Preparation method of in-situ gel sustained-release preparation for treating Bovine mastitis

A cow mastitis and in-situ gel technology, which is applied in the field of preparation of in-situ gel sustained-release preparations, can solve problems such as drug difficulty, achieve the effects of reduced toxic and side effects, significant curative effect, and simple preparation methods

Inactive Publication Date: 2010-03-10
TIANJIN SHENGJI GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the dosage form characteristics of the above-mentioned drugs used, it is difficult for the drugs used to concentrate on the target of the lesion, that is, the breast, to play a role.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Be 0.3: 1 by weight to take ciprofloxacin hydrochloride and film-forming macromolecular material chitosan, the above-mentioned two kinds of component mixtures are dissolved in water and make the aqueous solution that contains 1% chitosan, then the gained aqueous solution presses Conventional spray-drying removes the solvent to make chitosan microspheres containing ciprofloxacin hydrochloride; In the aqueous solution, the temperature-sensitive in-situ slow-release gel that can be used for intramammary perfusion is obtained.

[0016] The weight ratio of ciprofloxacin hydrochloride to the gel matrix in the gel is 0.05:1.

[0017] The weight ratio of the polymer materials poloxamer 188 and poloxamer 407 for preparing the temperature-sensitive in-situ gel is 1:1.

Embodiment 2

[0019] Weigh ciprofloxacin hydrochloride and film-forming polymer chitosan in a weight ratio of 0.1:1, dissolve the above two component mixtures in water to make an aqueous solution containing 1% chitosan, and spray the resulting aqueous solution Dry and remove the solvent to make chitosan microspheres containing ciprofloxacin hydrochloride; the obtained drug-containing microspheres are distributed in an aqueous solution of a mixture of poloxamer 188 and poloxamer 407 in a mass ratio of 0.1:1 In this process, a temperature-sensitive in-situ sustained-release gel that can be used for intramammary perfusion was obtained.

[0020] The weight ratio of ciprofloxacin hydrochloride to the gel matrix in the gel is 0.01:1.

[0021] The weight ratio of the polymer materials poloxamer 188 and poloxamer 407 for preparing the temperature-sensitive in-situ gel is 0.2:1.

[0022] Others are with embodiment 1.

Embodiment 3

[0024] Weigh ciprofloxacin hydrochloride and film-forming macromolecular material chitosan in a weight ratio of 0.5:1, dissolve the above two component mixtures in water to make an aqueous solution containing 1% chitosan, and then spray the resulting aqueous solution Dry and remove the solvent to make chitosan microspheres containing ciprofloxacin hydrochloride; the obtained drug-containing microspheres are distributed in an aqueous solution of a mixture consisting of poloxamer 188 and poloxamer 407 in a mass ratio of 5:1 In this process, a temperature-sensitive in-situ sustained-release gel that can be used for intramammary perfusion was obtained.

[0025] The weight ratio of ciprofloxacin hydrochloride to matrix in the gel is 0.1:1.

[0026] The weight ratio of the polymer materials poloxamer 188 and poloxamer 407 for preparing the temperature-sensitive in-situ gel is 2:1.

[0027] Others are with embodiment 1.

[0028] Application examples and curative effect determinatio...

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Abstract

The invention relates to a preparation method of in-situ gel sustained-release preparation for treating Bovine mastitis, which is characterized in that: the preparation steps are as follows: weighingciprofloxacin hydrochloride and film formation high molecular material chitosan according to a weight ratio of 0.1-0.5:1; dissolving the mixture of the two in water to prepare an aqueous solution containing 1 percent of chitosan, spraying and drying the aqueous solution to prepare a chitosan microsphere containing ciprofloxacin hydrochloride; distributing the obtained microsphere containing drug into the mixture aqueous solution formed by poloxamer 188 and poloxamer 407 according to the mass ratio of 0.1-5:1, thus obtaining the temperature-sensitive in-situ gel sustained-release preparation for treating Bovine mastitis. The sustained-release microcapsule containing inflammation diminishing medicine is distributed in the solution of high polymer material capable of forming gel at the body temperature. The in-situ gel containing inflammation diminishing medicine can treat Bovine mastitis by perfusion in breast; and the preparation method is simple, the product is safe in use, and the curative effect is accurate.

Description

technical field [0001] The invention relates to a preparation method of a preparation for treating dairy cow diseases, in particular to a preparation method of an in-situ gel sustained-release preparation containing bactericide sustained-release microcapsules perfused into the udder of a cow to treat cow mastitis. Background technique [0002] Mastitis is one of the most common diseases of dairy cows, and it is also the most harmful disease to dairy cows. According to statistics, clinical mastitis accounts for 21% to 23% of the total incidence of dairy cows. Mastitis leads to a decline in milk volume. In severe cases, the udder area is suppurated, gangrene, and atrophied, resulting in permanent loss of lactation ability. The number of cows eliminated due to mastitis accounts for 9% to 10% of the total number of dairy cows eliminated. [0003] Cow mastitis is mainly caused by a variety of non-specific pathogenic microorganisms, including bacteria, mycoplasma, fungi, and virus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/496A61K47/36A61P15/14A61P31/00
Inventor 田杏芳
Owner TIANJIN SHENGJI GRP CO LTD
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