243 results about "Active target" patented technology

A volumetric error compensation measurement system and method are disclosed wherein a laser tracker tracks an active target as the reference point. The active target has an optical retroreflector mounted at the center of two motorized gimbals to provide full 360 degree azimuth rotation of the retroreflector. A position sensitive detector is placed behind an aperture provided at the apex of the retroreflector to detect the relative orientation between the tracker laser beam and the retroreflector by measuring a small portion of the laser beam transmitted through the aperture. The detector's output is used as the feedback for the servo motors to drive the gimbals to maintain the retroreflector facing the tracker laser beam at all times. The gimbals are designed and the position of the retroreflector controlled such that the laser tracker always tracks to a pre-defined single point in the active target, which does not move in space when the gimbals and/or the retroreflector makes pure rotations. Special mechanism and alignment algorithm are used in the gimbal design and retroreflector centering alignment to achieve accurate rotational axis alignment and repeatability.

A three-dimensional imaging radar operating at high frequency e.g., 670 GHz, is disclosed. The active target illumination inherent in radar solves the problem of low signal power and narrow-band detection by using submillimeter heterodyne mixer receivers. A submillimeter imaging radar may use low phase-noise synthesizers and a fast chirper to generate a frequency-modulated continuous-wave (FMCW) waveform. Three-dimensional images are generated through range information derived for each pixel scanned over a target. A peak finding algorithm may be used in processing for each pixel to differentiate material layers of the target. Improved focusing is achieved through a compensation signal sampled from a point source calibration target and applied to received signals from active targets prior to FFT-based range compression to extract and display high-resolution target images. Such an imaging radar has particular application in detecting concealed weapons or contraband.

A method, mesh data structure and apparatus is disclosed for producing an improved/refined/derefined mesh of finite elements for a three-dimensional object showing boundaries and faces. The improvement/refinement method repeatedly searching, for consecutive sets of active target elements to be refined or improved, an associated submesh and set of terminal edges, the searching process not modifying the mesh data structure; then according to the point insertion method chosen, selection of the point or the points to be inserted between the midpoints of the terminal edges modified by some boundary considerations; inserting the selected point or points in the initial mesh; and then proceeding to the succeeding set of active target elements until an user-defined stopping criterion is achieved.The derefinement method, for each target vertex finding an associated set of neighbor vertices to be derefined; then eliminating each said vertex according an appropriate order such that the derefinement of said vertex allows to re-obtain a previous terminal edge whose bisection produced said vertex. The method, mesh data structure and apparatus of this invention allowing the parallel scaleable refinement/derefinement of the mesh by locally modifying sets of neighbor elements sharing the common longest-edge.

The invention relates to a multi-function nano prodrug system based on a dendrimer, which belongs to the technical field of biomedicines and nano medical science. The nano system comprises four function parts: an outermost layer RGD (arginyl-glycocoll-aspartate) cyclic peptide as an active targeting head group (1), a polyethylene glycol (PEG) hydrophilic chain segment (2) connected with the targeting head group and the dendrimer, an anti-tumour drug (3) connected with the dendrimer by an acid sensitive chemical bond and a dendrimer kernel (4). The general formula of the nano system is RGD-PEG-Dendrimer-DOX (doxorubicine), wherein the macromolecule attribute of a dendrimer vector makes a vector system passively target to tumor tissues through an EPR (Enhanced Permeability and retention) effect; the RGD cyclic peptide makes the vector system actively target to the tumor tissues through the interaction of a ligand and a receptor and promotes the endocytosis of the tumor tissues; the acid sensitive chemical bond ensures that a drug-carrying system is stable in systemic circulation and releases active drugs after arriving tumor positions and entering an acid organelle to perform the function of cytotoxicity.

The invention discloses a preparation method of PAMAM and CRISPR/Cas9 system recombinant plasmid delivering nanoparticles with tumor targeting. Firstly, Apt carboxyl is activated, Apt is reacted withamino on the surface of PAMAM to synthesize an Apt-PAMAM carrier, sgRNA is designed, an EGFR-sgRNA/Cas9 recombiant plasmid is constructed, and the recombiant plasmid and the carrier form an Apt-PAMAM/EGFR-sgRNA/Cas9 nano compound through electrostatic interaction. According to the compound, by means of compound surface-modified Apt active targeting tumor cell surface high expression EpCAM protein,tumor tissue targeting is improved; through a CRISPR/Cas9 gene editing technology, the recombiant plasmid of an EGFR-sgRNA gene is designed to knock out a high-expression EGFR gene in a tumor cell, so that the anti-tumor effect is achieved.

A hydropower station set LCU active pulse adjusting system disclosed by the present invention comprises a module of obtaining a set active target value, a module of obtaining a power adjusting mode, a module of obtaining opening mode initial values by an interpolation algorithm, a module of obtaining an adjustment pulse width by a modified proportional algorithm and a set active monitoring module. According to the present invention, and according to the head change, the interpolation algorithm is used to calculate the opening mode initial values comprising a set active current value, an adjustment target value, an adjustment dead zone value and a pulse adjustment proportion coefficient K value, and the modified proportional algorithm is used to calculate a power pulse width. The hydropower station set LCU active power pulse adjusting system is provided for the first time, and satisfies the set active adjustment rapid stability and reliability requirements of a large-scale hydropower station monitoring system.

An image display apparatus includes a communication unit to communicate with information processing apparatuses; an image synthesizing unit to synthesize a multi-segmented screen image composed of screen images of the information processing apparatuses; a projection unit to project the multi-segmented screen image onto a screen; a functional mode management unit to control switching between a normal projection mode and a multi-segmented screen operation mode; an image capture device to capture the multi-segmented screen image and a hand movement of an operator when switched to the multi-segmented screen operation mode; a designated screen image recognition unit to detect a hand movement of the operator based on the image captured by the image capture device, and to recognize a screen image designated as an active-target image; and a signal control unit to transmit a request of image data transmission to an information processing apparatus corresponding to the designated active-target image.

The invention relates to an underwater active vision tracking method applied to a bionic robot fish, which comprises embedded visual system based active target identification and target positioning. The method comprises the steps of S1, acquiring a digital underwater image by a digital camera; S2, carrying out target identification based on one of color features, shape features and contour features, and acquiring an underwater target region of one of the color features, the shape features and the contour features; and S3, carrying out feature description on the target on the underwater target region of one of the color features, the shape features and the contour features by adopting a weighted color histogram, and realizing positioning for the underwater target according to the target feature description. The underwater active vision tracking method provided by the invention does not need to carry out preprocessing on the image, is small in calculation amount, good in real-time performance, accurate in positioning and applicable to scenes in which system resources are limited and the environment is relatively simple; and the underwater active vision tracking method is also applicable to active vision tracking under different environments and particularly to embedded visual applications on the bionic robot fish.

The invention belongs to the field of organic synthesis or pharmaceutical preparations and relates to a synthesis method of a hyaluronic acid-photosensitizer/antitumor drug with synergistic anti-tumor efficacy and a preparation method of a nano drug delivery system. Conjugates are amphiphilic by connecting a photosensitizer and an indissolvable antitumor drug on a hyaluronic acid skeleton by ester bonds and are self-assembled in water to obtain a nanomicelle. The synthesis method and the preparation method are characterized by comprising the synthesis method of covalent linkage of hyaluronic acid and a photosensitizer/antitumor drug and a method for self-assembling the nano drug delivery system by the hyaluronic acid-photosensitizer/antitumor drug. The system is expected to have good biocompatibility and active targeting property of tumors in a body; the solubility of the indissolvable antitumor drug can be improved, the phagocytosis of a reticuloendothelial system is avoided, and the cycle time in the body is prolonged; after the system reaches a lesion location, the ester bonds of the system are fractured in a tumor microenvironment under the condition of a low pH value and releases the photosensitizer and the antitumor drug; the system is excited by near-infrared light to generate heat and fluorescence; on one hand, tumor cells are killed and wounded by a phototherapy and chemotherapy combined mode; on the other hand, distribution conditions of the tumor cells in the body can be characterized.

The invention discloses a preparation method and application of degradable hyperbranched polyamidoamine. Degradable hyperbranched polyamidoamine is prepared by taking a bifunctional monomer containing a disulfide bond or a ketal bond and an amino-containing trifunctional monomer N-aminoethylpiperazine (AEPZ) or diethylenetriamine (DETA) as main raw materials and employing a one-pot method to perform Michael addition polymerization reaction. By coupling polyethylene glycol (PEG) and folic acid (FA) with degradable hyperbranched polyamidoamine, folic-acid-targeted PEGylated degradable hyperbranched polyamidoamine is obtained. The raw materials are easily available, the preparation method is simple, and the prepared polymer medicine carrier has the advantages of hyperbranched polyamidoamine, such as three-dimension branching structure, a lot of cavities at the interior of molecules, low viscosity, a lot of functional groups, simple preparation method, biodegradability, and the like. Additionally, the water solubility and the stability of the carrier material are improved by grafting a PEG chain segment to the terminal, and the carrier is endowed with active targeting property on tumor cells through coupling of FA.

The invention provides a preparation method of a target compound nano particle, relating to a preparation method of target treatment integration compound nano particles. The invention solves the technical problems of poor carrier stability and small drug-loading quantity of the traditional antineoplastic drugs. The method comprises the following steps of: preparing a methanol solution of an integrated nano particle of a Fe3O4-HCPT@SiO2 coupling porphyrin photosensitizer; and stirring the methanol solution of the integrated nano particle of the Fe3O4-HCPT@SiO2 coupling porphyrin photosensitizer, N,N-dimethylformamide and target biomolecule or antitumor drug for reacting at the room temperature, and centrifuging to obtain the target compound nano particle. Polystyrolsulfon acid (PSS) and 10-hydroxycamptothecine are absorbed on a Fe3O4 magnetic nano particle through a self-assembly mode. The preparation method is high feasibility; the target compound nano particle has a physical target function of the magnetic nano particle and an active target function of further functionally modifying the biomolecule on the surface; and the medicine concentration can be increased under a dual-target function.

The invention belongs to the fields of polymer chemistry and medicinal preparations, and particularly relates to a method for synthesizing an active targeted hyaluronic acid-polylactic acid carrier, a method for preparing an anti-tumor medicinal micelle of the active targeted hyaluronic acid-polylactic acid carrier and an application thereof. By adopting a novel self-assembly technology, amphipathic PEG (polyethylene glycol) block polyester copolymer and tumor targeted ligand hyaluronic acid-polylactic acid copolymer are self-assembled by means of the electrostatic interaction to form a multifunctional composite micelle; the solubility of insoluble tumor medicaments and the drug loading capacity and encapsulation efficiency of water-soluble anti-tumor medicines can be remarkably improved by virtue of the anti-cancer drug-loaded micelle and composite micelle composition, the medicines can be biodegraded in a body, phagocytosis of a reticuloendothelial system (RES) and excretion of a kidney can be avoided. The active targeted hyaluronic acid-polylactic acid carrier has a long-circulating effect, the multifunctional composition has a prominent advantage of tumor active targeting effect, and parameters of pharmacodynamics in vitro and in vivo of the micelle are remarkably superior to those of common anti-tumor injections. Clinically acceptable administration means of the micelle includes injection administration or mucosal administration, and preparations of the micelle can be injection, transfusion, injection lyophilized powder injections or dry powder inhalation.

The invention provides a tumor active-targeting nano drug delivery system capable of reversing drug-resistance. The drug delivery system is polylactic-co-glycolic acid (PLGA) nanoparticles mixed with lipid, and the nanoparticle core is PLGA. Drug-loaded nanoparticles are prepared as follows: inserting AA-polyethylene glycol-cholesterol linkers and triphenylphosphine-cholesterol linkers in the surface of PLGA; encapsulating DOX into the PLGA nanoparticles mixed with lipid to obtain the drug-loaded nanoparticles. The drug delivery system has the acid sensitivity, which enables the drug delivery system to proactively recognize tumor cells and position and release DOX into the mitochondria and cell nuclei of tumor cells, thereby enhancing the anti-tumor activity, reversing the drug-resistance of the tumor and providing a new strategy for improving the efficacy of DOX.

Method for hyper-spectral imaging and analysis of a sample of matter, for identifying and characterizing an object of interest therein. Preparing test solution or suspension of the sample, including adding thereto a spectral marker specific to object of interest, such that if object of interest is in test solution or suspension, object of interest becomes a hyper-spectrally active target which is hyper spectrally detectable and identifiable; adding to test solution or suspension a background reducing chemical, for reducing background interfering effects caused by presence of objects of non-interest in test solution or suspension, thereby increasing hyper spectral detectability of hyper spectrally active target in test solution or suspension; generating and collecting hyper-spectral image data and information of test solution or suspension; and, processing and analyzing thereof. Exemplary objects of interest are biological agents—bacteria (Bacillus anthracis), viruses, fungi, toxins, or, chemical agents—nerve agents (sarin, tabun, soman), and chemical poisons.

The invention belongs to the field of pharmacology, and relates to stapled-RGD polypeptide, and applications thereof in tumor targeting delivery. Multifunctional targeting polypeptide molecule stapled-RGD with high combination activity with integrin and biological membrane barrier penetration capacity is designed and prepared based on binding peptide cyclization technology; and preparation of fluorescein, drugs, and high molecule carriers modified by the multifunctional targeting polypeptide molecule stapled-RGD, and applications of the fluorescein, the drugs, and the high molecule carriers in tumor imaging and construction of targeted therapy targeted drug delivery systems are disclosed. It is shown by results that specific uptaking of model drugs carried by stapled-RGD by positive cells, tumor mimicry vessels, and tumor ball tissues of expressed integrin is realized, higher tumor targeting capacity, imaging functions, and membrane barrier cell penetration capacity are achieved; nano targeted drug delivery systems constructed by the high molecule carriers modified by stapled-RGD can be used for delivering carried model drugs to target tissues, antitumor drug effect is improved obviously; and stapled-RGD possesses a promising application prospect in mediating drugs, nano targeted drug delivery system membrane barrier penetration, active target searching, tumor diagnosis, and targeted therapy.

The invention discloses a codon-optimized 7 beta-hydroxy steroid dehydrogenase gene, a recombination expression vector Pgex-6P-1-7 beta-HSDH containing an optimized gene and escherichia coli containing the recombination expression vector. Glutathione S-transferase (GST) fusion expression of the codon-optimized 7 beta-hydroxy steroid dehydrogenase gene and a prokaryotic expression vector Pgex-6P-1 in the escherichia coli is adopted, so that a large quantity of active target proteins with an integral structure can be generated in a short time; and a method for purifying the GST fusion expression protein is simple and quick, so that the active target proteins can be quickly obtained.

The invention discloses an active target contour tracking method with motion information combined. With a super pixel as a basic element, apparent characteristics and motion characteristics of a target and a background area are modeled respectively, a decision tree algorithm is adopted to fuse the two, dependence on the apparent characteristics by the traditional active target contour tracking method is overcome, and when the target and the background have similar characteristics such as the color and the texture, the tracking precision is enhanced obviously in a scene with an apparent relative motion, and the application prospect is good.

The invention discloses a protein-polymer composite nano-carrier and a preparation method thereof and relates to the field of nano preparations of antitumor medicines. The protein-polymer composite nano-carrier is designed and developed on the basis of the characteristics of a lipoprotein structure of a human body and comprises a polymer core and a hydrophilic protein shell; a targeting ligand can be flexibly modified according to the treatment requirement, so as to construct the protein-polymer composite nano-carrier with active targeting property; the in vivo stability of the medicine is improved; the tumor targeting property is increased. In order to increase the load rate of the protein on the polymer kernel, a cationic additive is added to the formula to prepare a cationic polymer nanoparticle; nano suspension is milk white liquid; spherical particles with relatively uniform distribution can be seen by scanning through a transmission electron microscope. A freeze-drying protective additive is added for freeze-drying the nano suspension to form powder, so that the protein-polymer composite nano-carrier is relatively easy to store and the stability is improved. The protein-polymer composite nano-carrier prepared by the method is uniform in particle size and good in stability; and a fat-soluble antitumor medicine can be effectively encapsulated.

The invention discloses an ultra-short baseline underwater positioning method based on an active target detection principle. The method comprises the following steps of adopting a microcontroller to generate a GOLD sequence; adopting a modulator to modulate a sinusoidal signal and form a modulating signal according to the GOLD sequence; adopting a matching amplifier to matching and amplifying the modulating signal; adopting an energy converter to emit an ultrasonic incident wave according to the matched and amplified modulating signal; adopting a receiving array to receive a reflected ultrasonic echo wave as the ultrasonic incident wave is contact with an object to be positioned; adopting a filter amplifier to filter and amplify the ultrasonic echo wave; adopting the microcontroller to collect and demodulate the filtered and amplified ultrasonic echo wave to obtain an echo wave sequence signal; utilizing an FFT (Fast Fourier Transform Algorithm) to calculate the period and the phase position of the echo wave sequence signal; adopting a relationship between a physical law and a solid geometry to obtain a three-dimensional coordinate of the object to be positioned according to the period and the phase position. The invention also discloses an ultra-short baseline underwater positioning system based on the active target detection principle. The method and the system can realize multisystem and multitarget detection.

The invention discloses an active target identification method based on a digital watermark technology in H.264, and aims to solve the problems of high calculation complexity, low precision and the like of a target identification algorithm in an intelligent video monitoring system. Different digital watermarks are embedded into a target region in a code reconstruction frame of the current frame and used as unchanged characteristics of a target according to interframe forecast and code reconstruction characteristics of the H.264; different types of watermark information are extracted from a target region in an interframe forecast reference frame (a reconstruction frame of the last frame) of the next frame, so that the target can be identified; and then matched watermarks are embedded into a motion detection and partition result of the reconstruction frame for recycling until motion targets in a complete video sequence are identified. The active target identification method has the advantages of simplicity, high accuracy and instantaneity, and the objective quality of video codes is not influenced greatly.

The present invention provides an active targeting polymer micelle encapsulating a drug, preventing an inappropriate release of a drug which may damage a normal cell. A polymer micelle 100 includes a backbone polymer unit 10 that has a target binding site 11 and a backbone polymer unit 20 that has a drug 14 and is free from the target binding site 11, such polymer units 10 and 20 being disposed in a radial arrangement in a state where the target binding site 11 is directed outward and the drug 14 is directed inward, in which: i) when the micelle is bound to a target 40 while maintaining the radial arrangement, the micelle is taken up into a cell 50 supplying the target 40 through endocytosis, and the drug 14 is released into the cell 50 by collapse of the radial arrangement in the cell 50; and ii) when the radial arrangement collapses in blood 60 before the micelle is bound to a target 40, the unit 20 is excreted through metabolism, to thereby prevent a normal cell from being damaged by the drug 14.

The invention discloses a hydrogel based on aptamer linking and a preparation method and application thereof. The hydrogel can connect different aptamers to realize the active targeting drug release to different cancer cells. The preparation method comprises the following steps: (1) connecting DNA single strand and acrylamide to obtain polymer chains, PS-A and PS-B; and (2) mixing the obtained PS-A, PS-B, an aptamer chain and an anticancer drug to obtain a drug loaded hydrogel. The hydrogel during preparation is directly mixed anticancer drugs, realizes drug entrapment during a self-assembly process. The hydrogel completes drug entrapment in the self-assembly process, is capable of specific recognition of cancer cells, achieves the targeting release of anticancer drug, and is suitable for targeted cancer therapy.

The present invention discloses albumin nanoparticles, a preparation method and applications, wherein the albumin nanoparticles and an antibody or antibody drug conjugate (such as doxorubicin) are subjected to adsorption connection. According to the present invention, the experiment results show that: compared with the single drug, the nanoparticles modified with the antibody or antibody drug conjugate have advantages of enhancement of targeting property, and reduction of toxic-side effects of drugs on the body; and the formed albumin nanoparticles use the enhanced permeability and retention effect (EPR) of the tumor tissue to enhance the intratumoral accumulation so as to provide a certain slow release effect and a certain drug efflux inhibition effect, enhance the biological utilization rate of the drug, and reduce the drug consumption, such that the efficient and low-toxicity nanometer treatment way is provided for the tumor targeting therapy.