6results about How to "Increase drug concentration" patented technology

This invention relates to the field of biopharmaceutical technology, providing a self-assembled peptide-rhein conjugate, its formulation, preparation method, and applications. The MMP-9-responsive self-assembled peptide-rhein conjugate of this invention, with the sequence Rhein-GFFPLGLAGACE, can respond to abnormally activated MMP-9 in atherosclerotic plaques, self-assembling in situ into a stable nanofiber structure at the lesion site. The rhein in this conjugate exhibits significant anti-inflammatory and antioxidant functions, but its water solubility and oral bioavailability are low. These are significantly improved after conjugation with the peptide, achieving targeted delivery and prolonging retention time. The introduction of the tripeptide ACE, which mimics the function of glutathione, further enhances the conjugate's ability to resist oxidative stress. Furthermore, this conjugate exhibits excellent anti-inflammatory and antioxidant effects, scavenging ROS, inhibiting inflammatory pathways, regulating macrophage phenotype, and inhibiting apoptosis, providing a new strategy for the treatment of atherosclerosis.

The invention particularly relates to a glycosylated dendrimer for co-delivery of small interfering RNA (Ribonucleic Acid) and small molecular drugs as well as a preparation method and application of the glycosylated dendrimer. The nano platform provided by the invention is characterized in that an anti-inflammatory drug resveratrol (Res) and electrostatic adsorption small interfering RNA (si-Cp2e1) are loaded in a glycosylated dendrimer G5-Gal. The preparation method and the application comprise the following steps: preparation of G5-Gal, preparation of Res (at) G5-Gal, and preparation of Res (at) G5-Gal / si-Cp2e1. The preparation method is simple, the required raw materials are easy to obtain, the synthesis process is simple and convenient, separation and purification are easy, and the synthesized nano-drug has a liver targeting capability, can realize dual treatment of small molecule drug-small interfering RNA, and has a potential application prospect in the aspect of treatment of alcohol-related liver diseases.

This invention discloses a bone repair scaffold material, its preparation method, and its application. The preparation method includes the following steps: preparation of a mineralized collagen core spinning solution; adding mangiferin to a PLGA electrospinning solution and stirring to obtain a shell spinning solution; and using the core spinning solution and the shell spinning solution, obtaining the bone repair scaffold material through coaxial electrospinning. In this invention, PLGA and mangiferin together form the shell of the scaffold structure, and the sustained release of mangiferin provides a guarantee for the anti-inflammatory and angiogenic effects of the scaffold material. Simultaneously, it simulates the fibrous structure of the bone matrix, achieving slow degradation of the core and achieving the goal of long-term promotion of bone repair.

This invention belongs to the field of biomedical technology and relates to an ultrasound-responsive microneedle for acne treatment, specifically a PVDF / curcumin hyaluronic acid microneedle for ultrasound-responsive acne treatment and its preparation method. It is prepared by mixing sodium hyaluronate, PVDF, and curcumin. The PVDF in the microneedle triggers the targeted release of curcumin under ultrasound stimulation, increasing the drug concentration at the lesion site; the antibacterial and anti-inflammatory effects of curcumin synergistically enhance the therapeutic effect of acne treatment with the repair function of hyaluronic acid; the hyaluronic acid matrix reduces skin irritation, making it suitable for long-term use; the preparation process is simple, reproducible, and easy to scale up.

The invention belongs to the technical field of pharmaceutical preparations, and particularly provides a salinomycin derivative sal-098 targeted liposome as well as a preparation method and application thereof. The membrane is prepared from a membrane material, a long circulating substance, a stabilizer, a salinomycin derivative and a tumor targeting substance through a membrane hydration method. The salinomycin derivative targeted liposome disclosed by the invention can target colorectal cancer tissues, more efficiently kill tumor cells and reduce the toxicity of salinomycin derivatives at the same time.

The application relates to a preparation and application of an FXI targeting siRNA molecule and a GalNAC conjugate thereof. The siRNA molecule takes TN7 sequence as a core, is obtained through precise bioinformatics design and high-throughput screening, and has excellent gene silencing activity. Through systematic chemical modification optimization, the stability of the molecule is significantly improved. More importantly, the TN7-GalNAC conjugate exhibits an unprecedented persistent inhibitory effect in a mouse in-vivo experiment, and the FXI protein level is maintained below 10% of the basic level within 28 days after single administration. The application provides a new molecular tool for precise treatment of thrombotic diseases, and has important clinical application value.