The invention relates to a cyclic nucleoside phosphate compound in a structure shown as a formula I described in the specification and a preparation method and an application thereof. The cyclic nucleoside phosphate compound in the structure shown as the formula I is a precursor drug with an antivirus effect, wherein X is selected from any one of hydrogen, fluorine, chlorine, bromine and iodine, Y is selected from any one of oxygen and sulfur, and Z is arycyclo or arycyclo with 1-3 substituents; the arycyclo is selected from any one of phenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furyl, 3-furyl, 2-thienyl and 3-thienyl, the substituent on the arycyclo is selected from any one of fluorine, chlorine, bromine, iodine, trifluoromethyl, C1-3 alkyl and -OR, and R is selected from any one of trifluoromethyl and C1-3 alkyl.