8 results about "Chitosan microspheres" patented technology

The application discloses a feed additive for removing microplastics, a preparation method and application. The composition consists of the following components in percentage by weight: modified chitosan microspheres 15-25%, nanoscale yeast cell wall derivatives 10-20%, fermentable dietary fiber complex 15-25%, glutamine 5-10%, complex probiotics and prebiotics 15-25%, and natural plant extract compound antioxidant 5-10%. The additive can be added to the feed at a weight ratio of 0.5-2.0% through a multi-target synergistic mechanism of 'adsorption-promoting excretion-repair-regulation', and can efficiently remove microplastics in aquatic products (the removal rate is up to 65% or more), improve intestinal health, enhance antioxidant function, reduce the residues of heavy metals and other complex pollutants, and significantly improve the edible safety and quality of aquatic products.

The application belongs to the technical field of water treatment, and particularly relates to a phosphorus-containing modified magnetic chitosan microsphere, a preparation method thereof and application of the phosphorus-containing modified magnetic chitosan microsphere in treatment of chromium-containing underground water. Compared with the prior art, the phosphorus-containing modified magnetic chitosan microsphere provided by the application takes magnetic nanoparticles as a core, can be quickly separated from a reaction system by relying on external magnetic force of a system, and forms hydrogen bonds through hydroxyl groups of the magnetic nanoparticles and amino groups and hydroxyl groups of a chitosan molecular chain, so that stability and dispersibility of the magnetic nanoparticles are improved. Furthermore, a tetramethylammonium hydroxide solution is used as a crosslinking agent, so that a phosphorus-containing cationic group in the tetramethylammonium hydroxide is grafted on the chitosan molecule, thereby greatly enhancing adsorption performance of the chitosan on anionic heavy metal pollutants such as Cr(VI), and having long-term stability in remediation of Cr(VI)-contaminated underground water.

This invention discloses a continuous flow method for preparing chitosan hollow microspheres. The invention utilizes ultrasonic microreactor technology combined with emulsion crosslinking to successfully prepare chitosan hollow microspheres. The hollow chitosan microspheres provided by this invention are suitable for encapsulating various drugs, with a precisely tunable particle size within the range of 200 nm to 1.5 μm. They exhibit excellent biocompatibility and biodegradability, and a high drug loading capacity. The preparation process is a continuous synthesis process, resulting in highly uniform particle size and morphology of the product. The preparation process is safe, efficient, and easily scaled up.

This invention discloses a chitosan-based lidocaine formulation for intra-articular use and its preparation method. Belonging to the field of pharmaceutical formulation technology, the formulation is prepared from chitosan, carboxymethyl chitosan, lidocaine, chitosan-PNIPAM microspheres, sulfated trehalose, and excipients. The chitosan-PNIPAM used in this invention exhibits dual temperature and pH response. With temperature changes, PNIPAM possesses both hydrophobic contractile and hydrophilic swelling states, thereby controlling the lidocaine release rate. Simultaneously, when the pH decreases, chitosan repels PNIPAM, further disintegrating the microspheres to release the drug, thus achieving targeted analgesia. Sulfated trehalose, as a cartilage matrix synthesis promoter, can activate intracellular signaling pathways in chondrocytes, promoting the synthesis of type II collagen and proteoglycans. Simultaneously, the sulfate groups can form electrostatic complexes with the amino groups of chitosan, enhancing drug retention. The formulation of this invention can inhibit synovial cells, release cytokines, and synergistically with carboxymethyl chitosan, increase the inhibition rate of inflammatory factors by 40%-50%.

The hemostatic gauze for hemodialysis comprises a gauze body, and a plurality of restraint straps are arranged on the gauze body. A contact layer, a hemostasis layer, an isolation layer and a fixing layer are sequentially arranged on the gauze body from bottom to top; the contact layer is made of a hydrophilic biocompatible material; thrombin, chitosan microspheres and gelatin sponge are arranged in the hemostatic layer; the isolating layer is made of a polytetrafluoroethylene film, and the fixing layer is made of elastic medical non-woven fabric. According to the multi-layer structural design that the gauze body is sequentially provided with the contact layer, the hemostasis layer, the isolation layer and the fixing layer from bottom to top, and all the layers are clear in function and cooperate with one another; the contact layer is in direct contact with the wound and is responsible for primary blood coagulation promotion and adhesion prevention; the hemostatic layer can stop bleeding efficiently; the isolating layer plays a dual role in blocking outside bacteria and preventing adhesion; the fixing layer ensures that the whole gauze is stably fixed at the wound part; due to the layered structural design, the hemostatic gauze can effectively meet various requirements for hemostasis and follow-up nursing of a hemodialysis puncture part.

The invention provides propranolol temperature-sensitive hydrogel as well as a preparation method and application thereof, and belongs to the technical field of medicines. The propranolol temperature-sensitive hydrogel disclosed by the invention is prepared from chitosan-beta-sodium glycerophosphate hydrogel and nano microspheres loaded on the chitosan-beta-sodium glycerophosphate hydrogel, wherein the chitosan-beta-sodium glycerophosphate hydrogel is a chitosan-beta-sodium glycerophosphate hydrogel; the nano microspheres are chitosan microspheres which are used for encapsulating propranolol; the mass of the nano microspheres is 1%-20% of the mass of the chitosan-beta-sodium glycerophosphate hydrogel. The propranolol temperature-sensitive hydrogel provided by the invention is a dual slow-release temperature-sensitive hydrogel system, not only has remarkable controlled release performance, can release drugs more continuously and stably, but also has good drug loading property and stable rheological property.

The application discloses an intravenous injection immunotargeting microsphere and a preparation method and application thereof, and relates to the field of lung tissue engineering.The method steps of the application comprise the following steps: preparing a drug-loaded chitosan solution; preparing the drug-loaded chitosan microsphere by using a water-in-oil emulsion method; grinding the drug-loaded microsphere in a mortar; then, the drug-loaded chitosan microsphere is soaked in a dopamine solution to react for a period of time to construct a dopamine active coating; finally, the abundant amino and hydroxyl functional groups of the chitosan microsphere are combined with an immunotargeting factor iNOS inhibitor through electrostatic interaction.The intravenous injection immunotargeting microsphere prepared in the application has good biocompatibility and size stability, can specifically recognize target cells and realize precise drug delivery, effectively improves the treatment efficiency of acute lung injury, and has good clinical application potential.

The present application relates to a kind of active wound dressings based on bacterial cellulose and chitosan microspheres encapsulating drugs and its preparation method, the chitosan microspheres utilize bacterial cellulose nanometer network as dispersed phase, let chitosan be dispersed in bacterial cellulose matrix into ball by ionic crosslinking method, and drug is encapsulated in ball, microsphere is attached on the nanometer fiber inside bacterial cellulose film or network inside pore.The active wound dressings of the present application has broad-spectrum antibacterial property and biological safety;Method is simple and efficient and avoid the use of toxic crosslinking agent, can make chitosan microspheres evenly distributed in film.When the encapsulated drug is berberine, it has the potential to treat diabetic foot.