet and slightly spicy in taste, cool in nature, and non-toxic. It enters the heart, lung, and kidney meridians. It nourishes lung yin, clears deficiency fire, and promotes the production of body fluids and quenches thirst. It treats chronic cough due to lung deficiency, blood loss, dry throat and thirst, and fatigue due to deficiency heat.

[0021] Astragalus: It is warm in nature and sweet in taste. It has the effects of tonifying qi and raising yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, generating fluids and nourishing blood, promoting circulation and relieving pain, promoting detoxification and draining pus, and astringing sores and promoting tissue regeneration. It is mainly used to treat all syndromes of qi deficiency and blood deficiency.

[0022] Fragrant Vine: Bitter and pungent in taste, neutral in nature. It enters the lung and heart meridians. It has the effects of dispelling wind and dampness, cooling the blood and detoxifying. It can be used for symptoms such as traumatic injuries and headaches.

[0023] Acanthopanax senticosus: pungent, slightly bitter, warm. It enters the spleen, kidney, and heart meridians. It invigorates qi and strengthens the spleen, tonifies the kidneys and calms the mind. It is used for spleen and kidney yang deficiency, physical weakness and fatigue, loss of appetite, lower back and knee pain, insomnia and excessive dreaming.

[0024] Sour jujube seed: sweet, neutral. Enters the heart, spleen, liver, and gallbladder meridians. Nourishes the liver, calms the mind, soothes the nerves, and reduces sweating. Treats insomnia due to deficiency and restlessness, palpitations, thirst, and night sweats.

[0025] Lily bulb: Sweet in taste and cold in nature. It enters the heart and lung meridians. It nourishes yin and moistens the lungs, clears the heart and calms the mind. It is used for dry cough due to yin deficiency, cough with blood due to overwork, restlessness and palpitations, insomnia and dreaminess, and mental confusion.

[0026] Licorice: Sweet in taste and neutral in nature. It enters the heart, lung, spleen, and stomach meridians. It tonifies the spleen and replenishes qi, clears heat and detoxifies, resolves phlegm and relieves cough, alleviates spasms and pain, and harmonizes other herbs. It is used for spleen and stomach weakness, fatigue, palpitations, shortness of breath, cough with excessive phlegm, abdominal and limb spasms and pain, carbuncles and boils, and to alleviate the toxicity and harshness of other drugs.

[0027] Compared with the prior art, the main advantages of the present invention are as follows:

[0028] This invention provides a traditional Chinese medicine preparation for combating fatigue, comprising American ginseng, astragalus, eleutherococcus senticosus, *Cinnamomum camphora*, jujube seed, lily bulb, and licorice. The proportions of these ingredients are rationally balanced. American ginseng and astragalus are the principal herbs, used to invigorate qi and nourish yin, clear heat and generate fluids, and replenish qi and raise yang. *Cinnamomum camphora* and eleutherococcus senticosus are the assistant herbs, used to regulate qi and blood circulation, dispel wind and dampness, tonify the middle jiao and replenish essence, and invigorate qi and strengthen the spleen. Jujube seed and lily bulb are the adjuvant herbs, used to nourish the liver and calm the mind, nourish yin and moisten the lungs, and clear the heart and calm the spirit. Licorice is the guiding herb to harmonize the effects of the other herbs. This traditional Chinese medicine prescription is safe, non-toxic, and mild in nature. It invigorates the spleen and replenishes qi without harming yin or depleting qi, and replenishes qi and blood without being cloying or cloying, thus not hindering stomach function.

[0029] This invention provides a method for preparing a traditional Chinese medicine preparation for fatigue relief. The method is simple to operate. By adding stabilizers xanthan gum and kaempferol-3-O-glucoside, the stability of the traditional Chinese medicine preparation is increased. Its active ingredients are easily absorbed by the human body and have significant anti-fatigue effects. Detailed Implementation

[0030] The technical solution of the present invention will be further described below with reference to specific embodiments. However, those skilled in the art should understand that the following embodiments are only for illustrating the present invention and should not be regarded as limiting the present invention. Specific conditions not specified in the embodiments are performed according to conventional conditions or conditions recommended by the manufacturer. Unless otherwise specified, the reagents or instruments used are all conventional products obtained through commercial channels.

[0031] Example 1

[0032] This embodiment provides a method for preparing a traditional Chinese medicine preparation for combating fatigue, including the following steps:

[0033] (1) Weigh each raw material according to the formula of the traditional Chinese medicine preparation and set aside;

[0034] The traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 22 parts American ginseng, 20 parts Astragalus membranaceus, 12 parts Citrus aurantium, 10 parts Acanthopanax senticosus, 8 parts Ziziphus jujuba var. spinosa, 12 parts Lilium brownii, and 5 parts Glycyrrhiza uralensis.

[0035] (2) First, remove impurities, wash, dry and crush the American ginseng, pass it through a 100-mesh sieve to obtain American ginseng powder for later use; then mix the powders of Astragalus membranaceus, Acanthopanax senticosus, Fraxinus chinensis, Ziziphus jujuba var. spinosa, Lilium brownii, Glycyrrhiza uralensis and American ginseng evenly, add water with a total weight of 9 times, decoct 3 times, 2.5 hours each time, combine the decoctions from each decoction, filter and concentrate to obtain concentrated liquid;

[0036] (3) Dilute the concentrate with distilled water to a concentration of 0.5 g / mL of crude drug to obtain a diluted solution; add stabilizers (xanthan gum and kaempferol-3-O-glucoside) to the diluted solution and adjust the pH to 5; wherein the amount of xanthan gum added is 0.4% of the mass of the diluted solution and the amount of kaempferol-3-O-glucoside added is 0.4% of the mass of the diluted solution; sterilize at 115℃ for 30 min to obtain an oral solution.

[0037] This embodiment also provides a traditional Chinese medicine preparation for combating fatigue, which is prepared by the aforementioned preparation method.

[0038] Example 2

[0039] This embodiment provides a method for preparing a traditional Chinese medicine preparation for combating fatigue, including the following steps:

[0040] (1) Weigh each raw material according to the formula of the traditional Chinese medicine preparation and set aside;

[0041] The traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 25 parts American ginseng, 23 parts Astragalus membranaceus, 15 parts Citrus aurantium, 12 parts Acanthopanax senticosus, 10 parts Ziziphus jujuba var. spinosa, 14 parts Lilium brownii, and 8 parts Glycyrrhiza uralensis.

[0042] (2) First, remove impurities, wash, dry and crush the American ginseng, pass it through a 100-mesh sieve to obtain American ginseng powder for later use; then mix the astragalus, Acanthopanax senticosus, sedum, jujube seed, lily bulb, licorice and American ginseng powder evenly, add 10 times the total weight of water, decoct 4 times, 2 hours each time, combine the decoctions from each decoction, filter and concentrate to obtain concentrated liquid;

[0043] (3) Dilute the concentrate with distilled water to a concentration of 0.5 g / mL of crude drug to obtain a diluted solution; add stabilizers (xanthan gum and kaempferol-3-O-glucoside) to the diluted solution and adjust the pH to 5; wherein the amount of xanthan gum added is 0.3% of the mass of the diluted solution and the amount of kaempferol-3-O-glucoside added is 0.3% of the mass of the diluted solution; sterilize at 115℃ for 30 min to obtain an oral solution.

[0044] This embodiment also provides a traditional Chinese medicine preparation for combating fatigue, which is prepared by the aforementioned preparation method.

[0045] Example 3

[0046] This embodiment provides a method for preparing a traditional Chinese medicine preparation for combating fatigue, including the following steps:

[0047] (1) Weigh each raw material according to the formula of the traditional Chinese medicine preparation and set aside;

[0048] The traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 20 parts American ginseng, 18 parts Astragalus membranaceus, 10 parts Citrus aurantium, 7 parts Acanthopanax senticosus, 5 parts Ziziphus jujuba var. spinosa, 9 parts Lilium brownii, and 3 parts Glycyrrhiza uralensis.

[0049] (2) First, remove impurities, wash, dry and crush the American ginseng, pass it through a 100-mesh sieve to obtain American ginseng powder for later use; then mix the astragalus, Acanthopanax senticosus, sedum, jujube seed, lily bulb, licorice and American ginseng powder evenly, add 8 times the total weight of water, decoct twice, 3 hours each time, combine the decoctions from each decoction, filter and concentrate to obtain concentrated liquid;

[0050] (3) Dilute the concentrate with distilled water to a concentration of 0.5 g / mL of crude drug to obtain a diluted solution; add stabilizers (xanthan gum and kaempferol-3-O-glucoside) to the diluted solution and adjust the pH to 5; wherein the amount of xanthan gum added is 0.2% of the mass of the diluted solution and the amount of kaempferol-3-O-glucoside added is 0.2% of the mass of the diluted solution; sterilize at 115℃ for 30 min to obtain an oral solution.

[0051] This embodiment also provides a traditional Chinese medicine preparation for combating fatigue, which is prepared by the aforementioned preparation method.

[0052] Comparative Example 1

[0053] The difference between this comparative example and Example 1 is that the fragrant vine is omitted from the raw material composition. That is, the traditional Chinese medicine preparation in this comparative example includes the following raw materials in parts by weight: American ginseng 22 parts, astragalus 20 parts, eleutherococcus senticosus 10 parts, jujube seed 8 parts, lily bulb 12 parts, licorice 5 parts, and the rest are the same as in Example 1.

[0054] Comparative Example 2

[0055] The difference between this comparative example and Example 1 is that the stabilizer kaempferol-3-O-glucoside in step (3) is replaced with xanthan gum, while the rest is the same as in Example 1.

[0056] Test case

[0057] 1. Accelerated testing was conducted according to the General Chapter 9001 - Guidelines for Stability Testing of Raw Materials and Preparations in Part IV of the Chinese Pharmacopoeia (2020 Edition). The traditional Chinese medicine preparations obtained in Examples 1-3 and Comparative Example 2 were placed in a sealed environment at 40±2℃ and 75±5% relative humidity for 6 months. The content of ginsenosides (i.e., the total amount of ginsenoside Rg1, ginsenoside Re, and ginsenoside Rb1) in each group of traditional Chinese medicine preparations was measured at month 0 (initial), month 3, and month 6, and the ginsenoside loss rate (%) was calculated. Ginsenoside loss rate (%) = (initial ginsenoside content - ginsenoside content at month n) / initial ginsenoside content × 100%. The results are shown in Table 1.

[0058] Table 1

[0059]

[0060] As shown in Table 1, compared to Example 1, the traditional Chinese medicine preparation obtained in Comparative Example 2, after replacing kaempferol-3-O-glucoside with xanthan gum, showed significantly worse stability in accelerated testing than that of Example 1. The reason for this is that the traditional Chinese medicine preparation of this invention increases its stability by adding the stabilizers xanthan gum and kaempferol-3-O-glucoside, making its active ingredients easily absorbed by the human body and exhibiting significant anti-fatigue effects.

[0061] 2. Ninety-six SPF-grade Kunming mice, half male and half female, weighing 18-22g, were randomly divided into eight groups (blank control group, positive control group, high-dose group of Example 1, medium-dose group of Example 1, low-dose group of Example 1, low-dose group of Example 2, low-dose group of Example 3, and low-dose group of Comparative Example 1), with 12 mice in each group. The laboratory temperature was 22-25℃ and the relative humidity was 60-80%. The mice had free access to food and water and were acclimatized for 5 days before the experiment began.

[0062] The positive control group was administered American ginseng tablets (0.5 g / kg) by gavage daily for 30 consecutive days. The high-dose group in Example 1 was administered the herbal preparation obtained in Example 1 (5.0 g crude drug / kg) by gavage daily for 30 consecutive days. The medium-dose group in Example 1 was administered the herbal preparation obtained in Example 1 (3.0 g crude drug / kg) by gavage daily for 30 consecutive days. The low-dose group in Example 1 was administered the herbal preparation obtained in Example 1 (1.0 g crude drug / kg) by gavage daily for 30 consecutive days. The low-dose group in Example 2 was administered the herbal preparation obtained in Example 2 (1.0 g crude drug / kg) by gavage daily for 30 consecutive days. The low-dose group in Example 3 was administered the herbal preparation obtained in Example 3 (1.0 g crude drug / kg) by gavage daily for 30 consecutive days. The low-dose group in Comparative Example 1 was administered the herbal preparation obtained in Comparative Example 1 (1.0 g crude drug / kg) by gavage daily for 30 consecutive days. The blank control group was administered physiological saline (10 mL / kg) by gavage daily for 30 consecutive days. Mice were normally fed and had free access to food and water during this period.

[0063] (1) Mouse condition: During the administration period, the mice in each group were in good condition, with no abnormalities in food intake, urination and defecation, and mental state.

[0064] (2) On the 29th day after administration, a preliminary swimming experiment was conducted on mice. Each mouse swam for 10 minutes. One hour after the last administration, each group of mice was placed in a swimming box with a lead wire bearing 5% of their body weight on their tails. The water depth was 30 cm and the water temperature was 25 °C. The exhaustion index was defined as when the mouse's nose was submerged in the water for 10 seconds and no longer floated to the surface. The swimming end time was recorded. The duration from entering the water to the end of swimming (i.e., the weighted swimming time) was recorded. The results are shown in Table 2.

[0065] Table 2

[0066]

[0067] (3) After the mice swam to exhaustion, they were taken out, dried, and their eyeballs were removed to collect blood. The blood was centrifuged at 3500 r / min for 10 min to collect serum, which was stored at -20℃ for the determination of blood lactate (BLA) and blood urea nitrogen (BUN) content. Immediately after blood collection, the mice were euthanized by cervical dislocation, and their livers were removed, rinsed with physiological saline, and excess liquid was absorbed with filter paper. The livers were stored at -20℃ for the determination of liver glycogen (LG) content. The results are shown in Table 3.

[0068] Table 3

[0069]

[0070] As can be seen from Table 2-3, compared with the blank control group, the groups of the examples and comparative examples all prolonged the weight-bearing swimming time of mice to varying degrees, indicating that the traditional Chinese medicine preparation of the present invention can relieve the physical fatigue of mice. Compared with the blank control group, the contents of BLA and BUN in the groups of the examples and comparative examples of mice decreased to varying degrees, indicating that the traditional Chinese medicine preparation of the present invention can reduce the accumulation of BLA and BUN metabolites in mice, thereby improving the exercise tolerance of the body. Compared with the blank control group, the content of LG in the groups of the examples and comparative examples of mice increased to varying degrees, indicating that the traditional Chinese medicine preparation of the present invention can increase the glycogen content in the liver of mice, thereby improving the fatigue tolerance of mice.

[0071] At the same time, combined with Table 2-3, it can be seen that compared with Example 1, Comparative Example 1 omitted Illigera fragrans in the raw materials of the traditional Chinese medicine preparation, and the obtained traditional Chinese medicine preparation was not as good as Example 1 in relieving the physical fatigue of mice and improving the exercise tolerance of mice. The reason for the analysis is that the anti-fatigue traditional Chinese medicine preparation of the present invention uses American ginseng and Astragalus membranaceus as the monarch drugs to nourish qi and yin, clear away heat and promote production of body fluid, invigorate qi and lift yang; Illigera fragrans and Acanthopanax senticosus as the ministerial drugs to regulate qi and activate blood circulation, dispel wind and dampness, replenish middle qi and benefit essence, replenish qi and strengthen the spleen; Ziziphus jujuba var. spinosa and Lilium brownii var. viridulum Baker as the adjuvant drugs to nourish the liver and calm the mind, nourish yin and moisten the lungs, clear the heart and calm the mind; Glycyrrhiza uralensis Fisch. as the guiding drug to harmonize various drugs. The obtained traditional Chinese medicine formula can strengthen the spleen and replenish qi without damaging yin and consuming qi, and tonify qi and blood without being greasy and obstructive to the stomach, and can effectively achieve the anti-fatigue effect.

[0072] Finally, it should be noted that the above examples are only used to illustrate the technical solutions of the present invention, rather than to limit them. The basic principles and main features of the present invention have been described with specific implementation schemes above. On the basis of the present invention, some modifications or replacements can be made, but these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the present invention claimed.

Claims

1. A method for preparing a traditional Chinese medicine preparation for combating fatigue, characterized in that, Includes the following steps: (1) Weigh each raw material according to the formula of the traditional Chinese medicine preparation and set aside; The traditional Chinese medicine preparation comprises the following raw materials in parts by weight: American ginseng 20-25 parts, astragalus 18-23 parts, fragrant vine 10-15 parts, eleutherococcus senticosus 7-12 parts, jujube seed 5-10 parts, lily bulb 9-14 parts, and licorice 3-8 parts. (2) First, crush the American ginseng, sieve it to obtain American ginseng powder, and set it aside; then mix the powdered astragalus, Acanthopanax senticosus, sinomenium acutum, jujube seed, lily bulb, licorice and American ginseng evenly, add water and decoct to obtain the medicinal liquid; after filtration and concentration, obtain the concentrated liquid. (3) Add distilled water to the concentrate to obtain a diluent; add a stabilizer to the diluent and sterilize to obtain a traditional Chinese medicine preparation; the stabilizer is xanthan gum and kaempferol-3-O-glucoside.

2. The preparation method according to claim 1, characterized in that, In step (1), the traditional Chinese medicine preparation includes the following raw materials in parts by weight: 22 parts of American ginseng, 20 parts of astragalus, 12 parts of fragrant vine, 10 parts of Acanthopanax senticosus, 8 parts of jujube seed, 12 parts of lily bulb, and 5 parts of licorice.

3. The preparation method according to claim 1, characterized in that, In step (2), the amount of water used during decoction is 8-10 times the total mass of Astragalus membranaceus, Acanthopanax senticosus, Citrus aurantium, Ziziphus jujuba var. spinosa, Lilium brownii, Glycyrrhiza uralensis and Panax quinquefolius powder; the number of decoctions is 2-4 times, and the time for each decoction is 2-3 hours.

4. The preparation method according to claim 1, characterized in that, The amount of xanthan gum added is 0.2-0.4% of the mass of the diluent; the amount of kaempferol-3-O-glucoside added is 0.2-0.4% of the mass of the diluent.

5. The preparation method according to claim 1, characterized in that, In step (3), the diluent contains 0.4-0.6 g / mL of crude drug.

6. A traditional Chinese medicine preparation for relieving fatigue, characterized in that, The traditional Chinese medicine preparation is prepared by the preparation method described in any one of claims 1-5.

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