103 results about "Drug consumption" patented technology

The present disclosure generally pertains to systems and methods for drug compliance monitoring. A drug compliance monitoring system in accordance with one exemplary embodiment of the present disclosure comprises a portable drug containment unit, which has a drug container, such as a pill bottle, for holding prescription or non-prescription drugs. The drug containment unit also comprises at least one sensor and control logic. The sensor is configured to automatically sense a parameter indicating when a drug, such as one or more pills or an amount of liquid, has been or is about to be removed from the drug container. The system, based on the sensor, automatically estimates and tracks drug consumption and provides a patient with reminders when a dosage is currently due. If the patient deviates from an expected drug regime, the system automatically senses this event and provides a notification to the patient or caregiver. In addition, the system stores a usage history indicating the approximate time and amount of each sensed dosage.

An augmented, adaptive algorithm utilizing model predictive control (MPC) is developed for closed-loop glucose control in type 1 diabetes. A linear empirical input-output subject model is used with an MPC algorithm to regulate blood glucose online, where the subject model is recursively adapted, and the control signal for delivery of insulin and a counter-regulatory agent such as glucagon is based solely on online glucose concentration measurements. The MPC signal is synthesized by optimizing an augmented objective function that minimizes local insulin accumulation in the subcutaneous depot and control signal aggressiveness, while simultaneously regulating glucose concentration to a preset reference set point. The mathematical formulation governing the subcutaneous accumulation of administered insulin is derived based on nominal temporal values pertaining to the pharmacokinetics (time-course of activity) of insulin in human, in terms of its absorption rate, peak absorption time, and overall time of action. The MPC algorithm is also formulated to provide control action with an integral effect, and in essence minimizes overall drug consumption. When employed as a modulator in an automated integrated glucose-control system for type 1 diabetes, the control algorithm provides the system with self-learning capability that enables it to operate under unrestricted activity of the subject.

The invention relates to the technical field of wastewater treatment, and in particular relates to a papermaking wastewater treating agent and a preparation method thereof. The papermaking wastewater treating agent comprises the following raw materials in parts by weight: 2-10 parts of ferrous sulfate, 10-20 parts of magnesium sulfate, 0.5-1.5 parts of polyacrylamide, 15-25 parts of ferric nitrate, 1-5 parts of nickel nitrate, 35-50 parts of polyaluminum chloride, 15-30 parts of starch xanthate, 2-5 parts of tetrasodium 2-phosphonobutane-1, 2, 4-tricarboxylate, 0.5-1 part of zinc sulfate, 1-3 parts of benzotriazole, 16-30 parts of modified kieselguhr, 5-20 parts of cross-linked rectorite and 5-8 parts of a chitosan-graphene composite material. The papermaking wastewater treating agent disclosed by the invention is wide in using range, simple in treatment process, small in drug consumption, good in treatment effect, stable in performance and good in effluent quality and is capable of effectively reducing the cost of water treatment, so that the papermaking wastewater treating agent has a very good economic benefit and a wide social benefit.

The invention discloses a three-dimensional high-flux drug screening PDMS-glass chip and the preparation method thereof, which makes uses of micro-electro processing and micro-plastic film technologies to produce the three-dimensional PDMS-glass chip with a two-layer micro-channel structure. A cell injection and waste liquid output channel of a first layer of PDMS chip is bonded with another layer of polydimethyl siloxane chip together, a drug concentration gradient channel and a quantitative cell culture chamber are arranged on the other layer of PDMS chip, the quantitative cell culture chamber is connected with an outlet channel of the drug concentration gradient channel, the quantitative cell culture chamber is respectively connected with a cell sample injection hole drilling position and a waste liquid outlet hole drilling position by the channel; the three-dimensional high-throughput drug screening PDMS-glass chip can overcome the shortcomings of heavy workload, great reagent and drug consumption, long screening period and high development cost of the traditional drug screening technology. The three-dimensional high-flux drug screening PDMS-glass chip can realize miniaturization of the chip, high flux, low cost, small reagent consumption, accurate and reliable test data and the simple design requirements of the operational process in the drug screening application on cell level.

The invention provides a deepwater circulating and enhanced coagulating sedimentation algae-removing water treatment system and a treatment method, belonging to the technical field of feed water treatment. The deepwater circulating and enhanced coagulating sedimentation algae-removing water treatment system comprises a water supply pump, a water treatment tank and a drug feeding device, wherein the water supply pump and the drug feeding device are respectively connected with the water treatment tank through a pipeline; the deepwater circulating and enhanced coagulating sedimentation algae-removing water treatment system is characterized by being provided with a deep water circulating well for stressing air bags in the algae crack; the circulating well is provided with an inlet and an outlet; the inlet of the circulating well is connected with the water supply pump; and the outlet of the circulating well is connected with the water treatment tank. The water supply pump injects algae-containing water into the circulating well and enters the water treatment tank; the air bags in algae cells crack under high-pressure effect of the deep water of the circulating well so that the algae lose buoyancy to be easy to precipitate. A coagulant, the algae and other impurity grains collide in a reaction tank to be combined into larger floc grains so as to precipitate and be removed in a sedimentation basin. With the adoption of the method, the air bags of the algae are enabled to crack, the sedimentation speed is high and the removing effect is good; the algae cells are not damaged and water supply is safe; and the drug consumption and the energy consumption are low and the operation cost is low.

The invention relates to an insecticide composition containing spinosad and neonicotinoid insecticide and the application thereof. The composition comprises spinosad which is used as a first active ingredient and neonicotinoid insecticide which is used as a second active ingredient; wherein the second active ingredient is selected from imidacloprid or thiamethoxam; the weight ratio between the first active ingredient and the second active ingredient is (0.01-200):1, preferably, (0.05-20) :1. The composition has the advantages that the components are reasonable, the disinsection effect is good, the drug consumption cost is low, the activity and the disinsection effect have remarkable synergistic action but not simple superposition of the activities of all the components, resistance can not be generated, the level of residue of the preparation is low, no pollution can be caused to crops, the security is good, and thereby the composition conforms to the security requirement for pesticide preparations. The composition has 87.11 to 96.04 percent of prevention and control effects on thysanoptera pests, for example, common thrips, and homoptera pests such as lice and aphides.

The invention provides a method for floating selecting coal mud, which combines surface modifier and micro foam floating selector, to select multiple coals and sink coals, to improve quality and accuracy, wherein the drug consumption (catcher and foaming agent) is reduced 20% and the floating extracting rate is improved more than 10%.

The invention relates to a non-needle injection method and relative device, formed by an adsorption cup, an adsorption depressurize device, and an injector, wherein, the cup clamps the skin; the depressurize device depressurizes the cup to form a passive area, to make the inner skin convex with increased volume and reduced inner pressure, to absorb nearby body fluid; at the same time, the piston of drug tube is fixed on the piston rod, and the convex skin will contact and press the injection drug tube to move it inwards along with the piston rod, to increase the liquid pressure in the drug tube, to be injected into the skin via the lower injection hole and absorbed. The invention has controllable drug consumption and injects several points at one time, without hurting the nerve organisms.

The invention belongs to the technical field of coal preparation plant's slime water treatment link and mainly relates to an automatic addition system and a method of slime water treatment equipment thickener drugs. According to the thickener automatic drug dosing system and the method and mainly in the coal preparation plant's slime water treatment link, a PLC, a reasonable sensor and an execution mechanism and a feedforward+feedback control strategy based on case-based reasoning are adopted. dosage can be modified and optimized in advance through thickener feed concentration and flow signals monitored at real time, and thickener overflow and underflow concentration signals are utilized reasonably. System destabilization caused by feedback signal lag is avoided; problems, such as quality reduction of circulating water from a coal preparation plant, high drug consumption, high water consumption, etc., which are caused by inaccurate measurement of thickener overflow and underflow concentration during slime water treatment process in an existing coal preparation plant, poor reliability of a drug dosing execution mechanism, backward automatic control strategy, etc., are solved; and product quality and benefit of the coal preparation plant are enhanced.

The invention discloses a combined oil-suspended injection composition used for weeding, comprising the following components by weight percent: 2-20% of mesotrione, 2-10% of nicosulfuron, 15-50% of atrazine, 5-15% of emulsifiers, 1-3% of dispersant and the balance plant oil or esters of the plant oil. The composition of the invention has good synergistic effect and has especially obvious synergistic effect on broadleaf weeds. The composition also expands the weed control spectrum, reduces the drug consumption, improves the safety of the succeeding crops and can achieve stable weeding effects in arid regions or at low temperature.

The present invention discloses albumin nanoparticles, a preparation method and applications, wherein the albumin nanoparticles and an antibody or antibody drug conjugate (such as doxorubicin) are subjected to adsorption connection. According to the present invention, the experiment results show that: compared with the single drug, the nanoparticles modified with the antibody or antibody drug conjugate have advantages of enhancement of targeting property, and reduction of toxic-side effects of drugs on the body; and the formed albumin nanoparticles use the enhanced permeability and retention effect (EPR) of the tumor tissue to enhance the intratumoral accumulation so as to provide a certain slow release effect and a certain drug efflux inhibition effect, enhance the biological utilization rate of the drug, and reduce the drug consumption, such that the efficient and low-toxicity nanometer treatment way is provided for the tumor targeting therapy.

Diagnostic devices and methods involve comparison of relative levels of first and second components and/or characteristics of a fluid sample (e.g., saliva), preferably using antibodies arranged to interact with selected components, and colorimetric indicators that are bound or released in proportion to relative concentration or amount of the components or characteristics, as indicative of a health condition such as dehydration state, shock state, stress state, disease state, drug consumption, and drug metabolization. Amylase and IgA may be selected as specific salivary components of interest.

The invention discloses optimization of a wastewater fluorine-removal method and process through a sludge refluxing effect; fluorine-containing substances in water can be effectively removed; through combination of a lime fluorine-removal method and an efficient sedimentation tank process, process parameters are optimized; sludge in a sedimentation zone of an efficient sedimentation tank is refluxed to a flocculation zone according to a certain proportion, so that the concentration of the sludge in the flocculation zone is increased; a carrier is provided for calcium fluoride, fluorine removal is strengthened, the disadvantages of large lime addition amount and low treatment efficiency in a conventional general treatment process are improved, and lime is efficiently used. The method and process have the characteristics of good water quality of effluent, less drug consumption, high sludge solid containing rate, and small occupied land area.

The invention relates to a self-set concentration gradient drug screening organ chip and a preparation method thereof. The organ chip comprises a multi-cell co-culture system, a seed cell culture system, a blank control system and a drug testing system. The organ chip simultaneously can carry out activity or toxicity test and blank control experiment on drugs of eight drug concentration gradients at a time, so that the organ chip is simple in operation, can realize the parallel implantation and co-culture of various cells, reduce the application amount of actual samples, implement low drug consumption, and simplify a cell implantation process, therefore, the organ chip has portable, economical, efficient and accurate characteristics. The organ chip can independently carry out cell growth and culture and carry out multi-concentration gradient detection on drugs, and can carry out in-vitro, real-time and online observation on the biological behaviors of cells, tissues and organs, thereby providing a brand-new technical platform for cell-drug research and high-throughput drug screening.

The present invention discloses a gemcitabine chemical transfer prodrug, a preparation method and applications thereof, wherein the gemcitabine chemical transfer prodrug mainly comprises gemcitabine and a dihydropyridine chemical delivery system. According to the present invention, based on the dihydropyridine-pyridine ion oxidation-reduction reaction, gemcitabine and a targeting agent 3-quinolinic acid are bonded to prepare the reduced gemcitabine chemical transfer prodrug, the conjugate is promoted to diffuse into the brain tissue through the high lipid solubility, and in the brain, the pyridine part in the dihydropyridine brain-targeting chemical delivery system conjugate is oxidized into the oxidized gemcitabine chemical transfer prodrug by a coenzyme system; and the gemcitabine chemical transfer prodrug has effects of improvement of the amount of the drug entering the brain, enhancement of the drug efficacy, reduction of the drug consumption, and reduction of the drug toxic-side effect.

The invention discloses a high-intensity active carbon sedimentation basin. The sedimentation process thereof is characterized by comprising the following steps: reflowing the enriched sludge and the active carbon to a mixing basin by using the concentrating and separating effects of the sedimentation process and the active carbon on the turbidity materials, and obtaining the mixed liquid of which the concentrations of the sludge and the active carbon particles are high; and strengthening the removal of the turbidity materials and the organics in water by the capturing and adsorbing effects of the two carriers. According to the invention, the defect of the original conventional treating process that the utilization ratio of the added active carbon is low is overcome, and relatively stronger removal ability for stink smell, chroma and organics is provided for the conventional sedimentation process. The high-intensity active carbon sedimentation basin has the characteristics of good water quality, small drug consumption, high solid content of sludge, small occupation area, flexible operation control and strong adaptation ability on raw water quality. The sedimentation basin is developed based on the III-type raw water or raw water higher than III type, and has double functions of conventional treatment and deep treatment; and a completely new path to treat the serious raw water is provided. The sedimentation basin can be applied to the conventional treatment process or combined with the deep processing process when the quality of the raw water is poor.

An illegal drug sensing device provides a sensor coupled to a processor which evaluates the likely presence of illegal drug consumption and/or manufacture at a particular location. Upon the processor determining that such a condition is likely, an alarm is transmitted to at least one of locally or remotely such as through wired or wireless systems which are employed to alert at least one interested party such as the authorities (i.e., the police department) or a land owner of the likely presence of illegal drug activity at the premises.

The invention discloses a cloud-computing-based method for evaluating the malignant tumor chemoradiotherapy standard execution level and provides a set of indicators for evaluating malignant tumor chemoradiotherapy standardization. The method includes the following steps: 1), setting up a private cloud computing platform; 2), submitting information to a background server by a foreground intelligent medical office system; 3), calculating the malignant tumor chemoradiotherapy standard execution level by the background server; 4), feeding acquired related data of the malignant tumor chemoradiotherapy standard execution level back to the foreground intelligent medical office system by the background server. By the method, utilization rate of medical equipment can be effectively increased, drug consumption can be reduced, efficiency and reliability of mid-long-term drug storage and transport are improved. In addition, a reliable scheme is provided for storage and timely synchronous sharing of resources and information of malignant tumor chemoradiotherapy in China. Consequently, due to popularization and timely evaluation of standard criteria, a hospital system is more environment-friendly and more energy-saving.

The invention relates to an aluminium alloy anodized waste water belt type press filteration system. The system mainly comprises a sewage sedimentation tank, a flocculant stirring tank, a coagulation reactor and a belt type pressure filter, wherein the sewage sedimentation tank and the flocculant stirring tank are respectively connected with the coagulation reactor by a pipeline; the coagulation reactor guides the mixed liquid therein into a blanking hopper positioned on the belt type pressure filter by the pipeline. Compared with the prior art, the aluminium alloy anodized waste water belt type press filteration system has the following advantages of continuous production, stable performance, low maintenance rate, strong corrosion resistance, low energy and drug consumption, large treatment capacity, low water content of filter cakes, easy operation, easy maintenance and easy cleaning and the like. The aluminium alloy anodized waste water belt type press filteration system really solves the actual problems that the dehydration treatment of industrial acid-base neutralization waste residue has high energy consumption and low slag-pressing efficiency, thus being ideal equipment for saving energy, protecting environment, treating sewage, improving production efficiency and reducing labor intensity.

The invention relates to a citrate mosapride pill preparation and a preparing method thereof. The preparation has short time limit of dissolution and high velocity of drug release. The pill mainly comprises drugs, pill matrixes and other auxiliary materials. The dropping method for preparing pills has the advantages of simple equipment, convenient operation, short production cycle, accurate dose, small drug consumption in the operation process and stable quality, and can improve the bioavailability of insoluble drugs.

The invention belongs to the technical field of medical devices, and discloses a novel nursing instrument for children with pneumonia. The instrument includes a power switch, a control switch, a display screen, a liquid storage tank, an air pump, a dosing device, an injection hole, a sputum suction pump, an atomizer, a plastic pipe joint, an air inlet pipe, a hook, a pull line, an air intake hole,a breathing mask, an air outlet, an air outlet pipe, a sputum storage tank and a waste liquid outlet. A single chip computer obtains the breathing frequency through a breathing mask breathing frequency acquisition sensor, the air output of the air pump is adjusted according to the breathing frequency, and the problems are solved that the drug consumption in the atomization process in the prior art is related to the air output of atomization and can not be adjusted according to the breath state of a patient, inhalation of an atomized drug can not be synchronized with breathing of the patient and thus causing many drugs wasted and the treatment effect of atomization can not be well achieved. The consumption of the atomized drugs is matched with breathing of the patient, and the optimum drugtreatment effect can be achieved.

The invention discloses an antibacterial peptide live bacteria fermented feed, which is prepared from the following components by weight percent: 10-30% of wheat bran, 10-30% of corn bran, 30-40% of rice husk meal, 5-15% of cottonseed meal, 2-10% of corn flour, and 5-15% of a Chinese medicine fermented bag, wherein the Chinese medicine fermented bag includes 10 traditional Chinese medicinal components. The invention also discloses a preparation method of the antibacterial peptide live bacteria fermented feed. The fermented feed provided by the invention applies the animal microecology principles, takes high energy agricultural and sideline products, cake meal and by-products thereof, high quality fiber and other raw materials, and is formed by combined fermentation of lactic acid bacteria, yeast, bacillus and a variety of traditional Chinese medicines. The product has definite functions, can improve the digestion and utilization rate of feed, reduce drug consumption and enhance animal immune function.

The invention relates to a nicosulfuron-atrazine mixed herbicide, which contains the following effective ingredients: 2% (weight) of nicosulfuron and 20% (weight) of atrazine. The effective ingredients and known assistants can be compounded into conventional dosage forms including powder, wettable powder, suspension emulsions, missible oil and granules. With a wide weed control spectrum, the nicosulfuron-atrazine mixed herbicide can prevent and remove weeds in corn fields, and also can kill weeds in other crop fields. With outstanding advantages in the aspects of improving the weeding effect, reducing pesticide residual activity, lowering phytotoxicity, delaying the drug resistance occurrence of weeds and community succession, lowering drug consumption, and reducing environmental pollution, the mixed herbicide also saves time, labor and money simultaneously, thus being more easily acceptable to farmers.